Clinical trials: sponsored by University Hospital, Ghent
Parkinson Disease
Extended Reality Rehabilitation in Parkinson's Disease
This study investigates how different types of extended reality, Virtual Reality (fully immersive) and Mixed Reality (partly real-world), can be used in rehabilitation for people with Parkinson's disease.
- Trial name
- XR-PD (NCT07863102)
- Testing
- Extended reality balance training
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- University Hospital, Ghent
HIV-1-infection, HIV Seropositivity
Immuno-virological Evaluation of Persons Living With HIV (PLWH)
This is a dual arm (arm 1 and arm 2) multi-centric non-randomized (prospective) study. Two new multicentric cohorts will be set up in 4 Belgian HIV reference centers (UZ Gent, UZ Brussel, University Hospital Liege and St.
- Trial name
- NCT05973825
- Testing
- Leucapheresis
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- University Hospital, Ghent
Carcinomatosis, Peritoneal, Pancreas Cancer
Characterization of Biophysical Stromal Properties in Human Cancer: Towards Personalized Computational Oncology
Drug delivery in solid tumors, whether administered systemically or locoregionally, is hindered by an elevated interstitial fluid pressure (IFP).
- Conditions
- Carcinomatosis, Peritoneal, Pancreas Cancer, Ovarian Cancer, Colon Cancer
- Trial name
- DCE-MRI (NCT04512209)
- Testing
- MRI
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- University Hospital, Ghent
HIV-1-infection
2DR Versus 3DR in a Prospective Randomized Controlled Switch Trial
The aim of this study is to monitor virological and immunological markers in participants who are switching from a classic triple drug regimen (3DR) to dual therapy (2DR).
- Trial name
- 2DR (NCT04553081)
- Testing
- Dual versus triple therapy in treatment of HIV-1 infection.
- Where
- Belgium
- Volunteers
- 134 people
- Sponsor
- University Hospital, Ghent
Pharmacokinetics, Amoxicillin-clavulanate
Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO)
Pharmacokinetics of antibiotics in critically ill neonates, infants and children on extracorporeal membrane oxygenation (ECMO).
- Conditions
- Pharmacokinetics, Amoxicillin-clavulanate, Piperacillin-tazobactam, Meropenem
- Trial name
- PADECMO (NCT06426836)
- Testing
- Amoxicillin-clavulanate, Piperacillin-tazobactam, Meropenem
- Where
- 3 sites in Belgium
- Volunteers
- 300 people
- Sponsor
- University Hospital, Ghent
Stroke Gait Rehabilitation
Optimizing Gait Rehabilitation After Stroke
Following a cerebrovascular accident (CVA, also known as a stroke), hemiparesis occurs on the side opposite to the brain injury. This can lead to problems with walking and balance, as well as with arm movements whilst walking.
- Trial name
- NMC (NCT07798388)
- Testing
- VR-feedback application
- Where
- 3 sites in Belgium
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Healthy, Stroke
The Influence of Cortical Lateralization on Selective Motor Control of the Arm Swing During Independent Walking After Stroke.
The upper limbs play an essential role for safe and efficient walking in healthy persons and persons post-stroke. Nevertheless, in current post-stroke gait rehabilitation (research) the upper limbs are barely targeted.
- Trial name
- NCT06442579
- Testing
- Walking on a treadmill
- Where
- 2 sites in Belgium
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Gait
Normative Database for Gait Analysis on the GRAIL UZ Gent
The aim of this study is to collect a large set of norm/control data on an instrumented treadmill (the Gait Real-time Analysis Interactive Lab - GRAIL) at the university hospital of Ghent for the purpose of clinical studies as…
- Trial name
- B670201942108 (NCT04987346)
- Testing
- Walking on an instrumented treadmill, Walking on an instrumented treadmill while dual-tasking
- Where
- Belgium
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Liver Transplant Failure, Prognostic Biomarkers
Serum GLYcomics to Predict Graft Loss and Mortality After Liver Transplantation
The first 12 months after liver transplantation (LT) are decisive in posttransplant outcome, as almost half of deaths and two thirds of graft loss requiring retransplant occur in the first year after LT.
- Trial name
- GLYGALT (NCT05866796)
- Testing
- GlycoTransplantTest
- Where
- Belgium
- Volunteers
- 600 people
- Sponsor
- University Hospital, Ghent
Retinal Neovascularization, Macular Edema
Longterm Efficiency and Safety of Intravitreal Injections With Bevacizumab in Patients With Neovascularisation or Macular Edema
Although the safety and efficacy of bevacizumab has been established in several phase 3 trials, there is only little documented about the long-term safety and efficacy in the 'real-world practice' in large populations from…
- Trial name
- 2013-005056-15 (NCT03211741)
- Testing
- Bevacizumab Injection [Avastin]
- Where
- Belgium
- Volunteers
- 583 people
- Sponsor
- University Hospital, Ghent
Contraception
Evaluation of the Safety and Efficacy of the ReLARC Inserter During the Insertion Procedure of GYNEFIX Intrauterine Copper Bearing Contraceptive Device With a Follow-up of 3 Years.
Insertion under vision such as hysteroscopy allows the ability to visualize the uterus prior to insertion, to assess uterine compatibility and the assurance of proper device placement.
- Trial name
- ReLARC - REL-0 (NCT05702281)
- Testing
- ReLARC
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Colorectal Neoplasms, Colonic Polyps
A Novel Clinical Decision Support Tool to Predict Submucosal Invasive Cancer Within Large Non-Pedunculated Colorectal Polyps
Colorectal cancer can be effectively prevented by removal of pre-malignant polyps during colonoscopy. Large (>=20mm) non-pedunculated colorectal polyps (LNPCPs) require careful assessment before treatment.
- Trial name
- NCT07705880
- Where
- Belgium
- Volunteers
- 886 people
- Sponsor
- University Hospital, Ghent
Physical and Psychological Evaluation of Hormonal Therapy in Transsexual Persons
A European Network for the Investigation of Gender Incongruence
The physical and psychological effects of the hormonal treatment of transsexual persons are not sufficiently described. 'Transparency' wants to answer this question in a prospective manner, in a multicenter study to describe…
- Trial name
- ENIGI (NCT01072825)
- Testing
- questionnaires, blood sampling, clinical evaluation
- Where
- 4 sites in Belgium, Italy and 2 more
- Volunteers
- 125 people
- Sponsor
- University Hospital, Ghent
Anastomotic Leak Esophagus
OBSiDiAN in a Stapled Circular Esophagogastric Anastomosis After Ivor Lewis Esophagectomy
Oesophagectomy is very invasive surgery. A leakage at the level of the connection between oesophagus and stomach made during surgery causes a lot more problems and can lead to death.
- Trial name
- Obsidian ph II (NCT05713955)
- Testing
- Obsidian
- Where
- 2 sites in Belgium
- Volunteers
- 90 people
- Sponsor
- University Hospital, Ghent
Nurse Practitioners, Implementation Research
Role Development, Implementation and Evaluation of Nurse Practitioners
Hospitals face new challenges in providing sustainable high quality care as the prevalence of chronic conditions, multimorbidity and the complexity of care increases.
- Conditions
- Nurse Practitioners, Implementation Research, Quality of Care
- Trial name
- NUPRA-DI (NCT05520203)
- Testing
- Care provided by the Nurse Practitioner
- Where
- 2 sites in Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Fetal Growth Restriction, Cardiac Remodeling, Ventricular
Speckle Tracking Echocardiography as a Tool for Early Diagnosis of Impaired Fetal Growth Twin Pregnancies
In this project there are 2 time points during the pregnancy included, namely at 21 weeks and 30 weeks of gestation, to measure the predictive values of FGR, strain and strain rate.
- Conditions
- Fetal Growth Restriction, Cardiac Remodeling, Ventricular, Placental Insufficiency, Air Pollution
- Trial name
- HEART (NCT05423665)
- Testing
- sample collection
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 360 people
- Sponsor
- University Hospital, Ghent
Lung Cancer (Locally Advanced or Metastatic)
Identification of Changes in Cancer-related Fatigue and Physical Activity and Their Association in Patients With Inoperable Lung Cancer: a Longitudinal Observational Study
The goal of this observational study is to learn how fatigue changes during lung cancer treatment and how it relates to physical activity levels in adults with locally advanced, inoperable, or metastatic lung cancer who are…
- Trial name
- AcTiF (NCT07799974)
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University Hospital, Ghent
HIV, Seroconversion, HIV
Accurate Staging of Immuno-virological Dynamics During Acute HIV Infection
In this prospective longitudinal study we aim to assess how immunologic and viral aspects of the human immunodeficiency virus (HIV) viral reservoir, established during early HIV infection and responsible for viral rebound at…
- Trial name
- ACS (NCT03449706)
- Testing
- Early combination anti-retroviral treatment
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Pharmacokinetics, Amoxicillin-clavulanate
Antibiotic Dosing in Pediatric Intensive Care
Pharmacokinetics of antibiotics in critically ill neonates, infants and children
- Conditions
- Pharmacokinetics, Amoxicillin-clavulanate, Piperacillin-tazobactam, Vancomycin
- Trial name
- ADIC (NCT02456974)
- Testing
- blood sampling in patients receiving amoxicillin-clavulanate as part of routine clinical care, blood sampling in patients receiving piperacilline-tazobactam as part of routine clinical care., blood sampling in patients receiving vancomycin as part of routine clinical care.
- Where
- Belgium
- Volunteers
- 640 people
- Sponsor
- University Hospital, Ghent
Amoxicillin-clavulanate, Piperacillin-tazobactam
Precision Dosing of Beta-lactam Antibiotics in Critically Ill Children
The overall objective of this study is to investigate the impact of early model-informed precision dosing (MIPD) on target attainment of three beta-lactam antibiotics (amoxicillin-clavulanic acid, piperacillin-tazobactam and…
- Conditions
- Amoxicillin-clavulanate, Piperacillin-tazobactam, Meropenem
- Trial name
- MOMENTUM (NCT06929702)
- Testing
- Beta-lactam antibiotic, Beta-lactam model-informed precision dosing
- Where
- Belgium
- Volunteers
- 58 people
- Sponsor
- University Hospital, Ghent