Clinical trials: sponsored by University Hospital, Lille
SARS-CoV Infection, Covid19
Rapid Detection of COVID-19 by Portable and Connected Biosensor : Biological Proof of Concept
The main objective of this CorDial-S proof-of-concept study is to evaluate the ability to detect COVID-19 infection in nasopharyngeal swabs with CorDial-S and compare it to the PCR technique currently in use.
- Trial name
- COR-DIAL-S (NCT04780334)
- Testing
- COVID-19 RT-PCR, Biosensor
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Lille
Rheumatoid Arthritis
Impact of Rheumatoid Arthritis on Body Composition, Bone Marrow Adiposity and Bone Mineral Density: a Case-control Study
During rheumatoid arthritis (RA) (in comparison with control subjects), body composition is altered with a loss of lean body mass, bone mass and an accumulation of fat mass.
- Trial name
- RAFAT (NCT05269069)
- Testing
- Assessment of body composition, bone mineral density and bone marrow adiposity.
- Where
- France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Infection Viral, Coronavirus
PREdiction of DIagnosed Covid-19 infecTion in IUC Patients
Coronavirus 2019 (COVID-19) is a respiratory tropism virus transmitted through droplets emitted into the environment of infected persons.
- Conditions
- Infection Viral, Coronavirus, ARDS, Pneumonia
- Trial name
- PREDICT (NCT04327180)
- Where
- France
- Volunteers
- 368 people
- Sponsor
- University Hospital, Lille
Length of Stay
Evaluation of a Software for the Secondary Prioritization of Patients in the Pediatric Emergency Department
The goal of this randomized, controlled, open-label trial is to test the use of secondary prioritization software (Optimum®) in the pediatric emergency department (PED). The aim of this study is to determine: 1.
- Trial name
- OPTIMUM (NCT05994196)
- Testing
- Optimum, a secondary prioritization software of patients in the pediatric emergency department (ED)
- Where
- France
- Volunteers
- 1,599 people
- Sponsor
- University Hospital, Lille
Cystic Fibrosis
Prognostic Value of Functional Exercise Test (EFX) in Cystic Fibrosis
The objective of study is to prospectively determine if CPET with blood gas analysis should have a prognostic value in CF. The study plans to include 300 cystic fibrosis patients.
- Trial name
- EFX (NCT02994017)
- Testing
- cardiopulmonary exercise testing
- Where
- France
- Volunteers
- 287 people
- Sponsor
- University Hospital, Lille
Flu
Efficiency of Antagonist Drugs of the Cellular Transcriptomic Signature of Influenza A Virus Infection.
The aim of this study is to evaluate the possibility to repropose marketed drugs as antiviral ones, based on their ability to reverse the transcriptomic signature of the infected cells.
- Trial name
- FLUNEXT (NCT03212716)
- Testing
- Oseltamivir, Diltiazem
- Where
- 19 sites in France
- Volunteers
- 85 people
- Sponsor
- University Hospital, Lille
Anesthesia
Newborn Infant Parasympathetic Evaluation (NIPE) Index After Standardized Tetanic Stimulations Under General Anesthesia
NIPE monitor is the recently developed pediatric version of the ANI monitor, which is used in adults to monitor analgesia during general anesthesia.
- Trial name
- NIPESTIM (NCT04381637)
- Testing
- NIPE monitor, Tetanic stimulations
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Lille
Anesthesia, Nociceptive Pain
NIPE Monitoring Values During Routine Pediatric Anesthesia
Description of the standard values and fluctuations of the new NIPE index during routine pediatric anesthesia. NIPE monitor connected to anesthesia monitor, displays an instantaneous value ranging from 0 to 100.
- Trial name
- OMNIPED (NCT04432480)
- Testing
- NIPE (Newborn Infant Parasympathetic Evaluation) monitoring
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Lille
Asthma
Multidimensional Assessment of Dyspnea in Asthma
Breathlessness is a symptom of asthma that occurs in relation with lower airway obstruction. However, this sensation is not specific of asthma and may be the expression of other disorders.
- Trial name
- MIDAS (NCT04286906)
- Testing
- Questionnaire
- Where
- 5 sites in France
- Volunteers
- 133 people
- Sponsor
- University Hospital, Lille
Intensive Care Unit Syndrome
Bedside Therapeutic Monitoring of β-Lactam Levels in Newborns, Children and Adolescents Admitted to Intensive Care.
This study evaluate the capacity of the MON4STRAT device for drug monitoring of β- lactam antibiotic concentrations in newborns, children, and adolescents admitted in intensive care units with a health care-associated infection.
- Trial name
- MON4STRAT (NCT03404089)
- Testing
- pharmacokinetic device
- Where
- France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Lille
Crohn Disease, Ulcerative Colitis
Quality of Life for Patients With Chronic Paediatric Onset Inflammatory Bowel Disease (IBD)
The main objective of the present study is to describe the quality of life of patients under 25 years of age with pediatric-onset IBD.
- Trial name
- QALY-ECOPED (NCT04881370)
- Where
- France
- Volunteers
- 298 people
- Sponsor
- University Hospital, Lille
Cryopyrin Associated Periodic Syndrome
Adult Outcomes of Children With CAPS
The patients included in this study were followed up in the Internal Medicine and Paediatrics Departments of the Lille CHU, the Paediatric Rheumatology and Immunology Department of the Necker Enfant Malade Hospital in Paris and…
- Trial name
- CAPS (NCT04856540)
- Where
- France
- Volunteers
- 54 people
- Sponsor
- University Hospital, Lille
Covid19, Systemic Autoimmune Disease
Mental Health Consequences of COVID19 Infection in the French RMD Cohort
this observational, cross-sectional, national, comparative study, including RMD patients followed in hospital centres of the FAI²R Rare Diseases Healthcare Pathway network and specialist private practitioners caring for patients…
- Conditions
- Covid19, Systemic Autoimmune Disease, Inflammatory Rheumatism, Auto Inflammatory Diseases
- Trial name
- MentCovid19RMD (NCT04510467)
- Where
- France
- Volunteers
- 296 people
- Sponsor
- University Hospital, Lille
Obstetric Labor
Multisensor Technology for Beat to Beat Fetal Heart Rate Measurement
The CIC-IT 1403 laboratory of the University Hospital of Lille has developed a technological solution for acquiring and synchronizing abdominal ECG, acoustic and Doppler signals.
- Trial name
- RCF-ABDO (NCT03741569)
- Testing
- Transabdominal Fetal Heart Rate
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Lille
Postoperative Pain, Chronic Pain
Preoperative Gabapentin for Chronic Pain After Thoracotomy (GABATHOMIE).
To assess the effects of prolonged preoperative gabapentin treatment (10 days) on chronic pain after thoracotomy.
- Trial name
- GABATHOMIE (NCT03158376)
- Testing
- Gabapentin
- Where
- France
- Volunteers
- 201 people
- Sponsor
- University Hospital, Lille
Thoracic Injuries
Comparison of McGrath and Macintosh Laryngoscopes for Insertion of a Double Lumen Tube by Residents
The insertion of double lumen tube is difficult even more if it is a resident with no experience. we think that using videolaryngoscopes for novice ones would facilitate insertion of double lumen tube thanks to the visualization…
- Trial name
- MacGrathDES (NCT03710096)
- Testing
- macGrath, Macintosh's
- Where
- France
- Volunteers
- 148 people
- Sponsor
- University Hospital, Lille
Fractures, Bone, Bone Marrow Disease
Bone Marrow Adiposity and Fragility Fractures in Postmenopausal Women
The purpose is to determine in a case-control study if an association exist between bone marrow adiposity and fragility fractures in post-menopausal women.
- Conditions
- Fractures, Bone, Bone Marrow Disease, Fat Disorder, Adiposity
- Trial name
- ADIMOS (NCT03219125)
- Testing
- Dixon Magnetic Resonance Imaging, dual-energy X-ray absorptiometry (DXA)
- Where
- France
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Critical Illness
Innate Immunity Gene Polymorphisms and Yeast Colonization
It is proposed to carry out the study in three medical or surgical intensive care units (ICU) in the CHRU, Lille, and the CHU, Besançon.
- Trial name
- Candigene (NCT02888860)
- Where
- 6 sites in France
- Volunteers
- 2,200 people
- Sponsor
- University Hospital, Lille
Endothelial Cell
IL-33, Endocan and Endothelial Cells
The study aims to investigate the inflammatory response of endothelial cells to various stimulations, in particular the production of IL33 and of endocan in response to allergens, agonists of microorganisms and pollutants.
- Trial name
- IL-33 (NCT03984383)
- Where
- France
- Sponsor
- University Hospital, Lille
Diabetic Foot
Physical Activity Assessment of Patients With Diabetic Foot Wounds
The study evaluates the compliance of patients who suffer from a diabetic foot wound to follow a physical activity program, adapted to their medical condition.
- Trial name
- EFADDIAP (NCT04582357)
- Testing
- Physical activity program
- Sponsor
- University Hospital, Lille