Clinical trials: sponsored by University Hospital, Lille
Cardiac Surgery
Optimization Strategy for Oxygen Delivery Under Cardiopulmonary Bypass
Cardiac surgery is a frequent procedure that can lead to serious complications, including acute kidney injury (AKI) or postoperative delirium.
- Trial name
- OPTI-DO2 (NCT05984563)
- Testing
- Cardiopulmonary bypass
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Lille
Alcoholic Liver Disease
Study of Alcohol-related Liver Disease in Europe
Alcohol-induced liver injury is made up of fatty liver, fibrosis and alcoholic hepatitis (AH), elementary lesions that may occur separately, simultaneously or sequentially in a same patient.
- Trial name
- SALVE (NCT04400604)
- Where
- France
- Volunteers
- 7,500 people
- Sponsor
- University Hospital, Lille
Alzheimer Disease, ELECTROENCEPHALOGRAPHIC VARIANT PATTERN 1 (Disorder)
Neurophysiological Correlates of Cognitive Tasks in Healthy Volunteers -WP3 P003
In the perspective to better evaluate the efficacy of new treatment strategies for Alzheimer disease (AD), it appears important to develop experimental paradigms to precisely measure cognitive endpoints/biomarkers that may be…
- Trial name
- PharmacogWP3 (NCT02899403)
- Testing
- Rapid Visual Information Processing (RVIP) test
- Where
- France
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Patient Treated With Lithium, With Bipolar or Schizo-affective Disorder, Hospitalized in a Psychiatric Ward
Validation of the French Version of the Lithium Knowledge Test (LKT)
Lithium is a drug used to treat several psychiatric illnesses. This medication requires particular vigilance because it has a narrow therapeutic margin: the dose necessary to obtain an effective treatment is close to the toxic…
- Trial name
- LKT (NCT06033326)
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Lille
Frontotemporal Dementia
GENetic Fronto Temporal Dementia Initiative in Lille
GENFI Lille is a French cohort that belongs to the international initiative GENFI2, a five year longitudinal biomarker cohort study of genetic FTD and its associated disorders (including MND/ALS) investigating members of families…
- Trial name
- GENFI-LILLE (NCT04639622)
- Testing
- Investigation procedures
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Lymphatic Malformation, Pediatric
Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations
To evaluate the efficacy of Rapamycin in extended cervicofacial lymphatic malformations in pediatric patients. Rapamycin is administered oral for a 6 month period.
- Trial name
- RAPAMALYMPH (NCT03243019)
- Testing
- rapamycin, MRI, Rapamycin dosage
- Where
- 2 sites in France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Lille
Heart Failure, Aortic Stenosis
Von Willebrand Factor As a Biological Sensor of Blood Flow in Percutaneous Cardiac Procedure
The WITAVI study was designed to explore the kinetic and associated outcome of Von Willebrand Factor-multimerizaton defects associated with devices in cardiovascular diseases.
- Trial name
- WiTAVi (NCT02628509)
- Testing
- cardiac devices
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Lille
Cerebral Microbleeds, Congenital Haemophilia, Congenital Von Willebrand Disease
Severe Congenital Hemostatic Defects, Cerebral MIcrobleeds and COGnition
Cerebral microbleeds (CMBs) are haemosiderin deposits, resulting from the leakage of erythrocytes from small cerebral vessels, which can be detected noninvasively using susceptibility-sensitive magnetic resonance imaging (MRI)…
- Trial name
- HEMICOG (NCT06090201)
- Testing
- 3-Tesla brain MRI and a comprehensive neuropsychological assessment
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Lille
Child Behavior Disorders, Mother-child Relations
MOther-Child Interaction Assessment TRAINING for Pediatricians
The originality of the MOCITRAINING study lies in the integration of infant and maternal care during the pediatric consultation and the assessment of the impact of this type of care in the short and medium term on The…
- Conditions
- Child Behavior Disorders, Mother-child Relations, Depression, Postpartum
- Trial name
- MOCITRAINING (NCT03300713)
- Testing
- MOCITRAINING program, usual follow-up
- Where
- France
- Volunteers
- 3,504 people
- Sponsor
- University Hospital, Lille
Attempted Suicide
Evaluation of the Links Between Sleep Disorders and the Risk of Suicide Attempt
Several studies have demonstrated an association between sleep disorders such as insomnia and nightmares to suicidal ideations and behaviors.
- Trial name
- HYPNOS (NCT03793699)
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Lille
Lymphoma, Follicular
Long-term Ovarian Fertility in Patients Treated for Lymphoma.
This is an observational, single-center, longitudinal cohort study. In order to evaluate the gonadotoxicity of chemotherapy, an AMH monitoring was initiated in 2006 in our fertility observatory in young patients with lymphoma…
- Trial name
- FERTILymph (NCT05616325)
- Where
- France
- Volunteers
- 270 people
- Sponsor
- University Hospital, Lille
Pediatric Cancer, Chronic Sinusitis
Post-radiotherapy Rhinosinusitis in Children
Chronic rhinosinusitis (CRS) is a frequent complication of facial cancer treatment, mainly related to radiotherapy. However, while radiological involvement is frequent, clinical expression seems less important.
- Trial name
- PRRSC (NCT05454163)
- Testing
- SNOT 22 questionnaire
- Sponsor
- University Hospital, Lille
Catatonia
Blood Concentration in Lorazepam and Treatment in Adult Catatonia
Catatonia is a severe form of psychomotor disturbance with a heterogenous presentation. It affects approximately 10% of acute psychiatric inpatients.
- Trial name
- PHARMAPREDICAT (NCT04530734)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Lille
Severity of Illness Index
Performance for French Pediatric Intensive Care Units
Introduction. The measurement of severity scores in adult and pediatric resuscitation provides a tool for evaluating the clinical performance of resuscitation services.
- Trial name
- QUAL-REAPED (NCT05491018)
- Volunteers
- 13,270 people
- Sponsor
- University Hospital, Lille
Alcohol Abuse
Evaluation of the Threshold for the Interpretation of the Results of a Method for the Blood Determination of Phosphatidyléthanol
For an analytical validation of the method for the determination of blood hosphatidylethathanol, it is necessary to: to compare the results of chronic and excessive ethanol patients with the cut-off proposed in the literature.
- Trial name
- PETHOXICO (NCT04557631)
- Sponsor
- University Hospital, Lille
Obesity, Diabetes
Comparison of Gastric By-Pass and Optimized Medical Treatment in Obese Diabetic Patients
The objectives are to compare the results of the Gastric By-Pass (GBP) to that of optimized medical therapy in patients with obesity and poorly controlled type 2 diabetes in terms of mortality, weight loss, glycemic control…
- Trial name
- DIABSURG (NCT01501201)
- Testing
- Gastric By-Pass, optimized medical management
- Where
- 10 sites in France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Lille
Stroke, Stroke Sequelae
Neural Bases of Post-stroke Emotion Perception Disorders
This monocentric physiological study will evaluate the neural bases of visual recognition of emotions in stroke patients vs. healthy controls using MRI (functional and structural connectivity) and EEG.
- Conditions
- Stroke, Stroke Sequelae, Emotions
- Trial name
- STROKEM (NCT05595005)
- Where
- France
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Lung Cancer
A Clinico-biological Database of Lung Cancers
This prospective, single-center, interventional study is conducted in order to achieve a biological bank accompanied by clinical data.
- Trial name
- Bio-lung (NCT03387865)
- Testing
- tissue biopsies, blood sampling, DNA banking
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Lille
Metabolic Disease
Signature of the Risk Profile of Mortality in a Hospital Cohort of Patients With Metabolic Diseases
Epidemiological studies are usually conducted in the general population in adults without complications or pathology at baseline. The results obtained are therefore often better designed for primary prevention use.
- Trial name
- INTEGRA (NCT04194372)
- Where
- 3 sites in France
- Volunteers
- 10,000 people
- Sponsor
- University Hospital, Lille
Covid19, SARS-CoV Infection
Collection of the Thrombo-VaxCov Cohort
In the context of anti-Covid19 vaccination, atypical thrombosis have occured and potential link with vaccination is under investigation.
- Conditions
- Covid19, SARS-CoV Infection, Venous Thrombosis, Thrombocytopenia
- Trial name
- THROMBO-VAXCOV (NCT04889326)
- Testing
- Retrospective data and biological samples
- Where
- France
- Sponsor
- University Hospital, Lille