Clinical trials: sponsored by University Hospital, Lille
Alcoholic Liver Disease, Severe Alcoholic Hepatitis
Study of Genetic Determinants in Alcoholic Hepatitis and Establishment of a Multicenter Prospective Cohort of Patients With Alcoholic Liver Disease
Alcoholic hepatitis carries a risk of high mortality at short term, especially in its severe form. Its diagnosis is confirmed by liver biopsy.
- Conditions
- Alcoholic Liver Disease, Severe Alcoholic Hepatitis, Alcoholic Cirrhosis
- Trial name
- COMADHAA (NCT04106518)
- Where
- 9 sites in France
- Volunteers
- 447 people
- Sponsor
- University Hospital, Lille
Intracerebral Hemorrhage, Hemorrhagic Risk Conditions
Ex Vivo Reproduction of Minimally Invasive Surgery With Hematoma Lysis Using Modified Tissue Plasminogen Activator for Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is associated with high mortality and long-term disability, and effective treatment options remain limited.
- Conditions
- Intracerebral Hemorrhage, Hemorrhagic Risk Conditions, Bleeding Disorders
- Trial name
- MIMICK-TIPITCH (NCT07411079)
- Testing
- Ex vivo exposure to modified rtPA
- Where
- France
- Volunteers
- 1,126 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Coxarthrosis
Comparison of the Restoration of Hip Biomechanical Parameters by CT Measurement Between the 3 Surgical Techniques: RSA/Minihip/THA - Hip Replacement: 3D Planning
The study will analyze hip biomechanical parameters using EOS radiographic measurements pre- and post-operatively (3 months) and post-operatively (3 months) CT scans after total hip replacement (THR), neck-preserving THR of the…
- Trial name
- HIP3D (NCT06272422)
- Testing
- hip arthroplasty
- Where
- France
- Volunteers
- 165 people
- Sponsor
- University Hospital, Lille
Nitrous Oxide Abuse
Biological Diagnosis and Monitoring of Chronic Nitrous Oxide Abuse
There is a toxicity linked to the chronic use of nitrous oxide, leading to neurological disorders such as combined sclerosis of the spinal cord.
- Trial name
- BALON (NCT05540561)
- Testing
- blood collection
- Where
- 8 sites in France
- Volunteers
- 356 people
- Sponsor
- University Hospital, Lille
Syndactyly
Remote Assesment of Functional Sequelae in Patients Operated for Congenital Syndactyly
The aim of th study is to evaluate patients who have been operated for congenital syndactylies. The surgical technique has evolved, and the donnor site for the total skin graft is not the same than 10 years ago.
- Trial name
- DISTSSEQUELO (NCT07596862)
- Testing
- Consultation
- Where
- France
- Volunteers
- 37 people
- Sponsor
- University Hospital, Lille
Specific Antibody Deficiency, Predominantly Antibody Deficiencies
Frequency of SPAD in Adult Patients
The DETECT study aims to demonstrate the importance of detecting SPAD in adult patients with recurrent benign and/or severe unexplained bacterial upper/lower respiratory tract infections.
- Trial name
- DETECT (NCT05664035)
- Testing
- Diagnosis of SPAD using immunization with PPV23
- Where
- France
- Volunteers
- 99 people
- Sponsor
- University Hospital, Lille
Alzheimer Disease, Frontotemporal Dementia
Tanycytes in Alzheimer's Disease and Frontotemporal Dementia
Metabolic and hormonal deregulations are both a risk factor and a hallmark of Alzheimer's disease (AD) and frontotemporal dementia (FTD), occurring early in the course of the disease.
- Trial name
- BIOWATCH (NCT05288842)
- Testing
- Lumbar puncture, blood sample
- Where
- France
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Von Willebrand Disease (VWD)
Algorithm-based Management to Reduce the Recurrence of GI Bleeding and Severe Epistaxis in Von Willebrand Disease
WILL MANAGE is a prospective multicenter controlled open label randomized trial comparing an algorithm-based multidisciplinary management to a standard of care to reduce the incidence of bleeding (GI bleeding or severe epistaxis)…
- Trial name
- WILL MANAGE (NCT06651255)
- Testing
- Optimized management, Standard of care management
- Where
- 17 sites in France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Lille
Palate, Cleft
Evaluation of Quality of Life After Orthognathic Surgery in a Cleft Lip and Palate Context
The purpose of this study is to compare, prospectively, the quality of life of patients with cleft lip and palate before and after orthognathic surgery.
- Trial name
- ORTHOQOL (NCT04049058)
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Lille
Mental Health Issue
Evaluation of the Mental, Physical and Social Conditions of Prison Entrants in the Nord-Pas-de-Calais Region" - Cross-sectional Survey Representative Sample, Prevalence Study
The aim of the study was to estimate prevalence rates of psychiatric and substance use disorders in male and female prisoners on admission to prison in the north of France and compare the frequency of these disorders to the…
- Trial name
- SPC (NCT07593703)
- Volunteers
- 697 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Obesity, Bariatric Surgery Candidate
Impact of Weight Loss Induced by Bariatric Surgery or Nutritional Management on Sexual Function in Men With Severe Obesity
Study of the impact of weight loss induced by surgery (interventional group) or optimal nutritional management (control group) on sexual function in men with severe obesity
- Trial name
- SexOb (NCT03528980)
- Where
- 3 sites in France
- Volunteers
- 59 people
- Sponsor
- University Hospital, Lille
Rhinosinusitis Chronic, Nasal Polyps
BIOlogics in Severe Nasal POlyposis SurvEy.: a French Registry
With a prevalence of 2-4% in western countries, Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is of major concern regarding its substantial impact on the social and physical quality of life.
- Trial name
- BIOPOSE2 (NCT06501807)
- Testing
- Biologic treatments available in Chronic Rhinosinusitis with Nasal Polyps (dupilumab, mepolizumab and benralizumab according to their marketing approval).
- Where
- 2 sites in France
- Volunteers
- 900 people
- Sponsor
- University Hospital, Lille
Multiple Sclerosis, Optic Neuritis, Demyelinating Disease
Visual (Path)Ways in Multiple Sclerosis - Part II
Multiple sclerosis (MS) is an inflammatory demyelinating and degenerative disease of the central nervous system. The mechanisms of neuro-axonal loss remain incompletely elucidated.
- Trial name
- VWIMS - II (NCT06776224)
- Testing
- Measurement of retinal vascular density and visual cognition
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Lille
Cannabis User
Effect of Acute Exercise on Cognitive Functions and Blood Markers of Brain Plasticity in Regular Chronic Cannabis Users
The endocannabinoid system (ECS) is a complex endogenous signaling system made up of transmembrane cannabinoid receptors (CB1 and CB2 receptors), their endogenous lipid-derived ligands (the endocannabinoids - eCBs), and enzymes…
- Trial name
- CANNABEX (NCT06081218)
- Testing
- activity test
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Bone Metastases
Regional Database for Collecting Clinical-biological and Imaging Data "Secondary Bone Oncology and Bone Localizations of Hematologic Diseases"
Improving the effectiveness of cancer treatments makes it possible to lengthen patient survival. It is therefore important to ensure that the quality of life is also maintained by reducing pain and handicap.
- Trial name
- OOSLOH (NCT05495802)
- Sponsor
- University Hospital, Lille
Stroke, Hemiparesis
rTMS Posterior Parietal Cortex Modulation and Upper Limb Movement After Stroke
This study evaluates the effect of a unique session of inhibitory rTMS (cTBS) over the contralesional posterio parietal cortex (PPC) on the spatio-temporal parameters of a pointing movement performed by stroke patients with their…
- Conditions
- Stroke, Hemiparesis, Transcranial Magnetic Stimulation, Brain Connectivity
- Trial name
- PPCstim (NCT03323255)
- Testing
- repeated transcranial magnetic stimulation continuous theta-burst stimulation
- Where
- France
- Volunteers
- 1 people
- Sponsor
- University Hospital, Lille
Cardiac Amyloidosis, Transthyretin Amyloidosis
Retrospective Identification of Scintigraphic Cardiac Amyloidosis (RISCA)
This study aims to determine the positive predictive value of incidental cardiac uptake on bone scintigraphy for diagnosing transthyretin cardiac amyloidosis, in patients who underwent scintigraphy for reasons other than…
- Trial name
- RISCA (NCT06921408)
- Volunteers
- 57 people
- Sponsor
- University Hospital, Lille
DRESS Syndrome
Interest of a Targeted Therapy for the Treatment of a Severe Form of Hypersensitivity to Drug (DRESS Syndrome)
Drug Reaction with eosinophilia and Systemic Symptoms (DRESS) is a rare and severe multiorgan drug reaction whose pathophysiological mechanisms underlying remain unclear, but may involve the role of several immune cells like…
- Trial name
- BENRADRESS (NCT06734884)
- Testing
- Benralizumab 30 MG/ML [Fasenra]
- Where
- France
- Volunteers
- 96 people
- Sponsor
- University Hospital, Lille
Thoracic Aortic Aneurysm
Incidence of Major Complication in Case of Thoracic Aortic Aneurysm
Thoracic aneurysm is a silent disease with a potential mid-term high risk of death or major complications. Few data are available on the real incidence of major complications in case of small and moderate thoracic aneurysm.
- Trial name
- MOTAAR (NCT05395598)
- Where
- France
- Volunteers
- 320 people
- Sponsor
- University Hospital, Lille
Parkinson Disease
Cognitive Phenotypes in Parkinson's Disease
a data driven approach has identified different cognitive phenotypes in Parkinson's disease (PD) this heterogeneity possibly reflects the diversity of the neuronal damage caused by the disease we hypothesize that the different…
- Trial name
- CogPhenoPark (NCT01792843)
- Testing
- data
- Where
- Netherlands
- Volunteers
- 158 people
- Sponsor
- University Hospital, Lille