Clinical trials: sponsored by University Hospital, Limoges
Healthy Volunteers
Epidemiology of Human Cytomegalovirus Excretion in the Saliva of Children Attending Nursery in France
Direct DNA amplification, viral isolation and specific antibody measurement in saliva from children attending nursery in France Sample collection will be done by the pediatrician the nurse, or one of the authorized investigators…
- Trial name
- CrèchMV (NCT01704222)
- Where
- France
- Volunteers
- 2,001 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Staphylococcus Aureus
Community-acquired Methicillin-Resistant Staphylococcus Aureus Carriage Among Athletes
There are only very few data about the prevalence of CA-MRSA in France and no in athletes. In USA, the clone USA300 is widely disseminated and in Europe the clone ST80 predominates.
- Trial name
- PSARM-S (NCT01148485)
- Testing
- Nasal, throat, inguinal and skin lesions swab samples will be performed
- Volunteers
- 300 people
- Sponsor
- University Hospital, Limoges
Liver Transplantation
Reduction in the Risk of Rejection by Mycophenolate Mofetil Dose Adjustment in Liver Transplant Patients With Side Effects Caused by the Calcineurine Inhibitors
The aim of this project is to determine whether, in liver transplant patients with side effects due to ICN, the use of MMF in monotherapy can be optimised by dose adjustment based on the area under the curve (AUC) of mycophenolic…
- Trial name
- MONOCEPT (NCT00456235)
- Testing
- Mycophénolate Mofétil, Ciclosporine A, Tacrolimus
- Where
- 17 sites in France
- Volunteers
- 92 people
- Sponsor
- University Hospital, Limoges
Chronic Hepatitis B
Evaluation of cccDNA and Total HBV DNA Kinetics in Lymphocytes, Total Blood and Serum in Chronic Hepatitis B Patients Treated With Adefovir Dipivoxil and Peg Interferon Alpha 2a
Serum HBV DNA is a referent but insufficient marker of therapeutic follow-up in chronic hepatitis B treatment. Intra hepatic cccDNA disappearance reflects HBV eradication in the liver.
- Trial name
- DNA-EVAL (NCT00199732)
- Where
- 4 sites in France
- Volunteers
- 19 people
- Sponsor
- University Hospital, Limoges
Primary Sjögren Syndrome
Neurotrophins Implications in Primary Sjögren Syndrome
Neurotrophins (NTs) constitute a family of growth factors, which regulated differentiation, proliferation, and survival of both neuronal cells and astrocytes.
- Trial name
- Neuro-SGSp (NCT01081184)
- Testing
- blood sample
- Where
- 2 sites in France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Colorectal Cancer
Positron Emission Tomography (PET) Interest in the Follow Up of Colorectal Cancer Stage II and III
The follow up of colorectal cancer after curative surgery has to find loco-regional relapses or synchronous metastases, and to detect adenomas and new cancer on the rest of the colon.
- Trial name
- NCT00199654
- Testing
- PET
- Where
- 5 sites in France
- Volunteers
- 376 people
- Sponsor
- University Hospital, Limoges
Lymphoma, Non-Hodgkin
Association of L-asparaginase-Methotrexate-Dexamethasone for Nasal and Nasal-type Natural Killer (NK)-T-cell Lymphoma
Nasal/nasal type NK-T-cell lymphoma is a rare and severe type of non-Hodgkin's lymphoma (NHL) more frequent in Asia than in western countries. When localised, radiotherapy seems to be the best treatment.
- Trial name
- NCT00283985
- Testing
- Kidrolase, Methotrexate, Dexamethasone
- Where
- 25 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Limoges
Pain
Drug Interactions Between Paracetamol and Setrons in Pain Management
The aim of this study is to demonstrate that the association paracetamol / ondansetron is not as effective as the association paracetamol / droperidol in the treatment of pain in children following tonsillectomy.
- Trial name
- PARATRON (NCT01432977)
- Testing
- paracetamol /droperidol, paracetamol / ondansetron
- Where
- 2 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Limoges
Cardio-vascular Events
Systolic Pressure Index in Assessing the Risk of Cardiovascular Events
To investigate whether the presence of a Systolic pressure index (<0.9 or> 1.4) is a marker of risk of cardiovascular events after peri-operative high-risk surgery outside the cardiac and vascular surgery.
- Trial name
- IPS (NCT00925964)
- Where
- France
- Volunteers
- 504 people
- Sponsor
- University Hospital, Limoges
Lymphocele
Prevention of Lymphorrhea by Lanreotide in Axillary Dissection for Breast Cancer
Injection the day before surgery of 90 mg of Lanreotide LP sub-cutaneously or placebo. Evaluation of the lymphorrhea in the 2 arms of the study
- Trial name
- NCT00630695
- Testing
- Lanreotide LP 90
- Where
- France
- Volunteers
- 148 people
- Sponsor
- University Hospital, Limoges
Acute Coronary Syndrome
Continuous Versus Interval Training in Patients With Coronary Artery Disease: FRAXIO Study
The benefits of cardiac rehabilitation have been clearly demonstrated. In particular exercise training is recognized to be part of modern management after coronary artery disease.
- Trial name
- FRAXIO (NCT00754533)
- Testing
- Continuous versus interval training
- Where
- 2 sites in France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Limoges
Hodgkin's Disease, Malignant Lymphomas High Grade
Prediction of the Response to Chemotherapy by Tomoscintigraphie the MIBI in the Balance Sheet Pre Hodgkin's Disease and Lymphoma Malins High Grade
Predicting response to chemotherapy in patients with Hodgkin's disease or lymphoma high-grade malignant de novo or recurrence. The non-Hodgkin's lymphoma and high-grade Hodgkin's disease may show resistance to chemotherapy…
- Conditions
- Hodgkin's Disease, Malignant Lymphomas High Grade, Chemoresistance
- Trial name
- MIBI (NCT00551798)
- Testing
- TEP au MIBI
- Where
- 5 sites in France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Limoges
Lung and Heart-lung Transplantation
Bayesian Dose Adjustment of Immunosuppressants After Lung Transplantation
The purpose of this study is to evaluate in lung or heart-lung transplant patients on tacrolimus and mycophenolate the impact of optimized mofetil (MMF) therapeutic drug monitoring and dose adjustment of both drugs on the…
- Trial name
- BASALT (NCT00975663)
- Testing
- Tacrolimus and MMF
- Where
- 9 sites in Belgium, France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Limoges
Cardiac Surgery, Bleeding
Perioperative Coagulation Management in Cardiac Surgery.
Cardiac surgery is bleeding requiring transfusion surgery . The haemorrhagic is related to the need to use high doses of anticoagulants to prevent thrombosis of blood .
- Trial name
- ROTEM (NCT00772239)
- Testing
- Rotation thromboelastometry (ROTEM), Standard coagulation managment procedure
- Where
- 4 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Limoges
Chondrocalcinosis, Articular Cartilage Calcification
Ultrasound and X-ray in Detecting Articular Cartilage Calcification
Prospective study with an echography of the 2 knees and radiography of the 2 knees (front and profile) for each patient. If found calcification on ultrasound further examination with ultrasound wrists, hips and shoulders.
- Trial name
- chondro (NCT00797537)
- Testing
- Echography
- Where
- France
- Volunteers
- 166 people
- Sponsor
- University Hospital, Limoges
Hallux Valgus
Chevron Osteotomy Versus SCARF Osteotomy in the Treatment of Hallux Valgus
Comparison between two techniques of osteotomy wich are more or less invasive : two criterias : clinical data and x-rays data. All patients operated for hallux valgus for 01/01/99 to 31/12/03 in the department of bone surgery CHU…
- Trial name
- NCT00455676
- Testing
- Chevron osteotomy versus Scarf osteotomy
- Where
- France
- Volunteers
- 74 people
- Sponsor
- University Hospital, Limoges
Spastic Equinovarus
Treatment of Spastic Equinovarus Foot After Stroke
This study evaluates treatment for spastic foot after stroke using ankle foot orthosis with or without selective injection of BTA (Botox).
- Trial name
- NCT00199589
- Testing
- Botulinic toxin (Botox)
- Where
- 2 sites in France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Limoges
Kidney Transplant Recipients
Concentration Controlled Versus Fixed Dose of MMF in Kidney Transplant Recipients
Acumulating data suggest that thrapeutic drug therapeutic may optimize efficacity and tolerance of MMF. It could guarantee better exposure to the drug in the first 3 months and then minimize side effects in the long term.
- Trial name
- NCT00199667
- Testing
- Mycophenolate Mofetil
- Where
- 11 sites in France
- Volunteers
- 137 people
- Sponsor
- University Hospital, Limoges
Bullous Pemphigoid
Leflunomide Associated With Topical Corticosteroids for Bullous Pemphigoid
Bullous pemphigoid (BP) is the most common blistering auto-immune disease of skin with an incidence estimated to 400 new cases per year.
- Trial name
- ARABUL (NCT00802243)
- Testing
- leflunomide
- Where
- 3 sites in France
- Volunteers
- 54 people
- Sponsor
- University Hospital, Limoges
Primary Systemic Amyloidosis (AL)
Intensive Versus Conventional Treatment in Patients With Primary Amyloidosis
AL amyloidosis is caused by a clonal plasma cell dyscrasia and characterized by progressive deposition of amyloid fibrils derived from monoclonal Ig light chains, leading to multisystem organ failure and death.
- Trial name
- NCT00344526
- Testing
- Melphalan, Dexamethasone, Autologous stem cell transplantation
- Where
- 8 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Limoges