Clinical trials: sponsored by University Hospital, Montpellier
Drug Hypersensitivity
Optimal Doses for Drug Provocation Tests to Beta-lactams
Drug provocation tests (DPT) are widely in case of suspicion of drug hypersensitivity (and in the absence of contraindications), but there are no standardized protocols and most groups use hypothesis (clinically-driven)…
- Trial name
- NewBL (NCT02839551)
- Testing
- simplified drug provocation test
- Where
- France
- Volunteers
- 1,252 people
- Sponsor
- University Hospital, Montpellier
Funnel Chest
Cardiorespiratory Assessment and Quality of Life After Surgical Correction of Congenital Wall Malformations
The main objective of this study is to characterize the cardiorespiratory functional gain in patients with pectus excavatum following corrective surgery.
- Trial name
- HeartSoar (NCT03770390)
- Testing
- Surgical correction of pectus excavatum
- Where
- France
- Volunteers
- 43 people
- Sponsor
- University Hospital, Montpellier
Parkinson Disease, Rest Tremor
Mindfulness-based Intervention for People With Parkinsonian Tremor
Mindfulness meditation is an approach that has shown interest in treatment of anxiety in Parkinson's disease. This pilot study aims to assess a more specific effect on tremor using Essential Tremor Embarrassment Assessment and…
- Trial name
- MEDITAPARK (NCT05168046)
- Testing
- Mindfulness based stress reduction
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Montpellier
Osteoarthritis, Mindfulness
A Mindfulness Program (MBSR) in the Management of Symptomatic Hip and Knee Osteoarthritis
Symptomatic osteoarthritis (OA) is the most common joint disease and the leading cause of disability in industrialized countries.
- Conditions
- Osteoarthritis, Mindfulness, MBSR
- Trial name
- MINDFULNESS_OA (NCT03644615)
- Testing
- Mindfluness and usual care, Usual care
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Primary Gougerot-Sjögren Syndrome, Systemic Sclerosis, Diffuse
Quantification and Characterization of Circulating Epithelial and Endothelial Cells in Gougerot-Sjögren Syndrome, Compared to Systemic Sclerosis
Primary Gougerot-Sjögren's syndrome is a systemic autoimmune disease belonging to the group of connectivities, whose physiopathology remains largely unknown.
- Trial name
- CIRCEE (NCT05528809)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Chronic Obstructive Pulmonary Disease
Long-term Maintenance Benefits of a Pulmonary Rehabilitation Program Using a Mobile Digital Solution: a Prospective, Randomized, Controlled, Multicenter Study in a Population of COPD Patients
Chronic obstructive pulmonary disease (COPD) is a public health problem: high prevalence; increasing morbidity and mortality; impact on health costs.
- Trial name
- m-Rehab COPD (NCT04550741)
- Testing
- telerehabilitation
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Disorder of Sex Development, 46,XY
Search for Structural Variants in Patients With DSD and Inconclusive Molecular Diagnosis
The goal of this clinical trial is to identify structural variants by Optical Genome Mapping (OGM) in the described participant population.
- Trial name
- GENEXPLOR (NCT05867979)
- Testing
- Identify structural variants by Optical Genome Mapping of DNA extracted from blood leukocytes
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Ventricular Arrythmia, Right Ventricular Dysfunction
Cardiovascular Consequences in Intense and Extended Physical Exercise
This research study because you participate in long distance triathlon of Embrun. In recent years, there has been a craze for races at increasingly longer distances (ultra-endurance) with risks to the cardiovascular system poorly…
- Trial name
- PHILIPPIDES (NCT03972865)
- Testing
- EmbrunMan race
- Where
- France
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Sleep Apnea Syndrome, Coronary Artery Disease
Evolution of Oxidative Stress in Coronary Patients With Moderate Sleep Apnea Syndrome After Treatment With Continuous Positive Airway Pressure
Published data indicate that obstructive sleep apnea syndrome (OSAS) worse the prognosis of coronary artery disease (CAD) and that oxidative stress can link this 2 diseases.
- Trial name
- CardioX SAS (NCT02893865)
- Testing
- Continuous positive airway pressure
- Where
- France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Montpellier
Relapsing Remitting Multiple Sclerosis, Progressive Multiple Sclerosis
Serum Neurofilaments and GFAP in Atypical Multiple Sclerosis
Idiopathic inflammatory disorders of the central nervous system include various disorders of which multiple sclerosis is the most common.
- Conditions
- Relapsing Remitting Multiple Sclerosis, Progressive Multiple Sclerosis, Controls, Multiple Sclerosis
- Trial name
- AMIS (NCT04201470)
- Testing
- Blood withdrawal, MRI, Neurologic / neuropsychologic tests - Patients
- Where
- France
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Low Back Pain, Recurrent
Effectiveness of a Pain Neuroscience Education Programme on Physical Activity in Patients With Chronic Low Back Pain
Proposing ways to effectively counter chronic low back pain through non-drug intervention is a major public health issue due to the prevalence and health costs of this condition.
- Trial name
- END-LC (NCT05840302)
- Testing
- Activity monitor, Questionnaire
- Where
- France
- Volunteers
- 82 people
- Sponsor
- University Hospital, Montpellier
Alzheimer Disease
REGEnLIFE RGn530 - Feasibility Pilot
REGEnLIFE RGn530 is a photobiomodulation medical device, consisting in a modular helmet and abdominal panel, composed of near-infrared low-level lasers (LLLT), near-infrared and red LEDs as well as a static magnetic field.
- Trial name
- NCT03672474
- Testing
- Photobiomodulation REGEnLIFE RGn530 device
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Cervical Spine Destabilization
Behavior of the Upper Cervical Spine in Rugby Players
Rugby players are often exposed to destabilisation of the upper cervical spine.This kind of trauma may lead to dramatic injuries, due to lesion of spinal cord.
- Trial name
- Cervistab (NCT03712514)
- Testing
- Destabilization of the upper cervical spine by Cervistab
- Where
- France
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
HPV Genital Infection (Primary Condition Studied), Bacterial Vaginosis
Kinetics and Ecology of Human Papillomavirus Genital Infections in Young Women
Most genital infections by human papillomaviruses (HPV) are asymptomatic or benign and clear within a few months or years. There infections are much less studies than chronic infections, even though they represent the main…
- Conditions
- HPV Genital Infection (Primary Condition Studied), Bacterial Vaginosis, Chlamydiae Infection
- Trial name
- PAPCLEAR (NCT02946346)
- Testing
- vaginal sampling
- Where
- France
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Hand Osteoarthritis
A Prospective Cohort Study of Patients Suffering From Hand Osteoarthritis Symptoms
The late-stage forms of degenerative osteoarthritis (OA) are very debilitating and less affordable to therapy. The main objective is to identify early onset symptoms of hand OA patients through imaging techniques (such as…
- Trial name
- COARDIG (NCT03650673)
- Testing
- Identification of subgroups of patients with early AD with risk of progression
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Montpellier
Recurrent Low Back Pain, Degenerative Disc Disease (DDD)
Efficacy of Intradiscal Injection of BM-MSC in Subjects With Chronic Low Back Pain (LBP) Due to Lumbar Degenerative Disc Disease (DDD) Unresponsive
This will be a multicenter, prospective, double blind, randomized phase 2/3 trial comparing culture-expanded allogeneic adult BM-MSCs with sham-treated controls.
- Trial name
- RESPINE (NCT03737461)
- Testing
- Allogenic BM-MSCs Injection
- Where
- 9 sites in France, Germany and 2 more
- Volunteers
- 113 people
- Sponsor
- University Hospital, Montpellier
Rheumatoid Arthritis
Use of Remote Monitoring by Smartphone in the Care Management of Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is the most common inflammatory rheumatism in adults, affecting nearly 0.4% of the general population. It is a real public health issue.
- Trial name
- SATIE-PR (NCT03005925)
- Testing
- Smartphone, physical follow up
- Where
- France
- Volunteers
- 94 people
- Sponsor
- University Hospital, Montpellier
Rheumatoid Arthritis
Effect of the Inhibitors of the Way JAK-STAT on Regulatory B Cells
This study will investigate whether inhibitors of the JAK / STAT signaling pathway can increase anti-inflammatory functions of B cells in patients with RA using in vitro and in vivo experiments.
- Trial name
- JAK-INH2 (NCT03755297)
- Testing
- Blood sample analysis of patients treated as standard care
- Where
- France
- Volunteers
- 27 people
- Sponsor
- University Hospital, Montpellier
Crohn's Disease, Ulcerative Colitis
Medico-economic Evaluation of the Therapeutic Drug Monitoring of Anti-TNF-α Agents in Inflammatory Bowel Diseases
Since their appearance more than a decade ago, anti-tumor necrosis factor (TNF) inhibitors have demonstrated beneficial activity in the treatment of inflammatory bowel diseases (IBD).
- Trial name
- ATAIM (NCT02508012)
- Testing
- Immuno monitoring
- Where
- France
- Volunteers
- 260 people
- Sponsor
- University Hospital, Montpellier
Positilonal Deformation of the Skull, Head Turn Preference
Preventive Osteopathic Treatment of Plagiocephaly
Positional cranial deformities (PCD), plagiocephaly and brachycephaly are a common reason for pediatric consultation, which has increased significantly since the recommendation to lay babies on their backs to prevent unexpected…
- Conditions
- Positilonal Deformation of the Skull, Head Turn Preference, Axial Hypertony
- Trial name
- TOPP PLAGIO (NCT03780920)
- Testing
- manual therapy/osteopathy
- Where
- France
- Volunteers
- 101 people
- Sponsor
- University Hospital, Montpellier
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