Clinical trials: sponsored by University Hospital, Montpellier
Cardiogenic Shock
Early Left Ventricular unLoading by Impella vs Intra-aortic Balloon Pump
Over the past decade, VA-ECMO has become the main mechanical support for cardiogenic shock (CS) unresponsive to medical therapy.
- Trial name
- ELLIPSE1 (NCT06645990)
- Testing
- Impella, IABP
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Cardiogenic Shock
IMPELLA, Complications and Tolerance
Myocardial infarction complicated by cardiogenic shock (AMICS) is associated with high morbidity and mortality, and devices like Impella® CP and Impella 5.0-5.5 are often used for hemodynamic support, either alone or combined…
- Trial name
- IMPACT (NCT06644963)
- Testing
- Impella (5, 5.5 or CP)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Montpellier
Liver Transplant
Long-term Mortality Post Liver Transplantation in the Era of Modern Immunosuppression.
Liver transplantation is the primary intervention for decompensated chronic liver diseases and some cases of hepatocellular carcinoma.
- Trial name
- NCT06636409
- Testing
- Collection of medical data
- Where
- France
- Volunteers
- 1,343 people
- Sponsor
- University Hospital, Montpellier
Coronary Total Occlusion
Long-term Clinical Follow-up After PCI for CTO
The research aimed to evaluate the impact of a successful Percutaneous coronary intervention of chronic total occlusions (CTO-PCI) on long-term MACE (Major Cardiovascular Events), symptoms, survival, Left Ventricular Ejection…
- Trial name
- LT-CTO (NCT06544174)
- Testing
- Percutaneous Coronary Intervention of CTO
- Where
- France
- Volunteers
- 448 people
- Sponsor
- University Hospital, Montpellier
Muscle Injury
Biological Variables Associated With the Response to Intensive Training in Athletes
There is in humans, at the muscular level, a great interindividual variability in response to the same mechanical stress. This phenotypic variability is multifactorial, influenced by environmental factors as well as multiple…
- Trial name
- CareStress (NCT05279196)
- Testing
- Quadriceps microbiopsy and blood collection
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Idiopathic Hypersomnia
Efficacy and Tolerance of Solriamfetol in Patients Affected with Idiopathic Hypersomnia.
This Phase II clinical trial is a monocenter, double-blind, randomized, placebo-controlled study aimed at evaluate the efficacy and safety of solriamfetol from 75 to 300 mg per day in IH patients.
- Trial name
- SOLR-IH (NCT06590662)
- Testing
- Solriamfetol
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Intensive Care Units, Pediatric
Cardiac Output Measurement in Pediatric Intensive Care Unit by Metabolic Monitor (Fick Method) (PEDIA-FICK-ICU)
Cardiac output measurement is one of the most frequently used haemodynamic parameter used for intensive care unit (ICU) patients.
- Trial name
- PEDIA-FICK-ICU (NCT05741918)
- Testing
- Fick's method, Echocardiography
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Bell Palsy
Screening for Prognostic Biomarkers of Severe Bell's Palsy in Adults
Bell's palsy (idiopathic peripheral facial palsy) is the most common cause of facial palsy, which is related to the inflammation of the facial nerve, possibly induced by herpesvirus reactivation.
- Trial name
- BIOFIPS (NCT05582915)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Montpellier
Limbal Stem Cell Deficiency
Implementation of a Protocol for the Transdifferentiation of Buccal Mucosal Epithelium Into Corneal Epithelium
Objectives The transparent surface of the eye, called the cornea, plays a crucial role in transmitting light to the retina and in protecting the eye.
- Trial name
- TransBuCor (NCT06265298)
- Testing
- Conjunctival reconstruction
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Montpellier
Hip Fractures
Clinical Validation of a Mobility Monitor to Measure and Predict Health Outcomes
Background and study aims The ability to move is important for general well-being. Ageing and chronic health conditions can lead to a loss of mobility and a loss of independence.
- Trial name
- MOBILISE-D (NCT04911231)
- Where
- 2 sites in France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Montpellier
Caries
Longitudinal Follow-up of High Viscosity Glassionomer IonoStar Plus Versus a Composite Bulk X-tra-Fil Combined With Futurabond U (Splith Mouth Study): Reunion Island, Circus of Mafate
The main objective is the longitudinal follow-up and comparison of the maintenance of the dental filling materials up to 24 months using the HVGIC IonoStar Plus versus Bulk X-Tra -Fil composite (Futurabond U adhesive system).
- Trial name
- CVB (NCT03568253)
- Testing
- Caries treatment
- Where
- France
- Volunteers
- 65 people
- Sponsor
- University Hospital, Montpellier
Bipolar Disorder, Caregiver Burden
Evaluation of Efficiency of One Day Patient/Caregiver Psychoeducation on the Caregiver's Burden
Bipolar disorder (BD) has a huge impact on the lives of patient and their relatives. Psychoeducation programs on BD has been shown to be effective on the burden of patients and their caregivers.
- Trial name
- BP ONEDAY (NCT05178966)
- Testing
- Bp OneDay psychoeducation program
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Suicide, Attempted, Suicidal Behavior
Psychoeducation for Suicidal Behavior
The aims of the recent World Health Organization report, highlighting that every 40 seconds a person dies from suicide somewhere in the world, are to increase awareness on the public health significance of suicide and make…
- Trial name
- PEPSUI (NCT03185026)
- Testing
- Interventional group : PEPSUI psychoeducational program, Relaxation group
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Aniridia
Proteomic Study of Tears From Patients With a PAX6 Mutation
This is a single-center prospective pilot study involving the ophthalmology and medical genetics departments of the Montpellier University Hospital, and the proteomics platform of the Montpellier University Hospital.
- Trial name
- PLAPAX6 (NCT05562115)
- Testing
- Tear collection
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Montpellier
Major Depressive Disorder, Suicidal Behavior
Basal Plasma Lithium Levels and Suicidal Events
Suicidal behavior is a major public health issue and there are currently no specific treatments for it. However, lithium, the reference treatment for bipolar disorder, have been shown to be effective in preventing suicidal risk.
- Conditions
- Major Depressive Disorder, Suicidal Behavior, Bipolar Disorder
- Trial name
- LIPS (NCT05409794)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 158 people
- Sponsor
- University Hospital, Montpellier
Lymphoma, B-Cell, Neurotoxicity
Magnetic Resonance Imaging in Immune Effector Cell-Associated Neurotoxicity Syndrome
The treatment of large-cell B-cell lymphomas refractory to more than 2 lines of therapy has recently been revolutionized by the use of immunotherapies consisting of autologous genetically modified cells or CAR-T CELLS (chimeric…
- Trial name
- MR-ICANS (NCT05510596)
- Testing
- Magnetic Resonance Imaging with contrast injection, Blood withdrawal, Neuropsychological tests
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Montpellier
Prosthetic-joint Infection
SHort Interval Full Two-stage Implant Exchange
This study is a prospective bicentric feasibility study, which aims to evaluate the feasibility of a two-stage full implant exchange with early prosthesis reimplantation between 16 and 30 days after implants removal for hip or…
- Trial name
- SHIFT (NCT05642013)
- Testing
- Early prosthesis reimplantation, Retrospective analysis of medical records
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
HIV Infections
Immune Activation as a Cause of Insulin Resistance in Adults Living With HIV-1 on Effective Antiretroviral Therapy
The aim of this study is to characterize in non-viremic HIV-1 patients under antiretroviral therapy an immune activation profile that the investigators have previously shown to be strongly linked to hyperinsulinemia.
- Trial name
- MetACTIVIH (NCT04028882)
- Testing
- Signaling, metabolomic and transcriptomic analysis
- Where
- France
- Volunteers
- 148 people
- Sponsor
- University Hospital, Montpellier
Lupus Erythematosus Disseminatus, Autoimmune Diseases
Glycosylation Analysis of Lupus Anti-DNA Antibodies (GALA)
Systemic lupus erythematosus (SLE) is a severe autoimmune disease in which patients often develop numerous autoantibodies (Abs).
- Conditions
- Lupus Erythematosus Disseminatus, Autoimmune Diseases, Chronic Disease
- Trial name
- GALA (NCT05394922)
- Where
- 2 sites in France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Montpellier
Psychiatric Disorder, Psychiatric Hospitalization
Advanced Chronic Liver Disease Screening by Transient Elstography in Patients Hospitalised in a Psychiatric Unit
Scares data exists concerning the prevalence of chronic liver diseases in people with psychiatric disorders. There are still many barriers to screening and linkage to care for patients having somatic illness.
- Conditions
- Psychiatric Disorder, Psychiatric Hospitalization, Advanced Chronic Liver Disease, Liver Fibrosis
- Trial name
- HEPSY (NCT05602870)
- Testing
- non invasive evaluation of liver fibrosis by transient elastography (Fibroscan ®)
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Montpellier
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