Clinical trials: sponsored by University Hospital, Montpellier
Rheumatoid Arthritis
Effect of Controlling Environmental Risk Factors in Established RA
The factors contributing to the development of rheumatoid arthritis are multiple, with a role of the environment and a predisposing genetic background.
- Trial name
- DISRUPT-estRA (NCT05198271)
- Testing
- Management of risk factors, Smoking cessation, weightloss
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Montpellier
Stroke
Minor Stroke Therapy Evaluation
Stroke represents the fourth leading cause of death in industrialized nations, after heart disease, cancer, and chronic lower respiratory disease.
- Trial name
- MOSTE (NCT03796468)
- Testing
- Best Medical Therapy, Mechanical Thrombectomy
- Where
- France
- Volunteers
- 824 people
- Sponsor
- University Hospital, Montpellier
Developmental Coordination Disorder
Rhythmic Handwriting Deficits and General Rhythmic Abilities in Children
Patients with Developmental Coordination Disorder (DCD), a neurodevelopmental disorder that affects motor skills and motor learning (APA, 2013), have been reported to manifest rhythmic deficits in handwriting domain, as well as…
- Trial name
- TDC-Rythme (NCT06006767)
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Montpellier
Sickle Cell, Children
VO2max & HRQoL in Children With Sickle Cell Disease
Sickle cell disease is the most common inherited genetic disorder, accounting for 300,000 births worldwide per year. It is caused by an autosomal recessive mutation of the β-globin gene, responsible for an abnormal hemoglobin…
- Trial name
- VO2drépano (NCT05995743)
- Where
- France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Montpellier
COVID-19, Acute Cardiovascular Condition
Covid-19, Acute Myocardial Infarctions and Strokes in France
The COVID-19 pandemic has had dramatic effects on health systems and on non-COVID health care. Using French inpatient claims data and retrospectively collected clinical data, the investigators will assess the changes in hospital…
- Conditions
- COVID-19, Acute Cardiovascular Condition, Acute Neurovascular Condition, Stroke
- Trial name
- COVUSI (NCT04542083)
- Where
- France
- Volunteers
- 911 people
- Sponsor
- University Hospital, Montpellier
Rheumatic Diseases, SARS-CoV Infection
Longitudinal Follow-up of Patients With Chronic Inflammatory Rheumatisms (CIRs) Vaccinated Against COVID-19 Compared to Patients Refusing Vaccination
To date, studies on SARS-CoV2and vaccines have been mostly from the general population not exposed to immunosuppressants. The efficacy and safety of COVID-19 vaccines need to be evaluated in these populations.
- Conditions
- Rheumatic Diseases, SARS-CoV Infection, COVID-19
- Trial name
- COVID-RIC3 (NCT04832022)
- Testing
- Biological samples
- Where
- 13 sites in France
- Volunteers
- 397 people
- Sponsor
- University Hospital, Montpellier
Irritable Mood
RESist Against Irritability Superiority Trial
Irritability is defined as developmentally inappropriate proneness to anger. Irritability is a symptom of several mental health conditions in children and adolescents such as attention deficit hyperactivity disorder (ADHD)…
- Trial name
- RESIST (NCT05528926)
- Testing
- Non-Violent Resistance, Parent Management Training, Treatment As Usual
- Where
- France
- Volunteers
- 270 people
- Sponsor
- University Hospital, Montpellier
Female With Osteoporosis and Chronic Kidney Disease
Study Evaluating Denosumab on Bone and Vascular Metabolism in Osteoporotic Chronic Kidney Disease
Aim of this study is to evaluate in a population of old osteoporotic chronic kidney disease females the effect of denosumab: on bone mineral density (femoral T-score) at 24 months on bone mineral density evolution (femoral…
- Trial name
- HDENO (NCT02792413)
- Testing
- Denosumab
- Where
- 9 sites in France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Montpellier
Periodontitis, Periodontal Diseases
Comparison of Salivary and Crevicular Protein Concentrations of FIBA, PLMN, HEMO and ApoH in Healthy and Periodontitis Patients
Periodontal disease is a multifactorial inflammatory disease of infectious origin. The last epidemiological study concerning periodontitis in France was carried out in 2002-2003 by Bourgeois et al and shows that 95.4% of the…
- Trial name
- PerioBioTIS (NCT05511454)
- Testing
- Salivary and crevicular samples
- Where
- France
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Actual Suicidal Behavior Disorder
Biomarkers of Efficiency of Acceptance and Commitment Therapy in Suicidal Behavior
Suicidal behaviors (SB) are a major health problem in France:10,000 suicides and 220,000 suicide attempts every year. SB management is therefore a major public health issue.
- Trial name
- IMPACT (NCT02936700)
- Testing
- Relaxation, ACT therapy
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Montpellier
Disorder of Maxillary and Mandibular Dental Arch Relationship
Impact of Complete Removable Prosthetic Rehabilitations Performed by an Innovative DDTENS Protocol, on the Quality of Masticatory Function and the Management of Completely Edentulous Patients
Total edentulism is a profound physical, psychic and social handicap, which affects 5 million people in France. The most frequent complaint of edentulous patients rehabilitated by conventional Complete Removable Prostheses (CRP)…
- Trial name
- DD-TENS (NCT05096624)
- Testing
- DD-TENS system, Gold Standard, Digital Denture system
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Headache, Migraine
Migraine in Electrohypersensitive Patients
The investigators propose here by the use of the French version of the migraine disease screening questionnaire (ID Migraine ™) to study the prevalence of migraine disease in a population of electrohypersensitive patients
- Trial name
- NCT04845152
- Where
- France
- Volunteers
- 317 people
- Sponsor
- University Hospital, Montpellier
Pulmonary Disease, Chronic Obstructive, Asthma
Ciliation and Mucus Rheology Parameters Determined Via Air-liquid-interface Cell Cultures in Non-smoking, Smoking, COPD and Asthmatic Patients
This is a prospective study comparing 4 groups: (1) non-smoking controls, (2) smokers without chronic obstructive pulmonary disease (COPD), (3) smokers with COPD, (4) severe asthma.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Asthma, Smoking
- Trial name
- RhéMuc (NCT03187860)
- Testing
- Bronchial Biopsy, ALI culture
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Montpellier
Primary Lymhedema
Validation of Metrological Properties of Lymphoqol
The constitutional lymphœdema is a rare disease with an annual incidence before the age of 20 years considered at 1,15/100 000. This chronic, incurable disease without hiring directly the prognosis for survival, alter the body…
- Trial name
- LYMPHOQOL (NCT01922635)
- Testing
- Valadation of the metrological properties of questionnaire of quality of life
- Where
- France
- Volunteers
- 37 people
- Sponsor
- University Hospital, Montpellier
Single-ventricle, Pulmonary Hypertension
Efficacy of Phosphodiesterase-type 5 Inhibitors in Patients With Univentricular Congenital Heart Disease
In univentricular hearts, selective lung vasodilators such as phosphodiesterase type 5 (PDE5) inhibitors would decrease pulmonary resistance and improve exercise tolerance.
- Conditions
- Single-ventricle, Pulmonary Hypertension, Univentricular Heart
- Trial name
- VU-INHIB (NCT03997097)
- Testing
- Sildenafil
- Sponsor
- University Hospital, Montpellier
Pregnancy Related
Artificial Induction of Labour in Full-term Singleton Pregnancy : Comparative Randomized Trial of Two Strategies
Labour induction is an obstetrical procedure, which artificially starts the process of cervix dilation, in order to induce labour.
- Trial name
- BESTWAY (NCT04452747)
- Testing
- Vaginal Dinoprostone system (Propess®), Dilatation balloon
- Where
- 2 sites in France
- Volunteers
- 450 people
- Sponsor
- University Hospital, Montpellier
Lobo-isthmectomy
Medico-economic Study of the Lobo-isthmectomy Assisted Robot
This is a study of health economics longitudinal cohort on the evaluation of direct medical cost of a surgical technique based on the use of an innovative device (the da Vinci® surgical robot Si) and its comprehensive care.
- Trial name
- LIRA (NCT02961322)
- Testing
- lobo-isthmectomy assisted robot
- Volunteers
- 9 people
- Sponsor
- University Hospital, Montpellier
Alzheimer Disease, Elderly With Normal Cognition
Blood Microbiota Signature of Alzheimer's Disease
This study aims to validate a difference in blood microbial signature between Alzheimer's patients and control subjects in order to propose potential innovative strategies
- Trial name
- MICMALZ (NCT04841135)
- Testing
- Multiomics quantification, Polysomnography
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Behavioral Disorders, Emotional Disorder of Childhood
Predictive Factors for the Outcome of Young Children Emotional and/or Behavioral Disorders After Psychotherapeutic Intervention
Behavioral disorders and emotional disorders represent frequent reasons for consultation in young children. Their prevalence is between 7% and 13% depending on the studies.
- Trial name
- NCT05820269
- Testing
- parents-child psychotherapy
- Where
- France
- Volunteers
- 272 people
- Sponsor
- University Hospital, Montpellier
Rheumatoid Arthritis, Spondyloarthritis
Information and Acceptability of Biosimilars
Patients with rheumatoid arthritis or spondyloarthritis, currently treated or about to be started with anti-TNF original drug adalimumab or etanercept will be included and randomized to either " information leaflet only " or "…
- Conditions
- Rheumatoid Arthritis, Spondyloarthritis, Psoriatic Arthritis
- Trial name
- BIOSIMINFO (NCT04321291)
- Testing
- Generic information leaflet, Individual information by nurse on biosimilars
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
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