Clinical trials: sponsored by University Hospital, Montpellier
Parkinson Disease
Assisted Device for Freezing in Parkinson Disease
Freezing of gait (FOG) is a particular and troublesome symptom occurring in some Parkinsonian patients. Our objective is to adapt and extend FOG detectors in order to include other associated gait pattern changes, like…
- Trial name
- demarpark (NCT02317289)
- Testing
- Detection of freezing
- Where
- France
- Volunteers
- 26 people
- Sponsor
- University Hospital, Montpellier
Alzheimer's Disease, Mild Cognitive Impairment
Use of Saliva for Alzheimer's Disease Diagnosis
Although saliva is not generally regarded as one of the most interesting biological fluids, the fact that it can be sampled using simple, noninvasive methods makes it an interesting alternative to cerebrospinal fluid (CSF) or…
- Trial name
- SalivALZ (NCT02864303)
- Testing
- Saliva samples
- Where
- France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Montpellier
COPD Exacerbation, Invasive Mechanical Ventilation
Sevoflurane in Chronic Obstructive Pulmonary Disease Exacerbation
Prospective, open-label, single-center, study to investigate the effect of sevoflurane sedation compared to a propofol-controlled arm during COPD exacerbation requiring invasive mechanical ventilation in ICU.
- Trial name
- SEVOCOPD (NCT03460015)
- Testing
- Sevoflurane, Propofol
- Where
- France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Montpellier
Inflammatory Bowel Diseases
Intestinal Mesenchymal Stem Stells and Inflammatory Bowel Diseases
The exact origin of inflammatory bowel disease (IBD) is still unknown. The current hypothesis is that IBD is secondary to an abnormal intestinal immun response directed to all or part of the intestinal flora in genetically…
- Trial name
- COSMIC (NCT03115749)
- Testing
- Intestinal biopsies during colonoscopy, Biopsies taken on surgical specimen
- Where
- France
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Isolated Cervical Dystonia, Complex Dystonia
Functional MRI and DTI in the Preoperative Assessment of Dystonia
The aim of this study is to evaluate the organization of the motor circuit in a group of patients suffering from dystonia compared with a group of healthy controls.
- Conditions
- Isolated Cervical Dystonia, Complex Dystonia, Spasticity
- Trial name
- IRMF-DIFF (NCT02877836)
- Testing
- magnetic resonance imaging (fMRI)
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Tinnitus
Tinnitus Related Cerebral Activities
The proposed research is to identify the brain areas activated or deactivated by tinnitus in humans. The identification of these areas is expected to be able to treat tinnitus refractory to traditional therapies by methods of…
- Trial name
- ACCELA (NCT02853812)
- Testing
- Functional brain MRI
- Volunteers
- 24 people
- Sponsor
- University Hospital, Montpellier
Major Depression
Blood Biomarkers in Suicidal Behaviour
Suicidal behavior (SB) is a major public health problem in France, with more than 10,000 suicides and 220,000 suicide attempts per year.
- Trial name
- 2BSB (NCT02855918)
- Testing
- Blood sample for genetic purpose
- Where
- France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Postnatal Complication, Mesenteric Pregnancy
Prenatal Screening of Intestinal Malrotation With a Higher Risk of Volvulus.
Digestive malrotation is an anatomical anomaly of the positionning of the mesenteric vessels and the digestive tract that can lead in some form to a dangerous neonatal complication: intestinal volvulus.
- Trial name
- MALROT (NCT05148429)
- Testing
- Ultrasound exam, Fetal MRI, Postnatal abdominal ultrasound
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Montpellier
Patients Recieving Anti-PD-1 or Anti-PD-L1 Immunotherapies
Impact of Immune Checkpoint Inhibitor Therapy on Type 2 Inflammation
The primary objective of this study is to determine the impact of anti-checkpoint immunotherapy on type 2 inflammation via a retrospective analysis of % eosinophilia.
- Trial name
- ImmunEO (NCT04609930)
- Testing
- Anti-PD-1 or anti-PD-L1
- Where
- France
- Volunteers
- 143 people
- Sponsor
- University Hospital, Montpellier
Parkinson's Disease, REM Sleep Behavior Disorder
Gait and REM Sleep Behavior Disorder
Many people with idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) have an underlying synucleinopathy, the most common of which are Parkinson's disease (PD) and Lewy body disease.
- Trial name
- RBD-M2H (NCT02554331)
- Testing
- FP-CIT single-photon emission computed tomography, neuropsychological evaluation, Gait recording with sensors
- Where
- France
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Sepsis, Septic Shock
A STUDY BEFORE/AFTER THE IMPLEMENTATION OF AN ANTI-INFECTIOUS PRESCRIPTION AID
Anti-infective strategy is a major public health problem. This is a before-and-after study of an anti-infectious prescription tool with a comparison of mortality at 30 days (then 3 and 6 months) between the two inclusion phases…
- Trial name
- NCT05140213
- Testing
- Anti-infectious prescription support tool
- Where
- France
- Volunteers
- 371 people
- Sponsor
- University Hospital, Montpellier
Pressure Ulcer, Bedsore
Quantification of the Pressure Threshold Related to Tissue Injury in Bedriden Paraplegics
The aim of this study is to correlate the intensity and the duration of a mechanical strain, applied over the skin of a bedridden paraplegics, with the microvascularization parameters (oxygen saturation, blood flow and blood…
- Conditions
- Pressure Ulcer, Bedsore, Spinal Cord Injury, Paraplegia
- Trial name
- NCT02412046
- Testing
- Muscle biopsy
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Montpellier
Burnout, Emotional Disturbances
Mindfulness-based Therapy Versus Relaxation in Prevention of Burnout in Medical Students
A recent survey exploring mental health in a large cohort of French medical students and young graduates (N = 21.768), observed that 68.2% of participants showed pathologic anxiety.
- Conditions
- Burnout, Emotional Disturbances, Depression
- Trial name
- MUSTPrevent (NCT04026594)
- Testing
- Mindfulness Based Stress Reduction, Relaxation group
- Where
- France
- Volunteers
- 612 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Drug Hypersensitivity
Medical Device for Drug Allergy Diagnosis
The COBIOPHAD project targets the development of a highly sensitive, selective, and multiplexed diagnostic device to provide a quick and inexpensive in vitro test to address the most prevalent drug hypersensitivity to betalactams…
- Trial name
- COBIOPHAD (NCT02839811)
- Testing
- Immediate hypersensitivity to BLC
- Where
- France
- Volunteers
- 145 people
- Sponsor
- University Hospital, Montpellier
Diabetes
Neuropsychiatric Factors
It is estimated that approximately 20-25% of diabetic patients will have at least one trophic disorder during their period. The appearance of a trophic disorder in a diabetic patient is a serious complication, indicating that…
- Trial name
- Diapepsy (NCT03323281)
- Testing
- Neuropsychological assessments
- Where
- France
- Volunteers
- 266 people
- Sponsor
- University Hospital, Montpellier
COVID-19, SARS-CoV Infection
Seroprevalence Study of CoV-2-SARS (COVID-19) Infection in Patients With Chronic Inflammatory Rheumatic Diseases
The prevalence of SARS-CoV-2 infection in chronic inflammatory rheumatic diseases has not yet been widely reported, and has been evaluated only in symptomatic patient samples.
- Conditions
- COVID-19, SARS-CoV Infection, Rheumatoid Arthritis, Spondyloarthritis
- Trial name
- COVID-RIC1 (NCT04655612)
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Montpellier
Obesity, Insulin Resistance
Assessing the Value of Red Grapes Polyphenol Supplementation on Metabolic Parameters in Obese Insulinoresistant Subjects
Obesity, chronic disease, is a real public health problem because of its high prevalence but also because of the high risk of complications, including insulin resistance (IR) and type 2 diabetes (T2D).
- Conditions
- Obesity, Insulin Resistance, Menopause
- Trial name
- POLYGIR (NCT02633150)
- Testing
- Supplementation with red grapes polyphenol
- Where
- France
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Chronic Obstructive Pulmonary Disease (COPD), Exacerbation Copd
Determinants of Lower Limb Muscle Atrophy Induced During an Hospitalization for Exacerbation of COPD
Chronic Obstructive Pulmonary Disease (COPD) is characterized by persistent airway obstruction and inflammatory response of the lungs and bronchi.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Exacerbation Copd, Muscle Atrophy
- Trial name
- AMI-EX-BPCO (NCT03153826)
- Testing
- Comparison of clinical and biological characteristics of patients
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Montpellier
Anorexia Nervosa
Transcranial Direct Current Stimulation (tDCS) and Anorexia Nervosa
Anorexia nervosa is an eating disorder characterized by intense fear of becoming fat despite the obvious thinness and extreme behaviors for weight loss. The result is a massive weight loss and / or pathological thinness.
- Trial name
- STAR (NCT02734108)
- Testing
- Transcranial direct current stimulation
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Montpellier
Eating Disorder
Impact of Neuropsychological Alteration of Decision-making Abilities on the Functioning of Patients With Eating Disorders
Eating disorders are multifactorial disorders currently conceptualized in a biopsychosocial model, but pathophysiology remains relatively unknown, and robust etiological models to guide treatment are therefore lacking.
- Trial name
- NEUROPSY_TCA (NCT03160443)
- Testing
- Ambulatory cares in a day-hospital (University Hospital of Montpellier) specialized in the evaluation of eating disorders
- Where
- France
- Volunteers
- 340 people
- Sponsor
- University Hospital, Montpellier
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