Clinical trials: sponsored by University Hospital, Rouen
Antiphospholipid Syndrome (APS)
Follow-up Cohort of Patients With Antiphospholipid Syndrome
Antiphospholipid syndrome (APLS) is a rare pathology characterized by the association of thrombotic (arterial, venous) or obstetric clinical manifestations and the persistent presence at least twelve weeks apart of…
- Trial name
- ReLaps (NCT07178925)
- Testing
- Study of Antiphospholipid Syndrome responding to the Sydney classification of 2006
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Rouen
Digestive System Neoplasms, Anxiety
Evaluation of Preoperative Anxiety in Digestive Surgery
This prospective observational study aims to evaluate the association between preoperative anxiety and postoperative complications in patients undergoing major oncological digestive surgery.
- Trial name
- EVAPOC (NCT07897942)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Rouen
Depressive Symptoms
Assessment of the Seasonality of Depressive Symptoms in Adolescents
The seasonality of affective disorders-particularly depressive symptoms-is well-documented in adults, yet it remains under-researched in adolescents.
- Trial name
- SPAQ-ADO (NCT07895758)
- Testing
- Measuring the intensity of the seasonality of depressive symptoms in adolescents
- Where
- France
- Volunteers
- 210 people
- Sponsor
- University Hospital, Rouen
Anismus, Distal Constipation
Is the Evaluation of Anal Distensibility by Endoflip® Technique Useful for the Diagnosis of Anismus?
Terminal constipation affects 13 to 20% of the french population. Anismus is defined by an absence of relaxation or a paradoxical contraction of the striated anal sphincter muscle during defecation.
- Trial name
- Endo-DC (NCT04155307)
- Testing
- Anal EndoFLIP®, Anal Manometry, Defecography
- Where
- France
- Volunteers
- 61 people
- Sponsor
- University Hospital, Rouen
Crohn's Diseases
Effect of Intestinal Carriage of *Pilosibacter Rotomagensis* on Intestinal Inflammatory Activity
Crohn's disease is a chronic inflammatory condition that can affect the entire digestive tract. The terminal ileum is the segment most frequently involved, and approximately one-third of patients present with disease limited to…
- Trial name
- ProsPec (NCT07871383)
- Testing
- Microbiota suspension
- Where
- France
- Volunteers
- 116 people
- Sponsor
- University Hospital, Rouen
MYT1L Syndrome
MYT1L Syndrome: a Rare Paediatric Genetic Syndrome Responsible for a Neurodevelopmental Disorder
MYT1L syndrome is a rare genetic syndrome, recently described in 2011, with paediatric onset, responsible for a neurodevelopmental disorder combining psychomotor retardation, learning difficulties and/or intellectual development…
- Trial name
- MYT1L (NCT07008612)
- Testing
- Patients with a genetic syndrome linked to the MYT1L gene, Patients with a neurodevelopmental disorder of genetic origin but not linked to MYT1L
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Rouen
Intermittent Fasting, Septic Shock
Evaluation of the Efficiency of Intermittent Enteral Nutrition on Multi-organ Failure From Patients With Mechanical Ventilation in Intensive Care Unit
This study aims to evaluate the efficiency of intermittent enteral nutrition versus continuous enteral nutrition to prevent from organ failures for patients at the acute phase of sepsis shock with mechanical ventilation in ICU.
- Conditions
- Intermittent Fasting, Septic Shock, Organ Failure, Multiple
- Trial name
- ENNUT-CI (NCT06330610)
- Testing
- Intermittent enteral nutrition
- Where
- France
- Volunteers
- 174 people
- Sponsor
- University Hospital, Rouen
Reproductive Disorder
Interest of Morphokinetic Parameters of Early Embryonic Development in the Birth Rates in Vitro Fertilization
In France, nearly 3% of children are conceived by the technique of Assisted Reproductive Medicine, of which nearly 70% by in vitro fertilization (IVF).
- Trial name
- EMCIMO (NCT03806153)
- Testing
- Morphokinetic
- Where
- 2 sites in France
- Volunteers
- 520 people
- Sponsor
- University Hospital, Rouen
Urinary Incontinence,Stress
Evaluation of the Effect of a Postural Reflex Rehabilitation Program on a Foam Surface on Stress Urinary Incontinence in Women
Urinary incontinence is defined by the International Continence Society as "any involuntary loss of urine complained by the patient". UI is a debilating condition affecting 25% to 45% of the female population.
- Trial name
- Protofoam (NCT04390204)
- Testing
- intervenions
- Where
- 5 sites in France
- Volunteers
- 86 people
- Sponsor
- University Hospital, Rouen
Atrial Fibrillation, Persistent
Noninvasive 3D Mapping in Persistent Atrial Fibrillation, to Describe Modifications of the Arrhythmogenic Substrate After Pulmonary Vein Isolation and Identify Potential Predicting Factors of Ablation Success
Atrial fibrillation (AF) is the most common cardiac arrhythmia in adults. It is a major cause of ischemic stroke and heart failure.
- Trial name
- CRYOVEST (NCT04229160)
- Testing
- Noninvasive mapping (Cardioinsight® system), long-term cardiac monitoring (LINQ system), Atrial Fibrillation ablation procedure
- Where
- 4 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Rouen
Axial or Predominantly Axial SpondyloArthritis With or Without Psoriasis
Evaluation of the Efficacy and Safety of Bimekizumab (BZK) or Adalimumab (ADA) in the Treatment of Anterior Chest Wall Pain Associated With Active Axial Spondyloarthritis Refractory to NSAIDs With Hypothesis of Superiority of Bimekizumab
The primary objective is to demonstrate the superiority of BKZ (dual inhibition of IL-17A and IL-17F) on the ASAS40 response at 6 months compared to a reference treatment (ADA) in patients with active axial or predominantly axial…
- Trial name
- ThoracSPA (NCT07836283)
- Testing
- bimekizumab, adalimumab
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Rouen
Cardiac Surgery
Ticagrelor Hemoadsorption Using Cytosorb® for Reduction of Bleeding During Cardiac Surgery
Cardiac surgery is at high risk of intraoperative bleeding. Inhibitors of the P2Y12 platelet receptor, such as ticagrelor, are recommended in patients with acute coronary stroke (ACS) to reduce the incidence of major…
- Trial name
- TICAdSORB (NCT07822620)
- Testing
- Device: Cytosorb hemoadsorption
- Where
- France
- Volunteers
- 232 people
- Sponsor
- University Hospital, Rouen
Ankle Surgery
Quality of Recovery at Days 5-7 After Ankle Surgery: a Multicenter Study in Seine-Maritime
Ankle fractures are among the most common fractures in trauma care, with an estimated annual incidence of 100 to 150 per 100,000 inhabitants and a marked increase after age 40.
- Trial name
- QoR - CHEVILLE (NCT07814937)
- Testing
- Assessment of recovery quality on days 5-7 after ankle surgery
- Where
- 4 sites in France
- Volunteers
- 260 people
- Sponsor
- University Hospital, Rouen
Non-hospitalised Men and Women Over 70 Years of Age
Oral Microbiota and Muscle Function in the Ageing Subject
Ageing of the general population may be a risk factor for various complications, including sarcopenia. Sarcopenia is a progressive loss of muscle mass and muscle strength, leading to a decrease in functional capacities.
- Trial name
- MYOBIOTA (NCT07687511)
- Testing
- Salivary and fecal microbiota sampling and muscle strength assessment
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Resuscitation Patients With Sepsis
Population Pharmacokinetic Modeling to Optimize the Dosage of the Piperacillin / Tazobactam Combination in Patients With Sepsis in Intensive Care
Population pharmacokinetic modeling mathematically describes the pharmacokinetics of a drug and the variables likely to influence it in a "typical" patient population.
- Trial name
- OPT-TAZ (NCT03748095)
- Testing
- Intensive Pharmacokinetic Sampling Cohort, Sparse Pharmacokinetic Sampling Cohort
- Where
- France
- Volunteers
- 91 people
- Sponsor
- University Hospital, Rouen
Kidney Transplant
Alloreactive Memory B Lymphocytes and Anti-HLA Sensitization
In transplantation, B lymphocytes are major cellular players in the alloreactive humoral response through the production of antibodies targeting allogeneic HLA molecules expressed by the transplant.
- Trial name
- ALLO-BMEM (NCT07011238)
- Testing
- Patients meeting HLA immunization criteria
- Where
- France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Rouen
Sleep Disorders Not Due to A Substance or Known Physiological Condition
Validity and Reliability of the French Translation of the Richards-Campbell Questionnaire
The validation of a sleep questionnaire (translated into French from a source questionnaire in English) will provide a reliable and easily administered tool for assessing sleep quality in intensive care, enabling better…
- Trial name
- French-RCSQ (NCT06945874)
- Testing
- Validation of sleep quality by the Richards-Campbell Sleep Questionnaire (RCSQ) in french version
- Where
- 2 sites in France
- Volunteers
- 190 people
- Sponsor
- University Hospital, Rouen
Colorectal Cancer
Study on Aspirin Versus Placebo in Resected Colon Cancer With PI3K Mutation Stage III or II High Risk
Four retrospective studies were recently published on efficacy of aspirin in patients with surgically resected colon cancer. Two of these studies strongly suggested that aspirin used in low doses (100 mg/d) after surgical…
- Trial name
- ASPIK French (NCT02945033)
- Testing
- aspirin intake, Surgical resection of colonic adenocarcinoma stage III or II high risk, Molecular analysis of exon 9 and 20 of PI3K
- Where
- France
- Volunteers
- 264 people
- Sponsor
- University Hospital, Rouen
Aortic Aneurysm, Surgery
Evaluation of the Effectiveness of Ischemic Pre-conditioning on the Morbidity and Mortality of Open Surgery of Thoracoabdominal Aortic Aneurysms.
Patients having a planned open surgery of thoracoabdominal aortic aneurysms and enrolled in the study will be randomized the day of the surgery in 2 groups: Arm 1 : Patients with aortic clamping with pre-conditioning Arm 2 …
- Trial name
- EPICATA (NCT03718312)
- Testing
- clamping with pre-conditioning (PCl)
- Where
- France
- Volunteers
- 65 people
- Sponsor
- University Hospital, Rouen
Neisseria Meningitidis
Evaluation of Immune Response Against the Strain of Neisseria Meningitidis B: 14, P1-7, 16 in Patients Having to be Vaccinated MenBVac® (Extension EFFIVAC)
The main objective of the study is to estimate the proportion of children, born between the 06/04/2004 and the 17/004/2008, living around Neufchatel en Bray, vaccinated by MenBVac, with a serum bactericidal activity against…
- Trial name
- Exten Effivac (NCT01621945)
- Testing
- MenBvac
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen