Clinical trials: sponsored by University Hospital, Rouen
Psychogenic Paralysis
rTMS and Functional Paralysis
Psychogenic paralysis presents a real treatment challenge. Despite psychotherapy, physiotherapy, antidepressants, acupuncture or hypnosis, the outcome is not always satisfactory with persistent symptoms after long-term follow-up.
- Trial name
- PARALYSTIM (NCT01352910)
- Testing
- rTMS
- Where
- 2 sites in France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Rouen
Developmental Disorders
Risk of Recurrence of de Novo Mutations: Research and Quantification of Paternal Germinal Mosaicism by the Combined Use of Genomic Tools
1. Inclusion of 5 families Inclusions will be made by the clinical genetics department of the Rouen University Hospital (monocentric study) and will correspond to trios of parents + child with unexplained developmental…
- Trial name
- RRMUT (NCT04564235)
- Testing
- genome-wide analyses, Search for de novo mutations in paternal sperm samples
- Where
- France
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Cardiac Resynchronisation Therapy
Acute Assessment of a Micro Multipolar Lead for Enhanced Cardiac Resynchronisation Therapy
Pilot study to evaluate the performance of a lead below 2 French with specific distal shape to deliver efficient LV pacing
- Trial name
- AXONE-Acute (NCT03750058)
- Testing
- Implant test procedure
- Where
- 4 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Rouen
Autosomal Dominant Cases of Alzheimer 's Disease
Genetics of Mendelian Forms of Young Onset Alzheimer Disease
Genetics of mendelian forms of young onset Alzheimer Disease (GMAJ project) Introduction : Autosomal dominant forms of Alzheimer disease (AD) are characterized by young age of onset.
- Trial name
- GMAJ (NCT01622894)
- Testing
- Genetic-Tailored AntiThrombotic Strategy
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Rouen
COVID, RT-ddPCR Multiplex
Development of a Molecular Diagnostic Strategy for SARS-CoV2 Based on Saliva in the Context of the COVID-19 Pandemic
The objective of the study is to develop and validate a molecular diagnostic strategy (RT-ddPCR multiplex) of COVID-19 based on a saliva sample and alternative to the RT-qPCR method, in order to : 1.
- Trial name
- MolCOVID (NCT04367545)
- Testing
- Saliva collection
- Where
- France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Rouen
Video Assisted Thoracoscopy, Anesthesia
Double Regional Anesthesia in Video Assisted Thoracoscopy
Monocentric, randomized, controlled, single-blind study who's aim is to demonstrate the efficacy of the association of paravertebral block and serratus plane block with paravertebral block alone
- Trial name
- DRAVATS (NCT03852862)
- Testing
- Serratus plane block and paravertebral block, paravertebral block
- Where
- France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Rouen
Cognitive Impairment, Mild, Dementia, Mild
Identify the Benefits CAREGIVERSPRO-MMD Platform Use Based on the Information and Communications Technology, Dedicated to the Support and Assistance of Dyads Living With Neurocognitive Diseases and Their Primary Caregivers
Our main goal is to test a web platform accessible by computers, smartphones and tablets, addressed specifically to caregivers and people with mild cognitive deterioration or mild to moderate dementia providing added value…
- Trial name
- CAREGIVERSPRO (NCT03536975)
- Testing
- Platform
- Where
- 2 sites in France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Anderson-Fabry Disease
Follow-up of Myocardial T1 Relaxation Time in Patients With Anderson Fabry Disease
Anderson Fabry disease (AFD) is an X-linked lysosomal storage disorder caused by a deficiency of the enzyme alpha-galactosidase. AFD can involve various organs and lead to a series of clinical abnormalities.
- Trial name
- MyFABT1 (NCT02956954)
- Testing
- Enzyme replacement therapy (Agalsidase alpha (Replagal®)), Magnetic Resonance Imaging
- Where
- France
- Volunteers
- 26 people
- Sponsor
- University Hospital, Rouen
Cardiac Surgery
Study of the Expression of Endoplasmic Reticulum Stress During Extracorporeal Circulation in Humans
The links between systemic inflammation, endothelial dysfunction and endoplasmic reticulum (ER) stress in pre-clinical models make it an interesting potential therapeutic target, but there are no data describing SRE during severe…
- Trial name
- STRECH (NCT03722979)
- Testing
- Cardiac surgery
- Where
- France
- Volunteers
- 53 people
- Sponsor
- University Hospital, Rouen
Healthy, Vascular Stiffness
Effect of Pharmacological Heart Rate Reduction on Visco-elastic Properties of the Arterial Wall (BRADYVASC)
The conduit arteries exhibit a viscoelastic behavior. Visco-elasticity is partially regulated by endothelium and contributes to the optimization of the heart-vessel coupling.
- Conditions
- Healthy, Vascular Stiffness, Aging
- Trial name
- BRADYVASC (NCT02584439)
- Testing
- ivabradine
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Kyphosis
Study of Spino-pelvic Sagittal Balance by Vicon® Optoelectronic System
Spinal diseases often induce gait disorders with multifactorial origins such as lumbar pain, radicular pain, neurologic complications, or spinal deformities.
- Trial name
- VICON-SPINE (NCT03536403)
- Testing
- EOS X-rays, 8-meters walk test
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Bullous Pemphigoid
Efficiency and Tolerance of Rituximab (mabthéra) in Bullous Pemphigoid
The aim of the study is to assess that it will be possible to control with a single cycle of rituximab patient with bullous pemphigoid.
- Trial name
- Rituximab2 (NCT00525616)
- Testing
- Mabthera
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Rouen
Colorectal Cancer
Prognostic Value of the Lymphocytic Infiltrate in Colon Cancers
Colorectal cancer (CRC) is one of the most common cancers in France (36,000 new cases / year) and nearly 16,000 people die each year from this disease.
- Trial name
- TIL (NCT02557061)
- Testing
- Colorectal surgery (resection), Blood sampling
- Where
- France
- Volunteers
- 56 people
- Sponsor
- University Hospital, Rouen
Pulmonary Nodule Persistent, Malignant Neoplasm of the Respiratory System
Assessment of Probe Based Confocal Laser Endo-microscopy for In-vivo Diagnosis of Peripheral Lung Nodules and Masses.
Solitary pulmonary nodule has become a major challenge in respiratory clinical practice. According to published guidelines, their management often requires close CT follow up, PET CT and invasive procedures to obtain a definite…
- Conditions
- Pulmonary Nodule Persistent, Malignant Neoplasm of the Respiratory System, Benign Neoplasms of the Respiratory System
- Trial name
- NODIVEM (NCT01931579)
- Testing
- confocal endo-microscopy
- Where
- 3 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Rouen
Urinary Tract Infection Empiric Antibiotic
Does the National Health Insurance Card Allow us to Predict Antibiotic Resistance?
The objective is to determine if data from the National Insurance Health card (giving antibiotics and hospitalizations in the past 18 months) allow to predict the individual risk of antibiotic resistance and to identify…
- Trial name
- NCT02292160
- Where
- 2 sites in France
- Volunteers
- 1,128 people
- Sponsor
- University Hospital, Rouen
Rectocele, Intussusception
Does the Stapled Transanal Rectal Resection (STARR Procedure) Has an Effect on Anal Compliance ?
The stapled transanal rectal resection (STARR) has recently been recommended for patients with obstructed defecation syndrome (ODS) caused by rectocele and rectal wall intussusception.
- Conditions
- Rectocele, Intussusception, Surgery, Sphincter Ani Incontinence
- Trial name
- Compli-STARR (NCT02052063)
- Testing
- stapled transanal rectal resection, Anal compliance measure with Endoflip system
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Rouen
Cancer
Oligogenic Determinism of Colorectal Cancer
The majority of the clinical situations suggestive of an increased genetic risk for colorectal cancer (CRC) are not explained by a simple monogenic model.
- Trial name
- DOCC (NCT01057953)
- Testing
- Blood drawn
- Where
- 16 sites in France
- Volunteers
- 1,550 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Weaning, Chronic Respiratory Failure
Non Invasive Ventilation and Weaning : VENISE Trial
The clinical efficacy of noninvasive ventilation (NIV) has now been demonstrated in the management of acute-on-chronic respiratory failure (ACRF) of various etiologies.
- Trial name
- VENISE (NCT00213499)
- Testing
- non invasive ventilation
- Where
- France
- Volunteers
- 205 people
- Sponsor
- University Hospital, Rouen
Essential Hypertension, Metabolic Syndrome
Vascular Impact of Omega-3 in Metabolic Syndrome
The overall aims of the present project are to investigate the impact of a nutritional approach based on omega-3 from vegetal origin on vascular function in hypertension associated with metabolic syndrome.
- Trial name
- CARDIOMEGA (NCT01566188)
- Testing
- omega-3 from vegetal origin
- Where
- 4 sites in France
- Volunteers
- 95 people
- Sponsor
- University Hospital, Rouen
Allergy to Egg, Allergy to Peanut
Basophil Activation Test (BAT) Sensitivity in Child Food Allergy
Child food allergy represent 6 to 8% of child in industrialised country. Within this allergy, peanuts and egg allergy are one of the most common.
- Trial name
- TAB-TPO (NCT01966640)
- Testing
- Basophil Activation Test
- Where
- France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Rouen