Clinical trials: sponsored by University Hospital, Toulouse
Idiopathic Scoliosis, ERAS
Early Standing in Minors Operated on for Idiopathic Scoliosis
The implementation of an enhanced rehabilitation after surgery (ERAS) program in major orthopedic surgery and in scoliosis surgery in children and adolescents has become a marker of good practice.
- Trial name
- LevPOS (NCT06152601)
- Testing
- anticipated bipedal standing position in the immediate post-operative phase
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Osteonecrosis of the Jaw
Leukocyte- and Platelet-Rich Fibrin in the Surgical Treatment of Medication-related Osteonecrosis of the Jaw
Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious side-effect of antiresorptive therapies used in the management of bone diseases, such as osteoporosis or bone metastases.
- Trial name
- PeRFOrMand (NCT06419010)
- Testing
- Surgery with the use of L-PRF, Standard surgery
- Where
- 7 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Toulouse
Cognitive Dysfunction
Electrophysiological Signatures of Cognitive Disorders Related to Intensive Care Unit (ICU) delirium_ BRAINSTORM-EEG
Early cognitive assessment of critically-ill acute respiratory distress syndrome (ARDS) patients with delirium using a multidimensional electrophysiological evaluation battery (mEEG) to identify and characterize the neural…
- Trial name
- B-EEG (NCT06089538)
- Testing
- mEEG battery
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Toulouse
Stroke
Executive Functions Computerized Rehabilitation Using Virtual Reality to Improve Activities of Daily Living Post-stroke
This research aims to evaluate the effects of a cognitive reeducation carried out with the COVIRTUA Cognition software using a virtual environment, on real-life execution of activities of daily living (ADL) for patients with…
- Trial name
- RéFEx (NCT04855903)
- Testing
- Covirtua Cognition software
- Where
- 2 sites in France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Toulouse
Schizophrenia Disorders
Cognitive Remediation Method Using Rhythmic, Vocal and Corporal Musical Learning for Schizophrenia
Schizophrenia, affecting 1% of the population, is a persistent disorder characterized by varied symptoms. Antipsychotic medications effectively address positive symptoms (delusions, hallucinations) and relapse but have limited…
- Trial name
- ARCoS-2 (NCT07055204)
- Testing
- "Diapason & Metronome" musical learning
- Where
- 6 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Toulouse
Idiopathic Hypersomnia, Mood Disorder
Psychiatric Co-morbidities and Socio-demographic Characteristics in Patients With Idiopathic Hypersomnia
This is a study of only patients with idiopathic hypersomnia. It is a rare and still poorly understood pathology. In clinical practice, we have found that the treatment and care offered were not always effective.
- Conditions
- Idiopathic Hypersomnia, Mood Disorder, Bipolar Disorder
- Trial name
- HYPERSOMNPSY (NCT05778721)
- Testing
- respond to questionnaires by telephone
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Toulouse
Schizophrenia
Bizarreness and Anomalous Self Experiences in Schizophrenia
Several authors suggest that the specific experience felt in clinical encounter, called Praecox Feeling, is directly linked to the psychopathology of Schizophrenia.
- Trial name
- BASES (NCT05966610)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Toulouse
Cirrhosis
"Anticipant"-TIPS After a First Portal-hypertension-related Complication in Cirrhosis
Further decompensation (FD) in cirrhosis represents a prognostic stage associated with an even higher mortality than that associated with the first decompensation.
- Trial name
- Ant-TIPS (NCT07889726)
- Testing
- TIPS, Standard of Care (SOC)
- Where
- 8 sites in France
- Volunteers
- 266 people
- Sponsor
- University Hospital, Toulouse
Epilepsy
Contribution of Fast-ripples to the Improvement of the Neurosurgical Management of Drug-refractory Epilepsy
The main aim of this study is to evaluate the contribution of fast-ripples (FR) information on the neurosurgery management of patients with drug-refractory epilepsy investigated by Stereo-ElectroEncephaloGraphy (SEEG), as…
- Trial name
- NENUFAR (NCT06105645)
- Testing
- DIXI Medical Microdeep® Micro- Macro Depth electrodes, Standard electrodes
- Where
- 12 sites in France
- Volunteers
- 440 people
- Sponsor
- University Hospital, Toulouse
Anesthesia
Feasibility and Quality of TeleConsultation in Pediatric Anesthesia
Teleconsultation (TLC) being a new method of anesthesia consultation, deployed as an emergency in healthcare facilities in the Covid context, it has never been evaluated either in terms of feasibility or in terms of quality.
- Trial name
- TéléCCCAP (NCT04583865)
- Testing
- teleconsultation
- Where
- 11 sites in France
- Volunteers
- 848 people
- Sponsor
- University Hospital, Toulouse
Severe Asthma
Withdrawal of Dupilumab in Severe Asthma
Asthma management has been revolutionised by the development of biological therapies. Dupilumab is an anti-interleukin4 receptor marketed in 2020 for severe asthmatic patients with 2 exacerbations or more within the last 12…
- Trial name
- WIDUSA (NCT06818019)
- Testing
- Stopping dupilumab
- Where
- 29 sites in France
- Volunteers
- 205 people
- Sponsor
- University Hospital, Toulouse
Alzheimer Disease
Impact of Therapeutic Educational Programme on the Alzheimer's Disease Affected Patient's Quality of Life
Therapeutic education expands in Alzheimer's Disease management in France. Several studies revealed a positive impact on caregiver's burden and/or quality of life.
- Trial name
- THERAD (NCT01796314)
- Testing
- Therapeutic Educational Program
- Where
- France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Toulouse
Pregnancy
Comparative Analysis of Labor Induction Using a Balloon Catheter at Home Versus in the Hospital
An increasing proportion of patients undergo labor induction at the end of pregnancy. Balloon induction at home is a method validated in the literature.
- Trial name
- BALHOME (NCT07848412)
- Testing
- Questionnaire and Physical Exam
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Toulouse
Post-traumatic Stress Disorder
Treatment of PTSD by Reduction of Traumatic Memory Reconsolidation by Propranolol : a Multisite Trial
The purpose of this study is to test whether propranolol, when given during a re-evocation of a traumatic memory, is capable of reducing subsequent PTSD symptoms associated with that memory.
- Trial name
- REDUCTRAUMA2 (NCT01713556)
- Testing
- Propranolol, Trauma reactivation
- Where
- 4 sites in France
- Volunteers
- 87 people
- Sponsor
- University Hospital, Toulouse
PARKINSON DISEASE (Disorder)
Effect of Botulinum Toxin on Resting Tremor of the Refractory Upper Limb in Parkinsonians
Tremor is one of the most common symptoms in Parkinson Disease (PD), affecting almost 60% of patients. There is currently no specific treatment for tremor in PD, and 30% of patients develop drug-resistant tremor, making its…
- Trial name
- TOX PARK (NCT07822893)
- Where
- 2 sites in France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Toulouse
Hearing Loss
Optimization of Hearing Performance in the Subject Implanted
In the past two decades, the selection criteria for cochlear implantation have been greatly relaxed so that about 60-70% of present cochlear implant (CI) candidates have significant residual hearing in their contralateral ear.
- Trial name
- OPERSA (NCT05325450)
- Testing
- Program A, Program B, Control
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Toulouse
Appetite Loss in Aging, Anorexia of Aging
Study on the Prevention of Weight Loss Through Physical Activity Among Nursing Home Residents
Appetite loss is frequent in institutionalized older adults. Physical activity is known for its benefits on appetite regulation but its effects in nursing home residents remain poorly investigated.
- Trial name
- EAT-PA (NCT07831733)
- Testing
- Physical activity, Appetite assessment, Food intake assessment
- Where
- France
- Volunteers
- 596 people
- Sponsor
- University Hospital, Toulouse
Asthma
Detection of Cav1 Calcium Channels in Inflammatory Cells of Asthmatic Children
Asthma affects about 10% of children and 6% of adults in industrialized countries. Lymphocytes (L) Th2, a T cell population (LT) producing interleukin (IL) -4, 5 and 13 are broadly involved in this pathology in experimental…
- Trial name
- CAVASTHME (NCT02809560)
- Testing
- Induced sputum method using hypertonic serum
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Netherton Syndrome
A Pilot Study of the Efficacy and Safety of Dupilumab Versus Placebo in Patients With Netherton Syndrome
To date, there are no effective therapy for the management of Netherton Syndrome (NS) Patients use emollients with a limited efficacy on scaling and no efficacy on skin inflammation and pruritus.
- Trial name
- NS-DUPI (NCT04244006)
- Testing
- Dupilumab Prefilled Syringe
- Where
- 2 sites in France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Toulouse
Cannabis Intoxication in Children
Contamination of Young Children Hair During Acute Cannabis Intoxication
Hair analysis in pediatric cannabis intoxication is limited by possible sudoral self-contamination, especially in young children due to hair porosity. However, adult studies show no THC-COOH in sweat, challenging this hypothesis.
- Trial name
- INTERACTION (NCT07524088)
- Testing
- sudoral and hairing sampling
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Toulouse