Clinical trials: sponsored by University Hospital, Tours
Certain Disorders Involving the Immune Mechanism
Development and Qualification of Methods for Analyzing the Mucosal Immune Response to COVID-19
The pandemic associated with the SARS-CoV-2 coronavirus has affected over 760 million individuals worldwide, resulting in more than 6.9 million deaths.
- Trial name
- MUCOVID (NCT06142279)
- Testing
- Sampling, PCR (polymerase chain reaction) SARS-CoV-2
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Cesarean Section, Pregnancy
Effect of Acupressure on the "Yin-Tang" and "Shen-Men" Points on Pre and Postoperative Anxiety in Elective Caesarean Section: a Prospective, Single-blind, Randomised, Controlled Trial
Preoperative anxiety occurs commonly in elective caesarean section and is associated with increased perioperative morbidity. Some groups have used non-pharmacological techniques such as acupressure for its treatment since drugs…
- Conditions
- Cesarean Section, Pregnancy, Preoperative Anxiety
- Trial name
- ACUCESAR (NCT06119971)
- Testing
- ACUPRESSURE
- Where
- France
- Volunteers
- 44 people
- Sponsor
- University Hospital, Tours
Acceptance of Visible Chronic Dermatological Disease, Disease Acceptance
Measure of Acceptance of chRonic Visible sKin conditionS
The objective of this protocol is to validate 4 scales for evaluating the acceptance of visible chronic dermatological diseases (port wine stains, alopecia areata, vitiligo, hyperpigmentation...) with a large number of patients…
- Conditions
- Acceptance of Visible Chronic Dermatological Disease, Disease Acceptance, Psychological Well-Being, Social Segregation
- Trial name
- MARKS (NCT06103903)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Tours
COVID-19
Risk Stratification of Patients With Suspected COVID-19 Presenting to the ED
Descriptive study of patients with suspected COVID-19 upon ED arrival of European hospitals between March 09 and April 08 2020. Justification:
- Trial name
- EuroCOV (NCT05465824)
- Where
- France
- Volunteers
- 7,876 people
- Sponsor
- University Hospital, Tours
Sensorineural Hearing Loss
Electrical Impulse Parameters and Neuronal Population in the Cochlear Implanted Patient-PULSE
The cochlear implant provides good auditory performance despite high inter-individual variability, but performance in noise remains limited. Modification of the coding strategies could improve these performances.
- Trial name
- PULSE (NCT06013215)
- Testing
- Cochlear implant (Oticon) stimulation parameter optimization
- Volunteers
- 15 people
- Sponsor
- University Hospital, Tours
Thrombotic Microangiopathy, Acute Kidney Injury
French National Cohort MATRIX "Renal and Systemic Thrombotic Microangiopathy"
Thrombotic microangiopathies (TMAs) are a diverse, rare but serious group of diseases. Progress has been made regarding the epidemiology of TMA (Bayer CJASN 2019).
- Conditions
- Thrombotic Microangiopathy, Acute Kidney Injury, Hemolytic Uremic Syndrome, Nephrology
- Trial name
- MATRIX (NCT05991245)
- Testing
- Collecting datas
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Tours
Pre-eclampsia
Early Placental Insufficiency Screening
To assess the role of uterine artery and maternal serum PlGf and sflt-1 and their combination in screening for pre-eclampsia and small -for-gestational age (SGA) fetuses at 12-14 weeks of gestation
- Trial name
- BIODOP-T1 (NCT01348711)
- Where
- 4 sites in France
- Volunteers
- 226 people
- Sponsor
- University Hospital, Tours
Depression, Burnout, Professional
Health cAre woRkers exposeD to COVID-19
Health care workers working in hospital or nursing home for elderly people involved in the coronavirus epidemic are facing several challenges such as direct exposure and involvement in the resolution of major public health…
- Conditions
- Depression, Burnout, Professional, Post Traumatic Stress Disorder
- Trial name
- HARD-COVID19 (NCT04570202)
- Testing
- EMDR
- Where
- 2 sites in France
- Volunteers
- 900 people
- Sponsor
- University Hospital, Tours
Non Small Cell Lung Cancer, Bladder Cancer
Prospective Study to Evaluate the Blood Kinetics of Immune Cells and Immunosuppressive Cytokines After Exposure to an Immunity Checkpoint Inhibitor (ICI): Study of the Impact of Chemotherapy
Non-small cell lung cancer (NSCLC) is the most common histological form, accounting for 85% of all bronchopulmonary cancers (PBC).
- Conditions
- Non Small Cell Lung Cancer, Bladder Cancer, ENT Cancer
- Trial name
- CINECI (NCT04487457)
- Testing
- Blood samples
- Where
- 2 sites in France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Tours
Lymphangioleiomyomatosis, Tuberous Sclerosis Complex
Lymphangioleiomyomatosis, a Study on Cathepsin K
This is a physiopathological case-control, non-interventional, monocentric study of adult patients with lymphangioleiomyomatosis.
- Trial name
- LAM-CAK (NCT05323370)
- Testing
- 24h urine, urine sample
- Where
- France
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Colorectal Cancer, Hepatic Metastases
Targeted Delivery of Chemotherapy With Ultrasound and Microbublles
The oscillations of ultrasound (US) contrast agent microbubbles under their activation by US waves engender a modulation of the permeability of biological barriers amplifying hence the extravasation of drugs and/or fluorescent…
- Trial name
- SONCHIMIO (NCT03458975)
- Testing
- MRI, Perfusion CT scan, Contrast enhanced ultrasound
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Tours
Quality of Work Life of Psychiatric Nurses, Impact on Quality of Care
Determinants of the Quality of Work Life of Psychiatric Nurses and Relief on the Quality of Care
Psychological well-being at work is a major public health issue. The number of sick personal leaving hospitals has increased by 10% in five years and the average cost of absenteeism is around 3000 euros per agent per year.
- Trial name
- DETERQVT (NCT04026854)
- Testing
- Quality of live at work
- Volunteers
- 400 people
- Sponsor
- University Hospital, Tours
Patient Starting Bevacizumab, Cancer
SAlt Diet and Various Biomarkers Effects on Blood Pressure and Proteinuria During Inhibition of VEGF)
Bevacizumab is an anti-angiogenic treatment used to treat various solid cancers. Previous studies have shown that this treatment may have adverse effects like hypertension and proteinuria.
- Trial name
- SAVE (NCT03842917)
- Testing
- Biological samples, Blood pressure measurement
- Where
- 3 sites in France
- Volunteers
- 26 people
- Sponsor
- University Hospital, Tours
Autistic Disorder
Clinical and Neurophysiological Evolutions Through a Functional Rehabilitation of Social Communication in ASD
This study aims to identify clinical and biological markers which would allow to evaluate precisely the evolution of children with autism spectrum disorders throughout intervention.
- Trial name
- NCT02444117
- Testing
- functional rehabilitation of social communication
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Tours
Personalized Pharmaceutical Plan After Transpantation
Establishment of a Personalized Pharmaceutical Plan in Renal or Hepatic Transplant Patients
The main objective of the study is to evaluate the impact of the Personalized Pharmaceutical Plan on the therapeutic adherence to immunosuppressive treatments one year after liver or kidney transplantation.
- Trial name
- GREPH (NCT04295928)
- Testing
- PPP
- Where
- 12 sites in France
- Volunteers
- 1,716 people
- Sponsor
- University Hospital, Tours
Transplantation, Kidney
Comparison of Two Techniques of Renal Pre-transplant Infusion on the Evolution of Renal Function in the Recipient
Comparison of two techniques of renal pre-transplant infusion on the evolution of renal function in the recipient: multicentre randomized trial
- Trial name
- RENOMAP (NCT02826213)
- Testing
- LifePort® perfusion device, Waves perfusion device
- Where
- 7 sites in France
- Volunteers
- 228 people
- Sponsor
- University Hospital, Tours
Presbyopia
Presbyopia Compensation: Looking for Electrophysiological Predictors
The main purpose of this study was to identify electrophysiological predictive markers of post-correction visual comfort for presbyopic patients.
- Trial name
- NCT02444130
- Testing
- contact lenses
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Tours
Adult Phenylketonuria Non Treated Patients
Glytactin EfficiEncy in Non or Insufficiently Treated Adult PHENylketonuria Patients
Phenylketonuria is the most common inherited metabolic disease in France and is screened for neonatal exposure. Management consists of a strict and restrictive hypoproteic diet and the intake of amino acid substitutes and dietary…
- Trial name
- GLEEPHEN (NCT03924180)
- Testing
- Dietary Supplement for PKU patients
- Where
- 7 sites in France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Tours
Memory Complaint, Mild Cognitive Impairment
PET Imaging of the Translocator Proteine Ligands (TSPO) With [18 F] DPA-714 Biomarker of NeuroInflammation in Cognitive Decline (NIDECO)
Alzheimer's disease (AD) is the most common cause of dementia in elderly subjects. AD is characterized by brain lesions like extracellular deposits of ß-amyloïd proteins in senile plaques and intracellular neurofibrillary tangles…
- Conditions
- Memory Complaint, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NIDeCo (NCT02062099)
- Testing
- [18F]DPA-714 PET/ [18F]AV-45 PET/neuropsychological assessment
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Tours
Alzheimer Disease
Neuroinflammation and Cognitive Decline in Alzheimer Disease
The purpose of this study is to assess the level of neuroinflammation in Alzheimer Disease subject (mild to moderate) estimated with Binding Potential (BP) of [18F]DPA-714, and its relationship with the kinetics of cognitive…
- Trial name
- NICAD (NCT02377206)
- Testing
- ADAS-Cog evaluation
- Where
- 3 sites in France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Tours