Clinical trials: sponsored by University Hospital, Tours
Alzheimer's Disease, Hearing Loss
Auditory Rehabilitation and Cognition in Alzheimer Patients
Alzheimer disease is a neurodegenerative disease. Recent studies suggest that subjects with hearing loss are more likely to develop Alzheimer's disease.
- Trial name
- RACO-MA (NCT03002142)
- Testing
- Hearing aids
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Tours
Rheumatoid Arthritis
Relationship Between T LYmphocytes Depletion and Clinical Response to RITUXimab in Rheumatoid Arthritis (LYRITUX)
Rituximab, an anti CD-20 monoclonal antibody targeting B lymphocytes is prescribed in rheumatoid arthritis (RA) patients refractory to TNF alpha antagonists.
- Trial name
- LYRITUX (NCT02304354)
- Testing
- Rituximab
- Where
- 8 sites in France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Tours
Pain, Traumatic Injury
Use of Methoxyflurane (Penthrox) as an Antalgic in Hospital Trauma
Study of traumatized patients treated in emergency departments of Tours, seeking to optimize the management of trauma pain in an inpatient setting, with the opportunity to integrate inhaled methoxyflurane (Penthrox®) into the…
- Trial name
- UMATH (NCT03927729)
- Testing
- Methoxyflurane
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Tours
Liver Transplant Infection, Surgical Site Infection
Pharmacological Study of Cefazolin Antibioprophylaxis in Liver Transplantation
This study describes Cefazolin pharmacokinetics variation to target levels during liver transplantation.
- Conditions
- Liver Transplant Infection, Surgical Site Infection, Antibiotic Prophylaxis, Cephazolin Adverse Reaction
- Trial name
- ProCeTH (NCT04280237)
- Testing
- Blood samples
- Where
- France
- Sponsor
- University Hospital, Tours
Hypothermia, Thoracic Neoplasm
Evaluation of the Reliability of Oesophageal Temperature in THOracic Surgery
Controlling hypothermia is essential in anesthesia to limit postoperative complications. Temperature monitoring is therefore essential.
- Conditions
- Hypothermia, Thoracic Neoplasm, Anesthesia
- Trial name
- ThoTem (NCT03903991)
- Testing
- Temperature recording
- Where
- 2 sites in France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Tours
Breast Cancer, Chemotherapy-induced Peripheral Neuropathy
Involvement of SK3 Calcium Channel in Taxane Neuropathy
Taxane neuropathy is a common and long-term side effect of long-term morbidity in patients surviving cancer. No preventive or symptomatic treatment has been shown to be effective.
- Conditions
- Breast Cancer, Chemotherapy-induced Peripheral Neuropathy, Prostate Cancer
- Trial name
- NEUROTAX (NCT03816904)
- Testing
- Blood samples
- Where
- 2 sites in France
- Volunteers
- 97 people
- Sponsor
- University Hospital, Tours
Peripheral Facial Paralysis
Lengthening Temporalis Myoplasty and Improvement of Primary Swallowing Disorders in Facial Paralysis
The facial paralysis is a frequent disease causing important functionals swallowing dysfunctions. The purpose of our study was to evaluate the improvement of the swallowing disorders after surgery by lengthening temporalis…
- Trial name
- MATPF (NCT03284125)
- Testing
- Swallowing disorders evaluation
- Where
- France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Tours
Sepsis
Evaluation of the Performance of Sepsis Predictive Scores on the Elderly Population in the Emergency Department.
The main objective of the research is to evaluate the prognostic performance of qSOFA, NEWS and MEDS scores in patients over 65 years of age presenting to the emergency department with a diagnosis of infection made by the…
- Trial name
- NCT04721275
- Testing
- measurement of pronostic sepsis scores
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Tours
Myelodysplastic Syndrome, Secondary Acute Myeloid Leukemia
Plasmatic L-AScorbic Acid in MYelodyplastic Syndroms and Controls
Myelodysplastic syndromes (MDS) is a group of heterogeneous diseases characterised by the clonal evolution of dysplastic hematopoietic stem cells.
- Trial name
- PLASMYC (NCT02809222)
- Testing
- Samples, Quality of life questionnaire
- Where
- 2 sites in France
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Liver Dysfunction, Circulatory; Change
Study of Hemodynamic Conditions Measured During Hepatectomy
Hepatocellular insufficiency is a dreaded complication after hepatectomy, since, if it is persistent, it leads to the death of the patient in the absence of liver transplantation.
- Trial name
- DEBIFOIE (NCT03371537)
- Testing
- Liver debit measure
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Tours
Lupus Erythematosus, Systemic
Role of the Neonatal Fc Receptor for IgG in the Pathophysiology of Lupus
This study evaluates the expression of the neonatal fc receptor (FcRn) in white blood cells and antigen-presenting cells (APC) in active lupus patients compared to inactive lupus patients and control to investigate if it's…
- Trial name
- RFPL (NCT03896373)
- Testing
- Blood samples
- Where
- 2 sites in France
- Volunteers
- 48 people
- Sponsor
- University Hospital, Tours
COVID-19 Infection, ANAKINRA Treatment
Anakinra for COVID-19 Respiratory Symptoms
The main objective of the ANACONDA-COVID-19 trial is to assess the efficacy of Anakinra + optimized Standard of Care (oSOC) as compared to oSOC alone on the condition of patients with COVID-19 infection and worsening respiratory…
- Conditions
- COVID-19 Infection, ANAKINRA Treatment, Optimized Standard of Care (oSOC)
- Trial name
- ANACONDA (NCT04364009)
- Testing
- Anakinra plus oSOC, oSOC
- Where
- France
- Volunteers
- 71 people
- Sponsor
- University Hospital, Tours
Memory Disorders, Age-Related Cognitive Decline
Effect of Vitamin D on Cognitive Decline of Patients With Memory Complaint
As recommended allowance of oral vitamine D are unable to ensure the recommended serum concentration of vitamine D, the purpose of this study is to show that a dose of vitamin D3 higher than the recommended allowance may slow the…
- Trial name
- D-COG (NCT02185222)
- Testing
- Cholecalciferol 100 000 UI
- Where
- 11 sites in France
- Volunteers
- 68 people
- Sponsor
- University Hospital, Tours
Kidney Transplant; Complications
Kidney Transplant Volumetry
This study assesses the reproducibility of 3 different formulas in calculating the volume of a transplanted kidney by ultrasound in-vivo measurements.
- Trial name
- NCT03855085
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Tours
Carbon Monoxide Poisoning
Is Transcutaneous Carbon Monoxide Saturation of E-cigarette Users Comparable to That of Smokers?
Suspicions of carbon monoxide poisoning that lead to the treatment of victims are numerous. Measurement of transcutaneous carbon monoxide saturation (SpCO) is a useful diagnostic and triage tool for victims and the toxic…
- Trial name
- COVAP (NCT03669848)
- Testing
- Pulse CO-oximetry
- Where
- France
- Volunteers
- 1,116 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Kidney Cancer, Lung Cancer
Study of the Concentration-effect Relationship of Nivolumab in Patients With Kidney or Lung Cancer
To assess the relationship between progression free survival of patients treated with nivolumab for metastatic non small cell lung carcinoma or a metastatic renal cell carcinoma and nivolumab blood concentration.
- Trial name
- NIVEAL (NCT03433534)
- Testing
- Pharmacokinetic of Nivolumab
- Where
- 2 sites in France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Tours
Prostate Cancer
Structural Network on Prostate Cancer in the French Greater West Region
The project aims at developing and structuring a network of clinicians, pathologists, and scientists, from the "Grand Ouest" area, most of them already involved in prostate cancer management and research.
- Trial name
- RESCAP (NCT03214315)
- Testing
- Visceral adipose tissue specimen
- Where
- 7 sites in France, Guadeloupe
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Tours
Shaken Baby Syndrome
Predictors of Sequelae Appearance in Shaken Baby Syndrome
This is an observational, prognostic and prospective study. It is about the Prognostic Factors for sequelae in children with a history of Shaken Baby Syndrome (SBS) in the Central region in France.
- Trial name
- FPASSBS (NCT04105673)
- Testing
- Clinical examination and survey
- Sponsor
- University Hospital, Tours
Hypertensive Disease, Elderly
Evaluation of Transcranial Doppler Vasoconstrictor Vasoreactivity During General Anesthesia in Hypertensive Patients
During a general anesthesia, people over 65 years old and hypertensive, have a modification of the vasoreactivity and their cerebral blood flow under vasoconstrictor such as norepinephrine or phenylephrine.
- Conditions
- Hypertensive Disease, Elderly, Vasopressors, General Anesthesia
- Trial name
- DiVADH (NCT03897790)
- Testing
- Transcranial Doppler (DTC)
- Sponsor
- University Hospital, Tours
Elderly, Iatrogenic Drug Risk
Iatrogenic Drug Risk in People Over 75, With or Without Cognitive Disorders, From an Inventory of Their Family Pharmacy
Many hospitalizations or emergency room visits are due to problems of iatrogenic medication, especially in elderly patients who are very often polymedicated. Moreover, they are more at risk because of fragility.
- Trial name
- RIMPAP (NCT03686943)
- Testing
- Family pharmacy
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Tours