Clinical trials: sponsored by University Hospital, Tours
Cancer Colorectal
Impact of EDUcation Strategy on Patients With COLorectal CANCER or Advanced Adenoma in the Detection of Colorectal Cancer of Their First-degree Relatives
The relative risk of colorectal cancer (CRC) is increased in first-degree relatives of patients with CRC or advanced adenoma. In the high-risk CCR population defined by a family history at the first stage of CRC or advanced…
- Trial name
- EDUCANCOLAGE (NCT03084133)
- Testing
- Therapeutic Education Strategy
- Where
- 8 sites in France
- Volunteers
- 68 people
- Sponsor
- University Hospital, Tours
Healthy
Changes in Brain Tissue Pulsatility With Musical Stimuli
Music Perception is well known to elicit emotions and neuronal activations. Changes in the cerebrovascular physiology have also been found in emotional tasks but only few studies have investigated markers of cerebrovascular…
- Trial name
- M-PULSE (NCT03867422)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Tours
Breast Cancer
Evaluation of the Short Message Service Effectiveness in the Screening Invitation Strategy for Breast Cancer (USIMaPI)
Each year in France, breast cancer affects about 48,000 women and is the first cause of cancer death in women with 11,900 deaths estimated.
- Trial name
- USIMaPI (NCT03000920)
- Testing
- SMS before invitation, SMS Reminder 1
- Where
- 4 sites in France
- Volunteers
- 12,000 people
- Sponsor
- University Hospital, Tours
Cancer Cervix
Carrying Out of Focus Group to Improve Cervical Screening Proposal by Vaginal Self-sampling (APACHE-4/FG).
Despite the existence of an effective screening test (pap smear), cervical cancer is, every year in France, the cause of more than 3,000 new cases and 1,100 deaths.
- Trial name
- APACHE-4/FG (NCT03420157)
- Testing
- Focus Group
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
ALS
Evaluation of Metabolomic Analysis in Early Diagnosis of ALS
This project is expected to answer the question of interest assays of metabolites in the CSF as a tool for early diagnosis and should show whether it is possible or not to use such markers in the blood or urine.
- Trial name
- METABALS (NCT01962311)
- Testing
- lumbar puncture
- Where
- 6 sites in France
- Volunteers
- 82 people
- Sponsor
- University Hospital, Tours
Cancer Colorectal
Identification of High Risk People for Colorectal Cancer and Evaluation of a Specific Surveillance System
Colorectal cancer is one the most frequent cancer in developed countries. In France, it rank third with 43000 new cases in 2015.
- Trial name
- ISIRECC (NCT02931825)
- Testing
- Reminder letter
- Where
- France
- Volunteers
- 7,101 people
- Sponsor
- University Hospital, Tours
Pain, Acute, Trauma Injury
Use of Penthrox in Extra-hospital Traumatology
In pre-hospital settings, the administration of analgesics is often delayed because of difficult patient access (incarceration), difficulty finding a venous pathway or patient refusal.
- Conditions
- Pain, Acute, Trauma Injury, Pain Management
- Trial name
- UPETEH (NCT03537001)
- Testing
- Penthrox
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Tours
Pupil, Analgesics
Validation of Pupillary Response to Nociceptive Stimulation in Cardiac Surgery During Extracorporeal Circulation Period
The relationship between the target effect site concentration of remifentanil and the pupil diameter and reactivity in response to a standard noxious stimulus in cardiac surgery during extra corporeal circulation will be…
- Conditions
- Pupil, Analgesics, Opioid Use, Dose-Response Relationship, Drug
- Trial name
- DOLOCEC (NCT03568396)
- Testing
- Pupillometer
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Tours
Maxillofacial Abnormalities, Post Procedural Discharge
Impact of Manual Lymphatic Drainage on Postoperative Edema of the Face and the Neck After Orthognathic Surgery
Orthognathic surgery aims to standardize position of the maxilla and the mandible and therefore chewing, breathing, phonation and swallowing functions.
- Trial name
- DLMOF (NCT01983436)
- Testing
- Manual Lymphatic drainage
- Where
- 2 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Tours
Tibial Fractures, Fractures, Open
Percutaneous Autologous Bone-marrow Grafting for Open Tibial Shaft Fracture
The treatment of open tibial shaft fracture is often complicated by delayed union or non-union. The objective of this study is to evaluate the efficacy of autologous concentrated bone-marrow to accelerate healing of open tibial…
- Trial name
- IMOCA (NCT00512434)
- Testing
- Osteosynthesis
- Where
- 11 sites in France
- Volunteers
- 85 people
- Sponsor
- University Hospital, Tours
Breast Cancer
Dead Space Closure With Quilting Suture Versus Conventional Closure With Drainage
The objective of this study is to compare quilting suture of the "dead space" without drainage of the pectoral area to conventional closure with drainage to prevent post-operative seroma requiring intervention (aspiration or…
- Trial name
- QUISERMAS (NCT02263651)
- Testing
- Quilting suture without drainage, Conventional closure with drainage
- Where
- 6 sites in France
- Volunteers
- 320 people
- Sponsor
- University Hospital, Tours
Genital Diseases, Female, Hysterotomy; Affecting Fetus
Effect of Salpingectomy During Conservative Hysterectomy
The study compares the effect of bilateral salpingectomy associated with conservative hysterectomy on ovarian function to the standard hysterectomy with conservation of both ovaries and tubes in terms of hormone assays, ovarian…
- Conditions
- Genital Diseases, Female, Hysterotomy; Affecting Fetus, Leiomyomata Uteri, Adenomyosis, Endometriosis
- Trial name
- SALPINGOVA (NCT01628432)
- Testing
- conservative hysterectomy I, Conservative hysterectomy II
- Where
- 7 sites in France
- Volunteers
- 350 people
- Sponsor
- University Hospital, Tours
Complication of Prematurity
Effects of Parenteral L-carnitine Supplementation in Premature Neonates
Background: Carnitine is the essential cofactor for various enzyme activities of human metabolism, especially for the mitochondrial carnitine shuttle that transfers long-chain fatty acids as acylcarnitine esters across the inner…
- Trial name
- CarniPrema (NCT00841295)
- Testing
- Parenteral L-carnitine supplementation, Parenteral supplementation with sterile water
- Where
- 2 sites in France
- Volunteers
- 53 people
- Sponsor
- University Hospital, Tours
Chronic Urticaria
Methotrexate in the Treatment of Chronic Idiopathic Urticaria
Chronic urticaria is defined by urticarial lesions persisting at 6 weeks. The cause is not found in about 75% of cases (chronic idiopathic urticaria). The gold standard treatment consists of anti-H1 molecules.
- Trial name
- MUCIS (NCT01960283)
- Testing
- Methotrexate (Novatrex ®) + anti-H1
- Where
- 11 sites in France
- Volunteers
- 83 people
- Sponsor
- University Hospital, Tours
Leukemia
Rituximab Maintenance Versus Observation After First-line Immunochemotherapy by FCR in Older Patients With Chronic Lymphocytic Leukemia
RATIONALE: Classical chemotherapy does not cure advanced chronic lymphocytic leukemia (CLL) despite new drugs. Rituximab is a monoclonal antibody directed against CD20 surface antigen on B lymphocytes and leads to apoptosis of…
- Trial name
- LLC2007SA (NCT00645606)
- Testing
- Rituximab
- Where
- France
- Volunteers
- 542 people
- Sponsor
- University Hospital, Tours
Stress Disorders, Post-Traumatic
Probabilistic Risk Modeling for Disorder Post Traumatic Stress (PTSD) After the Attacks in Paris In November 2015
The scientific approach of this project proposes to build a cohort of "psychological injuries" post-attack of 13 November 2015. This is called patients "involved", ie patients who directly witnessed the events and having the most…
- Trial name
- BV13 (NCT02853513)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Amyotrophic Lateral Sclerosis
Microglial Activation Role In ALS (MARIA)
Neuroinflammation, characterized in particular by microglia activation, is an essential component of Amyotrophic Lateral Sclerosis (ALS) pathogenesis.
- Trial name
- MARIA (NCT02405403)
- Testing
- [18F]DPA-714 PET
- Where
- France
- Sponsor
- University Hospital, Tours
Idiopathic Parkinson Disease
Quantification of Dopamine Active Transporter (DAT) in Humans: Validation of a New Radiophamaceutical, the [18F] LBT-999
Idiopathic Parkinson's disease (IPD) is a degenerative disease affecting the dopaminergic system. Clinical symptoms of IPD commonly begin after the loss of at least 40 to 50% of striatal dopaminergic terminals (specially…
- Trial name
- LBT 999 (NCT02393027)
- Testing
- [18F] LBT-999 PET
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
PostTraumatic Stress Disorder
PTSD Among Victims of Sexual Abuse and Changes in Structural and Functional Brain Connectivity
The goal of this study is to identify the early modifications in fronto-temporal connectivity in female victims who developed PTSD, compared to female victims who did not develop the disorder, and to healthy control females.
- Trial name
- COPTSD (NCT01405495)
- Testing
- MRI-based techniques (sMRI, fMRI, DTI, ASL)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Ischemic Stroke, Transient Ischemic Attack
Prognostic Value of Cardiac and Renal Markers in Ischemic Stroke and Transient Ischemic Attack
Patients with stroke or transient ischemic attack (TIA) are at high risk of poor outcome, recurrence of cardiovascular events or vascular death.Until now, no reliable predictive biological marker could be identified in the acute…
- Trial name
- ABC-AVC (NCT00479518)
- Where
- 3 sites in France
- Volunteers
- 159 people
- Sponsor
- University Hospital, Tours