Clinical trials: sponsored by University Hospital, Tours
De Novo Transplant Disease
Efficacy and Safety Study of a 4-Month Post-Renal Transplant Dose Reduction of Tacrolimus(ADEQUATE)
This prospective, interventional, open label, randomized, multicenter study was designed to determine the risk/benefit ratio of a 50 % reduction of Advagraf® daily dose, 4 months after transplantation.
- Trial name
- ADEQUATE (NCT01744470)
- Testing
- Tacrolimus targeted half-dose, Tacrolimus targeted plain dose
- Where
- 16 sites in France
- Volunteers
- 286 people
- Sponsor
- University Hospital, Tours
Treatment Error
Communication Between Hospital and Community Pharmacists: Impact on Drug Management at Discharge
This study will evaluate the impact of a communication between hospital pharmacist and community pharmacists in addition to drugs reconciliation procedure at discharge. It will be conducted in 21 french public hospitals.
- Trial name
- REPHVIM (NCT02006797)
- Testing
- reconciliation
- Where
- 21 sites in France
- Volunteers
- 1,176 people
- Sponsor
- University Hospital, Tours
Chronic Hepatitis C
Impact of Hepatitis C Virus Variability on Steatosis
Chronic infection by the hepatitis C virus (HCV) is a common cause of liver disease, which may progress to cirrhosis and eventually liver cancer.
- Trial name
- Viro-steatosis (NCT00843076)
- Where
- 6 sites in France
- Volunteers
- 27 people
- Sponsor
- University Hospital, Tours
Oral Lichen Planus
Efficacy of Topical Rapamycin to Treat Chronic Erosive Oral Lichen
The purpose of this study is to determine wether topical rapamycin is more efficient than topical steroids in the treatment of chronic erosive lichen planus.
- Trial name
- RALIB (NCT01061853)
- Testing
- TOPICAL SIROLIMUS (RAPAMUNE*), TOPICAL BETAMETHASONE 0.05%
- Where
- 9 sites in France
- Volunteers
- 76 people
- Sponsor
- University Hospital, Tours
Pre-Eclampsia, Fetal Growth Retardation
Doppler and Biological Second Trimester Placental Insufficiency Screening
To assess the role of uterine artery and maternal serum leptin and lipids and their combination in screening for pre-eclampsia and small-for-gestational-age (SGA) fetuses at 20-24 weeks of gestation
- Conditions
- Pre-Eclampsia, Fetal Growth Retardation, Placental Insufficiency
- Trial name
- ARTULEP (NCT00465634)
- Where
- France
- Volunteers
- 235 people
- Sponsor
- University Hospital, Tours
Infertility
C Terminal Variants of FSH Receptor
Follicle-stimulating hormone (FSH) is used in medically assisted procreation, to induce an ovarian stimulation in women. However, the FSH dose that has to be injected is quite hard to adjust, because an excess of exogenous…
- Trial name
- NCT01524588
- Where
- France
- Volunteers
- 814 people
- Sponsor
- University Hospital, Tours
Uterine Cervical Neoplasms, Uterine Cervical Dysplasia
Self-sampling and Human Papillomavirus (HPV)-Testing for Unscreened Women in Cervical Cancer Prevention
Scientific Context High-risk types of human papillomavirus (HPV) are the causative agents for cervical cancer. Cervical cancer screening strategies rely on periodic Papanicolaou (Pap) testing.
- Trial name
- APACHE-1 (NCT01014026)
- Testing
- Screening test
- Where
- 5 sites in France
- Volunteers
- 734 people
- Sponsor
- University Hospital, Tours
Developmental Reading Disorder, Dyslexia
Developmental Dyslexia and Functional Maturation of Auditory Cortex
Developmental dyslexia is a frequent learning disability. The aim of this study is to compare auditory evoked cortical responses to syllables and tones in developmental dyslexia and controls (paired with age, gender).
- Trial name
- DYS-AUT (NCT00245804)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Intrahepatic Cholestasis of Pregnancy
ABCB4 Gene Mutations in Intrahepatic Cholestasis of Pregnancy and Controls
Mutations of the ATP binding cassette subfamily B member 4 (ABCB4) gene, a gene involved in a subtype of progressive familial intrahepatic cholestasis, have been reported in women suffering from intrahepatic cholestasis of…
- Trial name
- NCT00700232
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Amyotrophic Lateral Sclerosis, Bulbar Disease
Molecular Imaging Modality by Positron Emission Tomography Using 18F-X : Study of Microglial Activation in Amyotrophic Lateral Sclerosis
PET imaging of activated microglia offers a tool of investigation of a range of brain diseases where neuroinflammation is a component. Amyotrophic lateral sclerosis is the most frequent motoneuronal disease in adult.
- Conditions
- Amyotrophic Lateral Sclerosis, Bulbar Disease, Spinal Disease
- Trial name
- NCT00563537
- Testing
- 18F-X PET SCAN
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Post-Traumatic Stress Disorders, Anxiety
fMRI in Posttraumatic Stress Disorder (PTSD) During Working Memory Updating
Neuropsychological studies investigating trauma-exposed and posttraumatic stress disorder (PTSD) subjects have generally underlined the significantly poorer performance of tasks that require attention, concentration, and verbal…
- Conditions
- Post-Traumatic Stress Disorders, Anxiety, Amnesia, Dissociative
- Trial name
- METRAPI (NCT00288314)
- Testing
- Magnetic Resonance Imaging, Functional
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Graft Rejection
Impact of Treatment With Rituximab on the Progression of Humoral Acute Rejection After Renal Transplantation
Assessing the impact of J12 curative treatment with rituximab (375 mg / m² on J5) based on a composite "TREATMENT FAILURE"
- Trial name
- RITUX-ERAH (NCT01066689)
- Testing
- MabThera, Physiological serum (Sodium Chloride, sodium citrate)
- Where
- 32 sites in France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Tours
Ovarian Cyst, Ultrasonography Prenatal
Effect of Fetal Ovarian Cyst Aspiration to Prevent Torsion
The purpose of this study is to determine whether prenatal ovarian cyst aspiration is effective and safe to prevent perinatal ovarian torsion.
- Trial name
- NCT00222066
- Testing
- Fetal ovarian cyst aspiration
- Where
- 3 sites in France
- Volunteers
- 61 people
- Sponsor
- University Hospital, Tours
Healthy Subjects
Measurement of MRP2 Function Using Urinary Coproporphyrins
Human Multidrug Related Protein 2 (MRP2) excretes several drugs and could therefore modulate their elimination. Individual's MRP2 activity is under genetic control.
- Trial name
- COVOL (NCT00746044)
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Rheumatoid Arthritis
Positron Emission Tomography in Rheumatoid Arthritis With Adalimumab (PETRA)
Biologics are routinely used for the treatment of rheumatoid arthritis (RA). Adalimumab is a human monoclonal antibody that inhibit the Tumor Necrosis Factor alpha (TNF-alpha).
- Trial name
- PETRA (NCT00497614)
- Testing
- adalimumab
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Tours
Bronchopulmonary Ignition, Condensate of Exhaled Air
Development of a Noninvasive Method of Evaluation of Pulmonary Inflammation in the Condensates of Exhaled Air
The aim of the study is identify biological parameters reflecting proteolytic activity in the exhaled condenstaes which might be useful to follow up pulmonary inflammation in various conditions including cystic fibrosis, COPD…
- Conditions
- Bronchopulmonary Ignition, Condensate of Exhaled Air, Mucoviscidosis, Asthma
- Trial name
- NCT00356629
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Obesity
Walking, Spontaneous Physical Activity and Lipid Oxidation After Dietary Treatment of Obesity
The purpose of this study is to determine whether walking exercise after dietary treatment of obesity is associated with a decrease of the daily spontaneous physical activity and\or with an increase of the time spent in sedentary…
- Trial name
- NCT00775970
- Testing
- walking activity
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Tours
Breast Tumors
A Pilot Study Evaluation of the Efficacy of SonoVue to Detect and Characterise Breast Lesions
Ultrasound is a well-established imaging modality for the evaluation of breast disease. The investigators' objective is to characterise the properties of an intravascular ultrasonographic contrast agent SonoVue (sulphur…
- Trial name
- NCT00243698
- Testing
- SonoVue (sulphur hexafluoride microbubbles)
- Where
- France
- Volunteers
- 59 people
- Sponsor
- University Hospital, Tours
Myoma
Myoma Microvascularization Analysis Using Sonovue Before and After Uterine Artery Embolization
Contrast-enhanced ultrasound is supposed to improve the detection of myomas as well as improve the follow-up after specific treatments like embolization.
- Trial name
- NCT00351494
- Testing
- contrast enhanced ultrasonography, embolization
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Tours
Ovarian Tumor
Contrast-Enhanced Ultrasound Ability in the Characterization of Ovarian Masses
This study intends to assess the ability of contrast-enhanced ultrasound in the detection of benign and malignant ovarian masses compared to unenhanced ultrasound.
- Trial name
- NCT00248820
- Testing
- Contrast-enhanced ultrasound
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Tours