Clinical trials: sponsored by University Hospital, Tours
Phenylketonuria (PKU)
Multiomics Approach in Adult Patients With Phenylketonuria
The GENOPHEN study aims to explore the links between the genome, metabolomic profile, and clinical phenotype in adults with early-treated PKU.
- Trial name
- GENOPHEN (NCT07484945)
- Where
- 15 sites in France
- Volunteers
- 149 people
- Sponsor
- University Hospital, Tours
Bone Infection, Joint Infection
Side Effects of Antibiotics in Bone and Joint Infections
Treatment for bone and joint infection (BJI) is not standardized, which allows a wide range of antibiotic therapy to potentially be given, most often in high doses over long periods of time.
- Trial name
- PROSEAB (NCT05927311)
- Where
- France
- Volunteers
- 73 people
- Sponsor
- University Hospital, Tours
Lateral Sclerosis
Validation of the French Version of the Primary Lateral Sclerosis Functioning Rating Scale (PLSFRS)
This is a national, multicentric, prospective, descriptive study evaluating the psychometric properties of the French version PLSFRS scale
- Trial name
- FRENPRILS (NCT06878235)
- Testing
- Assessment of the functional status
- Where
- 7 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Tours
Periodontal Diseases
High Frequency Intraoral Ultrasound Probe for Early Diagnosis of Periodontal Diseases
The goal of this clinical investigation is evaluation the agreement between the periodontal pocket depth measurement obtained by periodontal probing (gold standard) and the measurement obtained by the ultrasound device
- Trial name
- Oralus2 (NCT05809427)
- Testing
- Periodontal probing
- Where
- France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Tours
Community-acquired Pneumonia
Awake Prone Positioning of Patients Suffering Community Acquired Pneumonia Requiring Nasal High Flow Therapy
Community acquired pneumonia, in particular when requiring oxygen therapy because of acute hypoxemic respiratory failure and meeting acute respiratory distress syndrome (ARDS) criteria frequently leads to tracheal intubation and…
- Trial name
- PRONECAP (NCT06966310)
- Testing
- Prone position
- Where
- 38 sites in France
- Volunteers
- 1,078 people
- Sponsor
- University Hospital, Tours
Critical Care, Intensive Care
Communication Enhancement Among Ventilated Patients in Intensive Care
Intensive care is a unit that admits ventilated patients. Hospitalization is extremely challenging for these patients. Their vital prognosis is at stake, and they often have difficulty moving due to pain, edema, neuromyopathy, or…
- Trial name
- CESAR (NCT07251530)
- Testing
- Communication tool for ventilated patients in intensive care
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Tours
SARS-CoV 2 Pneumonia
Long Term Effects of Awake Prone Positioning in COVID-19 ICU Patients
Long term follow up of patients included in a randomized controlled trial evaluating awake prone positioning among patients suffering SARS-CoV2 pneumonia (NCT04358939)
- Trial name
- Long-termAPP (NCT06080737)
- Testing
- quality of life questionnaire
- Where
- France
- Volunteers
- 137 people
- Sponsor
- University Hospital, Tours
Ethics, Narrative
Ethical Deliberation in the Intensive Care Unit, Impact of Formalized Multidisciplinary Team Meetings, a Pilot Study
Most patients who die in the intensive care unit do so after a withholding or withdrawing of life sustaining treatments (WWLST) decision.
- Trial name
- NCT05722431
- Where
- France
- Volunteers
- 450 people
- Sponsor
- University Hospital, Tours
Brain Pulsatility, Idiopathic Normal Pressure Hydrocephalus (INPH)
Transcranial Ultrasound Assessment of Cerebral Pulsatility in Shunt Decision-making for Suspected Idiopathic Normal Pressure Hydrocephalus: a Prospective Cohort Study
This will be a single-center, prospective, analytical cohort study. All included patients will undergo transcranial ultrasound (TPI) with measurement of cerebral pulsatility parameters prior to subtractive lumbar puncture during…
- Trial name
- HYDROPULSE (NCT07285928)
- Where
- France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Tours
Rheumatoid Arthritis (RA)
Prospective Validation of a Pharmacological Biomarker for Low-Dose Rituximab in Rheumatoid Arthritis
Evaluation of the prediction of clinical response to rituximab at a dose of 1000 mg once using a pharmacological model including several pharmacokinetic and pharmacodynamic parameters.
- Trial name
- PROLOD-RA (NCT06933134)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Tours
Systemic Lupus Erythematosus, Physiopathology
Study of Neonatal IgG Fc Receptor Expression in Natural Killer T Cells Expressing an Invariant T Receptor : Implication in the Pathophysiology of Systemic Lupus
This study evaluates the variation of expression of the neonatal Fc receptor (FcRn) in Natural Killer T Cells Expressing an Invariant T Receptor (iNKT) and monocytes along with the surface expression of Fc gamma type II receptor…
- Trial name
- FiNKLUPUS (NCT05859191)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Hemivertebra
Assessment and Follow-up of Surgical Treatment of Hemivertebra in Children
The treatment of child's vertebral malformations has evolved a lot including the realization of surgical vertebral resections. The surgical techniques used are multiple, require heavy surgery, one or more approaches and surgical…
- Trial name
- NCT03772119
- Testing
- Surgical resection
- Where
- 13 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Tours
Rheumatoid Arthritis, Interstitial Lung Disease
dEtection of rheumAtoid aRthritis - Interstitial Lung dIseasE by Thoracic ultRasound
Rheumatoid arthritis is an autoimmune disease that can affect various organs, including the lungs, and lead to rheumatoid arthritis-interstitial lung disease (RA-ILD).
- Conditions
- Rheumatoid Arthritis, Interstitial Lung Disease, Thoracic Ultrasound, Lung Ultrasound
- Trial name
- EARLIER (NCT06235645)
- Testing
- Lung ultrasound (LUS)
- Where
- France
- Volunteers
- 280 people
- Sponsor
- University Hospital, Tours
Memory Disorders
Development, Standardisation and Standardisation Project for a New Memory Assessment
Episodic memory (EM) is a neuropsychological marker of Alzheimer's disease (AD) (Thomas-Anterion, 2006). Current tests for its assessment do not take into account the identity and emotional aspects of memory (Van der Linden et…
- Trial name
- NEM (NCT06564779)
- Testing
- New memory assessment
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Tours
Recurrent Erysipelas
Prophylaxis of Recurrent Erysipelas in Lower Limbs: compreSsion thErapy vs aNTibiotics and Compression Therapy.
Erysipelas (superficial cellulitis) is a frequent streptococcal bacterial infection. Each episode of erysipelas may worsen preexisting lymphedema and evolve to life-threatening necrotizing soft-tissue infection.
- Trial name
- PRESENT (NCT07549594)
- Testing
- elastic stockings, Phenoxymethylpenicillin
- Where
- 25 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Tours
Obesity (Disorder)
Role of the Environment in Pediatric Obesity
Childhood obesity is a particular concern in developed countries such as the United States, the United Kingdom, Canada, and certain European countries.
- Trial name
- REOP (NCT07545174)
- Testing
- Blood test, Urine sample, Hair sample
- Where
- 2 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Ankylosing Spondylitis
Effect of the Combination of Methotrexate and Adalimumab on Reduction of Immunization in Ankylosing Spondylitis (COMARIS)
The purpose of this study is to determine if association of methotrexate with adalimumab leads to decrease immunogenicity beside adalimumab alone in Ankylosing Spondylitis.
- Trial name
- COMARIS (NCT01895764)
- Testing
- Adalimumab, Methotrexate
- Where
- 11 sites in France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Tours
Anxiety
Impact of Sound Shower Music Diffusion on Family Anxiety in Intensive Care Unit Waiting Room
Hospitalization in intensive care is a source of intense stress for both patients and their family. Post-intensive care syndrome (PICS) may affect both patients and their family.
- Trial name
- MUSICALITY (NCT07506954)
- Testing
- Musical intervention (L-shaped musical sequence) broadcast by a sound shower lasting 20 to 30 minutes in waiting room.
- Where
- 3 sites in France
- Volunteers
- 224 people
- Sponsor
- University Hospital, Tours
Dental Consultation
Atlas of Ultrasound Imaging of the Oral Cavity: Characterization and Description of Anatomical Structures
Ultrasound imaging is a non-invasive and non-ionizing technique widely used for the evaluation of soft tissues in many medical specialties.
- Trial name
- ATLAS-US (NCT07463534)
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
ALS (Amyotrophic Lateral Sclerosis)
Characterization of Platelet Molecular Profiles in ALS for the Identification of Specific Diagnostic Biomarkers - A Pilot Study
The search for diagnostic biomarkers that can be used routinely is a major challenge to manage Amyotrophic lateral sclerosis (ALS) in order to characterize the pathophysiology and accelerate the management of the disease.
- Trial name
- SLA-PlaQ (NCT07479017)
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Tours