Clinical trials: sponsored by University Hospital Heidelberg
Breast Cancers
Partial Breast Re-irradiation for Breast Cancer
Breast cancer is the most common malignancy in women. Breast-conserving surgery (BCS) with adjuvant whole-breast irradiation (WBI) is currently the standard of care in the oncological treatment of primary breast cancer and offers…
- Trial name
- BREAST (NCT06954623)
- Testing
- Radiation Therapy
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Heidelberg
Hospital Emergency and Operations Planning, Pediatric Hospital
State of In-hospital Disaster Protection at Children's Hospitals in Germany
Catastrophic situations demand a heigh preparedness from hospitals. In Germany, all hospitals are required to maintain an emergency and response plan for such situations. However, these plans are often insufficient.
- Trial name
- NCT07766941
- Where
- Germany
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Soft Tissue Sarcoma
Neoadjuvant Irradiation of Extremity Soft Tissue Sarcoma With Ions
This randomized prospective open-label phase 2 trial testes the safety and feasibility of a hypofractionated accelerated neoadjuvant proton or carbon ion radiotherapy based on the rate of wound healing disorders from beginning of…
- Trial name
- EXTREM ION (NCT04946357)
- Testing
- Protons, carbon ions
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- University Hospital Heidelberg
Osteoarthritis, Arthroplasty
Heidelberg Registry for Hip and Knee Joint Implants and Revisions
The Endoprosthesis Registry Heidelberg (EPR-HD) is a clinical registry designed to systematically collect and analyze data from patients undergoing primary implantation or revision surgery of artificial hip and knee joints.
- Trial name
- EPR-HD (NCT06850818)
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- University Hospital Heidelberg
Borderline Personality Disorder (BPD)
The Role of Gender in Borderline Personality Disorder
This study is a mixed-methods, single-arm cross-sectional study comprising 1) a qualitative, exploratory, critical-constructivist content analysis examining the significance of gender in relationship experiences and…
- Trial name
- BPD-G (NCT07639957)
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- University Hospital Heidelberg
Brain Metastases, Radiotherapy
Neoadjuvant vs. Intraoperative vs. Adjuvant Resection Cavity Radiotherapy of Brain Metastases
Patients suffering from malignancies in advanced stages often develop brain metastases, which limit both the life span and the quality of life.
- Trial name
- Radcav (NCT05871307)
- Testing
- Preoperative Radiotherapy, Intraoperative Radiation, Postoperative Radiotherapy
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- University Hospital Heidelberg
Glioblastoma
Glioblastoma Radiotherapy Using IMRT or Proton Beams
Radiation therapy is an integral part of the multimodal primary therapy of glioblastomas. As the overall prognosis in this tumor entity remains unfavorable, current research is focused on additional drug therapies, which are…
- Trial name
- GRIPS (NCT04752280)
- Testing
- Proton irradiation, Photon irradiation
- Where
- 3 sites in Germany
- Volunteers
- 326 people
- Sponsor
- University Hospital Heidelberg
Breast Cancer
Intraoperative Electron Radiotherapy for Low-risk Early Breast Cancer
Breast cancer is the most frequent malignancy in women. Standard therapy for early-stage breast cancer is breast conserving surgery (BCS) followed by adjuvant whole breast irradiation (WBI), which usually requires a treatment…
- Trial name
- COSMOPOLITAN (NCT03838419)
- Testing
- intraoperative radiotherapy, whole breast irradiation
- Where
- Germany
- Volunteers
- 101 people
- Sponsor
- University Hospital Heidelberg
Brain Metastases
Supportive Care With or Without Repeated Whole Brain Radiotherapy in Patients With Recurrent Brain Metastases
Patients with solid cancers may develop cerebral metastases, requiring whole brain radiotherapy (WBRT). Furthermore, in several cases, a secondary course of WBRT might be required due to intracerebral recurrence and limited…
- Trial name
- RECARE (NCT04084431)
- Testing
- Radiation, OSC
- Where
- Germany
- Sponsor
- University Hospital Heidelberg
Takotsubo Cardiomyopathy
Cyclosporine In Takotsubo Syndrome
The goal of this clinical trial is to investigate the impact of repetitive acute Cyclosporine A (CsA) bolus therapy in patients suffering from TTS with an elevated risk of impaired outcome.
- Trial name
- CIT (NCT05946772)
- Testing
- Cyclosporine A
- Where
- 24 sites in Germany
- Volunteers
- 204 people
- Sponsor
- University Hospital Heidelberg
Stroke Thrombectomy
Mode of Sedation During Endovascular Treatment of Vertebrobasilar Stroke
Optimal anesthetic mode is not established for patients with vertebrobasilar stroke undergoing endovascular treatment. We want to investigate whether a procedural sedation mode approach is feasible compared to general anesthesia
- Trial name
- MOONRISE (NCT05525325)
- Testing
- General Anesthesia
- Where
- Germany
- Volunteers
- 128 people
- Sponsor
- University Hospital Heidelberg
Mediastinal Lymphoma
Registry Study of Proton Radiotherapy in Lymphoma
The aim is to record and document a mediastinal PT and the corresponding follow-up data (effectiveness and side effects). General recommendations for planning and feasibility are made within the framework of this study.
- Trial name
- NCT04613388
- Testing
- Assesment of Effectiveness and side effects
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital Heidelberg
Lung Cancer
Magnetic Resonance Guided Adaptive Stereotactic Body Radiotherapy for Lung Tumors in Ultracentral Location
MAGELLAN is a phase-I dose escalation trial that aims to identify the maximum tolerated dose (MTD) of MR-guided SBRT of ultracentral lung Tumors (primary objective).
- Trial name
- MAGELLAN (NCT04925583)
- Testing
- Stereotactic body radiotherapy (SBRT)
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- University Hospital Heidelberg
Ischemic Stroke, Transient Ischemic Attack (TIA)
Ambulatory Stroke Unit Treatment for Elderly Patients
ARTIFICE is a prospective, multicenter, randomized, controlled, exploratory non-inferiority trial evaluating whether an ambulatory stroke unit model (aSU) is non-inferior to conventional inpatient stroke unit care (SU) in…
- Conditions
- Ischemic Stroke, Transient Ischemic Attack (TIA), Retinal Ischemia
- Trial name
- ARTIFICE (NCT07420374)
- Testing
- Ambulatory Stroke Unit Care, Conventional Stroke Unit Care
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- University Hospital Heidelberg
Locally Advanced Head-and-Neck Cancer
Carbon Ion Re-Radiotherapy in Patients With Recurrent or Progressive Locally Advanced Head-and-Neck Cancer
After multimodal therapy of head-and-neck tumors, patients often develop local recurrence, locally progressive disease or second primary tumors. In this highly pre-treated patient cohort, therapeutic options are limited.
- Trial name
- CARE (NCT04185974)
- Testing
- C12 re-irradiation, Photon re-irradiation
- Where
- 2 sites in Germany
- Volunteers
- 72 people
- Sponsor
- University Hospital Heidelberg
Cardiomyopathy, Dilated, Heart Failure
activeDCM - Interventional Clinical Trial of Individualized Activity and Exercise Programs to Improve Outcome in Dilated Cardiomyopathy Guided by Longitudinal Biosensing With Apple Watch
The influence of an individualized sports program on dilated cardiomyopathy patients will be investigated in a randomized, prospective intervention study.
- Trial name
- ACTIVE-DCM (NCT04359238)
- Testing
- Individualized excercise
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital Heidelberg
Acute Ischemic Stroke Patients, Acute Ischemic Stroke
Guiding Catheters in Endovascular Stroke Therapy - Are Balloon Guided Catheters Superior?
The BEST study is an academically initiated, single-center, prospective, randomized controlled clinical trial investigating the potential advantages and disadvantages of using a guide catheter with or without a balloon in the…
- Conditions
- Acute Ischemic Stroke Patients, Acute Ischemic Stroke, Acute Ischemic Stroke AIS
- Trial name
- BEST (NCT07478042)
- Testing
- Ballon guide catheter, Guide catheter without balloon
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- University Hospital Heidelberg
Prostate Cancer
Stereotactic MRI-guided Radiation Therapy for Localized prostatE Cancer
As the most common carcinoma in men, prostate cancer is a significant tumor entity in oncology. In addition to the surgical approach, definitive radiotherapy is an equivalent therapy alternative in the non-metastatic primary…
- Trial name
- SMILE (NCT04845503)
- Testing
- MR-guided Radiotherapy
- Where
- Germany
- Volunteers
- 68 people
- Sponsor
- University Hospital Heidelberg
Pancreatic Cancer
Pancreatic Cancer and Carbon Ion Radiotherapy
Irradiation of non-operable pancreatic cancer with carbon ions (C12). This therapy is expected to be more effective than the current Gold Standard of photon irradiation applied in the case of non-operable pancreatic cancer.
- Trial name
- PACK (NCT04194268)
- Testing
- Carbon Ion
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- University Hospital Heidelberg
Brain Metastases, Nsclc
The CyberChallenge Trial How Much is Too Much - What is the Role of Cyberknife Radiosurgery in Patients With Multiple Brain Metastases?
Patients suffering from malignancies in advanced stages often develop brain metastases, which limit both the life span and the quality of life.
- Trial name
- CyberChallenge (NCT05378633)
- Testing
- SRS, Whole Brain Radiotherapy
- Where
- Germany
- Volunteers
- 190 people
- Sponsor
- University Hospital Heidelberg