Clinical trials: sponsored by University Hospital Heidelberg
Meningioma
Plasma Extracellular Vesicles in Meningioma Patients
While surgical resection remains the primary treatment approach for symptomatic or growing meningiomas, radiotherapy represents an auspicious alternative in patients with meningiomas not safely amenable to surgery.
- Trial name
- MOLI (NCT06104930)
- Testing
- Explorative biomarker study
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Heidelberg
Esophagus Cancer, Stage I, Esophagus Cancer, Stage II
Predicting Esophageal Cancer Borders Using PET-Imaging
The study examines the diagnostic precision of endosonography, mpMRI and PET/CT in defining tumor boundaries and tumor spread before and after neoadjuvant therapy and definitive surgery.
- Trial name
- PEGASUS (NCT06408116)
- Testing
- photon, surgical therapy, Chemotherapy
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Heidelberg
Sarcoma,Soft Tissue
Neoadjuvant Irradiation of Retroperitoneal Soft Tissue Sarcoma With Ions Retro-Ion
The study is a randomized, open, prospective phase II study. The aim of the study is to evaluate the safety and feasibility of a hypofractionated, accelerated radiation approach based on the incidence of grade 3-5 NCI Common…
- Trial name
- Retro-Ion (NCT04219202)
- Testing
- Proton radiation, Carbon Ion radiation
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- University Hospital Heidelberg
Hepatic Metastasis
Magnetic Resonance-guided Adaptive Stereotactic Body Radiotherapy for Hepatic Metastases
Stereotactic body radiotherapy (SBRT) is an established local treatment method for patients with hepatic oligometastases. Liver metastases often occur in close proximity to radiosensitive organs at risk (OARs).
- Trial name
- MAESTRO (NCT05027711)
- Testing
- ITV (Internal target volume)-based Stereotactic Body Radiotherapy (ITV-SBRT), MRgSBRT (Magnetic Resonance-guided Stereotactic Body Radiotherapy)
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- University Hospital Heidelberg
Non-small Cell Lung Cancer
Pulmonary Magnetic Resonance-guided Online Adaptive Radiotherapy of Locally Advanced Non-Small Cell Lung Cancer
MR-guided radiotherapy is an innovative technique which supports sophisticated approaches towards pulmonary adaptive radiotherapy (ART).
- Trial name
- PUMA (NCT05237453)
- Testing
- Photons
- Where
- 3 sites in Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Heidelberg
Prostate Cancer
Prostate Cancer Patients Treated With Alternative Radiation Oncology Strategies
As the most common male carcinoma, prostate cancer is a major tumor entity in oncology. In addition to definitive radiotherapy, surgical procedure is considered to be an oncologically equivalent therapeutic alternative for…
- Trial name
- PAROS (NCT04083937)
- Testing
- Hypofractionated radiotherapy with photons, Hypofractionated radiotherapy with protons, Normofractionated radiotherapy with photons
- Where
- Germany
- Volunteers
- 897 people
- Sponsor
- University Hospital Heidelberg
Periodontitis, Adult, Periodontitis (Stage 3)
Microbiological and Clinical Effects of Pre- and Probiotics in Non-Surgical Periodontal Therapy
Periodontitis is a prevalent chronic inflammatory disease driven by a dysbiotic oral biofilm and a dysregulated host immune response.
- Conditions
- Periodontitis, Adult, Periodontitis (Stage 3), Periodontitis Stage IV
- Trial name
- PROPARO (NCT07443410)
- Testing
- Non-surgical periodontal therapy (NSPT) and supportive periodontal therapy (SPT), Probiotic lozenge (Limosilactobacillus reuteri; GUM® PerioBalance®), Vitamin B12 drops (natural elements)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Multiple Myeloma Bone Lesions
Exercise Therapy for Multiple Myeloma Patients
Physical exercise is an important supportive therapy for cancer patients, as it improves quality of life in general and might mitigate the side effects of drug treatment.
- Trial name
- SAPPHIRE-MM (NCT07388147)
- Testing
- Orthopedic consultation and rehabilitation by excercise therapy
- Where
- Germany
- Volunteers
- 71 people
- Sponsor
- University Hospital Heidelberg
Oligodendroglioma
A Clinical Study to Improve Brain Function and Quality of Life of Patients With Newly Diagnosed Brain Tumors (Gliomas).
Oligodendrogliomas in the novel edition of the Central Nervous System (CNS) World Health Organization (WHO) classification are now molecularly defined by isocitrate dehydrogenase (IDH)1 or IDH2 mutations and 1p/19q co-deletion.
- Trial name
- ImproveCodel (NCT05331521)
- Testing
- CETEG, PCV, RT
- Where
- 19 sites in Germany
- Volunteers
- 406 people
- Sponsor
- University Hospital Heidelberg
Intraventricular Hemorrhage, Lumbar Drainage
Lumbar Drainage of Intraventricular Hemorrhage
Intracerebral hemorrhage (ICH) is a debilitating and fatal disease, especially when the hemorrhage is also entering the cerebral ventricles leading to acute hydrocephalus.
- Conditions
- Intraventricular Hemorrhage, Lumbar Drainage, External Ventricular Drainage
- Trial name
- DRAIN IVH (NCT06510842)
- Testing
- External drainage of intraventricular hemorrhage
- Where
- 12 sites in Germany
- Volunteers
- 354 people
- Sponsor
- University Hospital Heidelberg
Fuchs Endothelial Corneal Dystrophy, Descemet Membrane Endothelial Keratoplasty (DMEK)
Influence of Supine Positioning on the Outcomes After Descemet Membrane Endothelial Keratoplasty (DMEK)
The goal of this clinical trial is to learn if a longer period of lying on the back after corneal transplant surgery (Descemet Membrane Endothelial Keratoplasty, DMEK) helps the transplant stick better in the eye.
- Trial name
- SUPINE (NCT07373821)
- Testing
- Duration of Supine Positioning
- Where
- Germany
- Volunteers
- 102 people
- Sponsor
- University Hospital Heidelberg
Multiple Myeloma, Fall Risk Factors
Fall Risk Assessment and an Exercise Intervention for Prevention of Falls in Multiple Myeloma Patients
Approximately one third of the population over the age of 65 falls at least once a year. The risk of falling is in increased in older patients with tumor diseases.
- Conditions
- Multiple Myeloma, Fall Risk Factors, Strength Training Effects, Balance Training Effects
- Trial name
- Myfall (NCT07044427)
- Testing
- Strength and balance training in combination with a treadmill-based pertubation intervention
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Heidelberg
Kidney Transplant, Renal Transplant
Predictive Accuracy of Machine Perfusion for Kidney Transplant Outcomes in Germany
Kidney transplantation remains the only definitive treatment for end-stage renal disease, yet the increasing use of extended criteria donor (ECD) kidneys heightens the risk of ischemia-reperfusion injury, particularly under…
- Conditions
- Kidney Transplant, Renal Transplant, Organ Preservation
- Trial name
- PRE-MAP-Kidney (NCT07348874)
- Volunteers
- 300 people
- Sponsor
- University Hospital Heidelberg
Interstitial Lung Diseases (ILD)
Functional MRI for Monitoring Progression and Assessing Trends in ILD
The main objective of this study is to investigate the utility of functional MRI to differentiate, characterize, and monitor subgroups of ILD.
- Trial name
- IMPACT-ILD (NCT07300696)
- Testing
- Lung MRI Protocol with Functional and Contrast-Enhanced Sequences
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital Heidelberg
Conduct Disorders in Adolescence, Oppositional Defiant Disorder
Is Mentalization-based Therapy More Effective Than Treatment-as-usual for Adolescents With Dissocial Disorders?
The goal of this clinical trial is to investigate if Mentalization-based therapy (MBT) is superior to enhanced usual care (treatment-as-usual-plus (TAU-plus)) for adolescents with disruptive behavior or dissocial disorders.
- Trial name
- MEDAL (NCT07181928)
- Testing
- Mentalization-Based Therapy (MBT), Treatment-as-usual-plus (TAU-plus)
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- University Hospital Heidelberg
Disaster, Crisis Response Plan
DV 100 as a Framework for the Hospital Incident Command System
There is limited scientific research on the organizational structure of the Hospital Incident Command System. The Hospital Alarm and Emergency Planning manual by the German Federal Office of Civil Protection and Disaster…
- Conditions
- Disaster, Crisis Response Plan, Emergency, Communication
- Trial name
- OrAKEL (NCT06913010)
- Testing
- No interventions.
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Heidelberg
Cognitive Change, Well-Being, Psychological
Impact of GPT Use on Essay Writing Performance and Cognitive Abilities
The goal of this randomized controlled lab experiment is to examine if using generated artificial intelligence (AI) technology will affect people's academic performance and cognitive abilities in the context of analytical writing…
- Trial name
- NCT06511102
- Testing
- GPT Support
- Where
- Germany
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Multiple Myeloma Bone Lesions
Feasibility, Safety and Effectivity of an Exercise Intervention for Newly Diagnosed Multiple Myeloma Patients During Induction Therapy
Physical exercise is an important supportive therapy for cancer patients, which improves quality of life and can effectively counteract the side effects of drug therapy.
- Trial name
- GMMG-HD8-INDEX (NCT07026799)
- Testing
- Exercise, Control group
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Heidelberg
Acute Myocardial Infarction
Disparities in the Proportion of Ticagrelor and Prasugrel-eligible Patients with Acute Coronary Syndrome in a Real-world Registry
The primary objective of this study is to compare patients eligible for ASS and Ticagrelor against those eligible for ASS and Prasugrel.
- Trial name
- AZ-DAPT (NCT05774431)
- Testing
- There was no intervention necessary.
- Where
- Germany
- Volunteers
- 6,789 people
- Sponsor
- University Hospital Heidelberg
Cardiomyopathies, Skeletal Muscle Disorder
Observational Study on Cardiac Biomarkers Testing in Patients with Muscular Dystrophy Cardiomyopathy
The objective of this study is to evaluate acute changes of cardiac troponin (and other cardiac biomarkers) and mid-term biovariability in patients with cardiomyopathy associated with chronic skeletal muscle disease.
- Trial name
- KYMA (NCT05779202)
- Testing
- No intervention is planned.
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- University Hospital Heidelberg