Clinical trials: sponsored by University Hospital Heidelberg
Prostate Cancer, Prostate Ectomy
Effects of Kieser Resistance Training Plus Kieser Pelvic Floor Training vs. Kieser Resistance Training Plus Traditional Pelvic Floor Exercise on Urinary Incontinence in Prostate Cancer Patients After Radical Prostatectomy
Surgical removal of the prostate (radical prostatectomy) is the most common therapy in prostate cancer patients. However, urinary incontinence often occurs as a side effect.
- Conditions
- Prostate Cancer, Prostate Ectomy, Pelvic Floor Disorders, Incontinence, Urinary
- Trial name
- RECON (NCT06206993)
- Testing
- Resistance training including the Kieser A5 pelvic floor trainer, Resistance training without pelvic floor biofeedback Kieser A5 pelvic floor trainer
- Where
- Germany
- Volunteers
- 99 people
- Sponsor
- University Hospital Heidelberg
Atrial Fibrillation
HERA FIb Registry for Patients With Atrial Fibrillation
The single-center HERA AFIb registry was created to assess real-world prevalence, demographic characteristics and management of patients with atrial fibrillation (AF) in the era of novel oral anticoagulant regimes (NOAC)…
- Trial name
- NCT05995561
- Testing
- no intervention is planned.
- Where
- Germany
- Volunteers
- 12,297 people
- Sponsor
- University Hospital Heidelberg
Lung Adenocarcinoma
Tumor Microenvironment
Cancer immunotherapy has the great potential to achieve long-term survival in patients with a solid malignancy. However, the beneficial effect of cancer immunotherapy is seen in only a minority of patients.
- Trial name
- NCT05982574
- Volunteers
- 300 people
- Sponsor
- University Hospital Heidelberg
Jaw, Edentulous, Dental Impression Techniques
Intraoral Scanning Accuracy in the Edentulous Mandible
Today, tooth- or implant-supported single crowns and short-span fixed partial dentures can be fabricated on the basis of an intraoral scan, but the scanning accuracy decreases with increasing length of the jaw section to be…
- Trial name
- NCT05032170
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- University Hospital Heidelberg
Patients With Brain Masses/Lesions
Register for Longitudinal Recording of Brain Function
The aim of this observational register study is to establish a registry that completely records and compiles the data from routinely performed technical examinations (navigated transcranial magnetic stimulation, intraoperative…
- Trial name
- NCT06401057
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University Hospital Heidelberg
CNS Tumor, Solid Tumor
INFORM2 Study Uses Nivolumab and Entinostat in Children and Adolescents With High-risk Refractory Malignancies
The aim of this trial is to determine preliminary activity of the combination treatment with nivolumab and entinostat in children and adolescents with high risk refractory/relapsed/progressive tumors harboring a high mutational…
- Trial name
- NCT03838042
- Testing
- Nivolumab and Entinostat
- Where
- 14 sites in Australia, Austria and 5 more
- Volunteers
- 91 people
- Sponsor
- University Hospital Heidelberg
Meningioma
Carbon Ion Radiotherapy for Atypical Meningiomas
Treatment standard for patients with atypical or anaplastic meningioma is neurosurgical resection. With this approach, local control ranges between 50 and 70%, depending on resection status.
- Trial name
- MARCIE (NCT01166321)
- Testing
- Carbon Ion Radiotherapy
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- University Hospital Heidelberg
Low Grade Glioma
Feasibility of Individualized, Model-guided Optimization of Proton Beam Treatment Planning in Patients With Low Grade Glioma
Low-grade glioma (LGG) represent typically slowly growing primary brain tumors with world health organization (WHO) grade I or II who affect young adults around their fourth decade.
- Trial name
- INDIGO (NCT05964569)
- Testing
- model-guided optimization of treatment plan, standard treatment plan, no optimization
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University Hospital Heidelberg
Head and Neck Cancer
Multiparametric Photoacoustic Imaging in the Course of Radiation Therapy of Malignant Head and Neck Tumors
Multispectral photoacoustic imaging enables the measurement of the optical absorption of various tissue components or exogenous contrast agents in vivo.
- Trial name
- NCT04437030
- Testing
- MSOT Acuity Echo device
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Liver Cancer, Liver Failure
Quantitative MRI and Outcomes of Liver Resection
The present observational study aims to assess the benefit of this quantitative multiparametric magnetic resonance imaging (MRI) in clinical practice, to quantify future liver remnant performance, and to accurately predict the…
- Conditions
- Liver Cancer, Liver Failure, Bile Leak, Liver Metastases
- Trial name
- NCT06181318
- Testing
- Multiparametric MRI scan of the liver
- Volunteers
- 33 people
- Sponsor
- University Hospital Heidelberg
Unsatisfactory or Defective Restoration of Tooth
Minimal Invasive Rehabilitation of Tooth Loss in the Posterior Segment (MIZE-S)
Tooth loss can be addressed by different rehabilitative strategies. Implant-supported crowns and conventional bridges (fixed dental prostheses [FDPs]) are well established treatment alternatives.
- Trial name
- MIZE-S (NCT01997710)
- Testing
- all-ceramic inlay-retained RBFDP, all-ceramic RBFDP
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Cancer
Financial Effects of a Tumor Disease - Development and Validation of a Patient Reported Outcome Measure in Germany
This study aims to develop and to validate a standardised German-language instrument for measuring experienced financial effects of a cancer diagnosis and therapy in a cross-sectional bi-centre study.
- Trial name
- FIAT (NCT05319925)
- Testing
- Patient reported outcome measure
- Where
- Germany
- Volunteers
- 213 people
- Sponsor
- University Hospital Heidelberg
Pancreas Cancer, Pancreatectomy
Gastric Venous Reconstruction After Total Pancreatectomy
Total pancreatoduodenectomy (TP) is the standard surgical approach for treatment of extended pancreas tumors. If the gastric coronary vein has to be sacrificed for oncologic or for technical reasons in total pancreatectomy with…
- Trial name
- GENDER (NCT04850430)
- Testing
- Gastric venous reconstruction
- Where
- 2 sites in Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Heidelberg
Stroke, Acute, Cerebral Stroke
Efficacy and Safety of Thrombectomy in Stroke With Extended Lesion and Extended Time Window
TENSION (Efficacy and safety of ThrombEctomy iN Stroke with extended leSION and extended time window) is a prospective, open label, blinded endpoint (PROBE), European two-arm, randomized, controlled, post-market study to compare…
- Conditions
- Stroke, Acute, Cerebral Stroke, Cerebrovascular Stroke, Apoplexy; Brain
- Trial name
- Tension (NCT03094715)
- Testing
- Thrombectomy, Best medical care
- Where
- 42 sites in Austria, Canada and 8 more
- Volunteers
- 253 people
- Sponsor
- University Hospital Heidelberg
Non-ischemic Cardiomyopathy, DCM - Dilated Cardiomyopathy
DZHK TORCH-Plus is a Registry for Patients With Cardiomyopathies and Serves as Source for Cardiovascular Research Studies
The DZHK TranslatiOnal Registry for CardiomyopatHies (DZHK TORCH) represents a unique resource of clinical data and high quality biological samples to enable innovative clinical and molecular studies on cardiomyopathies (CMP).
- Conditions
- Non-ischemic Cardiomyopathy, DCM - Dilated Cardiomyopathy, HCM - Hypertrophic Cardiomyopathy, HOCM - Hypertrophic Obstructive Cardiomyopathy
- Trial name
- TORCH-Plus (NCT04265040)
- Where
- Germany
- Volunteers
- 2,040 people
- Sponsor
- University Hospital Heidelberg
COVID-19 Pandemic, Emergencies
Towards Better Preparedness for Future Catastrophes - Local Lessons-learned From COVID-19
The research question of this study is: "what lessons have been learned from the civil-military cooperation in Heidelberg, Germany, during the COVID-19 pandemic, and what needs to be done to be better prepared for future…
- Trial name
- NCT05552989
- Testing
- this is a non-interventional study
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University Hospital Heidelberg
Ischemic Stroke, Vascular Diseases
Schlaganfallkonsortium Rhein-Neckar (Stroke Consortium Rhine-Neckar)
FAST is an investigator-initiated multicenter study embedded in a German multistate acute stroke network. The main objectives of the FAST study are to improve outcomes and quality of care for stroke patients, to quantify the…
- Conditions
- Ischemic Stroke, Vascular Diseases, Cardiovascular Diseases
- Trial name
- FAST (NCT03157934)
- Testing
- not applicable (observational study)
- Where
- Germany
- Volunteers
- 12,000 people
- Sponsor
- University Hospital Heidelberg
Head and Neck Cancer
Tissue Retractors for Radiation Therapy of Head and Neck Tumors
The rate of therapy-associated side effects during and after radiotherapy of head and neck tumors is essential. The most effective approach to reducing acute toxicity is to cut out healthy tissue from the radiation field.
- Trial name
- GUARD (NCT04454697)
- Testing
- tissue retractors
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- University Hospital Heidelberg
Acute Coronary Syndrome
Myocardial Infarction Registry
The single-center MIR-registry was created to assess real-world prevalence, demographic characteristics and management of patients with acute coronary syndrome presenting in the emergency department (ED) of University of…
- Trial name
- MIR (NCT06128317)
- Testing
- no intervention is intended.
- Where
- Germany
- Volunteers
- 2,500 people
- Sponsor
- University Hospital Heidelberg
Colorectal Cancer Metastatic, Pancreatic Cancer Metastatic
Ipilimumab, Maraviroc and Nivolumab in Advanced Metastatic Colorectal and Pancreatic Cancer the LUMINESCENCE Trial
The study will be conducted in compliance with Good Clinical Practices (ICH-GCP) and the Declaration of Helsinki, and in accordance with applicable legal and regulatory requirements, including archiving of essential documents.
- Trial name
- NCT04721301
- Testing
- Nivolumab plus Ipilimumab plus Maraviroc
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Heidelberg