Clinical trials: sponsored by University Hospital Heidelberg
Osteosarcoma
Therapy Trial to Determine the Safety and Efficacy of Heavy Ion Radiotherapy in Patients With Osteosarcoma
The primary objectives of this trial are the determination of feasibility and toxicity of Heavy Ion Radiotherapy (C12) in patients with non-resectable osteosarcoma.
- Trial name
- NCT01005043
- Testing
- heavy ion radiotherapy (C12)
- Where
- Germany
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Major Hepatectomy
Evaluation of Trans-Hepatic Flow Changes in Major Hepatectomy
Changes in trans-hepatic flow after major and extended hepatectomy (EH) can lead to small for size and flow syndrome (SFSF), which is associated with a significantly higher rate of morbidity and mortality.
- Trial name
- THEFLOW (NCT03762876)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Heidelberg
Infertility/Sterility
Positive Adjustment Coping Intervention
Involuntary childlessness is experienced as emotionally stressful, however psychosocial counseling is not always available on the spot.
- Trial name
- PACI (NCT03118219)
- Testing
- Positive adjustment coping intervention, Brainteaser
- Where
- Germany
- Volunteers
- 401 people
- Sponsor
- University Hospital Heidelberg
Atrial Fibrillation
hsTnT in Patients Admitted to the ED With Atrial Fibrillation in the Era of NOACs - Heidelberg Registry of Atrial Fibrillation
The purpose of the Heidelberg Registry of Atrial Fibrillation (HERA-FIB) is to collect data on the prevalence and clinical significance of elevated cardiac troponin in a large registry of unselected patients with atrial…
- Trial name
- HERA-FIB (NCT03344237)
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- University Hospital Heidelberg
Vascular Surgery
Association of PeriOPerative Aspirin-ResisTance and CardioVascular Outcome
The aim of our study is to investigate the association between perioperative aspirin resistance and Myocardial Injury after Non-cardiac Surgery (MINS) in patients undergoing vascular surgery.
- Trial name
- POPART-CVO (NCT04053894)
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- University Hospital Heidelberg
Doctor-Patient-Communication
RCT Regarding SDM Online Training and Face-to-face SDM Training
Cancer patients often report that they are not included in important treatment decisions. Numerous studies have shown that a training concerning Shared Decision Making (SDM) for physicians can improve this situation.
- Trial name
- NCT02674360
- Testing
- SDM Training
- Where
- 2 sites in Germany
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Trauma, Burns
Point of Care Testing of Cholinesterase Activity During Burn- and Polytrauma
Goal of this study is to measure serum cholinesterase activity in patients with traumatic and/or burns injury admitted to the emergency room by using point-of- care-test system (POCT).
- Trial name
- POCCET (NCT02691650)
- Where
- Germany
- Volunteers
- 85 people
- Sponsor
- University Hospital Heidelberg
Acute Coronary Syndrome, NSTEMI - Non-ST Segment Elevation MI
Safety of Accelerated Rule-out Protocols in Patients Admitted With Chest Pain to a Crowded Chest Pain Unit (CPU)
The aim of this observational study registry is to assess the safety of a Non-ST-elevation myocardial infarction (STEMI) rapid rule-out strategy as proposed by European Guidelines in patients presenting with suspected acute…
- Trial name
- NCT03111862
- Testing
- NSTEMI Rule-Out according to hs-TnT
- Where
- Germany
- Volunteers
- 3,567 people
- Sponsor
- University Hospital Heidelberg
Non Cardiac Surgery
Presepsin (sCD14-ST) for Prediction of Perioperative Risk - MET-REPAIR Nested Cohort Study
Multicentre international prospective cohort study designed to evaluate whether preoperative presepsin (sCD14-ST) is associated with the composite endpoint: all-cause mortality and major adverse cardiovascular or cerebrovascular…
- Trial name
- P^3-MET-REPAIR (NCT03489486)
- Where
- Germany
- Volunteers
- 1,695 people
- Sponsor
- University Hospital Heidelberg
Kidney Transplantation
Preventive Fenestration With and Without Clipping in Kidney Transplantation
Post-Kidney Transplantation Lymphatic complications include lymphorrhea and lymphocele, and are some of the most challenging issues after kidney transplantation.
- Trial name
- PREFEN (NCT03682627)
- Testing
- Fenestration, Fenestration and clipping
- Where
- Germany
- Volunteers
- 78 people
- Sponsor
- University Hospital Heidelberg
Coronary Artery Disease, Noninvasive Plaque Characterization
CCTA-based Coronary Plaque Characterization and High-sensitive Troponin T for the Prediction of Cardiovascular Outcomes
To determine the ability of semi-automated plaque assessment in cardiac computed tomography angiography (CCTA) and high sensitive troponin T (hsTnT) for the risk stratification of patients at intermediate risk for coronary artery…
- Trial name
- NCT02030704
- Where
- 2 sites in Germany, Hungary
- Volunteers
- 300 people
- Sponsor
- University Hospital Heidelberg
Hepatectomy
The Use of Technical Vessel Sealing Devices for Recipient Hepatectomy in Liver Transplantation
The surgical technique used in liver transplantation has undergone constant Evolution in an effort towards towards a safe, highly standardized procedure.
- Trial name
- SEALIVE (NCT03323242)
- Testing
- LigaSure, Harmonic Ultrasonic dissector
- Volunteers
- 69 people
- Sponsor
- University Hospital Heidelberg
Ischemic Stroke
Thrombectomy in Patients Ineligible for iv tPA
the purpose of this study is to to compare the safety and effectiveness of stent-retrievers as a device class group with best medical care alone in the treatment of acute ischemic stroke (AIS) in patients who are not eligible for…
- Trial name
- THRILL (NCT02135926)
- Testing
- Thrombectomy, Best medical care
- Where
- 19 sites in Austria, Germany
- Volunteers
- 4 people
- Sponsor
- University Hospital Heidelberg
Coronary Artery Disease
Myocardial Injury After Elective Coronary Stenting
This pilot study aims to identify patients at moderate to high risk for peri-procedural (type 4) myocardial infarction or injury after after undergoing an elective coronary intervention (PCI) as measured by high sensitivity…
- Trial name
- NCT01986621
- Where
- Germany
- Volunteers
- 530 people
- Sponsor
- University Hospital Heidelberg
Glioma
Carbon Ion Radiotherapy for Recurrent Gliomas
Treatment of patients with recurrent glioma includes neurosurgical resection, chemotherapy, or radiation therapy. In most cases, a full course of radiotherapy has been applied after primary diagnosis, therefore application of…
- Trial name
- CINDERELLA (NCT01166308)
- Testing
- Carbon Ion Radiotherapy, Fractionated Stereotactic Radiotherapy (FSRT)
- Where
- Germany
- Volunteers
- 56 people
- Sponsor
- University Hospital Heidelberg
Particle Therapy
Monitoring of Patients Treated With Particle Therapy Using Positron-Emission-Tomography (PET): The MIRANDA Study
The purpose of this clinical study is to investigate the clinical feasibility and effectiveness of off-line Positron-Emission-Tomography (PET) quality assurance for promoting the accuracy of proton and carbon ion beam therapy.
- Trial name
- MIRANDA (NCT01528670)
- Where
- Germany
- Sponsor
- University Hospital Heidelberg
Recurrent Rectal Cancer
Phase I/II Trial Evaluating Carbon Ion Radiotherapy for the Treatment of Recurrent Rectal Cancer
Treatment standard for patients with rectal cancer depends on the initial staging and includes surgical resection, radiotherapy as well as chemotherapy.
- Trial name
- PANDORA (NCT01528683)
- Testing
- Carbon Ion Radiotherapy
- Where
- Germany
- Volunteers
- 14 people
- Sponsor
- University Hospital Heidelberg
Locally Advanced Pancreatic Cancer
Phase I Study Evaluating the Treatment of Patients With Locally Advanced Pancreatic Cancer With Carbon Ion Radiotherapy: The PHOENIX-01 Trial
The physical and biological properties of the carbon ion beam promise to improve the therapeutic ratio in patients with pancreatic cancer: Due to the inverted dose profile dose deposition in the entry channel of the beam leads to…
- Trial name
- PHOENIX-01 (NCT01795274)
- Testing
- Carbon Ion Radiotherapy
- Where
- Germany
- Sponsor
- University Hospital Heidelberg
Tumor, Effects of; Movement
Evaluation of Intrafractional Motion of Liver Tumors Using Markers
Radioopaque fiducial markers or electro-magnetic transponders will be implanted into or in close proximity of the tumor. During a radiotherapy treatment session image and/or signal acquisition will be performed by ultrasound…
- Conditions
- Tumor, Effects of; Movement, Radiation; Lesion
- Trial name
- ESMERALDA (NCT02095236)
- Testing
- organ motion
- Where
- Germany
- Sponsor
- University Hospital Heidelberg
Donor Nephrectomy
Hand-assisted Laparoscopic Donor Nephrectomy Periumbilical Versus Pfannenstiel Incision
Despite efforts to optimize the transplantation of deceased donor kidneys, the number of available kidneys continues to fall short of the demand. Living donor kidneys have been used to overcome this shortage.
- Trial name
- HAPERPACT (NCT03317184)
- Testing
- Periumbilical incision, Pfannenstiel incision
- Where
- Germany
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg