Clinical trials: sponsored by University of Aarhus
Binge Eating Disorder, Binge Eating
Effectiveness of a 10-week Multicomponent Intervention Combined With Parent Education on Binge Eating Behavior in Children and Adolescents
The main purpose is to investigate the effectiveness of a 10-week multicomponent camp intervention to reduce BE behavior in children and adolescents and explore in a randomized controlled setting if a parent-based…
- Conditions
- Binge Eating Disorder, Binge Eating, Loss of Control Eating, Overweight , Obesity
- Trial name
- STOB (NCT07301541)
- Testing
- A 10-week multicomponent camp intervention for children, A BED intervention for parents
- Where
- 2 sites in Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Achilles Tendon Rupture
Blood Flow Restriction Exercise in Patients With an Achilles Tendon Rupture
The goal of this clinical trial is to gain insights into the effects of Blood Flow Restriction Exercise (BFRE) in patients with an acute Achilles tendon Rupture.
- Trial name
- BEAN (NCT06434272)
- Testing
- Early exercise with partial Blood Flow Restriction, Late exercise with partial Blood Flow Restriction
- Where
- Denmark
- Volunteers
- 218 people
- Sponsor
- University of Aarhus
Locally Advanced Rectal Cancer, Rectal Adenocarcinoma
Dose-Escalated Short-Course Proton Therapy for Locally Advanced Rectal Cancer
This prospective national multicentre feasibility study evaluates dose-escalated short-course proton radiotherapy followed by total neoadjuvant chemotherapy in patients with primary high-risk locally advanced rectal…
- Trial name
- PROSPECT-WW (NCT07903883)
- Testing
- Intensity modulated proton therapy
- Where
- 8 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- University of Aarhus
Acute Lymphoblastic Leukemia
Pharmacokinetics of Dexamethasone in Childhood ALL and Reduction in Bone Mineral Density
The goal of this observational study is to learn about systemic and central nervous system (CNS) exposure to dexamethasone in childhood acute lymphoblastic leukaemia (ALL).
- Trial name
- NCT06367725
- Where
- 4 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
Heart Transplantation
Donor Derived Cell Free DNA (Dd-cfDNA) as a Biomarker for Allograft Rejection in Heart Transplant Recipients
Following heart transplantation (HTx), lifelong immunosuppressive treatment is required to prevent the immune system from attacking, damaging, and rejecting the donor hear (allograft).
- Trial name
- TRANSCEND (NCT07886489)
- Testing
- Donor-derived cell free DNA
- Where
- 3 sites in Denmark, Norway
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
Pregnancy, Obesity
When to INDuce for OverWeight? (WINDOW)
The rate of overweight and obese women becoming pregnant is increasing. Obesity in pregnancy along with delivery by cesarean section in obese women is associated with several complications as compared to normal weight women.
- Conditions
- Pregnancy, Obesity, Parturition
- Trial name
- WINDOW (NCT04603859)
- Testing
- Elective induction of labor at 39 gestational weeks and 0 to 3 days
- Where
- 12 sites in Denmark
- Volunteers
- 1,901 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Kidney Transplant Recipient, Kidney Transplant; Complications
Vascular Complications After Kidney Transplantation
To determine the incidence of arterial inflow problems and venous outflow problems as causes of impaired renal function and/or treatment-resistant hypertension after kidney transplantation, when all kidney-transplant recipients…
- Conditions
- Kidney Transplant Recipient, Kidney Transplant; Complications, Transplant Renal Artery Stenosis, Renovascular Disease
- Trial name
- DAN-PTRAIII (NCT07531966)
- Testing
- Catheter-based angiography, Measurement of translesional pressure gradients, Intravascular ultrasound (IVUS)
- Where
- 3 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Clostridium Difficile Infection, Clostridioides Difficile Infection
Fecal Microbiota Transplantation (FMT) for Clostridium Difficile
Faecal microbiota transplantation (FMT) is used for Clostridioides difficile infection (CDI) as part of an quality improvement initiative and conducted within the framework of Center for Faecal Microbiota Transplantation at…
- Trial name
- CEFTA (NCT03712722)
- Testing
- Faecal microbiota transplantation (FMT)
- Where
- Denmark
- Volunteers
- 2,000 people
- Sponsor
- University of Aarhus
Papillary Thyroid Carcinoma
Detection of BRAF Mutation on FNAB From Papillary Thyroid Carcinoma
Immunohistochemical detection of the BRAF-V600E mutation on pre-operative fine needle aspiration biopsy (FNAB) from patients suspected for papillary thyroid carcinoma, using the mutation specific antibody VE1.
- Trial name
- NCT02561533
- Testing
- BRAF detection on fine needle aspiration biopsy (FNAB)
- Where
- Denmark
- Volunteers
- 53 people
- Sponsor
- University of Aarhus
Knee Osteoarthritis
Anatomic Congruent Prosthetic Knee Design
This double-blinded randomized control study will use kinematic and kinetic measures to compare an anatomical congruent prosthetic knee design to a standard prosthetic knee design.
- Trial name
- NCT03633201
- Testing
- Cruciate Retaining, Medial Congruent
- Where
- Denmark
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Primary Hyperparathyroidism
Bisphosphonate Prior to Parathyroidectomy in Primary Hyperparathyroidism
This study is a randomized, double-blinded, placebo-controlled trial investigating the effects of zoledronic acid (ZOL) versus placebo in patients with primary hyperparathyroidism (PHPT) undergoing parathyroidectomy (PTX).
- Trial name
- ZOLPHPT (NCT06859580)
- Testing
- Zoledronic acid 4 mg, Natriumklorid 9 mg/ml, Fresenius Kabi
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- University of Aarhus
Emergency Medicine, POCUS
Point-of-Care Ultrasound for Diagnosing Abdominal Pain in the Emergency Department
The goal of this clinical trial is to learn if adding an abdominal ultrasound scan to the standard examination helps emergency physicians make a correct diagnosis in adults with acute abdominal pain in the emergency department.
- Conditions
- Emergency Medicine, POCUS, Abdominal Pain (AP), Acute Abdominal Pain
- Trial name
- AbdoPOCUS (NCT07849569)
- Testing
- Point of care ultrasound
- Where
- 3 sites in Denmark
- Volunteers
- 508 people
- Sponsor
- University of Aarhus
Systemic Sclerosis (SSc)
Home-based Exercise for Improving Health-related Quality of Life in Systemic Sclerosis
The goal of this randomised controlled trial is to evaluate whether a partially supervised, home-based exercise programme in addition to usual care improves health-related quality of life in adults with systemic sclerosis.
- Trial name
- ScleroStrong (NCT07840430)
- Testing
- Home-based exercise programme, Usual Care
- Where
- 3 sites in Denmark
- Volunteers
- 270 people
- Sponsor
- University of Aarhus
Physiological Conditions, Distress, Emotional
Hand in Hand: Feasibility of a Compassion-Focused App to Support Parents of Children With Mental Health Problems
Parents of children and adolescents with mental health problems may experience substantial caregiving burden and emotional distress, including persistent stress, self-criticism, shame, and parental burnout.
- Conditions
- Physiological Conditions, Distress, Emotional, Caregiving Stress, Burnout
- Trial name
- NCT07840404
- Testing
- App-based Compassion Program
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
HIV-1-infection
Administration of Venetoclax to Promote Apoptosis of HIV-infected Cells and Reduce the Size of the HIV Reservoir Among People Living With HIV on ART
In summary, there is a compelling rationale for investigating venetoclax as an intervention to sensitise virus-expressing cells to apoptosis and thereby reduce the size of the latent HIV reservoir.
- Trial name
- AMBER (NCT05668026)
- Testing
- Venetoclax
- Where
- 2 sites in Australia, Denmark
- Volunteers
- 18 people
- Sponsor
- University of Aarhus
Thyroid Cancer, Active Surveillance
Patients With a Single, Small (2 cm or Less) Cancer Nodule in the Thyroid Gland Will be Offered Active Surveillance Initially for 5 Years. In Case of Cancer Growth or Changes in Ultrasonographic Appearance, Further Treatment Will be Offered.
Patients with a single, small (less than 2 cm) cancer nodule in the thyroid gland will be offered active surveillance initially for 5 years.
- Trial name
- NCT07822217
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- University of Aarhus
Thyroid Cancer
Radiofrequency Ablation Versus Hemithyroidectomy for Small Thyroid Cancers
This is a multicenter randomized controlled trial including patients with small (<2 cm) suspected or confirmed thyroid cancers. Patients are included after informed consent and randomized to one of two treatments.
- Trial name
- NCT06796348
- Testing
- Radiofrequency ablation alone, Surgery
- Where
- Denmark
- Volunteers
- 88 people
- Sponsor
- University of Aarhus
Rectal Cancer, Total Mesorectal Excision
Examination of Rectal Blood Supply During Rectal Cancer Surgery Using Laser Speckle Contrast Imaging
This multicentre feasibility study evaluates the feasibility of performing laparoscopic Laser Speckle Contrast Imaging (LSCI) measurements of rectal perfusion during rectal cancer surgery.
- Conditions
- Rectal Cancer, Total Mesorectal Excision, Laser Speckle Contrast Imaging, Indocyanine Green (ICG)
- Trial name
- LIRA (NCT07799740)
- Testing
- Laser speckle contrast imaging
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
Chronic Kidney Disease (Stages 4 and 5)
Feasibility of the COMFORT (COmplex Symptom Management Intervention FOR adulTs With Advanced Kidney Disease) Intervention for Adults With Advanced Kidney Disease and Their Informal Caregivers
The purpose of this randomized feasibility study is to examine whether the COMFORT intervention is feasible and acceptable for adults with advanced kidney disease and their informal caregivers.
- Trial name
- COMFORT (NCT07815639)
- Testing
- COMFORT Intervention, Usual Care
- Where
- 2 sites in Denmark
- Volunteers
- 112 people
- Sponsor
- University of Aarhus
Rehabilitation, Follow up
The mHTX APP Program
Current Danish studies emphasize the importance of better integrated and efficient lifelong health care to heart-transplant recipients regardless of socioeconomic position.
- Trial name
- NCT07813416
- Testing
- Intervention
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- University of Aarhus
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