Clinical trials: open to volunteers, sponsored by University of Alabama at Birmingham
Neurofibromatosis 1, Plexiform Neurofibroma
Selumetinib for the Prevention of Plexiform Neurofibroma Growth in NF Type 1
Plexiform neurofibromas (PN) are known to cause significant morbidity in children with NF1. The recent FDA approval for selumetinib in children 2 years and older with inoperable symptomatic PN was based on the finding that…
- Trial name
- NF114 (NCT06188741)
- Testing
- Selumetinib
- Where
- 15 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Alabama at Birmingham
Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Video-Conferenced Stress Management and Relaxation Training (VSMART) For Alabama Breast Cancer Survivors
In a sample of Alabama breast cancer survivors, the proposed study tests the feasibility and acceptability of a stress management program that has been shown to improve health and wellbeing in a general population of patients…
- Trial name
- VSMART (NCT06924788)
- Testing
- Video-Conferenced Stress Management and Relaxation Training (VSMART)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Alabama at Birmingham
ACL Reconstruction
Methylprednisolone Addition to Multimodal Pain Regimens After Anterior Cruciate Ligament Reconstruction
Patients who are being seen for ACL tears will be approached in the UAB Orthopedic Clinic. Included patients will be those aged 14-65 undergoing ACL Reconstruction.
- Trial name
- NCT07605923
- Testing
- Methyl Prednisolone (MP), Standard Post-Operative Pain Control, Surgeon's Standard ACL Postoperative Regimen
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Alabama at Birmingham
Obesity and Obesity-related Medical Conditions
Evaluation of a Primary Care Based Lifestyle Medicine Clinic at UAB
This is a randomized quality improvement project (i.e., not a research study) that will test the implementation and effectiveness of a lifestyle medicine clinic at the University of Alabama at Birmingham.
- Trial name
- NCT06989281
- Testing
- FLOW Lifestyle Medicine Clinic
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Alabama at Birmingham
Type 2 Diabetes, Medication Adherence
MEDBRIDGE-Guided NCM/CHW Post-Discharge Support for High-Risk T2D Patients
This study tests whether a support program led by a nurse case manager and community health worker can help patients with type 2 diabetes manage their medications after leaving the hospital.
- Conditions
- Type 2 Diabetes, Medication Adherence, Care Transition, Medication Discrepancy
- Trial name
- MEDBRIDGE (NCT07599852)
- Testing
- MEDBRIDGE-Guided NCM/CHW Post-Discharge Support Intervention
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Alabama at Birmingham
Cancer Survivor, Cancer
Leading Healthy Eating and Activity Promotion Program
The goal of the LEAP project is to improve the health and well-being of cancer survivors and their co-survivors living in persistent poverty areas by providing healthy behavior change support.
- Conditions
- Cancer Survivor, Cancer, Oncology
- Trial name
- LEAP (NCT06868524)
- Testing
- LEAP Program
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
HIV, HIV Linkage to Care
Implementation Trial to Evaluate a Population Health Combination Intervention to Meet HIV Testing, Linkage, and Viral Suppression Goals in Alabama
The purpose of this study is to adapt and evaluate a combination intervention that includes: (1) a data-driven approach to directed community-based HIV testing to areas with high need, (2) Project Connect to expedite linkage to…
- Conditions
- HIV, HIV Linkage to Care, HIV Testing, HIV Treatment
- Trial name
- COAST-AL (NCT05384145)
- Testing
- COAST-AL
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Hepatitis B, HIV
Hep Mec Cohort in Zambia
Observational cohort of adults with acute and chronic hepatitis B infection in Zambia, with and without HIV coinfection. Participants join the study at the time of diagnosis and before or at the time when they are starting…
- Trial name
- Hep Mec (NCT07589985)
- Where
- 3 sites in Zambia
- Volunteers
- 390 people
- Sponsor
- University of Alabama at Birmingham
Kidney Stones
Oxalate-Driven Host Responses in Kidney Stone Disease
This study is looking to understand the role of oxalate on kidney stone development and immunity. This study will enroll healthy participants and participants with calcium oxalate kidney stones (CaOx KS).
- Trial name
- NCT05417568
- Testing
- Low Oxalate Diet, High Oxalate Diet
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
ASC-US, LSIL
Study of Treatment for HPV16+ ASC-US or LSIL
Phase I clinical trial to assess safety of pNGVL4aCRTE6E7L2 DNA and TA-CIN protein vaccinations, and to seek the appropriate dose of the pNGVL4aCRTE6E7L2 DNA vaccine
- Trial name
- PVX-6 (NCT03913117)
- Testing
- pNGVL4aCRTE6E7L2, TA-CIN
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Cerebral Palsy (CP)
Leveraging Extended Reality Exergaming and Telehealth to Improve Physical Activity and Health in Children With Disabilities
This phase II RCT evaluates the efficacy of a telehealth-delivered extended reality (XR) exergaming intervention on physical activity, cardiometabolic health, and physical fitness in physically inactive children with cerebral…
- Trial name
- NCT07564934
- Testing
- Extended Reality Exergaming
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of Alabama at Birmingham
Cardiometabolic Risk Factors in Adult Wheelchair Users
Cardiometabolic Health Intervention Using Movement-to-Music Exercise
The study aims to test the benefits of a 24-week, cardio-emphasized Movement-to-Music exercise program for reversing cardiometabolic health risk factors compared to asynchronous, standard exercise programs among 132 adult…
- Trial name
- CHIME (NCT05606432)
- Testing
- Instructor-led, one-on-one M2M exercise group, Self-guided control with pre-recorded standard exercise videos
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- University of Alabama at Birmingham
Mobility Disability
Cocoa to Maximize Exercise Training in Older Adults - The COMET Trial
The purpose of the study is to see if regular exercise when combined with a cocoa supplement will improve physical performance and muscle strength compared to regular exercise alone.
- Trial name
- COMET (NCT07161726)
- Testing
- (-)-Epicatechin-rich cocoa supplementation combined with exercise training
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Alabama at Birmingham
Healthy Aging, Health Knowledge, Attitudes, Practice
African Americans (AA) Communities Speak
African Americans are less likely to receive quality end-of-life (EoL) care. Addressing disparities in EoL care will need efforts to support a better understanding of African American patients' EoL cultural values and preferences…
- Conditions
- Healthy Aging, Health Knowledge, Attitudes, Practice, Social Responsibility, Care Eliciting Behavior
- Trial name
- AACS (NCT05908487)
- Testing
- AA Communities Speak to Healthcare Professionals
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Osteoporosis, Osteoporotic Fractures
RESTORE: REducing Future fractureS and Improving ouTcOmes of fRagility fracturE
RESTORE tests whether Augmented-FLS, where patients are contacted by a patient navigator (serving as the liaison) and referred to a bone health provider, is better than Enhanced Usual Care, which includes patient and PCP…
- Conditions
- Osteoporosis, Osteoporotic Fractures, Fragility Fracture
- Trial name
- RESTORE (NCT06455085)
- Testing
- Augmented-Fracture Liaison Service Arm, Enhanced Usual Care Arm
- Where
- 23 sites in United States
- Volunteers
- 2,634 people
- Sponsor
- University of Alabama at Birmingham
Common Variable Immunodeficiency
Usage of Spirometry in Managing IgG Therapy in CVID With Airway Disease
Although there is evidence in the literature that gammaglobulin replacement therapy can lead to a reduction in the prevalence of pulmonary infection and improved lung function, there is no published study to guide immunologists…
- Trial name
- NCT05193552
- Testing
- Hizentra
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Peripheral Artery Disease, Claudication, Intermittent
Red Light Treatment in Peripheral Artery Disease
Subjects with a known diagnosis of peripheral artery disease as measured by an abnormal ankle brachial index (<.9 or >1.1) will undergo a single 5 min exposure of 670 nm light, 1 cm above the gastrocnemius muscle.
- Conditions
- Peripheral Artery Disease, Claudication, Intermittent, Vasodilation
- Trial name
- NCT03203239
- Testing
- Red Light (670 nm energy), Octafluoropropane
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Exposure to Man-made Visible Light
Peripheral Blood Flow Responses to Electromagnetic Energy
This study evaluates 670 nm energy in the form of red light to stimulate blood flow changes in healthy adults. All participants will receive red light to their leg.
- Trial name
- NCT02370199
- Testing
- 670 nm light, octafluropropane
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Arsenic and/or Arsenic Compound Adverse Reaction
Mitigation Efforts in Arsenic Exposure With Folic Acid Supplementation
The purpose of this study is to evaluate the effects on folic acid supplementation in a population living in an environment with chronic arsenic exposure in Birmingham, Alabama.
- Trial name
- NCT05656664
- Testing
- Folic Acid
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cognitive Impairment, Dementia
Investigating Dynamic Interactions in Distributed Cognitive Control Networks
The purpose of this study is to investigate the brain activity associated with cognitive tasks (thinking, reasoning, remembering) in order to understand how the brain works during certain tasks and to improve treatment for…
- Conditions
- Cognitive Impairment, Dementia, ADD, Depression
- Trial name
- NCT05927974
- Testing
- Passive testing, Active testing
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham