Clinical trials: sponsored by University of Alberta
Depressive Disorder, Treatment-Resistant
rTMS With and Without Text4Support for the Treatment of Resistant Depression.
This study is a multicenter prospective, parallel design, two-arm, rater-blinded randomized controlled pilot trial. Participants will be randomly assigned to one of two treatment conditions.
- Trial name
- NCT05570344
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), Repetitive Transcranial Magnetic Stimulation (rTMS) Plus Text4Support
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- University of Alberta
Stroke
The Whole Day Matters After Stroke (BIG-STEPS)
Goal of research program: To understand person-specific factors, such as imaging markers and activity patterns early after stroke, that may guide precision rehabilitation to optimize function and improve recovery. Objectives: 1.
- Trial name
- BIG-STEPS (NCT05753761)
- Testing
- Behaviour- & Imaging-Guided Stepping Training Early Post-Stroke (BIG STEPS) intervention
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- University of Alberta
Type 1 Diabetes Mellitus
An Adaptive Design Study of MTX228
MTX228 has been identified as a medication that might allow the re-growth of insulin producing beta cells in people with Type 1 Diabetes.
- Trial name
- NCT06474598
- Testing
- MTX228, DEXCOM G6
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of Alberta
Attention Deficit Hyperactivity Disorder
Does the Format of the Adult ADHD Self-Report Scale Impact the Results
The World Health Organization Adult ADHD Self-Report Scale v1.1 (ASRS) is frequently used in family medicine clinics to screen for ADHD. Numerous studies have found the ASRS has a low positive predictive value.
- Trial name
- NCT06530758
- Testing
- Altered ASRS format, without shading and with grouping, Altered ASRS format, with shading and without grouping, Altered ASRS format, without shading and without grouping
- Where
- Canada
- Volunteers
- 587 people
- Sponsor
- University of Alberta
Spinal Cord Injuries, Stroke
Transcutaneous Spinal Cord Stimulation for Upper Extremity Function
Transcutaneous electrical stimulation (tcES) of the spinal cord has shown great promise in restoring upper extremity function after spinal cord injury (SCI).
- Trial name
- NCT06596369
- Testing
- Transcutaneous spinal cord stimulation, Upper extremity rehabilitation
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Multiple Sclerosis, Menstrual Cycle
My MS and My Menstrual Cycle
The goal of this observational study is to understand how MS symptoms change during different phases of the menstrual cycle in individuals who menstruate living with MS (Multiple Sclerosis).
- Trial name
- NCT06832293
- Where
- 2 sites in Canada
- Volunteers
- 300 people
- Sponsor
- University of Alberta
Low Back Pain
GLA:D Back Canada - a Program for Chronic and Persistent Low Back Pain
GLA:D Back is a program developed in Denmark to help people with persistent low back pain. This study will assist in contextualizing Danish content into an English version of the program.
- Trial name
- NCT06924671
- Testing
- GLA:D Back
- Where
- Canada
- Volunteers
- 2,200 people
- Sponsor
- University of Alberta
Respiratory Failure
Transpulmonary Assessment for Individualized Lung Optimization in Obese Patients
This protocol describes a randomized controlled feasibility vanguard study designed to investigate the implementation and effects of esophageal pressure-guided positive end-expiratory pressure (PEEP) titration in patients with…
- Trial name
- TAILOR-PEEP (NCT07359261)
- Testing
- Esophageal pressure-guided PEEP titration, Standard care PEEP management
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Cardiac Arrest Neonatal
Vasopressin vs. Epinephrine During Neonatal Cardiopulmonary Resuscitation
When a baby is born with a low heart rate or no heart rate, the clinical team must provide breathing support and chest compressions (what is call cardiopulmonary resuscitation or CPR).
- Trial name
- NCT05738148
- Testing
- Vasopressin, Epinephrine
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of Alberta
Cirrhosis, Liver, Liver Transplant Surgery
Online Prehabilitation for Patients Awaiting Liver Transplantation
Physical frailty is common in patients awaiting liver transplantation and has been associated with poor health outcomes. There is promising data from small studies showing that behavioural, nutrition, exercise therapy…
- Conditions
- Cirrhosis, Liver, Liver Transplant Surgery, Liver Disease
- Trial name
- OPAL (NCT05899231)
- Testing
- Prehabilitation Programming
- Where
- 6 sites in Canada
- Volunteers
- 177 people
- Sponsor
- University of Alberta
Osteoarthritis of the Carpometacarpal Joint, Thumb Osteoarthritis
The Use of Intra-articular Corticosteroid Injection to Treat Osteoarthritis of the Carpometacarpal Joint
This randomized clinical trial (RCT) will evaluate 6-month outcomes following intra-articular injections for arthritis of the thumb carpometacarpal (CMC) joint by comparing corticosteroid plus local anesthetic versus saline…
- Trial name
- NCT04177433
- Testing
- Depo-Medrol Injectable Product, Saline
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of Alberta
Apnea, Airway Obstruction, Nasal
Upper Airway's Pressure Drop Analyses After Mandibular Advancement and Maxillary Expansion
Breathing is a crucial function for everyone. Breathing impairment in children could lead to behavioral and cognitive problems at least.
- Conditions
- Apnea, Airway Obstruction, Nasal, Mandible Small, Maxillary Hypoplasia
- Trial name
- NCT04190953
- Testing
- Twin block then Hyrax, Hyrax then Twin block
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Sleep Apnea, Obstructive, Occlusal Splints
Comparing Two Mandibular Positioning Techniques for Dental Sleep Appliances
This is a prospective study that directly compares the use of speech vs an anterior protrusive technique for mandibular positioning.
- Trial name
- NCT05553860
- Testing
- Speech positioning technique
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Postoperative Hemorrhage, Postoperative Anemia
Autologous Whole Blood Management for Transfusion Reduction in Adult Cardiac Surgery Patients
The goal of this pilot trial is to test a protocol for a planned Canada-wide clinical trial looking at whether or not the use of a patients own blood works as good as the current standard of care using donated blood products to…
- Conditions
- Postoperative Hemorrhage, Postoperative Anemia, Postoperative Blood Loss
- Trial name
- NCT05889494
- Testing
- Autologous Whole Blood Management, Standard Care involving allogenic and/or derivative transfusion.
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Chronic Kidney Disease Requiring Chronic Dialysis
Evaluation of Routinely Measured Patient-reported Outcomes in Hemodialysis Care
Patient-reported outcome measures (PROMs) are reports coming directly from patients about how they function or feel in relation to a health condition and its therapy, without interpretation of the patient's responses by a…
- Trial name
- EMPATHY (NCT03535922)
- Testing
- PROMs Assessment
- Where
- 3 sites in Canada
- Volunteers
- 3,977 people
- Sponsor
- University of Alberta
Pituitary Diseases, Pituitary Neoplasms
Long Term Outcome Study in Patients With Pituitary Disorders
To determine the outcomes of patients with different pituitary disorders whether they are managed medically, surgically or expectantly.
- Trial name
- NCT03665064
- Volunteers
- 1,500 people
- Sponsor
- University of Alberta
Cytomegalovirus Infections
Breakthrough CMV Lung Transplant -Multicentre
Cytomegalovirus (CMV) infection is the most common opportunistic infection in lung transplantation leading to direct and indirect effects that can result in life threatening complications.
- Trial name
- NCT04439916
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Stable Ischemic Heart Disease, Coronary Artery Disease
De-Adoption of Beta-Blockers in Patients With Stable Ischemic Heart Disease
Patients with heart disease are often prescribed many medications and these patients may experience drug interactions or negative drug related side effects.
- Conditions
- Stable Ischemic Heart Disease, Coronary Artery Disease, Beta-blocker Therapy
- Trial name
- ABBREVIATE (NCT05081999)
- Testing
- Medical Assessment, Quality of Life Assessment
- Where
- Canada
- Volunteers
- 59 people
- Sponsor
- University of Alberta
Small Bowel Bleeding
Early Videocapsule Endoscopy for Upper Gastrointestinal Bleeding
The objective of this study is to determine whether early video capsule endoscopy (VCE) immediately after a negative gastroscopy in the setting of suspected upper gastrointestinal bleeding (UGIB) improves patient outcomes as…
- Trial name
- NCT05108844
- Testing
- Videocapsule endoscopy
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University of Alberta
Type 1 Diabetes, Post-menopause
Aerobic vs Resistance Exercise in Post-menopausal Women With Type 1 Diabetes
Participants will be asked to wear a continuous glucose monitor for at least three days on three separate occasions. One testing session will be a no-exercise resting control session (90 minutes).
- Trial name
- NCT05188027
- Testing
- Aerobic Exercise, Resistance Exercise, No exercise
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- University of Alberta