Clinical trials: sponsored by University of Alberta
Cytomegalovirus Infections
Breakthrough CMV Lung Transplant -Multicentre
Cytomegalovirus (CMV) infection is the most common opportunistic infection in lung transplantation leading to direct and indirect effects that can result in life threatening complications.
- Trial name
- NCT04439916
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Pediatric ALL, Congenital Heart Disease
Exercise MRI to Evaluate Cardiorespiratory Fitness in Children With Heart Disease
There are many barriers to heart-healthy lifestyles in pediatric patients with acquired and congenital heart disease. Investigators want to further understand how participants heart and skeletal muscles work together during…
- Conditions
- Pediatric ALL, Congenital Heart Disease, Heart Transplantation
- Trial name
- NCT06325280
- Testing
- Exercise cardiac MRI Assessment, Cardiopulmonary Exercise Test
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Alberta
Hemianopsia, Visual Field Defect, Peripheral
Hemianopsia Rehabilitation After Stroke or Brain Injury
In patients with hemianopsia following stroke or brain injury, we will determine if stimulating the visual field with images from a PowerPoint slide set can increase the visual field.
- Conditions
- Hemianopsia, Visual Field Defect, Peripheral, Visual Impairment
- Trial name
- NCT06241209
- Testing
- PowerPoint program visual stimulation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Middle Cerebral Artery Aneurysm
Middle Cerebral Artery Aneurysm Trial
Intracranial aneurysms located on the middle cerebral artery (MCA) are considered by many surgeons to represent a distinct subgroup of aneurysms for which clipping may still be the best management option.
- Trial name
- MCAAT (NCT05161377)
- Testing
- Surgical management, Endovascular management
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- University of Alberta
Hyperbaric Oxygen Therapy, Carbon Monoxide Poisoning
Optimal Number of Hyperbaric Oxygen Treatments for Carbon Monoxide Poisoning
The optimal treatment strategy with hyperbaric oxygen therapy has been the subject of some debate over the past 3 decades. Initial landmark studies showed a decrease in the incidence of DNS with a single treatment and also with…
- Trial name
- NCT06619717
- Testing
- Hyperbaric Oxygen Therapy
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of Alberta
Congenital Heart Disease, Congenital Heart Disease in Adolescence
The Impact of an Innovative eHealth Transition Intervention on Self-Management Skills Among Young Adults With Congenital Heart Disease
Congenital heart disease (CHD) survivors constitute one of the fastest growing populations in adult cardiology practices. This population is vulnerable to gaps in care, particularly as they graduate from the pediatric to adult…
- Trial name
- READYorNot CHD (NCT04463446)
- Testing
- Use of the CHD app, Nurse-led intervention
- Where
- Canada
- Volunteers
- 207 people
- Sponsor
- University of Alberta
Pediatric ALL, Transplant; Failure, Heart
HIIT in Pediatric Heart Transplant Recipients (MedBIKE™)
Heart transplantation is the long-term treatment for children and adults with advanced heart failure. Post-transplant outcomes have improved over time, such that 50% of pediatric heart transplant recipients (HTR) remain alive…
- Trial name
- NCT05451979
- Testing
- MedBIKE HIIT
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Alberta
Idiopathic Toe Walking, Cerebral Palsy
The Effect of Targeting the Plantaris Muscle-tendon in Surgical Correction of Ankle Equinus in Children
Tight ankle muscles can produce ankle equinus (limited ability to pull the foot upward) and occur often in children, significantly impacting their ability to walk.
- Conditions
- Idiopathic Toe Walking, Cerebral Palsy, Hereditary Spastic Paraparesis, Traumatic Brain Injury
- Trial name
- Plantaris Sx (NCT07090057)
- Testing
- Tendoachilles (TA) lengthening or gastrocnemius (GN) recession, then Plantaris tenotomy, Plantaris tenotomy, then Tendoachilles (TA) lengthening or gastrocnemius (GN) recession
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- University of Alberta
Cancer, Adults
Cycling-Based Aerobic Exercise Intervention for Individuals With Chemotherapy-Induced Peripheral Neuropathy (CIPN)
CYCLE-CIPN is a proof-of-concept study designed to evaluate whether a prescribed aerobic exercise intervention has the potential to reduce the symptoms and functional impact of CIPN.
- Trial name
- CYCLE-CIPN (NCT07150117)
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
ST Elevation Myocardial Infarction
SONOthrombolysis in Patients With an ST-segment Elevation Myocardial Infarction With fibrinoLYSIS (SONOSTEMI-LYSIS) Trial
This study will assess the safety and feasibility of sonothrombolysis in the acute management of STEMI undergoing reperfusion therapy with systemic fibrinolysis as part of a pharmacoinvasive approach
- Trial name
- SONOSTEMILYSIS (NCT04217304)
- Testing
- Definity® with High Mechanical Index Ultrasound
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- University of Alberta
TBI (Traumatic Brain Injury), Status Epilepticus
Augmented Renal Clearance in Neurocritical Care
Stroke, severe brain injury, uncontrolled seizures and brain infections are the most common life-threatening neurological illnesses in the world with an estimated combined annual hospital management cost of up to 44 billion…
- Conditions
- TBI (Traumatic Brain Injury), Status Epilepticus, Bacterial Meningitis, Augmented Renal Clearance (ARC)
- Trial name
- Neuro-ARC (NCT07410624)
- Where
- 3 sites in United States, Canada
- Volunteers
- 512 people
- Sponsor
- University of Alberta
Obstructive Sleep Apnea
Effectiveness of NOA OATMAD
This study is looking at how well the OrthoApnea NOA appliance, a special custom-made mouthpiece, helps treat people with obstructive sleep apnea (OSA).
- Trial name
- NCT07111962
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University of Alberta
Congenital Hyperinsulinism, Neuroblastoma
18F-DOPA II - PET Imaging Optimization
A single centre non-randomized, non-blinded phase III prospective cohort study of 18F-DOPA PET/CT imaging in specific patient populations: 1. Pediatric patients (less than 18 years old) with congenital hyperinsulinism. 2.
- Conditions
- Congenital Hyperinsulinism, Neuroblastoma, Parkinson Disease, Lewy Body Disease
- Trial name
- NCT04706910
- Testing
- 18F-DOPA, Furosemide Injection
- Where
- Canada
- Volunteers
- 800 people
- Sponsor
- University of Alberta
Acute Pain, Lidocaine
Pharmacokinetic Profile of Lidocaine Given as a Weight-based Infusion for Postoperative Surgical Pain Control
Study Summary Title Pharmacokinetic profile of lidocaine given as a weight-based infusion for postoperative surgical pain control Short Title Pharmacokinetic profile of lidocaine given as a weight-based infusion for postoperative…
- Conditions
- Acute Pain, Lidocaine, Administration and Dosage
- Trial name
- NCT05402293
- Testing
- Blood samples to measure lidocaine levels
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- University of Alberta
Peripheral Nerve Injuries
Non-invasive Therapy to Drive Nerve Regeneration
Peripheral nerve injuries are common and often associated with poor outcomes including incomplete repair, debilitating pain states and compromised function.
- Trial name
- NCT05848778
- Testing
- Acute Intermittent Hypoxia, Normoxia
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of Alberta
Subarachnoid Aneurysm Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Nimodipine Variability in SAH
Aneurysmal subarachnoid hemorrhage (SAH) is a life-threatening neurological illness: it is bleeding in the brain after a bulging blood vessel (a brain aneurysm) ruptures.
- Trial name
- ASH-II (NCT07065903)
- Where
- 3 sites in United States, Canada
- Volunteers
- 500 people
- Sponsor
- University of Alberta
Hemiparetic Cerebral Palsy
Using Neurotechology to Help Children With Physical Disability Due to Cerebral Palsy
Hemiparetic cerebral palsy is a condition in which one side of a child's body becomes weak due to brain injury occurring around birth, often caused by stroke.
- Trial name
- NCT07269353
- Testing
- Brain Computer Interface - Functional Electrical Stimulations
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of Alberta
Cubital Tunnel Syndrome, Electrical Stimulation
Conditioning Electrical Stimulation to Improve Outcomes in Cubital Tunnel Syndrome
Cubital tunnel syndrome is the second most common compression neuropathy. In severe cases, functional recovery, even with surgery, is often poor.
- Trial name
- NCT05395715
- Testing
- Electrical stimulation
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Relapsed Non Hodgkin Lymphoma, Relapsed Adult ALL
Anti-CD19, Dual Co-stimulatory (4-1BB, CD3ζ) Chimeric Antigen Receptor T-cells in Patients With Relapsed/Refractory Aggressive Lymphoma or Acute Lymphoblastic Leukemia (ALL)
Autologous, unselected CD3+ lymphocytes collected from apheresis, transfected with a lentiviral vector containing a 2nd generation chimeric antigen receptor (CAR) consisting of a scFv recognizing CD19 and dual co-stimulatory…
- Conditions
- Relapsed Non Hodgkin Lymphoma, Relapsed Adult ALL, Relapsed Pediatric ALL
- Trial name
- ACIT001/EXC002 (NCT03938987)
- Testing
- autologous CD19-directed chimeric antigen receptor (CAR) T-cells
- Where
- 6 sites in Canada
- Volunteers
- 63 people
- Sponsor
- University of Alberta
Neoplasms, Pediatric Cancer
Pediatric Early Rehabilitation in Acute Lymphoblastic Leukemia
The purpose of this study is to determine the feasibility and acceptability of a hybrid in-person and virtual individualized physiotherapy program using the Healthy Eating and Active Living (HEAL-ME) online platform for children…
- Conditions
- Neoplasms, Pediatric Cancer, Physical Therapy, Telemedicine
- Trial name
- PEACE (NCT06170385)
- Testing
- Physical Therapy
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Alberta