Clinical trials: sponsored by University of Alberta
Migraine, Headache
Intravenous Fluid for Pediatric Migraine in the Emergency Department
The purpose of this study is to evaluate the effect of intravenous fluid (0.9% sodium chloride and water) alone on headache pain in children with migraine visiting the Emergency Department.
- Trial name
- EDMigraine3 (NCT01073787)
- Testing
- Normal saline
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- University of Alberta
Mammaplasty
Electrical Stimulation for Improving Postoperative Breast Sensation
Described as the "Angelina Jolie Effect", rates of prophylactic mastectomy with immediate implant-based reconstruction are increasing dramatically as more women with genetic predisposition towards breast cancer are seeking…
- Trial name
- NCT03240900
- Testing
- Electrical Stimulation
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Congenital Heart Disease, Pediatric ALL
HIIT in Youth With Congenital Heart Disease (MedBIKE)
Congenital heart disease (CHD), the most common birth defect, is present in nearly 1% of the population. CHD patients are associated with intense resource utilization and premature death in adulthood.
- Trial name
- NCT04575883
- Testing
- MedBIKE HIIT
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University of Alberta
Reading Disorders
Impact of Motor Tasks and Lidocaine on Reading Unfamiliar Words in Adults With and Without Dyslexia
Recent claims report that reading ability is partially dependent on speech production. While the evidence for this claim is compelling, it is not known to what extent, the speech production system contributes to successful…
- Trial name
- NCT05854082
- Testing
- Lidocaine 2% Polyampoule
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Breast Cancer, Upper Extremity Dysfunction
Exercise Rehabilitation Via a Mobile Application for Individuals With Breast Cancer Undergoing Chemotherapy
The primary purpose of this study is to determine the feasibility of our proposed intervention approach involving (1) an integrated physiotherapy and exercise intervention for individuals with breast cancer who are undergoing…
- Trial name
- Empower (NCT05254678)
- Testing
- general exercise
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of Alberta
Low Back Pain, Brace
Lumbar Brace Deployment in the Emergency Department for Benign Low Back Pain
Low back pain accounts for billions of dollars in health care expenditures. Most cases of back pain do not have a clear cause. Thus, low back pain management methods usually rely on targeting people' pain and discomfort.
- Conditions
- Low Back Pain, Brace, Emergencies, Pain
- Trial name
- NCT03829631
- Testing
- Horizon 627 Lumbar Brace, Aspen Medical Company, Oak Canyon, Irvine, CA 92618
- Where
- Australia
- Volunteers
- 152 people
- Sponsor
- University of Alberta
Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant
NESBID: Neuro-Stimulation of the Brain in Depression
In Canada, approximately 20% of patients with Major Depressive Disorder (MDD) have treatment-resistance and fail to respond to trials of pharmacotherapy or psychotherapy.
- Conditions
- Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant, Transcranial Direct Current Stimulation, Electric Stimulation Therapy
- Trial name
- NESBID (NCT04159012)
- Testing
- Transcranial direct current stimulation
- Where
- Canada
- Sponsor
- University of Alberta
Vasoplegia
Midodrine for the Early Liberation of Vasopressor Support in the ICU (LIBERATE Multi-Site)
Vasopressors are medications that are given intravenously to increase the blood pressure of patients with illnesses that cause dangerous blood pressure drops.
- Trial name
- NCT05058612
- Testing
- Midodrine
- Where
- Canada
- Volunteers
- 870 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Diabetes Mellitus, Hypertension
Implementation and Evaluation of a Pharmacist-led Diabetes Care Pathway in Alberta Community Pharmacies
As of 2024, nine percent of Albertans are living with Type 2 diabetes, which increases their risk for cardiovascular disease, stroke, blindness, and kidney failure.
- Conditions
- Diabetes Mellitus, Hypertension, Hyperlipidaemia
- Trial name
- D-PATH (NCT07339852)
- Testing
- Pharmacist-led diabetes care pathway
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- University of Alberta
Neonatal Respiratory Distress
Volume Targeted Mask Ventilation Versus Pressure Ventilation in Preterm Infants
This is a pilot trial to assess the feasibility of volume Targeted Ventilation in the Delivery Room. Preterm infants will be randomized to pressure guided or volume targeted ventilation during respiratory support in the delivery…
- Trial name
- VOLT (NCT05144724)
- Testing
- Volume targeted ventilation, Pressure targeted ventilation
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- University of Alberta
Breast Neoplasm, Lymphedema
Decongestive Exercise and Compression for Breast Cancer Related Lymphedema Management
Women who have undergone breast cancer surgery may develop swelling of the arm on the side the breast cancer occurred. If the swelling becomes chronic it is called lymphedema.
- Trial name
- DREAM (NCT02992782)
- Testing
- Standard Care, Exercise and Compression Garment, Exercise and Adjustable Compression Wrap
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Alberta
Aging, Adverse Drug Interaction
MinMed: Do Older Adults do Better With Less Medication
Many health care providers believe "less-is-more" for older adults, and evidence suggests minimizing certain medications might improve health outcomes.
- Conditions
- Aging, Adverse Drug Interaction, Frailty
- Trial name
- NCT05307666
- Testing
- Medication minimization
- Where
- Canada
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Breast Cancer, Disability Physical
Breast cancEr, FITness and ExeRcise for Heart Health: The BE-FITTER Study
The chemotherapy medications used for breast cancer treatment are important for achieving a cure, but a potential side effect is that they can cause a decline in functional capacity (reduced exercise tolerance and impaired…
- Conditions
- Breast Cancer, Disability Physical, Heart Failure, Cardiotoxicity
- Trial name
- BE-FITTER (NCT06595147)
- Testing
- Structured Exercise Training, Group-based Yoga and Stretching
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Alberta
Fragile X Syndrome, Fragile X Mental Retardation Syndrome
A Trial of Metformin in Individuals With Fragile X Syndrome (Met)
This study is a controlled trial of metformin in individuals with fragile X syndrome between the ages of 6 and 35 years. Participants will be randomized in a double-blind design to either drug or placebo and will attend three…
- Conditions
- Fragile X Syndrome, Fragile X Mental Retardation Syndrome, Mental Retardation, X-Linked, Genetic Diseases, X-Linked
- Trial name
- NCT03862950
- Testing
- Metformin
- Where
- 2 sites in Canada
- Volunteers
- 125 people
- Sponsor
- University of Alberta
Vasoconstriction, Vasodilation
Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences
The main purpose of this interventional study is to examine differences in resting blood pressure control between healthy males and females. The main questions it aims to answer are: 1.
- Trial name
- STARS (NCT05997732)
- Testing
- Phenylephrine Hydrochloride, Isoproterenol Hydrochloride, Norepinephrine Bitartrate
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Hypertension, Frailty
Antihypertensive Deprescribing in Long-term Care
Frail older adults are commonly prescribed blood pressure medication, yet it is unclear if blood pressure medication is actually beneficial for them.
- Trial name
- OptimizeBP (NCT05047731)
- Testing
- Antihypertensive medication
- Where
- Canada
- Volunteers
- 522 people
- Sponsor
- University of Alberta
Child Obesity
Attrition in Pediatric Obesity Management
Our feasibility study will assess the feasibility and acceptability of Family Navigation (FN) to address attrition (dropout) in pediatric obesity management.
- Trial name
- NCT05403658
- Testing
- Family Navigation, Usual Care
- Where
- Canada
- Volunteers
- 108 people
- Sponsor
- University of Alberta
Spinal Cord Injuries
Electrical Stimulation for Spasticity in Spinal Cord Injury
This study examines the immediate and long-term effects of lumbosacral TENS on spasticity and residual voluntary force control in spinal cord injury in comparison to no TENS.
- Trial name
- NCT05103436
- Testing
- TENS
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Immunosuppression
Fibroscan to Guide Post Transplant Immunosuppression Minimization
Following Liver transplantation, recipients remain on life long immunosuppression. Prolonged exposure to immunosuppression is associated with side effects and complications including kidney dysfunction, diabetes, heart disease…
- Trial name
- NCT07206277
- Testing
- Immunosuppression reduction
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Living Donor Kidney Transplantation
Multidisciplinary Support To Access Living Donor Kidney Transplant-Pilot
For patients with kidney failure the two treatment options are kidney transplantation or dialysis. Transplantation offers longer survival, better quality of life and provides cost savings for the health system (>$60,000/year per…
- Trial name
- MuST AKT (NCT04666545)
- Testing
- MuST AKT
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- University of Alberta