Clinical trials: sponsored by University of Alberta
Microbial Colonization
Rewilding the Human Gut: Reintroduction of the Species Limosilactobacillus Reuteri
The large intestine is home to trillions of microbes, known as the gut microbiome, which perform essential functions, such as digesting food and fighting disease.
- Trial name
- NCT03501082
- Testing
- L Reuteri PB-W1 Strain, L. Reuteri DSM20016T Strain, Non-Industrialized-Type Diet
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Congestive Heart Failure Chronic
Evaluating the Clinical Efficacy of Resveratrol in Improving Metabolic and Skeletal Muscle Function in Patients With Heart Failure
This is a randomized, double-blind, placebo-controlled trial evaluating the effect of resveratrol on metabolic and skeletal muscle function.
- Trial name
- REV-HF (NCT03525379)
- Testing
- Resveratrol
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- University of Alberta
Retinopathy of Prematurity, Pain
Acupuncture for Preterm Infants Requiring Eye-exam
The purpose is to investigate whether non-invasive acupuncture - NIA (i.e. acupuncture without needles) will help reduce pain for babies in the Neonatal Intensive Care Unit (NICU) during their routine weekly eye-exam for…
- Conditions
- Retinopathy of Prematurity, Pain, Acupuncture, Premature Infant
- Trial name
- MAGNIFIC-ROP (NCT03650621)
- Testing
- Magnetic acupuncture, stickers (magnets removed)
- Where
- 3 sites in Australia, Canada and 1 more
- Volunteers
- 100 people
- Sponsor
- University of Alberta
Healthy
Influence of Coffee Consumption on BIA-derived Body Composition Parameters
Body composition analysis is frequently used in both clinical and research settings for evaluation of nutritional status and follow-up.
- Trial name
- NCT03745508
- Testing
- Instant Coffee
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Musculoskeletal Injury
Non-Steroidal or Opioid Analgesia Use for Children With Musculoskeletal Injuries
Musculoskeletal (MSK) injuries, including limb injuries, are the most common cause for Emergency Department (ED) visits for children with pain.
- Trial name
- No OUCH (NCT03767933)
- Testing
- Ibuprofen, Acetaminophen, Hydromorphone
- Where
- 6 sites in Canada
- Volunteers
- 710 people
- Sponsor
- University of Alberta
Adolescent Obesity, Life Style
Piloting Conversation Cards for Adolescents
Providers are not opportunistic enough in addressing lifestyle habits of teens, and can benefit from appropriate tools to support their conversations with families as well as engage all family members in making changes.
- Conditions
- Adolescent Obesity, Life Style, Health Behavior, Health Communication
- Trial name
- NCT03821896
- Testing
- Conversation Cards for Adolescents and Goal-Setting, Goal-Setting
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- University of Alberta
Asphyxia Neonatorum, Birth Asphyxia
Heart Rate Assessment at Birth Comparing Stethoscope Versus Tap-based Application
Some newborn babies have difficulty breathing at birth and need help. When babies need help with breathing the clinical team, the team measures heart rate using a stethoscope to check its heart rate and figure out what kind of…
- Trial name
- NCT03913533
- Testing
- Heart rate assessment using the Neonatal Resuscitation Program 6-sec assessment method, Heart rate assessment using Tap-based smartphone application
- Where
- Canada
- Sponsor
- University of Alberta
Sedative Adverse Reaction
Target Controlled Infusion Using Propofol and Remifentanil for Moderate Sedation in Dentistry
The purpose of this university study is to evaluate the use of an advanced dental sedation technique involving two syringe-type pumps called Target Controlled Infusion (TCI) pumps.
- Trial name
- NCT03995134
- Testing
- Propofol and Remifentanil administered by TCI pump
- Where
- 2 sites in Canada, New Zealand
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Breast Cancer, Body Image
Rise Up After Breast Cancer
The objectives of this pilot study are to determine the feasibility of a community-based moderate intensity resistance exercise training (RET) program in combination with an art sculpting class on body image in breast cancer…
- Trial name
- RISE-UP (NCT04088877)
- Testing
- Exercise, Art Sculpting Class
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Alberta
Aphasia
Voice Adaptive Tablet-Based Naming Treatment for Adults With Aphasia
Rising life expectancy is leading to a rising incidence of strokes worldwide. Approximately one third of people who had a stroke live with a communication disorder, aphasia, which is associated with the largest negative…
- Trial name
- VoiceAdapt (NCT04108364)
- Testing
- Voice adaptive training for aphasia
- Where
- 2 sites in Canada
- Volunteers
- 38 people
- Sponsor
- University of Alberta
Dyspnea
The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in Interstitial Lung Disease.
Interstitial Lung Disease (ILD) is a is a lung disorder which makes breathing more difficult. During exercise, patients with ILD are not efficient breathers and this leads to serious breathing difficulties, which often causes…
- Trial name
- iNO (NCT04181359)
- Testing
- Nitric Oxide
- Sponsor
- University of Alberta
Carpal Tunnel Syndrome
Conditioning Electrical Stimulation to Improve Outcomes in Carpal Tunnel Syndrome
Carpal tunnel syndrome is common, identified in 3% of the general population. Symptoms including numbness and pain are due to compression of the median nerve as it travels through a tunnel entering the wrist and can result in…
- Trial name
- NCT04191538
- Testing
- Conditioning electrical stimulation, Postoperative electrical stimulation, No electrical stimulation
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- University of Alberta
Coronary Artery Bypass Grafting, Hypotension
The PRESSURE CABG Cardiac Surgery Trial
This study will be a pragmatic, prospective, single-centre, unit-based cluster crossover, open-label registry trial. The cardiac surgical intensive care unit (CSICU) will be cluster assigned to alternating MAP targets in 6-month…
- Trial name
- PRESSURECABG (NCT04197700)
- Testing
- Target MAP Management
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- University of Alberta
Hypoxia
The Effect of Inhaled Nitric Oxide on Maximal Oxygen Consumption During Exercise in Hypoxia
During exercise in conditions of low oxygen (termed hypoxia), such as mountaineering at high altitudes, the lung blood vessels constrict in an attempt to protect the body from the negative effects of hypoxia.
- Trial name
- iNO (NCT04231773)
- Testing
- Nitric Oxide
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Hypercholesterolemia
Kefir Cholesterol Lowering Pilot Study
High cholesterol (a type of fat in humans blood) may be one factor that can lead to heart disease. If people have higher cholesterol, it is possible that kefir (a food similar to yogurt) may help to control blood cholesterol…
- Trial name
- NCT04247139
- Testing
- Kefir
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Covid-19 Infection, Rheumatoid Arthritis
IMPACT: IMPact of Antimalarials on Covid-19 Infections in RAPPORT
This study aims to evaluate the experience of Alberta patients with inflammatory arthritis who participate in the the RAPPORT-ONTRAAC registry during the COVID-19 pandemic, specifically comparing the experience of those taking…
- Conditions
- Covid-19 Infection, Rheumatoid Arthritis, Psoriatic Arthritis, Hydroxychloroquine
- Trial name
- IMPACT (NCT04347798)
- Testing
- Hydroxychloroquine/Chloroquine
- Where
- Canada
- Volunteers
- 773 people
- Sponsor
- University of Alberta
Multiple Sclerosis, Nurse's Role
The Effect of Nurse Practitioner (NP-led) Care Upon Mood in People With Multiple Sclerosis
MS is the leading cause of non-traumatic disability in young adults. Canada and Alberta, have the highest prevalence of people with multiple sclerosis (PwMS) in the world.
- Trial name
- NCT04388592
- Testing
- Nurse Practitioner (NP) Led Care Arm
- Where
- Canada
- Volunteers
- 248 people
- Sponsor
- University of Alberta
Spasticity, Muscle, Spinal Cord Injuries
Effects of Baclofen on Presynaptic Inhibition in Humans
This study examines the role of the GABA-B receptor in long-lasting presynaptic inhibition of primary afferents in human participants.
- Trial name
- NCT04471714
- Testing
- Baclofen
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alberta
Stroke (CVA) or TIA, Headache, Migraine
Onabotulinum Toxin A (Botox) for the Treatment of Persistent Post-Stroke and Vascular Headache
Post stroke headache occurs in approximately 10-23% of all stroke patients. Its onset is shortly after experiencing a stroke, or stroke like event, and persists for at least three months.
- Conditions
- Stroke (CVA) or TIA, Headache, Migraine, Botulinum Toxins, Type A, Cerebral Venous Sinus Thrombosis
- Trial name
- NCT04580238
- Testing
- Botox 200 UNT Injection, Non Botox based Standard of Care Treatments for Headache/Migraine
- Where
- Canada
- Sponsor
- University of Alberta
Bladder Cancer
Bladder Cancer and ExeRcise Training During IntraVesical ThErapy
Bladder cancer is the fifth most common cancer in Canada and has the eighth highest cancer mortality rate. The treatment for the most frequent type of bladder cancer is surgically removing the tumour followed by six weeks of…
- Trial name
- BRAVE (NCT04593862)
- Testing
- High-Intensity Interval Training
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Alberta