Clinical trials: sponsored by University of Alberta
Major Depressive Disorder
Supportive Text Messaging Versus Supportive E-mail Messaging for Patients With Major Depressive Disorder
Background: In 2012, over 3.2 million Canadians over 15 (11.3%) years reported symptoms of major depressive disorder (MDD), and barriers such as lack of readily available care system, stigma and affordability of health care…
- Trial name
- STEM (NCT04638231)
- Testing
- Supportive messages
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- University of Alberta
Pain, Postoperative, Ketamine Adverse Reaction
Efficacy of Ketamine in Post Anesthesia Recovery Room
Observational study to assess efficacy of IV ketamine bolus when used in the post anesthesia recovery unit for uncontrolled pain despite use of opioids.
- Conditions
- Pain, Postoperative, Ketamine Adverse Reaction, Pain, Refractory, Pain, Intractable
- Trial name
- NCT04701008
- Testing
- Ketamine
- Where
- Canada
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Prostate Cancer
18F-PSMA-1007 PET/CT Imaging in Patients with Biochemically Recurrent or High-risk Prostate Cancer
Single centre prospective cohort phase II study of 18F-PSMA-1007 PET/CT imaging in patients with biochemically recurrent or high-risk prostate cancer.
- Trial name
- NCT04733768
- Testing
- 18F-PSMA-1007
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Alberta
Covid19, COVID-19 Pneumonia
Efficacy and Safety of Antimicrobial Stewardship Intervention in Hospitalized COVID-19 Patients (COVASP)
COVID-19 is respiratory disease caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2), a novel coronavirus which has spread rapidly across the world with over 149.9 million laboratory confirmed cases and over 3.1…
- Conditions
- Covid19, COVID-19 Pneumonia, COVID-19 Lower Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- COVASP (NCT04896866)
- Testing
- Antimicrobial stewardship prospective audit and feedback
- Where
- 3 sites in Canada
- Volunteers
- 833 people
- Sponsor
- University of Alberta
Alveolar Bone Loss, Periodontitis
Intraoral Ultrasound Imaging of Tooth-periodontium Complex
Misaligned teeth are very common in the population and are commonly known as malocclusion. This happens when the upper teeth do not align properly with the lower teeth.
- Trial name
- NCT04971642
- Testing
- Intraoral ultrasound
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Multiple Sclerosis, Anxiety
Using Patient-Reported Outcomes To Improve the Care of People With Multiple Sclerosis
The proposed trial is a prospective, randomized (1:1) trial plan examining whether more routine and frequent measurement of Patient Related Outcome Measures (PROMs) in the care of patients with MS improves patient depression and…
- Conditions
- Multiple Sclerosis, Anxiety, Depression, Patient Satisfaction
- Trial name
- NCT04979546
- Testing
- Intensive Use of Patient Reported Outcome Measures and Open PROM Availability to Treating Neurologist, Conservative Use of Patient Reported Outcome Measures and Blinded PROM Availability to Treating Neurologist
- Where
- Canada
- Volunteers
- 237 people
- Sponsor
- University of Alberta
Healthy
The Impact of Sildenafil on the Pulmonary Circulation in Healthy Trained and Untrained Humans
There is emerging evidence suggesting that the pulmonary vasculature and right heart may play a role in the limitation of exercise capacity in healthy individuals.
- Trial name
- NCT04985929
- Testing
- Sildenafil 50 mg
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Respiratory Distress Syndrome, Apnea of Newborn
Confirmation of Tube Placement in Newborns
Tracheal intubation remains a common procedure in the neonatal intensive care unit (NICU) and the delivery room (DR). Current guidelines recommend Estimation of correct endotracheal tube (ETT) insertion Our hospital policy…
- Trial name
- NCT05229887
- Testing
- Nostril-Tragus-Length, Vocal cord marking
- Where
- Canada
- Sponsor
- University of Alberta
Acute Spinal Cord Injury
Early FES Cycling in Acute Spinal Cord Injury for Neuromuscular Preservation and Neurorecovery
Spinal cord injury (SCI) is a devastating condition that often leads to paralysis and multiple health problems such as muscle wasting, bone loss and spasticity.
- Trial name
- NCT05255679
- Testing
- Early FES, Delayed FES
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- University of Alberta
Obstructive Sleep Apnea
The Effect of Mandibular Advancement Devices on Markers of Cardiovascular Health in Obstructive Sleep Apnea Patients
Obstructive sleep apnea (OSA) is a type of disordered breathing defined by the repetitive obstruction of airflow during sleep due to upper airway collapse. Each obstructive event contributes to decreased blood oxygen, or hypoxia.
- Trial name
- NCT05387122
- Testing
- mandibular advancement device (MAD)
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University of Alberta
Risk Reduction, Occupational Exposure
Aerosol Generation in Dental Clinics
The study examines 4 different methods to reduce dental bioaerosol spread in orthodontic procedures.
- Conditions
- Risk Reduction, Occupational Exposure, Dentist-Patient Transmission
- Trial name
- NCT05468099
- Testing
- Chlorhexidine mouthwash and Povidone-Iodine, High volume evacuator, High volume evactuator and saliva ejector
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Vasodilation, Vasoconstriction
Sex Differences in Sympathetic Vascular Reactivity at High Altitude
This study aims to investigate sex differences in blood pressure control associated with exposure to acute hypoxia (low oxygen), and short term acclimatization to hypoxia at high altitude.
- Trial name
- NCT05525416
- Testing
- Sodium Nitroprusside, Phenylephrine Hydrochloride, Norepinephrine
- Where
- 2 sites in Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Coagulopathy, Congenital Heart Disease
FFP Usage in Pediatric CV Surgery
When small children undergo heart surgery with the heart-lung machine, in the past, blood products to help the blood clot such as Fresh Frozen Plasma (FFP) was routinely used in children under 10kg.
- Trial name
- NCT05819788
- Where
- Canada
- Volunteers
- 431 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Osteo Arthritis Knee, Hip Osteoarthritis
Adapting REhabilitation Delivery for Maximum Impact at Home
Hip and knee osteoarthritis (OA) is a burden of disability in adults, with many seeking total joint arthroplasty (TJA) to reduce their symptoms.
- Conditions
- Osteo Arthritis Knee, Hip Osteoarthritis, Knee Osteoarthritis, Osteoarthritis
- Trial name
- ReDI@Home (NCT05164575)
- Testing
- progressive resistance exercise, self-management strategies
- Where
- Canada
- Volunteers
- 112 people
- Sponsor
- University of Alberta
Heart Arrest, Birth Asphyxia
SI + CC Versus 3:1 C:V Ratio During Neonatal CPR
Research question In newborn infants requiring CPR, does CC superimposed by sustained inflation compared to 3:1 compression to ventilation ratio improves return of spontaneous circulation? Overall objective: CC superimposed by…
- Conditions
- Heart Arrest, Birth Asphyxia, Bradycardia
- Trial name
- SURV1VE (NCT02858583)
- Testing
- CC+SI, 3:1 C:V
- Where
- 4 sites in Austria, Canada
- Volunteers
- 27 people
- Sponsor
- University of Alberta
Stroke, Acute Ischemic, Small Vessel Cerebrovascular Disease
Remote Ischemic Conditioning With Novel Optical Sensor Feedback Device in Acute Ischemic Stroke
Stroke is a leading cause of physical and cognitive disabilities. The most common type of stroke is ischemic (lack of blood flow to the brain due to clot blocking a blood vessel).
- Trial name
- NCT05408130
- Testing
- Remote Ischemic Conditioning with Novel Optical Sensor Feedback Device
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- University of Alberta
Hypertension
The Effect of Antihypertensive Medication Timing on Morbidity and Mortality
High blood pressure is common and its presence increases the risk of cardiovascular mortality and morbidity (most notably stroke, myocardial infarction, and congestive heart failure).
- Trial name
- NCT02990663
- Testing
- Use of blood pressure lowering medication at bedtime, Use of blood pressure lowering medication in the morning
- Where
- 5 sites in Canada
- Volunteers
- 3,357 people
- Sponsor
- University of Alberta
Hypertension, Dementia
BedMed-Frail: Does the Potential Benefit of Bedtime Antihypertensive Prescribing Extend to Frail Populations?
High blood pressure (present in 1 of 5 Canadian adults) increases the risk of heart attack and stroke. Blood pressure lowering pills reduce this risk - but perhaps not optimally.
- Trial name
- NCT04054648
- Testing
- Bedtime administration of the participant's pre-existing antihypertensive medications
- Where
- Canada
- Volunteers
- 776 people
- Sponsor
- University of Alberta
Hypercholesterolemia
U of A/ U of M Beans and Peas Health Claim Project
The purpose of this study is to compare how regularly eating (dried, cooked) beans or peas or rice (control) contained in foods (such as stews or soups) lowers blood lipids, particularly Low Density Lipoprotein cholesterol…
- Trial name
- NCT01661543
- Testing
- Beans, Control (rice), Peas
- Where
- 2 sites in Canada
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Frailty, Frailty Syndrome
Smart Home Technologies for Assessing and Monitoring Frailty in Older Adults
This project aims to address the impact of frailty on older adults, particularly its connection to cognitive impairments such as dementia.
- Conditions
- Frailty, Frailty Syndrome, Frail Elderly Syndrome, Pre-Frailty
- Trial name
- NCT05961319
- Testing
- Smart-Home Monitoring
- Where
- 2 sites in Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Alberta