Clinical trials: sponsored by University of Alberta
Diagnosis, Educational Problems
Examining Clinical Reasoning With Eye-tracking
The process of medical information intake, interpretation and diagnosis, commonly referred to as clinical reasoning, involves a complex interaction between visual perception and multiple cognitive processes.
- Trial name
- NCT06470269
- Testing
- Eye tracking
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Alberta
End Stage Liver Disease, Liver Diseases
Normothermic Liver Preservation Trial
This trial is to assess the safety and efficacy of normothermic machine perfusion (NMP) as an organ preservation method prior to transplantation using the OrganOx metra™ device.
- Trial name
- NCT03089840
- Testing
- OrganOx metra
- Where
- Canada
- Volunteers
- 106 people
- Sponsor
- University of Alberta
Pregnancy Related, Diabetes
Exercise Timing and Gestational Diabetes
The aim of this study is to understand if the timing of exercise around food intake can help improve blood sugar management in pregnant individuals with diabetes.
- Conditions
- Pregnancy Related, Diabetes, Diabete Mellitus, Type 2 Diabetes
- Trial name
- NCT05256615
- Testing
- 30-minute walking intervention, 10-minute
- Where
- Canada
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Diabetes Mellitus, Type 1
Stem Cell Mobilization (Plerixafor) and Immunologic Reset in Type 1 Diabetes (T1DM)
Type 1 diabetes is an autoimmune disease characterized by destruction of pancreatic beta-cells, resulting in absolute deficiency of insulin. Presently there is no known cure.
- Trial name
- NCT03182426
- Testing
- Plerixafor, Alemtuzumab, Anakinra
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of Alberta
Asthma, Inflammation
Vascular Implications of a Naturally Occurring Asthma Exacerbation
Although asthma is a disease of the airways, research is now showing that asthmatics are more likely to develop cardiovascular disease (CVD) compared to non-asthmatics.
- Conditions
- Asthma, Inflammation, Cardiovascular Risk Factor
- Trial name
- NCT03679299
- Testing
- Observational - No intervention
- Where
- 2 sites in Canada
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Hypoxia, Apnea
Characterizing Hypoxic Apnea Intra-individual Repeatability
Apneas (breath-holds) are increasingly being tested in human subjects to understand how the human body operates. Apneas decrease heart rate and increase blood pressure.
- Trial name
- CHAIR (NCT06399575)
- Testing
- Apnea Following Isocapnic Hypoxia
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Perception, Self
Patients' Perception of Climate Change and Healthcare
This study aims to investigate the patients' perception of the negative impact of the healthcare industry on climate change, their attitude of climate change and their health, and their view of seeing a change in the healthcare…
- Trial name
- NCT05816447
- Testing
- interview
- Where
- Canada
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Adolescent Idiopathic Scoliosis
A New Spinal Brace Design Concept for the Treatment of Adolescent Idiopathic Scoliosis
Adolescent Idiopathic Scoliosis (AIS) is a three-dimensional deformity of the spine due to an unknown cause. Bracing is a proven non-surgical treatment for scoliosis.
- Trial name
- NCT03365804
- Testing
- 3D Printed Brace
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Alberta
Prostate Cancer
18F-PSMA PET and MRI in the Primary Staging of Prostate Cancer Patients
This prospective phase II study assesses the accuracy of second generation prostate specific membrane antigen (PSMA) positron emission tomography (PET; utilizing 18F-PSMA-1007)) and multiparametric magnetic resonance imaging…
- Trial name
- NCT05141760
- Testing
- PSMA-1007 Positron Emission Tomography (PET) scan and 3T Magnetic Resonance Imaging (MRI)
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University of Alberta
Rotator Cuff Injuries, Anesthesia; Functional
The Impact of a Preoperative Nerve Block on the Consumption of Sevoflurane in Total Shoulder Arthroplasty
Total arthroplasty surgery of the shoulder is performed under general anesthesia. Pain control for after the surgery can be achieved purely with intravenous and oral pain medication or in combination with freezing of the nerves.
- Trial name
- NCT04020601
- Testing
- Ropivacaine, Dextrose
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Ankle Arthropathy, Anesthesia; Functional
The Impact of a Preoperative Nerve Block in Foot and Ankle Surgery on the Consumption of Sevoflurane
Reconstructive foot and ankle surgery is performed under general anesthesia. Included in this spectrum of surgery are ankle arthroplasties, various fusions, corrective arthrodesis, and more.
- Conditions
- Ankle Arthropathy, Anesthesia; Functional, Ankle Arthritis
- Trial name
- NCT04022057
- Testing
- Ropivacaine injection, Dextrose 5
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alberta
Clostridia Difficile Colitis, Clostridium Difficile Diarrhea
Multicentre Blinded Comparison of Lyophilized Sterile Fecal Filtrate to Lyophilized Fecal Microbiota Transplant in Recurrent Clostridioides Difficile Infection
Fecal microbiota transplantation (FMT) is a treatment that restores the balance of gut bacteria and is the most effective treatment for patients who suffer from recurrent Clostridioides difficile infection (CDI) brought on by…
- Trial name
- NCT03806803
- Testing
- Lyophilized fecal microbiota transplant, Lyophilized sterile fecal filtrate
- Where
- 5 sites in Canada
- Volunteers
- 138 people
- Sponsor
- University of Alberta
Low Back Pain, Bone Marrow Edema
Lumbar Bracing for People With Type I Modic Changes
Despite the high prevalence of low back pain, little is still known about its underlying pathology. Only a small proportion of people (~1%) have a diagnosable pathoanatomical entity causing low back pain.
- Conditions
- Low Back Pain, Bone Marrow Edema, Brace, Modic Changes
- Trial name
- NCT03829644
- Testing
- Horizon 627 Lumbar Brace, Aspen Medical Company, Oak Canyon, Irvine, CA 92618
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of Alberta
Transition, Congenital Heart Defect
The Transitioning Rural Adolescents to Adult Care Study
Approximately 1 in 10 teenagers lives with a chronic health condition that will require ongoing care as they enter adulthood. Birth defects of the heart, also known as congenital heart disease (CHD) are more common than any other…
- Trial name
- TRAAC (NCT04090827)
- Testing
- Nurse-led transition intervention and access to the iHeartChange website
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- University of Alberta
Healthy First Degree Relatives of Crohn's Disease Patients
Prebiotics and Diet to Reduce "Leaky" Gut in First Degree Relatives of Crohn's Disease Patients
Crohn's disease (CD) is a recurring inflammation of the intestines. The etiology is unknown; however evidence suggests that it could be a combination of gut microbes, environmental factors and genetics.
- Trial name
- NCT03950336
- Testing
- Prebiotics, Low n-6 PUFA Diet, Maltodextrin
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- University of Alberta
Pain, Acute, Opioid Use
Comparison of Short-term Sustained-release Opioid in Open Abdominal Urologic Surgeries
The advantage of slow-release opioid allows for less fluctuation in drug (pain killer) levels in the blood and an extended period within the effective range for pain relief.
- Trial name
- NCT05375916
- Testing
- Hydromorphone
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of Alberta
Covid19, Dyspnea
Understanding Exertional Dyspnea and Exercise Intolerance in COVID-19
A novel corona virus emerged in 2019 causing Corona Virus Disease 2019 (covid-19). In one year more than 80 000 000 cases worldwide were documented.
- Trial name
- NCT04732663
- Testing
- No Intervention
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Suicidal Ideation
RCT Investigating EMDR for Suicidal Ideation
Suicide is a major public health issue, and is the 9th leading cause of death overall. Suicidal thinking and behaviours have been linked to painful childhood experiences, stressors, and psychological trauma.
- Trial name
- NCT04181047
- Testing
- Eye Movement Desensitization and Reprocessing (EMDR), Usual care
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- University of Alberta
Ischemic Stroke, Atrial Fibrillation
Lixiana Acute Stroke Evaluation Registry
Study Design: Lixiana Acute Stroke Evaluation Registry (LASER) is a randomized controlled trial with an associated registry. Patients with previously known or newly diagnosed atrial fibrillation (AF) and acute ischemic stroke…
- Conditions
- Ischemic Stroke, Atrial Fibrillation, Hemorrhagic Transformation Stroke
- Trial name
- LASER (NCT03494530)
- Testing
- Edoxaban 60 MG, Edoxaban 30 mg
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University of Alberta
Hypertension
Fluid Overload Management and Vascular Stiffness in Chronic Kidney Disease Patients With Hypertension
This study aims to reduce fluid overload in order to control blood pressure of hypertensive CKD patients using bio-impedance assessment of fluid status and using a diuretic therapy algorithm.
- Trial name
- NCT05378750
- Testing
- Diuretic algorithm
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of Alberta