Clinical trials: sponsored by University of Alberta
Chronic Obstructive Pulmonary Disease, Sleep Related Hypoventilation
Health Outcomes With CPAP or NIV in Patients With COPD and a Sleep Related Breathing Disorder
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease affecting an estimated 1 in 10 Canadians. Symptoms include persistent shortness of breath, cough and sputum production.
- Conditions
- Chronic Obstructive Pulmonary Disease, Sleep Related Hypoventilation, Obstructive Sleep Apnea, Hypoventilation
- Trial name
- NCT05623709
- Testing
- Positive airway pressure with continuous positive airway pressure or noninvasive ventilation
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Stroke, Atrial Fibrillation
Post-Embolic Rhythm Detection With Implantable Versus External Monitoring
The overall aim of this trial is to determine the most cost effective approach to diagnose paroxysmal atrial fibrillation (PAF) following transient ischemic attack (TIA) and stroke.
- Conditions
- Stroke, Atrial Fibrillation, Arrhythmias, Cardiac
- Trial name
- PERDIEM (NCT02428140)
- Testing
- Medtronic Reveal LINQ, Sorin Spiderflash-t
- Where
- 3 sites in Canada
- Volunteers
- 300 people
- Sponsor
- University of Alberta
Appendicitis Acute
Laparoscopically Guided Rectus Sheath Block in Pediatric Appendicitis
The study will investigate the pain control effects of a rectus sheath block after laparoscopic surgery to remove the appendix. A rectus sheath block is the injection of local anesthetic (numbing agent) into the space between the…
- Trial name
- NCT04717193
- Testing
- Rectus Sheath Block with 0.25% bupivicaine with 1:200 000 epinephrine, Local Anesthetic Infiltration with 0.25% bupivicaine with 1:200 000 epinephrine
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- University of Alberta
Primary Biliary Cholangitis
Combination Antiretroviral Therapy (cART) for PBC
Placebo Controlled, double-blind randomized controlled trial (RCT) with 12 months Tenofovir Disoproxil and Raltegravir for primary biliary cholangitis (PBC) patients unresponsive to Ursodeoxycholic Acid (UDCA).
- Trial name
- NCT03954327
- Testing
- Emtricitabine (FTC)/Tenofovir Disoproxil (TDF), Raltegravir
- Where
- 6 sites in Canada
- Volunteers
- 37 people
- Sponsor
- University of Alberta
Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis
Digital Smartwatch Measurements as Potential Biomarkers for Remote Disease Tracking in ALS
This observational study will use new smartwatch technology to continuously and remotely monitor the health of ALS patients and healthy controls over time. This information will be used to develop digital biomarkers for ALS.
- Conditions
- Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis, Muscular Atrophy, Progressive, Frontotemporal Dementia
- Trial name
- NCT05830214
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alberta
Diabetes Mellitus, Type 2, Obesity
The Alberta NutrIMM Study - Nutrition and Immunity
This study will investigate the effect of body weight, diet, and high blood sugar levels, under controlled feeding conditions, on immune function in individuals with and without obesity.
- Trial name
- NutrIMM (NCT04291391)
- Testing
- North American-type diet
- Where
- Canada
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Neurotrophic Keratitis
Topical Insulin Drops for the Treatment of Neurotrophic Keratopathy.
Many diseases can affect corneal nerves. Corneas that lack normal sensation are considered neurotrophic. Neurotrophic corneas are predisposed to persistent epithelial defects, recurrent erosions, and corneal ulcers.
- Trial name
- NCT05321251
- Testing
- Insulin, Tarsorrhaphy
- Where
- 6 sites in Canada
- Sponsor
- University of Alberta
Dysphagia, Head and Neck Cancer
Swallowing Therapy With the Assistance of a Mobile Health Device in Head and Neck Cancer Patients: a Pan-Alberta Study
Dysphagia affects 22% of those over the age of 50, which equates to 250 million people worldwide and 360,000 in Alberta. At high risk are survivors of head and neck cancer (70%).
- Trial name
- NCT04698499
- Testing
- Swallowing exercise from home
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- University of Alberta
Pain
Evaluating the Manage My Pain App in Pain Clinics
Chronic Pain is one of the most common reasons adults seek medical care, and has been linked to restrictions in mobility and daily activities, dependence on opioids, anxiety and depression, and poor perceived health or reduced…
- Trial name
- NCT05946239
- Testing
- Manage My Pain App
- Where
- Canada
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Osteoarthritis, Knee, Obesity
The POMELO (Prevention Of MusclE Loss in Osteoarthritis) Trial
Treatment options for individuals who have advanced knee osteoarthritis (OA) and a body mass index (BMI) ≥35 kg/m2 are limited, and this patient population may be neglected in current clinical care pathways for OA management.
- Trial name
- POMELO (NCT05026385)
- Testing
- Intervention
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Pediatric Obstructive Sleep Apnea, Pediatric Obesity
Treating Children With Obstructive Sleep Apnea After Surgery Failure
The aim of this study is to evaluate the potential improvement of sleep quality in children who have residual obstructive sleep apnea, using either an orthodontic intervention or continuous positive airway pressure (CPAP), versus…
- Trial name
- NCT03821831
- Testing
- Continuous Positive Airway Pressure, Orthodontic intervention
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of Alberta
Thin Gingiva, Transverse Maxillary Deficiency
Evaluation of Geistlich Fibro-Gide ® and Autogenous Connective Tissue Graft Prior to Orthodontic Maxillary Expansion.
Teenage children and adults often undergo orthodontic treatment each year to improve their dental esthetics and chewing function. One common problem they present with is having a small maxilla compared to the mandible.
- Conditions
- Thin Gingiva, Transverse Maxillary Deficiency, Cross Bite
- Trial name
- NCT05295771
- Testing
- Gingival Phenotype Modification
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alberta
Crohn's Disease
Synbiotics and Post-op Crohn's Disease
Crohn's disease (CD) is a lifelong incurable condition that causes inflammation of the intestinal tract of humans. The exact cause of CD is unknown, but genetics, diet, and the gut microbiome are all thought to play a major role.
- Trial name
- NCT04804046
- Testing
- Synbiotic, Digestible Maltodextrin
- Where
- 5 sites in Canada
- Volunteers
- 4 people
- Sponsor
- University of Alberta
Primary Biliary Cirrhosis
Online Wellness Intervention for Primary Biliary Cholangitis (PBC)
Primary biliary cholangitis (PBC) is a chronic autoimmune condition of the liver. Persons with PBC have high rates of liver disease-related symptoms and poor health-related quality of life - amongst the lowest of all chronic…
- Trial name
- NCT04791527
- Testing
- Mind-body therapy
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University of Alberta
Dyspnea
The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in COPD
Chronic Obstructive Pulmonary Disease (COPD) is a lung disorder commonly caused by smoking, which makes breathing more difficult.
- Trial name
- iNO (NCT03679312)
- Testing
- Nitric Oxide
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Atrial Fibrillation, Stroke
Improving Stroke Prevention in Atrial Fibrillation Through Pharmacist Prescribing
The purpose of this study is to compare the effectiveness of prescribing oral anticoagulation therapy by pharmacist intervention compared to enhanced usual care in participants with unrecognized AF and/or known AF but not taking…
- Trial name
- PIAAFRx (NCT03126214)
- Testing
- Anticoagulants
- Where
- Canada
- Volunteers
- 79 people
- Sponsor
- University of Alberta
Type 1 Diabetes
Repeatability of Blood Glucose Responses to Resistance Exercise in Type 1 Diabetes
This study proposes to examine the impact of time of day (morning versus afternoon) on the variability of blood glucose responses to high resistance exercise in a single group of patients with type 1 diabetes.
- Trial name
- NCT05168488
- Testing
- Fasted morning resistance exercise, Afternoon resistance exercise
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- University of Alberta
Head and Neck Neoplasms, Accessory Nerve Injury
Therapeutic Resistance Group Exercise Training for Head & Neck Cancer Survivors
The investigators will conduct a randomized controlled trial examining 12-week, 24-week and one year outcomes from a combined therapeutic and physical exercise program that aims to bridge head-and-neck cancer survivors from acute…
- Conditions
- Head and Neck Neoplasms, Accessory Nerve Injury, Fatigue
- Trial name
- TARGET (NCT02647021)
- Testing
- Therapeutic Exercise, Therapeutic + Lower Body Exercise
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Alberta
Post-operative Pain
Sternotomies and PectoIntercostal Fascia Blocks in Fast-Track Cardiac Anesthesiology
This study is looking to see if a regional block placed on each side of the incision after surgery helps with pain relief. Ultrasound-guided pectointercostal fascia blocks will be placed at the conclusion of surgery following…
- Trial name
- SPIFFY (NCT05146453)
- Testing
- Pectointercostal fascia blocks
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Alberta
Dietary Modification
The Impact of a Powdered Meal Replacement on Metabolism and Gut Microbiota
This study will investigate the impact of a 12-week powdered meal replacement on inflammatory, metabolic, and hormonal markers of obesity-associated conditions and to correlate this response to compositional shifts within the gut…
- Trial name
- PREMIUM (NCT03235804)
- Testing
- Soy protein, honey and yogurt.
- Where
- Canada
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Alberta