Clinical trials: sponsored by University of Alberta
Type 1 Diabetes Mellitus
Aralast NP in Islet Transplant
Islet transplantation is a relatively new procedure used in people with difficult to control Type 1 diabetes. Insulin producing cells (islets) are isolated from a pancreas donated by the next of kin of a person who is brain dead.
- Trial name
- NCT02520076
- Testing
- Alpha-1 Antitrypsin
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University of Alberta
Osteoporosis
C-STOP Fracture Trial
The objective of the proposed research is to improve quality of care for older outpatients who present to Emergency Departments and Fracture Clinics with an osteoporosis-related wrist or other upper extremity fracture.
- Trial name
- C-STOP# (NCT01401556)
- Testing
- case management, Multifaceted quality improvement intervention
- Where
- Canada
- Volunteers
- 441 people
- Sponsor
- University of Alberta
Overbite (Excessive) Deep
Orthodontic Approaches to Correct Deep Bite in Mixed Dentition Patients
A deep bite is a bite where the upper front teeth cover almost all, if not all the lower front teeth. Currently there is no clarity which of the available treatment approaches is better when these patients still have some baby…
- Trial name
- NCT03641196
- Testing
- Fixed appliance, Composite bite plane
- Where
- Canada
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Cleft Palate
The Use of Fibrin Sealant to Reduce Post Operative Pain in Cleft Palate Surgery
Cleft Palate is a condition which affects up to 1 in 500 live births. Current treatment is surgery to correct the underlying anomaly. Children born with cleft palate typically undergo surgery at age 12 months.
- Trial name
- NCT02953145
- Testing
- Tisseel
- Where
- Canada
- Sponsor
- University of Alberta
Hemodynamic Instability
Multimodal Monitoring of Hemodynamics in Extremely Low Birth Weight Preterm Infant in a Canadian Tertiary Level Unit
Low blood pressure is a common problem in the premature newborn and can affect over 30% of all Extremely Low Gestational Age Neonates (ELGAN) babies delivered less than 28 weeks completed.
- Trial name
- MUSE (NCT03841929)
- Testing
- Hemodynamic report
- Where
- Canada
- Volunteers
- 128 people
- Sponsor
- University of Alberta
Choroideremia
An Open Label Clinical Trial of Retinal Gene Therapy for Choroideremia
A project has been developed in Edmonton, Alberta, Canada to enable male patients with choroideremia to access a clinical trial that replaces the defective gene with a normal copy.
- Trial name
- NCT02077361
- Testing
- rAAV2.REP1 vector
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University of Alberta
Neoplasms
A New Tool for Assessing Fatigue in Individuals With Advanced Cancer
Fatigue is a common problem in advanced cancer and palliative care. The development of tools to measure fatigue, however, has been slowed by their inability to distinguish between fatigue and other related symptoms, such as…
- Trial name
- NCT00428675
- Testing
- ACI instrument
- Where
- Canada
- Volunteers
- 228 people
- Sponsor
- University of Alberta
Nephrectomy
Systemic Effects of Lidocaine Infusion for TAP Block Catheter
Lidocaine is a local anesthetic that is usually used for nerve blocks to sensory/motor blockade. However, lidocaine can also been given intravenously, and it has been shown that this method can be used to help alleviate chronic…
- Trial name
- NCT03971708
- Testing
- Lidocaine, Ropivacaine
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Type I Diabetes
A Phase I/II Study of the Safety and Efficacy of Sernova's Cell PouchTM for Therapeutic Islet Transplantation
This is an open-label, single arm, non-randomized safety and efficacy study, where participants with Type-1 diabetes will receive the Sernova Cell Pouch™ implanted in the subcutaneous site, two to approximately twelve weeks prior…
- Trial name
- NCT01652911
- Testing
- Sernova Cell Pouch
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University of Alberta
Type 1 Diabetes
Islet Isolation Using MnTE-2-PyP (BMX-010) - Pilot Study
In this study, the investigators hypothesize that the addition of antioxidant BMX-010 to perfusion solution, digestion solution and culture medium during islet isolation process, can lead to greater preservation of islet mass and…
- Trial name
- NCT02457858
- Testing
- Islet isolation using BMX-010
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University of Alberta
Type 1 Diabetes
Omental Islet Transplant
Islet transplantation is a relatively new procedure used in people with difficult to control Type 1 diabetes. Insulin producing cells (islets) are isolated from a pancreas of a deceased organ donor.
- Trial name
- NCT02821026
- Testing
- Omental Islet transplant, Anti-Thymocyte Globulin, Mycophenolate mofetil
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University of Alberta
Heart Failure
Understanding and Treating Heart Failure With Preserved Ejection Fraction: Novel Mechanisms, Diagnostics and Potential Therapeutics
The objectives of this study are: 1) to design new diagnostic criteria used to accurately define heart failure with preserved ejection fraction (HFpEF); 2) to better define the risk factors associated with HFpEF; 3) to elucidate…
- Trial name
- Alberta HEART (NCT02052804)
- Where
- 2 sites in Canada
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Prostate Cancer
Exercise During Active Surveillance for Prostate Cancer
The broad goal of the Exercise During Active Surveillance for Prostate Cancer (ERASE) trial is to examine the effects of exercise in prostate cancer patients undergoing active surveillance.
- Trial name
- ERASE (NCT03203460)
- Testing
- High-intensity aerobic interval training (HIIT)
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- University of Alberta
Diabetes
Caspase Inhibition in Islet Transplantation
This is an Investigator Initiated, Phase I/II study, where Type 1 diabetic participants will receive a 14 day oral treatment of the investigational caspase inhibitor drug IDN-6556 following their first islet transplant.
- Trial name
- NCT01653899
- Testing
- IDN-6556
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Alberta
Covid19
Corticosteroids for COVID-19
This trial is an interventional, randomized, placebo-controlled, adaptive clinical trial in outpatients with symptomatic microbiologically-confirmed SARS-CoV-2, in stable clinical condition, and increased levels of serum…
- Trial name
- CORE-COVID (NCT04795583)
- Testing
- Prednisone, Point of Care testing device for C-reactive protein
- Where
- 2 sites in Colombia, Mexico
- Sponsor
- University of Alberta
Ulcerative Colitis
Ulcerative Colitis Relapse Prevention by Prebiotics
Ulcerative colitis (UC) is a relapsing chronic intestinal inflammation with no existing cure, that affects over 300 per 100.000 Canadians, the highest prevalence in the world.
- Trial name
- NCT02865707
- Testing
- Synergy-1, Maltodextrin
- Where
- Canada
- Volunteers
- 89 people
- Sponsor
- University of Alberta
Osteoporosis
Addressing Vertebral Osteoporosis Incidentally Detected to Prevent Future Fractures
Osteoporosis is a common and progressive condition that leads to broken bones (fractures), which cause pain, disability, deformity, and even death.
- Trial name
- AVOID Fracture (NCT00388908)
- Testing
- Reminders and opinion leader generated guidelines +/- leaflets and counselling, Usual Care
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- University of Alberta
Depressive Disorder
The ACHIEVA Study of Enhanced Pharmacist Care on Antidepressant Use and Response
This a comparative study of enhanced pharmacist care and regular care of patients starting on antidepressants. When providing participants with enhanced care pharmacists will use the Health Professional's Antidepressant…
- Trial name
- NCT00356655
- Testing
- Psychoeducation
- Where
- Canada
- Volunteers
- 106 people
- Sponsor
- University of Alberta
Sciatica, Lumbosacral Radiculopathy
Mechanical Diagnosis and Treatment and/or Steroid Injections for Lumbar Radiculopathy
Aim 1: The primary aim of this study is to test the feasibility of Mechanical Diagnosis and Treatment (MDT) +/- transforaminal epidural steroid injections (TESI) on pain and disability in patients awaiting physiatry consult for…
- Conditions
- Sciatica, Lumbosacral Radiculopathy, Lumbar Disc Rupture
- Trial name
- NCT02951377
- Testing
- Exercise (MDT approach), Transforaminal epidural steroid injection (20mg dexamethasone 0.5cc lidocaine 2%)
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- University of Alberta
Thyroid Gland Diseases
A Study to Compare the Safety and Imaging Pattern of Cyclotron-produced Technetium (CTC) vs. Generator-produced Technetium (G-PERT) in People With Thyroid Disorders Who Need Surgery
A 99mTc Pertechnetate (G-PERT) scan is a nuclear medicine test that can create an image of the thyroid gland and other organs. G-PERT is approved by Health Canada for the direct imaging and measurement of thyroid uptake.
- Trial name
- NCT02980679
- Testing
- CTC, G-PERT
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Alberta