Clinical trials: sponsored by University of Alberta
Total Knee Arthroplasty
Clinical Outcomes and Cost-effectiveness Analysis of ShapeMatch Technology
The currently held belief is that total knee replacement (TKR) requires the restoration of the overall limb alignment to coincide with the mechanical limb axis.
- Trial name
- NCT01483066
- Testing
- ShapeMatch Technology
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- University of Alberta
Total Hip Replacement
Randomized Clinical Trial of Ceramic Bearing Primary Total Hip Arthroplasty
Primary total hip arthroplasty (THA) has been a very successful surgical intervention in the geriatric population. Numerous studies have reported good mid and long term results of THA in patients over the age of 60 years.
- Trial name
- NCT01522014
- Testing
- Secure-Fit™ arc-deposited Hydroxylapatite (HA) shell - surface ceramic and an Alumina Bearing Couple (ABC) ceramic insert and Ceramic C-taper head, Secure-Fit™ arc-deposited hydroxylapatite shell, a Crossfire® insert and a Ceramic C-taper head
- Where
- 2 sites in Canada
- Volunteers
- 92 people
- Sponsor
- University of Alberta
Total Knee Replacement
Patellar Resurfacing Versus Patellar Retention in Total Knee Arthroplasty - A Randomized Clinical Trial
Background: Despite the excellent results of total knee replacement, also known as total knee arthroplasty (TKA) there is persistent controversy over whether or not to replace the surface of the kneecap.
- Trial name
- PROFIX (NCT01500252)
- Testing
- Patellar Replacement Prosthesis, Profix TKR with Patellar Retention
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- University of Alberta
Chronic Obstructive Pulmonary Disease (COPD)
Examine the Impact of Early Education on COPD Management
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease primarily caused by smoking. COPD creates a tremendous burden to the healthcare system, as disease exacerbations result in frequent, prolonged…
- Trial name
- NCT02398643
- Testing
- Pulmonary Education (PE), Usual Care
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Alberta
Arthroplasty, Replacement, Knee, Knee Arthroplasty, Total
Posterior Cruciate Retaining (PCR) Versus Posterior Cruciate Substituting (PCS) Total Knee Arthroplasty (TKA)
This randomized clinical trial (RCT) examined 10 year outcomes comparing SCORPIO™ Posterior Cruciate Substituting (PCS) versus Posterior Cruciate Retaining (PCR) Total Knee Arthroplasty (TKA) as the primary outcome.
- Trial name
- SCORPIO™ (NCT02429856)
- Testing
- SCORPIO™
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Alberta
Asthma
Asthma Exacerbations and Vascular Function
Although asthma is a disease of the airways, research is now showing that asthmatics are more likely to develop cardiovascular disease (CVD) compared to non-asthmatics.
- Trial name
- NCT02630511
- Testing
- Mannitol, Methacholine, Rest
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Inflammatory Bowel Diseases, Remission
Assessing the Effectiveness of a Stress Reduction Intervention in Inflammatory Bowel Disease (IBD)
The investigators have designed a guided, online, tri-component, stress reduction intervention for participants with inflammatory bowel diseases.
- Conditions
- Inflammatory Bowel Diseases, Remission, Perceived Stress
- Trial name
- NCT03831750
- Testing
- Stress Reduction Intervention
- Where
- Canada
- Volunteers
- 101 people
- Sponsor
- University of Alberta
Pulmonary Disease, Chronic Obstructive
COPD Discharge Bundle Delivered Alone or Enhanced Through a Care Coordinator
Chronic obstructive pulmonary disease (COPD) is a common, chronic progressive lung disease that is characterized by shortness of breath, activity limitation, and a predisposition to flare-ups resulting in frequent emergency…
- Trial name
- PRIHS (NCT03358771)
- Testing
- COPD discharge care bundle, COPD discharge care bundle & coordinator
- Where
- 5 sites in Canada
- Volunteers
- 3,710 people
- Sponsor
- University of Alberta
Chronic Kidney Diseases
Physical Activity in Renal Disease (PAIRED): The Effect on Hypertension
Background and importance: Hypertension is highly prevalent among Canadians with non-dialysis dependent chronic kidney disease (CKD). It is a modifiable risk factor for both cardiovascular (CV) events and CKD progression.
- Trial name
- NCT03551119
- Testing
- Exercise, Enhanced usual care
- Where
- 3 sites in Canada
- Volunteers
- 44 people
- Sponsor
- University of Alberta
Motor Activity, Parent-Child Relations
Parent PLAYSHOP: A Physical Literacy Training Workshop for Parents
The objective of this research is to 1) determine the impact of a physical literacy training workshop for parents of preschool children (3-5 years) on their knowledge and confidence levels in regards to engaging in meaningful…
- Trial name
- NCT04394312
- Testing
- Parent PLAYSHOP
- Where
- 2 sites in Canada
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Depressive Disorder
Effects of Low-dose Ketamine as an Adjunct to Propofol-based Anesthesia for Electroconvulsive Therapy
Ketamine has been used successfully as the sole medication for anesthesia in the setting of electroconvulsive therapy (ECT), and has more recently been studied as an adjunct agent in combination with propofol (the most commonly…
- Trial name
- NCT02579642
- Testing
- Ketamine
- Where
- 2 sites in Canada
- Volunteers
- 48 people
- Sponsor
- University of Alberta
Atrial Fibrillation
The Effect of Nurse Practitioner Led-Care on Quality of Life in Patients With Atrial Fibrillation
Atrial fibrillation (AF) is the most common heart rhythm disease characterized by an irregular heart rhythm of the top part (atria) of the heart.
- Trial name
- NCT02745236
- Testing
- Nurse Practitioner Led-Care, Cardiologist Led-Care
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University of Alberta
Ex-Vivo Lung Transplantation
The University of Alberta Negative Pressure Ventilation Ex-Vivo Lung Perfusion (NPV-EVLP) Trial
This project is focused on helping one of the most vulnerable patient populations in medicine, patients with end-stage chronic lung disease.
- Trial name
- UA NPV-EVLP (NCT03293043)
- Testing
- NPV-EVLP
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Depression, Bipolar Disorder
Peer Support Experience for Patients Discharged From Acute Psychiatric Care
The aim of the project is to conduct a four arm randomized controlled pilot trial to evaluate the effectiveness of an innovative peer support program that incorporates leadership training, mentorship, recognition, reward systems…
- Conditions
- Depression, Bipolar Disorder, Schizophrenia
- Trial name
- NCT03404882
- Testing
- Supportive/reminder text messaging plus peer support, Supportive/reminder text messaging, Peer support only
- Where
- 5 sites in Canada
- Volunteers
- 182 people
- Sponsor
- University of Alberta
Chronic Obstructive Pulmonary Disease (COPD)
Examining Pulmonary Rehabilitation on Discharged COPD Patients
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease primarily caused by smoking. COPD creates a tremendous burden to the healthcare system, as disease exacerbations result in frequent, prolonged…
- Trial name
- NCT02426437
- Testing
- Pulmonary Rehabilitation (PR), Usual Care
- Where
- Canada
- Volunteers
- 87 people
- Sponsor
- University of Alberta
Fever
Biomarkers of Mortality and Morbidity in Children Hospitalized With Fever
The objective of this study is to identify clinically informative biomarkers of host defense pathways with potential utility as diagnostic and prognostic tools among children hospitalized with acute febrile illness in a…
- Trial name
- NCT04726826
- Testing
- Diagnostic and prognostic biomarkers
- Where
- Uganda
- Volunteers
- 2,500 people
- Sponsor
- University of Alberta
Urinary Incontinence
A Trial of effectIveness of a Smart Sensor for Continence Care: the ARCTICC Study
The purpose of this study is to compare the use of an electronic incontinence identification system with nursing home support (Tena Identifi) versus usual care on the quality, resource use and outcomes of continence care for…
- Trial name
- ARCTICC (NCT02511314)
- Testing
- TENA Identifi
- Where
- Canada
- Volunteers
- 89 people
- Sponsor
- University of Alberta
Stress, Anxiety
Mindful Kangaroo Care: Mindfulness Intervention for Mothers During Skin-to-skin Care
Very high levels of stress have been reported in parents with their infants admitted to Neonatal Intensive Care Unit (NICU). Review of literature shows that the symptoms are consistent with Post-Traumatic Stress Disorder (PTSD)…
- Conditions
- Stress, Anxiety, Depression
- Trial name
- NCT04696770
- Testing
- Mindfulness
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of Alberta
Amyotrophic Lateral Sclerosis, ALS
MRI Biomarkers in ALS
Amyotrophic lateral sclerosis (ALS) is a disabling and rapidly progressive neurodegenerative disorder. There is no treatment that significantly slows progression.
- Conditions
- Amyotrophic Lateral Sclerosis, ALS, Motor Neuron Diseases
- Trial name
- NCT02405182
- Testing
- Magnetic Resonance Imaging
- Where
- 6 sites in Canada
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Morbid Obesity
The Microbiology of Bariatric Surgery
Obesity and its associated diseases are increasing worldwide. However, the mechanisms behind the development of obesity is not fully understood.
- Trial name
- NCT03181347
- Testing
- RYGB, SG, Dietary and behavioral
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- University of Alberta