Clinical trials: sponsored by University of Alberta
Open Angle Glaucoma
Trabectome Versus Trabeculectomy With Mitomycin C in Patients With Open Angle Glaucoma
The purpose of this study is to compare the efficacy and safety of Trabectome versus Trabeculectomy with adjunctive Mitomycin C, combined with cataract surgery, in patients with open angle glaucoma.
- Trial name
- NCT00901108
- Testing
- Trabectome-IOL, Trab-IOL
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- University of Alberta
Breast Cancer, Heart Failure
Multidisciplinary Approach to Novel Therapies in Cardiology Oncology Research
While trastuzumab has been shown to prevent recurrences of breast cancer, some women may also experience damage to their heart muscle (including heart failure) as a result of their treatment.
- Trial name
- MANTICORE (NCT01016886)
- Where
- Canada
- Volunteers
- 99 people
- Sponsor
- University of Alberta
Breast Cancer
Feasibility Testing and Evaluation of an Online Toolkit for Male Spouses of Women With Breast Cancer
Male partners of women with breast cancer experience distress, so we want to develop a way to support them so they, in turn, can care for their wives.
- Trial name
- NCT02058615
- Testing
- Male Spouse Transition Toolkit
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- University of Alberta
Enuresis, Obstructive Sleep Apnea
Intranasal Steroids for the Treatment of Nocturnal Enuresis With Associated Obstructive Sleep Apnea
Enuresis (E) or bedwetting is a common pediatric complaint, and recent research has discovered a link with obstructive sleep apnea (OSA).
- Conditions
- Enuresis, Obstructive Sleep Apnea, Sleep Disordered Breathing
- Trial name
- NCT01861145
- Testing
- Bed Alarm, Nasonex
- Where
- 2 sites in Canada
- Sponsor
- University of Alberta
Depression, Suicide
Comprehensive Program for Youth Mental Health
The majority of addiction and mental health problems seen in adults present first in youth. There is strong evidence that prevention and early identification during childhood can mitigate some of these risks.
- Conditions
- Depression, Suicide, Anxiety
- Trial name
- EMPATHY (NCT02169960)
- Testing
- Smart, Positive, Active, Realistic X-factor thoughts (SPARX), Breaking Free, This Way Up
- Where
- Canada
- Volunteers
- 5,514 people, healthy volunteers welcome
- Sponsor
- University of Alberta
NSTEMI
Providing Rapid Out of Hospital Acute Cardiovascular Treatment (PROACT)
The purpose of this study is to determine if early diagnosis and risk stratification acquired through pre-hospital clinical assessment, 12-lead electrocardiogram and point of care biomarkers will facilitate enhanced triage and…
- Trial name
- PROACT (NCT01634425)
- Testing
- Alere Triage Meter Pro
- Where
- 5 sites in Canada
- Volunteers
- 601 people
- Sponsor
- University of Alberta
Acute Renal Failure
Furosemide in Early Acute Kidney Injury
Acute renal failure, now referred to as acute kidney injury, is common in intensive care unit patients, contributes to high morbidity and mortality, and has no proven interventions with benefit once established.
- Trial name
- SPARK (NCT00978354)
- Testing
- Furosemide, Normal Saline
- Where
- 4 sites in Australia, Canada
- Volunteers
- 72 people
- Sponsor
- University of Alberta
Apnea
A Novel Method of Non-invasive Ventilation in Children
The purpose of this study is to quantify the tidal volume generated by the pressure release immediately following the application of pressure to the chest.
- Trial name
- NCT01394172
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Alberta
Low Back Pain, Degeneration of Lumbosacral Intervertebral Disc
The Underlying Mechanism of Spinal Manipulative Therapy and the Effect of Pain on Physical Outcome Measures
The purpose of this study is to compare changes in spinal stiffness and back muscle activity between spinal manipulative therapy (SMT) responders, non-responders and asymptomatic participants.
- Conditions
- Low Back Pain, Degeneration of Lumbosacral Intervertebral Disc, Muscle Weakness, Spine Stiffness
- Trial name
- NCT01761838
- Testing
- SMT for low back pain patients, Pain induction (optional), Low back pain participants without SMT
- Where
- Canada
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Osteoporosis, Fractures
Strategies Targeting Osteoporosis to Prevent Recurrent Fractures
An evidence-based quality improvement intervention will overcome multiple barriers to best practice and improve rates of diagnosis and effective treatment for osteoporosis in high-risk patients.
- Trial name
- NCT00152321
- Testing
- Patients (education, counseling) and Physicians (reminders,1-page guidelines)., Multifaceted intervention, Usual Care
- Where
- Canada
- Volunteers
- 242 people
- Sponsor
- University of Alberta
Coronary Disease, Ischemic Heart Disease
Enhancing the Secondary Prevention of Coronary Artery Disease
People with coronary artery disease can reduce their chance of having a heart attack by making healthy lifestyle choices (diet, exercise, quitting smoking,etc.).
- Trial name
- NCT00175240
- Testing
- Evidence summaries endorsed by local opinion leaders
- Where
- Canada
- Volunteers
- 480 people
- Sponsor
- University of Alberta
Type 1 Diabetes
Incretin Effect and Use After Clinical Islet Transplantation
We aim to study if the administration of medications to increase the secretion of hormones from the intestines can improve glycemic control, reduce insulin use and promote β-cell regeneration/expansion in subjects with type 1…
- Trial name
- NCT00768651
- Testing
- Pantoprazole, Sitagliptin
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of Alberta
Influenza Virus, Influenza Vaccine
Intradermal Versus Intramuscular Trivalent Influenza Vaccine in Adult Lung Transplant Recipients
The influenza virus, commonly called the flu, is a common source of infection in lung transplant patients and can often lead to pneumonia and possibly rejection.
- Trial name
- NCT00760175
- Testing
- Vaxigrip (Aventis-Pasteur Canada)
- Where
- 2 sites in Canada, Switzerland
- Volunteers
- 85 people
- Sponsor
- University of Alberta
Influenza Vaccine
Intradermal Versus Intramuscular Trivalent Influenza Vaccine in Adult Solid Organ Transplant Recipients
Influenza virus is an important cause of morbidity in the transplant population and can lead to viral and bacterial pneumonia and contribute to the development of rejection.
- Trial name
- NCT01180699
- Testing
- Influenza vaccine: Vaxigrip or Fluviral and Intanza
- Where
- Canada
- Volunteers
- 229 people
- Sponsor
- University of Alberta
Operable Early Stage NSCLC by the VATS Approach
Health Related Quality of Life After Video Assisted Thoracoscopic Lobectomy for Lung Cancer
To test the effect of post operative complications on the health related quality of life (HRQOL) after Video Assisted Thoracoscopic Surgery (VATS) for Non-Small Cell Lung Cancer (NSCLC).
- Trial name
- NCT01555502
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Gastroesophageal Reflux Disease (GERD)
Evaluation of the Safety and Effectiveness of Tailored Transoral Incisionless Fundoplication (TIF) Using EsophyX for the Treatment of GERD
Objectives of the Study: The primary objective of this study is to evaluate the relative merits, safety and effectiveness of the tailored TIF2 procedure in treating GERD patients who have persistent GERD symptoms despite PPI…
- Trial name
- NCT01025739
- Testing
- EsophyX™ system with SerosaFuse fasteners
- Where
- Canada
- Sponsor
- University of Alberta
Hypertension
Alberta Clinical Trial in Optimizing Hypertension
The purpose of this study is to evaluate the effect of enhanced pharmacist care (patient identification, assessment, education, prescribing/titration of antihypertensive medications and close follow-up) on systolic blood pressure…
- Trial name
- RxAction (NCT00878566)
- Testing
- Enhanced pharmacist care, Usual Care
- Where
- Canada
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Heart Failure, Congestive
Heart Failure Evaluation Acute Referral Team Trial (HEARTT)
The purpose of this study is to assess the impact of a multidisciplinary team clinic including a clinical pharmacist, a registered nurse (RN), dietician and physician providing short-term sub-acute management of patients with…
- Trial name
- NCT00355511
- Testing
- education: disease, medication, self-care, diet
- Where
- Canada
- Sponsor
- University of Alberta
Dyslipidemias
A Community Based Approach to Dyslipidemia Management: Pharmacist Prescribing to Achieve Cholesterol Targets
Background: Cardiovascular disease (CVD) is the cause of one-third of all deaths in Canada. One important risk factor for CVD is dyslipidemia.
- Trial name
- RxACT (NCT01581372)
- Testing
- Pharmacist care
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- University of Alberta
Morphea
Imiquimod 5% Cream in Plaque-type Morphea: A Pilot, Prospective Open-label Study
Localized scleroderma or morphea is a fibrotic disease, imiquimod induces cytokines which inhibit fibrotic activity . We propose that topical imiquimod 5% cream is efficacious and safe in treating plaque-type morphea.
- Trial name
- NCT00230373
- Testing
- imiquimod 5% cream (Aldara)
- Where
- 3 sites in Canada
- Sponsor
- University of Alberta