Clinical trials: sponsored by University of Alberta
Intracerebral Hemorrhage
Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial
Rationale: Management of blood pressure (BP) in the acute phase of intracerebral hemorrhage (ICH) remains controversial. Although it has been established that there is a transient moderate reduction of perihematoma cerebral blood…
- Trial name
- ICH ADAPT (NCT00963976)
- Testing
- labetalol/hydralazine/enalapril
- Where
- 4 sites in Canada
- Volunteers
- 74 people
- Sponsor
- University of Alberta
Portal Hypertension
The Effect of Probiotics (VSL) on Portal Hypertension
The investigators will address the hypothesis that portal hypertension is mediated in part by bacterial or endotoxin translocation and the production of inflammatory mediators (tumor necrosis factor-α (TNFα), etc.).
- Trial name
- NCT01032941
- Testing
- Probiotic
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Type 2 Diabetes Mellitus
Exercise Intensity, Glycemic Control and Abdominal Fat in People With Type 2 Diabetes: A Pilot Study
Body fat is an important risk factors for type 2 diabetes. However, not all body fat is the same. Research suggests that fat stored in the abdomen is most harmful. This is known as intra-abdominal fat.
- Trial name
- NCT01144078
- Testing
- Traditional Intensity Exercise, High Intensity Interval Exercise
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of Alberta
Osteoporosis
Trial of Osteoporosis Intervention Strategies in Hip Fracture Patients
The objective of this study is to determine if an intervention with a fracture manager to arrange bone densitometry after a hip fracture is more effective in diagnosing and treating osteoporosis when compared to "usual care".
- Trial name
- NCT00136058
- Testing
- bone densitometry (DEXA), alendronate or risedronate
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- University of Alberta
Myocardial Infarction, Stroke
Using AtorVASTatin to Prevent VAscular Inflammatory OccLUSion in the Critically Ill
Patients are admitted to the critical care unit of the hospital because of medical conditions that have a high likelihood of causing severe problems with blood flow, breathing, or brain function.
- Conditions
- Myocardial Infarction, Stroke, Renal Failure
- Trial name
- VASTVALUS (NCT01073800)
- Testing
- atorvastatin 80 mg per os daily
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Alberta
Intubation, Intratracheal
Different Techniques for Emergency Cricothyroidotomy
This educational study will examine two different techniques for training emergency residents and staff on achieving a surgical airway (called a cricothyroidotomy).
- Trial name
- CRIC (NCT01107561)
- Testing
- Seldinger technique, Surgical Airway Approach
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Coronary Artery Disease
Canadian Anticoagulant Percutaneous Coronary Intervention Registry
Advances in mechanical intervention (PCI) and anticoagulation therapy have been the cornerstone of treatment of patients with coronary artery disease.
- Trial name
- CAPCIR (NCT00773006)
- Where
- Canada
- Volunteers
- 747 people
- Sponsor
- University of Alberta
Heart Failure
Congestive Heart Failure Outreach Program
Heart failure is a very common condition and is one of the main reasons people are admitted to hospital. There are many things people with heart failure can do to manage their condition at home.
- Trial name
- COPE (NCT00371085)
- Testing
- education
- Where
- Canada
- Volunteers
- 539 people
- Sponsor
- University of Alberta
Hepatitis C Virus
Assessment of Biomarkers for Recurrent HCV Infection Post-liver Transplantation
The purpose of this study is to learn about how different immunosuppressant therapies impact on recurrent hepatitis C virus infection in the new liver after liver transplant.
- Trial name
- NCT00710801
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Kidney Transplant
Cell-mediated Immune Response to Influenza Vaccine
Influenza virus is an important cause of morbidity in the transplant population and can lead to viral and bacterial pneumonia. Although the annual influenza vaccine is recommended for organ transplant patients, studies have shown…
- Trial name
- NCT00677547
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Type 1 Diabetes, Hypoglycemia
Using Glucose Sensors to Prevent Hypoglycemia
Hypoglycemia is the most common complication of Type 1 diabetes particularly in those who strive for good glycemic control. In some patients there is a loss of awareness of hypoglycaemia so that the first manifestation of…
- Trial name
- NCT00554281
- Testing
- Use of glucose sensor (Paradigm Guardian)
- Where
- 2 sites in Canada
- Volunteers
- 16 people
- Sponsor
- University of Alberta
Bariatric Surgery
Absorption of Drugs Post-Bariatric Surgery (Absorb-Azithromycin)
Bariatric (obesity) surgery has become the preferred treatment option for patients with severe obesity and is increasing in popularity. It is commonly performed, with nearly 350 000 operations in the world every year.
- Trial name
- Absorb-Azithro (NCT01154569)
- Testing
- Azithromycin
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Contrast-induced Nephropathy, Acute Renal Failure
Prevention of Contrast-Induced Nephropathy
Patients with pre-existing kidney disease are at high risk of acute renal failure when exposed to radio-contrast dyes, for example during a cardiac angiogram.
- Conditions
- Contrast-induced Nephropathy, Acute Renal Failure, Chronic Renal Failure
- Trial name
- NCT00175227
- Testing
- intravenous saline hydration + mannitol + furosemide, intravenous saline hydration
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Alberta
Coronary Disease, Ischemic Heart Disease
A Cluster Randomized Trial to Assess the Impact of Opinion Leader Endorsed Evidence Summaries on Improving Quality of Prescribing for Patients With Chronic Cardiovascular Disease
BACKGROUND: Although much has been written about the influence of local opinion leaders on clinical practice, there have been few controlled studies of their effect, and almost none have attempted to change prescribing in the…
- Conditions
- Coronary Disease, Ischemic Heart Disease, Heart Failure
- Trial name
- NCT00175279
- Testing
- Opinion leader generated and endorsed evidence summaries
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- University of Alberta
Constipation, Palliative Care
Effectiveness of Docusate in Preventing/Treating Constipation in Palliative Care Patients
The purpose of this study is to determine if docusate is effective in the treatment of constipation in palliative care patients.
- Trial name
- NCT00902031
- Testing
- Docusate Sodium, Sennoside
- Where
- 3 sites in Canada
- Volunteers
- 70 people
- Sponsor
- University of Alberta
Colorectal Cancer
Scope Pilot Research Study
Colorectal cancer is a major public health concern in Alberta. Colorectal Cancer is the fourth most common diagnosed cancer and second overall in terms of cancer deaths in Canada.
- Trial name
- SCOPE (NCT00893503)
- Testing
- colonoscopy
- Where
- 2 sites in Canada
- Volunteers
- 1,248 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Obesity, Gastric Bypass
Effect of Gastric Bypass on the Absorption of Metformin
Background: Gastric bypass is the most commonly performed type of bariatric (obesity) surgery, has dramatically increased in popularity and is now considered to be preferred treatments in severely obese patients that fail…
- Trial name
- ABSORB-Met (NCT01013051)
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University of Alberta
Amyotrophic Lateral Sclerosis
The Effect of Memantine on Functional Outcomes and Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis (ALS)
The purpose of the study is to investigate the effects of memantine in ALS patients using functional outcome measures.
- Trial name
- NCT00409721
- Testing
- Memantine
- Where
- 2 sites in Canada
- Volunteers
- 42 people
- Sponsor
- University of Alberta
Crohn's Disease
Drug-Disease Interaction in Crohn's Disease
Objective: To determine the effect of C-reactive protein (CRP) status, and infliximab treatment on the pharmacodynamics and pharmacokinetics of verapamil, a model drug for L-type calcium channel blocking, in Crohn's disease (CD)…
- Trial name
- NCT01261286
- Testing
- verapamil
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alberta
Crohn's Disease, Low Bone Mineral Density
Risedronate Therapy in the Treatment of Low Bone Mineral Density in Crohn's Disease
The occurrence of bone loss in Crohn's disease patients is an important clinical problem for both patients with and without active disease.
- Trial name
- NCT01215890
- Testing
- risedronate
- Where
- Canada
- Sponsor
- University of Alberta