Clinical trials: sponsored by University of Alberta
Ulcerative Colitis
Personalized Anti-Inflammatory Fibres in Ulcerative Colitis
The goal of this clinical trial is to determine the clinical effects of two different dietary fibre supplements, acacia gum (AG) and microcrystalline cellulose (MCC), in patients with ulcerative colitis.
- Trial name
- PAIF-UC (NCT06515210)
- Testing
- Acacia Gum, Microcrystalline Cellulose
- Where
- Canada
- Volunteers
- 69 people
- Sponsor
- University of Alberta
Cardiac Transplant Disorder
Diagnostic and Therapeutic Applications of Microarrays in Heart Transplantation
Demonstrate the impact of the Molecular Microscope Diagnostic System as the standard of care for heart transplant patients.
- Trial name
- NCT02670408
- Testing
- Endomyocardial biopsy
- Where
- 13 sites in United States, Australia and 6 more
- Volunteers
- 900 people
- Sponsor
- University of Alberta
Ulcerative Colitis, Inflammatory Bowel Diseases
Fecal Microbiota Transplantation in an Expanded Ulcerative Colitis Population
This is a multi-centre, randomised controlled trial comparing fecal microbiota transplantation to placebo in an expanded ulcerative colitis population: a feasibility study (FRONTIER-UC) to determine whether a full-scale…
- Conditions
- Ulcerative Colitis, Inflammatory Bowel Diseases, Clostridioides Difficile Infection
- Trial name
- FRONTIER-UC (NCT07401680)
- Testing
- Lyophilized Fecal Microbiota Transplantation (LFMT)
- Where
- 2 sites in Canada
- Volunteers
- 85 people
- Sponsor
- University of Alberta
Pelvic Organ Prolapse (POP)
Evaluation of a Personalizable Pessary for Pelvic Organ Prolapse
Pelvic organ prolapse (POP) is a common health issue. It will impact about half of Canadian women over their lifetime. With POP, organs like the bladder, uterus, and bowel may push into the vagina.
- Trial name
- NPP-POP (NCT06954701)
- Testing
- Novel Personalizable Pessary
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- University of Alberta
Liver Dysfunction
Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation
INTERLIVER is a prospective observational study of the relationship of the molecular phenotype of 300 liver transplant biopsies to the histologic phenotype and the clinical features and outcomes.
- Trial name
- INTERLIVER (NCT03193151)
- Testing
- liver biopsy
- Where
- 15 sites in United States, Australia and 3 more
- Volunteers
- 300 people
- Sponsor
- University of Alberta
Prostate Cancer, Localized Prostate Carcinoma
PSMA-Guided Ablation of the Prostate
The goal of this phase 2 multicenter randomized controlled trial is to study the accuracy of second generation prostate specific membrane antigen (PSMA) positron emission tomography (PET; utilizing 18F-PSMA-1007) compared to…
- Trial name
- P-GAP (NCT06003556)
- Testing
- PSMA-1007 Positron Emission Tomography (PET) scan
- Where
- 4 sites in Canada
- Volunteers
- 138 people
- Sponsor
- University of Alberta
Stroke
Reaching the Unreached: Home-Based Telerehabilitation for Stroke Survivors
After a stroke, many people have trouble using their arms and hands. This can make daily tasks-like eating, dressing, or writing-very hard.
- Trial name
- NCT07467785
- Testing
- Standard of Care (SOC), Telerehabilitation with Tenzr
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Alberta
Facial Nerve Palsy, Corneal Exposure
Suture Lid Spring for Lid Closure in Patients With Facial Nerve Palsy
The eyelids protect the cornea and eyelid closure is essential to ocular health and clear vision. Patients with permanent Bells palsy or facial nerve palsy from other reasons such as tumours or trauma may be unable to blink and…
- Conditions
- Facial Nerve Palsy, Corneal Exposure, Paralytic Lagophthalmos
- Trial name
- SESPL (NCT06895902)
- Testing
- Polypropylene Suture Eyelid Spring for Paralytic Lagophthalmos
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- University of Alberta
Validation Study of Molecular Diagnostic System, Development of Reporting System for Molecular Diagnosis
Diagnostic and Therapeutic Applications in Microarrays in Organ Transplantation
The current standard for biopsy-based diagnoses of dysfunction of kidney transplants is the Banff Classification which represents arbitrary international consensus.
- Conditions
- Validation Study of Molecular Diagnostic System, Development of Reporting System for Molecular Diagnosis, Incorporate Molecular Diagnosis Into Diagnostic Standards
- Trial name
- NCT01299168
- Where
- 26 sites in United States, Austria and 12 more
- Volunteers
- 500 people
- Sponsor
- University of Alberta
Kidney Transplant Rejection
Trifecta-Kidney cfDNA-MMDx Study
Demonstrate the relationship between DD-cfDNA levels and HLA antibodies in blood, and the Molecular Microscope® (MMDx) Diagnostic System results in indication biopsies.
- Trial name
- NCT04239703
- Testing
- MMDx, Prospera, HLA antibody
- Where
- 31 sites in United States, Australia and 8 more
- Volunteers
- 300 people
- Sponsor
- University of Alberta
Obstructive Sleep Apnea
Phototherapy for Non-responders to Oral Appliance Therapy for Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a medical condition where a person has great difficulty with breathing, or stops breathing all together, while asleep.
- Trial name
- NCT06960200
- Testing
- Phototherapy
- Where
- Canada
- Volunteers
- 528 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Heart Failure
3D Assessment of RV Function in Patients Undergoing LVAD Implantation
This goal of this study is to analyze images of the right ventricle taken via 3D transesophageal echocardiography (TEE) during left ventricular assist device (LVAD) implantation.
- Trial name
- NCT05376254
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Spinal Cord Injury Cervical
Non-Invasive Neuromodulation for Upper Extremity Function in Spinal Cord Injury: A Crossover Trial
This study explores two promising therapies for restoring arm and hand function in people with chronic cervical spinal cord injury (SCI), a condition that affects independence and quality of life.
- Trial name
- NCT06903416
- Testing
- Transcutaneous Cervical Spinal Cord Stimulation, Paired Corticospinal Motoneuronal Stimulation, Functional Task Practice
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Alberta
Lung Transplant Rejection
Diagnostic and Therapeutic Applications of Microarrays in Lung Transplantation
Objective: To evaluate the potential impact of molecular phenotyping of transbronchial biopsies in lung transplant recipients with allograft dysfunction, and the potential for developing a safer endobronchial mucosal biopsy…
- Trial name
- INTERLUNG (NCT02812290)
- Testing
- Lung transplant biopsy bites.
- Where
- 11 sites in United States, Australia and 4 more
- Volunteers
- 700 people
- Sponsor
- University of Alberta
Communication Research
Language Translation of Knowledge Mobilization Resources
Knowledge mobilization (KM) resources are tools designed to facilitate the use of research evidence in healthcare decision-making.
- Trial name
- NCT07127887
- Testing
- KM Resource - AI, KM Resource - Professional
- Where
- Canada
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Celiac Disease in Children, Gluten Enteropathy
Influence of a Gluten Free Food Guide on Diet Quality and Adherence to the GFD in Youth With Celiac Disease
Celiac disease (CD) is an autoimmune gastrointestinal disease that is caused by intolerance to gluten in the diet. The mainstay of treatment is a gluten-free diet (GFD).
- Conditions
- Celiac Disease in Children, Gluten Enteropathy, Diet; Deficiency, Adherence, Treatment
- Trial name
- NCT06038344
- Testing
- Gluten-free food guide teaching
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Diabetes Type 2, Frailty
Home-based Interventions for FrAilty preveNTion in AdultS With DIabeTes and Chronic Kidney Disease
One of the most common problems in people with diabetes (DM) and chronic kidney disease (CKD) is the high frequency of other coinciding medical conditions such as osteoporosis and frailty.
- Conditions
- Diabetes Type 2, Frailty, Kidney Diseases
- Trial name
- Fantastic (NCT05527574)
- Testing
- Resistance Exercise
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of Alberta
Cancer Distress
Northern Alberta Psychosocial Telecare (NAPT) Screening for HNC Patients
This is a randomized controlled trial comparing a web-based psychosocial screening application to usual care in a cohort of surgically-treated head and neck cancer patients to determine its efficacy in monitoring depression and…
- Trial name
- NAPT (NCT03215199)
- Testing
- NAPT
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- University of Alberta
Compensation Strategies, Serious Games
Feasibility of the Glenrose Grocery Game for Cognitive and Functional Outcomes in Older Inpatients
Older adults could benefit from computer serious games as a strategy for improving not only their cognitive functions but also their functioning and performance in daily activities, which are often compromised with age.
- Trial name
- NCT07584408
- Testing
- Experimental: Glenrose Grocery Game sessions, Standard cognitive rehabilitation
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Vocal Cord Dysfunction, Speech Disorders
Clinical Feasibility & Validation of the Virtual Reality GlenxRose Speech-Language Therapies
Factors related to successful rehabilitation are often directly related to adherence; for instance, dosage, frequency, and intensity can burden the patient regarding time and motivational factors.
- Trial name
- NCT05695131
- Testing
- GlenXRose Virtual Reality Speech Therapies
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta