Clinical trials: open to volunteers, sponsored by University of British Columbia
Kidney Transplant, Kidney Transplant Failure
Prevent Allosensitization in Patients Who Have Failed a First Renal Transplant (PART)
Kidney transplant is often the best treatment for people with kidney failure, but transplanted kidneys don't always last a lifetime.
- Conditions
- Kidney Transplant, Kidney Transplant Failure, Immunosuppresion
- Trial name
- NCT06802822
- Testing
- Prevention of Allosensitization
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- University of British Columbia
Healthy
How the Mediterranean Diet Affects You: Predicting Responses Based on Your Microbiome
People respond differently to various diets-some may see significant benefits, while others may not. This project aims to personalize dietary recommendations by analyzing the gut microbiome to predict who will benefit most from…
- Trial name
- MAP-Med (NCT06765369)
- Testing
- Mediterranean diet, Westernized Diet
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Prematurity
Creating a Calmer NICU: Optimizing Growth and Brain Development in Preterm Infants
Infants born preterm can spend months in the neonatal intensive care unit (NICU) where they experience stressful but essential procedures. Untreated stress is associated with altered brain development.
- Trial name
- NCT04911452
- Testing
- Calmer
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
Neuroma of Lower Limb
Does RPNI Reduce Incidence of Neuroma Formation Following Sural Nerve Biopsy
The purpose of our project is to determine if incorporating preventative surgical techniques such as regenerative peripheral nerve interfaces (RPNI) into sural nerve biopsy can reduce the incidence of symptomatic neuroma…
- Trial name
- NBxPilot (NCT06754969)
- Testing
- Peripheral Nerve Regenerative Interface (RPNI) and Nerve/Muscle Biopsy, Biopsy Alone
- Where
- 3 sites in Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Healthy Individuals, Allergic Rhinitis
Health Effects of Wood Smoke and Traffic-Related Air Pollution Exposures: a Necessary Comparison
Accumulating evidence demonstrates that breathing air pollutants leads to devastating increases in sickness and death worldwide over time.
- Trial name
- WADE (NCT06749093)
- Testing
- Filtered Air (FA), Wood Smoke (WS), Diesel Exhaust (DE)
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Depression, Treatment Resistant Depression
Neurocardiac Predictors of Treatment Response to RTMS in Depression
Heartbeat is controlled by the brain and is regular but flexible to change in response to environmental and internal stimuli. This feature is known as heart rate variability (HRV).
- Trial name
- NCP (NCT05139862)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Sepsis
Precision Exercise to Improve Outcomes in Sepsis
The goal of this interventional clinical research study is to assess the efficacy of a 12-week precision exercise training intervention to improve exercise tolerance in sepsis survivors.
- Trial name
- PRECISE (NCT05784740)
- Testing
- 12-week precision exercise training
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Living Donor Kidney Transplantation, Health Equity
Storytelling to Promote Living Donor Kidney Transplant
This study will examine the effectiveness of first-person storytelling in encouraging patients with end-stage renal disease to pursue Living Donor Kidney Transplant (LDKT).
- Conditions
- Living Donor Kidney Transplantation, Health Equity, Patient Education, Narrative Medicine
- Trial name
- LDKT Stories (NCT06734819)
- Testing
- Storytelling Video, Standard Patient Education
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of British Columbia
Breast Reconstruction
BREAST ADM Trial for Alloplastic Breast Reconstruction
This study is a randomized single blinded prospective clinical trial comparing the surgical outcomes of four different acellular dermal matrixes (ADMs) after primary breast reconstruction.
- Trial name
- Breast_ADM (NCT04661501)
- Testing
- AlloDerm, AlloMax, DermACELL
- Where
- 4 sites in Canada
- Volunteers
- 328 people
- Sponsor
- University of British Columbia
Wound Complication, Surgical Wound Infection
Cosmetic Outcome of Electrocautery, Scalpel and PEAK PlasmaBlade for Surgical Breast Incisions
This study will compare the cosmetic scar result from the use of scalpel, electrocautery, and pulsed electron avalanche knife (PEAK) PlasmaBlade (PPB) for the initial skin incision for total mastectomy procedures without…
- Conditions
- Wound Complication, Surgical Wound Infection, Post-operative Pain, Postoperative Complications
- Trial name
- SCPPB (NCT06191159)
- Testing
- Scalpel and standard electrocautery or PEAK PlasmaBlade, PEAK PlasmaBlade, Standard Electrocautery
- Where
- Canada
- Volunteers
- 186 people
- Sponsor
- University of British Columbia
Recurrent Pregnancy Loss
Prospective Recurrent Pregnancy Loss Registry
The purpose of this Registry is to prospectively collect data of Recurrent Pregnancy Loss (RPL) patients attending the specialized care centre at the BC Women's Hospital, in order to evaluate investigation practices, treatment…
- Trial name
- NCT05989178
- Testing
- Data Registry
- Where
- Canada
- Volunteers
- 3,000 people
- Sponsor
- University of British Columbia
Elbow Fracture, Trauma
Management of Type 1 Supracondylar Humeral Fractures
This study compares the clinical outcomes of treating pediatric Type 1 supracondylar fracture with a long arm soft cast and no clinical or radiographic follow-up versus the standard treatment in a long arm cast with clinical…
- Trial name
- NCT04642807
- Testing
- Long arm soft cast, Long arm full cast
- Where
- 2 sites in Australia, Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Major Depressive Disorder, Recurrent, in Remission
Light and Ion Maintenance In Treatment for Depression (LIMIT-D): Feasibility Study
Antidepressants are widely used as first-line treatments for major depressive disorder (MDD). Clinical guidelines recommend 6-24 months of "maintenance" antidepressant treatment, after patients achieve symptom remission, to…
- Trial name
- NCT05423275
- Testing
- Negative ion therapy, Light therapy
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of British Columbia
Post Intensive Care Syndrome (PICS), Polypharmacy
The Critical Care Recovery Program: Use of a Structured Clinic Visit to Reduce Adverse Drug Events in ICU Survivors
Background and Objective: Intensive Care Units (ICUs) save lives, but many ICU survivors face ongoing health issues, including adverse drug events (ADEs) from medications started during their hospital stay.
- Conditions
- Post Intensive Care Syndrome (PICS), Polypharmacy, Adverse Drug Events, Critical Care, Intensive Care
- Trial name
- CCRP (NCT06723860)
- Volunteers
- 3,000 people
- Sponsor
- University of British Columbia
Hip Dislocation, Congenital, Hip Dysplasia, Congenital, Nonsyndromic
Global Hip Dysplasia Registry
Developmental dysplasia of the hip (DDH) is the most common hip condition affecting infants and children. DDH represents a spectrum of issues affecting the hip joint - a "ball-and-socket" joint.
- Conditions
- Hip Dislocation, Congenital, Hip Dysplasia, Congenital, Nonsyndromic, Congenital Dysplasia of the Hip, Congenital Hip Dislocation
- Trial name
- GHDR (NCT04117685)
- Testing
- Observational
- Where
- Canada
- Volunteers
- 5,000 people
- Sponsor
- University of British Columbia
Circulatory Arrest
The Physiology of Circulatory Arrest in Humans
The purpose of this study is to better understand what happens in the brain during the dying process. This is a prospective observational study conducted at the end of life in the ICU at VGH.
- Trial name
- EVALUATE (NCT06130033)
- Testing
- Neuromonitoring
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
Folate, Folate Bioavailability
PREconception Folic Acid Clinical Efficacy (PREFACE) Trial
A study to help understand what forms of folic acid are most effective to increase folate status during pregnancy for the best protection against neural tube defects
- Conditions
- Folate, Folate Bioavailability, Clinical Trials, Pregnancy
- Trial name
- PREFACE (NCT06641245)
- Testing
- Folic Acid, 5-MTHF (5-methyltetrahydrofolate)
- Volunteers
- 272 people
- Sponsor
- University of British Columbia
Aging, Physical Inactivity
Provincial Scale-up of Choose to Move (CTM) Phase 4
Choose to Move (CTM) is a 3-month, choice-based health-promoting program for low active older adults being scaled-up across British Columbia (BC), Canada.
- Conditions
- Aging, Physical Inactivity, Mobility Limitation, Loneliness
- Trial name
- NCT06434298
- Testing
- Choose to Move
- Where
- Canada
- Volunteers
- 5,720 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Knee Injuries, Anterior Cruciate Ligament Rupture
Stopping OsteoARthritis After an ACL Tear
By 2040, 25% of Canadians will have osteoarthritis, a disabling joint condition. Most people think osteoarthritis only affects older adults, but 50% of the 700,000 Canadian youth who hurt their knee playing sports annually will…
- Conditions
- Knee Injuries, Anterior Cruciate Ligament Rupture, Osteoarthritis, Knee
- Trial name
- SOAR (NCT06195423)
- Testing
- Stop OsteoARthritis (SOAR) program, Living Well after ACLR program
- Where
- 2 sites in Canada
- Volunteers
- 210 people
- Sponsor
- University of British Columbia
Isthmic Spondylolisthesis
Anterior vs Posterior Surgery for Lumbar Isthmic Spondylolisthesis
Currently there is no consensus on the best surgical treatment of patients with symptomatic isthmic spondylolisthesis (IS). Clinical equipoise exists amongst experienced clinicians on the various surgical techniques available.
- Trial name
- NCT05701046
- Testing
- Interbody fusion surgery
- Where
- Canada
- Volunteers
- 489 people, healthy volunteers welcome
- Sponsor
- University of British Columbia