Clinical trials: sponsored by University of Calgary
Atrial Fibrillation
RAPID AFib Decision Aid for Stroke Prevention in Atrial Fibrillation
The goal of this pilot clinical trial is to evaluate the utility of a new electronic patient decision aid for stroke prevention therapy in patients with atrial fibrillation.
- Trial name
- NCT05900414
- Testing
- Electronic patient decision aid, Information
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Calgary
Knee Osteoarthritis
Clinical Evaluation of the Levitation Knee Brace
Osteoarthritis (OA) is a debilitating disease affecting approximately 1/3 of Canadians over the age of 25. Knee OA typically involves at least 2 of 3 compartments in the knee joint.
- Trial name
- NCT05543486
- Testing
- Levitation 2 Tri-Compartment Offloader (TCO) knee brace, Knee sleeve
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- University of Calgary
Primary Aldosteronism
Prospective Evaluation of Confirmatory Testing for Primary Aldosteronism
This study is to evaluate the performance characteristics of the seated saline infusion test and the ultra low-dose ACTH stimulation test for the diagnosis of primary aldosteronism.
- Trial name
- NCT04422756
- Testing
- Seated intravenous saline infusion test, Ultra low-dose ACTH stimulation test
- Where
- Canada
- Volunteers
- 183 people
- Sponsor
- University of Calgary
Health Care Quality, Access, and Evaluation
ICP for Patients With Complex Care Needs in Ontario and Alberta, Canada
The Integrated Care Pathway (ICP) model can reduce hospital readmissions and emergency department (ED) visits while improving continuity of care.
- Trial name
- NCT06679309
- Testing
- Integrated care plan
- Where
- Canada
- Volunteers
- 2,000 people
- Sponsor
- University of Calgary
Hormone Therapy
Hormone Therapy and Angiotensin-Dependent Arterial and Renal Vasoconstriction in Humans
1. to investigate the association between route of administration of exogenous estrogen (transdermal vs. oral) and cardiorenal risk in cisgender (gender identity aligning with sex at birth) and transgender (gender identity not…
- Trial name
- NCT05442463
- Testing
- Captopril Tablets, Iohexol
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Migraine Disorders
A Pilot Clinical Trial of a New Neuromodulation Device for Acute Attacks of Migraine in Children and Adolescents
Migraine is a neurological disease characterized by severe and recurrent headaches. Children and adolescents with migraine often present to the emergency department (ED) with acute attacks, where migraine accounts for up to ~30%…
- Trial name
- NCT05102591
- Testing
- Ketorolac, Metoclopramide, Active Remote Electrical Neuromodulation Device
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of Calgary
Pediatric Cancer, Pediatric Hematology
IMPACT: IMplementation of Physical Activity for Children and Adolescents on Treatment
Physical activity can enhance well-being among youth diagnosed with oncological or hematological diseases. We developed a tailored, 1:1, online physical activity program (i.e., IMPACT), to promote physical activity in this…
- Trial name
- NCT04956133
- Testing
- Physical Activity
- Where
- 2 sites in Canada
- Volunteers
- 250 people
- Sponsor
- University of Calgary
Copd
RELVAR Effects on Parasternal Muscle Activity, Diaphragm, and Ventilation in Severe COPD
This study examines the effect of the ultra long acting beta agonist/corticosteroid bronchodilator combination fluticasone furoate/vilanterol trifenatate, on respiratory muscles and ventilation in adults with severe bronchitis or…
- Trial name
- NCT02989935
- Testing
- Ventilation, Parasternal EMG, Phrenic magnetic stimulation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Necrotizing Enterocolitis (NEC)
Multi-strain Probiotics to Prevent Necrotizing Enterocolitis in Very Preterm Infants
The goal of this clinical trial is to evaluate whether multi-strain probiotics of lactobacillus and bifidobacterium can prevent necrotizing enterocolitis (NEC) in preterm infants born at less than 32 weeks of gestation.
- Trial name
- NCT06810154
- Testing
- Multi-strain probiotics
- Where
- 4 sites in Canada
- Volunteers
- 2,170 people
- Sponsor
- University of Calgary
Stroke, Acute
A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion
This trial will enroll patients that have been diagnosed with a transient ischemic attack (TIA) or minor stroke that has occurred within the past 12 hours.
- Trial name
- TEMPO-2 (NCT02398656)
- Testing
- Tenecteplase, Antiplatelet treatment
- Where
- 61 sites in Australia, Austria and 8 more
- Volunteers
- 1,274 people
- Sponsor
- University of Calgary
Delirium, Intensive Care Unit Delirium
Partnering With Family Members to Prevent, Detect and Manage Delirium in Critically Ill Patients.
Almost half of critically ill patients experience delirium. Delirium is associated with impaired cognition, mortality, and increased healthcare costs.
- Conditions
- Delirium, Intensive Care Unit Delirium, Post Intensive Care Unit Syndrome, Post Intensive Care Unit Syndrome Family
- Trial name
- NCT04099472
- Testing
- Delirium Education, Prevention, and Management, Standard Care
- Where
- 4 sites in Canada
- Volunteers
- 128 people
- Sponsor
- University of Calgary
Cerebral Palsy, Exercise
Resistance Intensive Personal Training for Youth with Cerebral Palsy
Changes related to Cerebral Palsy (CP) include differences in muscle architecture and cortical activity. These result in weakness, decreased functional ability and limited participation in physical activity.
- Conditions
- Cerebral Palsy, Exercise, Resistance Training
- Trial name
- RIPT (NCT05731609)
- Testing
- Resistance Intensive Personal Training
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of Calgary
Cerebral Palsy, Mobility Limitation
Robotic Walking for Children Who Cannot Walk
A common problem among children with nervous system disorders is difficulty walking on their own. This has impacts beyond mobility including short and long-term health conditions associated with physical inactivity and different…
- Conditions
- Cerebral Palsy, Mobility Limitation, Brain Injuries, Spinal Cord Injuries
- Trial name
- RoWaCaWa (NCT05473676)
- Testing
- Robotic Training Period
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- University of Calgary
Parkinson Disease
Exploring the Relationship Between L-dopa Responsiveness and Small Intestinal Microbiome in Parkinson's Disease
The investigators hypothesize that small intestinal (SI) microbiome biomarkers predict the responsiveness to oral levodopa/carbidopa in people with Parkinson's disease (PwPD).
- Trial name
- LENSER (NCT06762028)
- Testing
- SIMBA capsule
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Physical Inactivity
Makoyoh'Sokoi - The Wolf Trail Program Expansion Project - Supporting Indigenous Women to Celebrate Good Health
During the MKS+ program participants complete health education modules that expose them to health information, a substantial portion of which relate to healthy nutrition and prevention, and on occasion to local healthcare…
- Trial name
- MKS+ (NCT05362435)
- Testing
- Physical activity-based wellness programs
- Where
- 7 sites in Canada
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Cerebral Small Vessel Diseases, Cerebral Small Vessel Ischemic Disease
Testing of a System for Remote Ischemic Conditioning in Cerebral Small Vessel Disease and Pre-hospital Stroke Care
This early phase trial will address the following key objectives: 1. Completion of initial safety and tolerability testing of our viable prototype for remote ischemic conditioning (RIC) with patients with (a) CSVD and (b) acute…
- Conditions
- Cerebral Small Vessel Diseases, Cerebral Small Vessel Ischemic Disease, Ischemic Stroke, Vascular Cognitive Impairment
- Trial name
- TRIC-SVD (NCT05967728)
- Testing
- Remote ischemic conditioning (RIC) progammable device
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of Calgary
Stroke, Acute
Head COOLing in IscHemic Stroke Patients Undergoing EndovAscular Thrombectomy: a Feasibility and Safety StuDy
This is an investigator-initiated, prospective, open-label, single-arm, non-randomized study to assess the safety and feasibility of external active conductive head cooling during endovascular thrombectomy procedures.
- Trial name
- COOLHEAD-2a (NCT06335641)
- Testing
- External active conductive head cooling
- Where
- 2 sites in Canada, New Zealand
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Neurogenic Orthostatic Hypotension
Controlled CO2 Inhalation in NOH
This study focuses on neurogenic orthostatic hypotension (nOH), which is a disorder characterized by an abnormal drop in blood pressure (BP) within 3-minutes of standing.
- Trial name
- CO2-nOH (NCT06751888)
- Testing
- Controlled CO2 delivery
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- University of Calgary
Infant Conditions, Infant, Premature, Diseases
The Alberta BLOOM Premature Child Study
This is a prospective, observational clinical cohort study involving 405 children born premature (at less than 37 weeks gestation) and their mother/parent/guardian.
- Conditions
- Infant Conditions, Infant, Premature, Diseases, Asthma, Asthma in Children
- Trial name
- BLOOM-PCS (NCT05011071)
- Where
- Canada
- Volunteers
- 535 people
- Sponsor
- University of Calgary
ERCP
Guidewire Management in ERCP
Intra-procedural guidewire management is a parameter whose impact remains incompletely understood in terms of its association with post- endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP).
- Trial name
- NCT05219123
- Testing
- ERCP with no PD cannulation, ERCP with single PD cannulation
- Where
- Canada
- Volunteers
- 7,461 people
- Sponsor
- University of Calgary