Clinical trials: sponsored by University of Calgary
Transcranial Magnetic Stimulation, Functional Near-Infrared Spectroscopy
Treatment of Post-concussion Syndrome With TMS: Using FNIRS as a Biomarker of Response
Every year, approximately 2 million people in the United States and 280,000 in Canada experience a mild traumatic brain injury/concussion.
- Conditions
- Transcranial Magnetic Stimulation, Functional Near-Infrared Spectroscopy, Post-Concussion Syndrome, Concussion
- Trial name
- NCT04568369
- Testing
- rTMS
- Where
- Canada
- Volunteers
- 91 people
- Sponsor
- University of Calgary
Bronchiectasis, Non-Tuberculous Mycobacterial Pneumonia
Development of a Canadian Bronchiectasis and NTM Database
The investigators aim to develop a comprehensive patient registry of patients with non-CF bronchiectasis and/or Nontuberculosis Mycobacteria (NTM)
- Trial name
- NCT06144996
- Where
- Canada
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Insomnia, Sleep Disturbance
Sleeping For Two: Trial for CBT for Insomnia in Pregnancy
Cognitive-behavioural therapy for insomnia (CBT-I) has been shown to be an effective treatment for insomnia in multiple populations, including women during pregnancy and postpartum.
- Trial name
- NCT03918057
- Testing
- Cognitive Behavioural Therapy for Insomnia, Active Control
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- University of Calgary
Chronic Kidney Diseases, Cardiovascular Diseases
Testosterone and Vascular Function in Reproductive-Aged Females With Chronic Kidney Disease
Cardiovascular disease (CVD) is the leading cause of death among women and women with chronic kidney disease are at an even greater risk of CVD.
- Trial name
- NCT06107166
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of Calgary
Brain Injuries, Traumatic, Concussion, Brain
Treating Persistent Post-concussion Symptoms With Exercise
The objective of this study is to investigate an aerobic exercise program as a treatment for adults with persistent post-concussive symptoms (PPCS) following mild traumatic brain injury.
- Conditions
- Brain Injuries, Traumatic, Concussion, Brain, Mild Traumatic Brain Injury, Post-Concussion Syndrome
- Trial name
- NCT03895450
- Testing
- Aerobic Exercise Protocol, Stretching Protocol
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- University of Calgary
Cancer, Psychosocial Problem
The Chemo-Gut Probiotic Trial for Cancer Survivors
Purpose: The goal of this clinical trial is to determine whether probiotics can reduce gastrointestinal and psychosocial symptoms in post-treatment cancer survivors by impacting the gut microbiome.
- Conditions
- Cancer, Psychosocial Problem, Gastrointestinal Dysfunction
- Trial name
- NCT06088940
- Testing
- Multistrain Probiotic
- Volunteers
- 66 people
- Sponsor
- University of Calgary
Parkinson's Disease and Parkinsonism
Caregiving in Advanced PD: A Tailored Support Group
The goal of this study is to understand how support groups can help people who care for individuals with Parkinson's Disease and Related Disorders (PDRD).
- Trial name
- NCT06074393
- Testing
- Tailored Support Group
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Stroke, Aphasia, Non-fluent
rTMS and Multi-Modality Aphasia Therapy for Post-Stroke Aphasia
Many stroke survivors experience aphasia, a loss or impairment of language affecting the production or understanding of speech. One common type of aphasia is known as non-fluent aphasia.
- Trial name
- TMAT (NCT04901156)
- Testing
- 1Hz inhibitory rTMS, Multi-Modality Aphasia Therapy (M-MAT)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Postpartum Depression, Antepartum Depression
rTMS for Peripartum Depression
Repetitive Transcranial Magnetic Stimulation (rTMS) is a neuromodulatory technique that is effective in major depression. There is preliminary evidence suggesting that rTMS is effective in peripartum depression as well, however…
- Conditions
- Postpartum Depression, Antepartum Depression, Peripartum Depression
- Trial name
- NCT03949465
- Testing
- Transcranial Magnetic Stimulator
- Where
- Canada
- Sponsor
- University of Calgary
Obsessive-Compulsive Disorder
iTBS-DCS in Obsessive Compulsive Disorder
Obsessive Compulsive Disorder (OCD)is a common and debilitating illness. For an unacceptable proportion of patients, depressive symptoms remain impairing despite multiple treatments.
- Trial name
- NCT05177601
- Testing
- iTBS repetitive Transcranial Magnetic Stimulation (rTMS), D-cycloserine
- Where
- Canada
- Volunteers
- 81 people
- Sponsor
- University of Calgary
Venous Thromboembolism, Postpartum Period
Pilot PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
The pilot PARTUM trial is a randomized, multicenter, placebo-controlled trial. Women who are at modest risk of VTE (as defined by the inclusion criteria) will be identified during pregnancy, labor and delivery and up to 48 hours…
- Conditions
- Venous Thromboembolism, Postpartum Period, Aspirin
- Trial name
- PARTUM (NCT04153760)
- Testing
- Aspirin 81 mg
- Where
- 7 sites in Canada, France and 2 more
- Volunteers
- 257 people
- Sponsor
- University of Calgary
Major Depressive Disorder
D-Cycloserine+iTBS PK Study
Background \& Rationale: Major Depressive Disorder (MDD) is a common and debilitating illness that that commonly does not respond to conventional treatments.
- Trial name
- NCT05731323
- Testing
- D-cycloserine, Transcranial Magnetic Stimulator
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Calgary
Motor Activity
Repeated iTBS Cycloserine Motor Plasticity
Repetitive transcranial magnetic stimulation (rTMS) is a modality for probing and altering brain function in humans non-invasively.
- Trial name
- NCT05081986
- Testing
- Transcranial Magnetic Stimulation, Cycloserine
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Parent-Child Relations
ATTACH™ Online Platform: Helping Children Vulnerable to Early Adversity
Addressing the impact of early childhood adversity (e.g., family violence, parental depression, and low income) can promote children's mental health and development, giving children the best start in life and reducing societal…
- Trial name
- ATTACH™ (NCT05994027)
- Testing
- ATTACH™ Online Platform Parenting Program
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Calgary
COVID-19
A Pilot Study of a PhysiOthErapy-based Tailored Intervention for Long COVID (COVID-19)
The purpose of this study is to determine the benefits and feasibility of physiotherapy in the recovery of ongoing symptoms after COVID-19 illness.
- Trial name
- POETIC (NCT05040893)
- Testing
- Physiotherapy
- Where
- 2 sites in Canada
- Volunteers
- 15 people
- Sponsor
- University of Calgary
Motor Vehicle Injury
Traffic Safety Study at Calgary Elementary Schools
Installing specific traffic calming features designed to reduce vehicle speed and volume around schools may lead to a reduction in injury risk for child pedestrians and bicyclists, and may increase numbers of children walking and…
- Trial name
- NCT04956250
- Testing
- Traffic Calming Curbs, In-Street Pedestrian Sign
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Calgary
Acute Respiratory Distress Syndrome, Hypoxemic Respiratory Failure
Treatment of Hypoxemic Respiratory Failure and ARDS With Protection, Paralysis, and Proning (TheraPPP) Pathway
Treatment of patients with Hypoxemic respiratory failure (HRF) and Acute Respiratory Distress Syndrome (ARDS) is complex. Therapies that have been shown to save the lives of patients with HRF and ARDS are available but they are…
- Conditions
- Acute Respiratory Distress Syndrome, Hypoxemic Respiratory Failure, ARDS, Human
- Trial name
- TheraPPP (NCT04070053)
- Testing
- TheraPPP Pathway
- Where
- Canada
- Volunteers
- 920 people
- Sponsor
- University of Calgary
Diabetes, Endocrine System Diseases
Evaluating Innovations in Transition From Pediatric to Adult Care - The Transition Navigator Trial
The Transition Navigator Trial (TNT) is a pragmatic randomized controlled trial evaluating the effectiveness of usual care plus a patient navigator service versus usual care plus newsletters and other educational materials, to…
- Conditions
- Diabetes, Endocrine System Diseases, Gastro-Intestinal Disorder, Neuro-Degenerative Disease
- Trial name
- TNT (NCT03342495)
- Testing
- Patient Navigator, Usual Care
- Where
- 3 sites in Canada
- Volunteers
- 337 people
- Sponsor
- University of Calgary
Diabetes Mellitus Type 1 Pre-Existing, Pregnancy Related
Closed-Loop Insulin in Mothers With Type 1 Diabetes and Baby Feeding Practices
This study will is a parallel two-group randomized controlled trial that will use the MiniMed 670G hybrid closed-loop system's continuous glucose monitor (GCM) insulin pump and computer algorithm to deliver insulin when in "auto…
- Conditions
- Diabetes Mellitus Type 1 Pre-Existing, Pregnancy Related, Feeding Behavior, Infant Development
- Trial name
- CLIMB (NCT04420728)
- Testing
- Early auto-mode, Delayed auto mode
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Clavicle Fracture
Surgically Treated Displaced Mid-diaphyseal Clavicle Fractures
This prospective, multi-centre study aims to determine clinical, radiographic, and patient-reported outcomes (PROMs) following surgical fixation of displaced mid-diaphyseal clavicle fractures and to compare implant removal rates…
- Trial name
- NCT05867355
- Testing
- surgical fixation
- Where
- Canada
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- University of Calgary