Clinical trials: sponsored by University of Calgary
Abdominal Sepsis, Abdominal Infection
Closed or Open Abdomen for the Management of Abdominal Sepsis
This is a prospective randomized clinical study. The study will comprise the randomized decision to either A) primarily close the fascia after laparotomy for intra-abdominal infection (CLOSED); or B) leave the fascia open after…
- Trial name
- NCT03163095
- Testing
- Open Abdomen Management with ANPPT dressing, Closed Abdomen Management
- Where
- Canada
- Volunteers
- 550 people
- Sponsor
- University of Calgary
Functional Abdominal Pain Syndrome
Reducing Pain and Anxiety Through Dietary Fiber Supplementation in Children With Abdominal Pain
Background - Mental health and pain problems in early childhood are major risk factors for serious mental health problems into adulthood.
- Trial name
- NCT04619095
- Testing
- Psyllium
- Where
- Canada
- Sponsor
- University of Calgary
Cancer, Brain Tumor, Primary
A Tailored Exercise Oncology Program for Neuro-Oncology Patients
Background: Exercise, or physical activity, is beneficial for all cancer survivors. Despite this knowledge, there is generally a gap between the evidence and practice.
- Trial name
- ACE-Neuro (NCT04831190)
- Testing
- Tailored Exercise Intervention
- Where
- 4 sites in Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Growth Hormone Treatment, Growth Hormone Deficiency
Growth Hormone Deficiency in Mild Traumatic Brain Injury
The goal of this randomized control trial is to test if growth hormone therapy is a safe and effective treatment for patients suffering from growth hormone deficiency and persistent post-concussion symptoms.
- Conditions
- Growth Hormone Treatment, Growth Hormone Deficiency, Concussion, Mild, Concussion Post Syndrome
- Trial name
- NCT05660356
- Testing
- Growth Hormone
- Volunteers
- 20 people
- Sponsor
- University of Calgary
COVID-19
BREATHE: Virtual Self-management for Long COVID-19
A mixed-methods evaluation of a virtual self-management program for people living with long COVID in Alberta.
- Trial name
- NCT05107440
- Testing
- BREATHE
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- University of Calgary
Leukemia
Multiphasic Prehab Allo-HSCT
The purpose of this study is to implement a prehabilitation intervention to enhance recovery for people undergoing allogeneic stem cell transplant for hematologic malignancies.
- Trial name
- NCT05649371
- Testing
- Prehabilitation
- Volunteers
- 60 people
- Sponsor
- University of Calgary
Cystitis
Efficacy of Oxybutynin in Paediatric Cystitis
The primary goal of this study is to determine if the addition of the bladder antispasmotic oxybutynin to standard antimicrobial therapy in the treatment of childhood cystitis will decrease the associated pain and discomfort.
- Trial name
- NCT03877289
- Testing
- Oxybutynin, Antibiotics
- Where
- Canada
- Volunteers
- 81 people
- Sponsor
- University of Calgary
Wrist Injuries, Carpal Bone Fracture
The Canadian Prospective Pragmatic Perilunate Outcomes Trial
This is a unique three-fold prospective and retrospective study. With this approach, all previous and current PLIs presented at participating study sites will have the potential to be included in the study.
- Conditions
- Wrist Injuries, Carpal Bone Fracture, Dislocation of Wrist, Trauma
- Trial name
- C3PO (NCT04370626)
- Where
- Canada
- Volunteers
- 450 people
- Sponsor
- University of Calgary
Pregnancy Induced Hypertension, Pregnancy Related
SD-OCT Measurement of the Human Retina in Pregnancy With Pre-existing or De Novo Hypertension and Without Hypertension
The complications of long-standing severe and acute severe elevations in systemic blood pressure (hypertension) may involve large vessels as well as smaller vessels, these latter comprising what is known as the microcirculation.
- Trial name
- NCT04286217
- Volunteers
- 155 people
- Sponsor
- University of Calgary
Atrial Fibrillation
Validation of the Advisor HD Grid Mapping Catheter in Atrial Fibrillation Ablation
The primary study concept is to evaluate the superiority of the HD Grid high-density mapping catheter over the current standard 20-pole circular mapping catheter in pulmonary vein isolation (PVI) in atrial fibrillation.
- Trial name
- NCT04850508
- Testing
- Mapping and ablation with the Advisor HD Grid catheter
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Stereotactic Radioablation for Ventricular Tachycardia
Stereotactic Arrhythmia Radioablation for Ventricular Tachycardia Management
Stereotactic Arrhythmia Radioablation (STAR) ablation is a safe and feasible option for cardiomyopathy patients for management of refractory ventricular tachycardia.
- Trial name
- STAR VTM (NCT04065802)
- Testing
- Stereotactic Radioablation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Closed Fracture Dislocation, Tarsometatarsal Joint, Open Fracture Dislocation, Tarsometatarsal Joint
Fixation Insitu Versus Removal for Midfoot Lisfranc Injuries
This study is a multicenter prospective randomized control trial comparing hardware retention (HR) to removal of hardware (RH).
- Trial name
- FIRM (NCT02374944)
- Testing
- Hardware removal
- Where
- 3 sites in Canada
- Volunteers
- 94 people
- Sponsor
- University of Calgary
Nutrition, Pediatric Obesity
Metabolic and Genetic Impacts of Energy Drinks in Youth
Caffeine containing energy drinks (CCED) are beverages that typically contain mixtures of simple sugars, caffeine and may contain vitamin, mineral and/or herbal preparations.
- Conditions
- Nutrition, Pediatric Obesity, Pediatric, Caffeine
- Trial name
- NCT03512496
- Testing
- Acute energy drink - Caffein, Acute energy drink - Decaf
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Calgary
Postnatal Growth Restriction, Necrotizing Enterocolitis
Human Milk-derived Fortification in Preterm Infants
Human Milk alone is unable to meet the high nutritional requirements of preterm infants. The American Academy of Pediatrics recommends fortification of human milk as a standard practice in all very low birth weight (VLBW)…
- Trial name
- NCT05228847
- Testing
- Human milk-derived HMF, bovine milk-derived HMF
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- University of Calgary
Pulmonary Hypertension
Remote Exercise Program Delivery Using a Mobile Application for Pulmonary Arterial Hypertension
This study will determine the feasibility of a mobile application-based home exercise rehabilitation program for patients with pulmonary hypertension.
- Trial name
- REVAMP (NCT04559516)
- Testing
- Exercise Intervention, Standard Care
- Where
- Canada
- Sponsor
- University of Calgary
Very Low Birth Weight Infant, Bronchopulmonary Dysplasia
SMOFlipid and Incidence of BPD in Preterm Infants
Despite many advances in neonatal care in the recent years, bronchopulmonary dysplasia (BPD) continues to be the major cause of chronic lung morbidity in infants.
- Trial name
- NCT04078906
- Testing
- n3-LCPUFA enriched Intravenous Lipid Emulsion
- Where
- Canada
- Volunteers
- 384 people
- Sponsor
- University of Calgary
Aging, Physical Activity
Effects of Regular Exercise on Cerebrovascular Reserve in Older Adults
While it is well established that physical inactivity is a modifiable risk factor for vascular disease and cognitive decline, the mechanism by which exercise exerts its protective effect on the cerebral circulation and cognition…
- Conditions
- Aging, Physical Activity, Cognitive Function
- Trial name
- BIM (NCT03158337)
- Testing
- Aerobic exercise
- Where
- Canada
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Stress Disorders, Post-Traumatic, Brain Injuries
Pathophysiological Understanding and Treatment of PTSD: an rTMS Approach
In Canada, the prevalence of PTSD is approximately 12%, similar to Canadian military personnel. Current treatments for PTSD are limited in efficacy and durability - indicating a dire need for novel interventions in this…
- Conditions
- Stress Disorders, Post-Traumatic, Brain Injuries, Transcranial Magnetic Stimulation, Magnetic Resonance Spectroscopy
- Trial name
- PTSD (NCT03840369)
- Testing
- Repetitive Transcranial Magnetic Stimulation to Right Dorsolateral Prefrontal Cortex, Repetitive Transcranial Magnetic Stimulation to Right Dorsomedial Prefrontal Cortex
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Calgary
Delirium
Family Assessment of Pediatric Delirium
In this study the investigators will assess the validity, reliability and acceptability of utilizing family members to complete a delirium screen using the Cornell Assessment of Pediatric Delirium (CAPD).
- Trial name
- FAM-CAPD (NCT05220761)
- Testing
- Cornell Assessment of Pediatric Delirium
- Where
- 2 sites in Canada
- Volunteers
- 235 people
- Sponsor
- University of Calgary
Critical Illness
Critical Care OptimizatIon of Albumin Ordering
Strong evidence suggests that human albumin solutions should not be used for fluid resuscitation except among patients undergoing therapeutic plasmapheresis and select patients with complications of liver cirrhosis (i.e.
- Trial name
- RATIONALE (NCT04187534)
- Testing
- Albumin Fluid Resuscitation Optimization Intervention, Usual Practice
- Where
- 15 sites in Canada
- Volunteers
- 50,000 people
- Sponsor
- University of Calgary