Clinical trials: sponsored by University of Calgary
Critical Illness
Critical Care OptimizatIon of Albumin Ordering
Strong evidence suggests that human albumin solutions should not be used for fluid resuscitation except among patients undergoing therapeutic plasmapheresis and select patients with complications of liver cirrhosis (i.e.
- Trial name
- RATIONALE (NCT04187534)
- Testing
- Albumin Fluid Resuscitation Optimization Intervention, Usual Practice
- Where
- 15 sites in Canada
- Volunteers
- 50,000 people
- Sponsor
- University of Calgary
Covid19, SARS-CoV-2
Asymptomatic SARS-CoV-2 Detection in Children
The primary objective of this study is quantify the transmission risk posted by SARS-CoV-2 in pre/asymptomatic infected children in order to inform the public health response to the COVID-19 pandemic.
- Trial name
- NCT04853316
- Where
- 5 sites in United States, Canada
- Volunteers
- 372 people
- Sponsor
- University of Calgary
Parkinson's Disease and Parkinsonism
The Calgary Movement Disorders Advanced Care Pilot Program
The goal of this clinical trial is to analyse the effect of palliative care interventions on quality of life, patient satisfaction, carepartner burden and health care utilization patterns in patients living with parkisonism and…
- Trial name
- ACT for PD (NCT05599659)
- Testing
- Palliative care
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Stroke/Brain Attack
The Tele-Taking Charge After Stroke Randomized Controlled Feasibility Trial
Take Charge is a novel, community-based treatment for stroke developed to harness a person's self-determination. Two prior clinical trials with 572 stroke survivors showed that Take Charge improves quality of life, independence…
- Trial name
- TeleTaCAS (NCT05588947)
- Testing
- Take Charge session, Active Control
- Where
- 2 sites in Canada
- Volunteers
- 150 people
- Sponsor
- University of Calgary
Neurologic Disorder, Adiposity
Childhood Adiposity and Neurodevelopmental Outcomes Among Offspring of Women With Type 1 Diabetes (CONCEPTT Kids)
This is a follow-up study of children born to mothers who participated in the CONCEPTT Trial. CONCEPTT (a multicentre randomized controlled trial of continuous glucose monitoring (CGM) in women with Type 1 diabetes during…
- Trial name
- NCT04098679
- Where
- 4 sites in Canada
- Volunteers
- 174 people
- Sponsor
- University of Calgary
Proof of Concept, Irritable Bowel Syndrome
Validation of the Small Intestine Microbiome Aspiration (SIMBA) Capsule
Prospective, open label trial to establish the ability of the SIMBA Capsule to accurately obtain a sample from the small bowel of participants with IBS (10 constipation-predominant (IBS-C) and 10 diarrhea-predominant (IBS-D)) and…
- Trial name
- NCT04094558
- Testing
- Ingestible capsule, Sedated EGD, Lactulose Breath Test
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Fracture, Trauma
Surgical Treatment Versus Non-surgical Treatment of Ulnar Fractures
The purpose of this study is to determine if surgery using a plate and screws to fix a forearm fracture (ulnar shaft) will improve functional outcome compared to non-operative treatment out to 1 year of follow-up.
- Conditions
- Fracture, Trauma, Ulna Fracture, Orthopedic
- Trial name
- NCT01123447
- Testing
- Open reduction and internal fixation, Closed reduction and short-arm cast
- Where
- 9 sites in Canada, United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Cannabis Hyperemesis Syndrome
Treatment Strategies in CHS
Background: In the gastrointestinal (GI) system, the most well-described manifestation of prolonged cannabis use is cannabinoid hyperemesis syndrome (CHS).
- Trial name
- HALO (NCT04176055)
- Testing
- Haloperidol
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University of Calgary
Post-Intensive Care Recovery
A Recovery-Oriented Counselling Group
The purpose of this study is to evaluate a recovery-oriented group counselling program for post-discharged critical illness survivors and their caregivers.
- Trial name
- NCT03925181
- Testing
- Counselling Group
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Calgary
End-stage Kidney Failure
ACCESS HD: Comparing Catheters to Fistulas in Elderly Patients Starting Hemodialysis
This randomized controlled trial (RCT) is multi-center, parallel-arm, and open label. It will test the feasibility and safety of randomizing elderly patients with end-stage kidney failure starting hemodialysis with a…
- Trial name
- ACCESS HD (NCT02675569)
- Testing
- Catheter, Fistula
- Where
- 13 sites in Australia, Canada
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Lisfranc Injuries
Fixation In-situ vs Removal for Midfoot Lisfranc Injuries
Injuries to the midfoot tarsometatarsal joint, or Lisfranc joint, are notoriously debilitating. Poor functional outcomes following Lisfranc injuries have motivated surgeons to look for potential improvements in post-operative…
- Trial name
- FIRM (NCT03694288)
- Testing
- Implant removal
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Bile Duct Diseases
Infection Control in ERCP Using a Duodenoscope With a Disposable Cap
1. Background \& Rationale Over 650,000 endoscopic retrograde cholangio-pancreatography (ERCP) procedures are performed annually in the United States alone.
- Trial name
- ICECAP (NCT04040504)
- Testing
- ERCP procedure with Pentax ED-34i10T2 Duodenoscope with Disposable Cap (DEC), ERCP procedure with Pentax ED-34i10T Duodenoscope
- Where
- Canada
- Volunteers
- 520 people
- Sponsor
- University of Calgary
Vascular Dementia, Cerebral Small Vessel Diseases
Trial of Remote Ischemic Pre-conditioning in Vascular Cognitive Impairment
Cerebral small vessel disease is a common cause of cognitive impairment. Remote ischemic pre-conditioning (RIC) is a technique to induce brief periods of limb ischemia-reperfusion that is hypothesized to increase tolerance of the…
- Conditions
- Vascular Dementia, Cerebral Small Vessel Diseases, Cerebral Small Vessel Ischaemic Disease, Vascular Cognitive Impairment
- Trial name
- TRIC-VCI (NCT04109963)
- Testing
- Remote ischemic conditioning
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of Calgary
Bacterial Urinary Tract Infection
MicroUDxTM: a Rapid Diagnostic Tool That Will Prevent Death and Disability From Common Infections
Background \& Rational: Antibiotics are a major underpinning of modern medicine. The global rise of antimicrobial resistant (AMR) organisms is a serious world health problem.
- Trial name
- MicroUDxTM (NCT04228081)
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- University of Calgary
Colorectal Cancer, Colorectal Adenoma
The Colorectal Cancer Chemoprevention Acceleration and Improvement Platform (CRC-CHAMP) Study
The overall goal of this study is to develop a platform for both large-scale chemoprevention trials and real-world chemoprevention studies for colorectal cancer (CRC) prevention.
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colorectal Adenomatous Polyp
- Trial name
- NCT05402124
- Testing
- acetylsalicylic acid delayed release tablets, 81mg
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Gambling
The Effect of Regular Naltrexone Dosing on Disordered Gamblers
This study examines the effect of regular naltrexone dosing on disordered gamblers. Gamblers will also be scanned pre- and post-treatment where we will investigate the functional changes to tasks designed to engage brain region…
- Trial name
- NCT02537197
- Testing
- Naltrexone
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Minimally Invasive Cardiac Valvular Surgery
Valvular Surgery: Minimally Invasive vs Conventional Sternotomy
The conventional approach to heart valve operations is through a sternotomy. This involves a vertical incision in the sternum (breastbone) to gain access to the heart and its related structures.
- Trial name
- NCT04514315
- Testing
- Minimally invasive cardiac valvular surgery, Conventional cardiac valvular surgery
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of Calgary
Colorectal Neoplasms
Fecal Immunochemical Test for Post-polypectomy Surveillance to Reduce Unnecessary eNdoscopy
This is an observational study in a clinical setting to estimate the prevalence of advanced colorectal neoplasia (ACN) at colonoscopy in those with a history of low or high risk polyps or a family history of CRC/polyps and to…
- Trial name
- FIT2RUN (NCT05396560)
- Where
- Canada
- Volunteers
- 3,000 people
- Sponsor
- University of Calgary
Atrial Fibrillation
Carvedilol for Prevention of Paroxysmal Atrial Fibrillation
Atrial fibrillation (AF) is the most common sustained heart rhythm disorder and is associated with significant symptoms and health problems including an increased risk of stroke and death.
- Trial name
- NCT01608893
- Testing
- Carvedilol, Metoprolol
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Concussion, Brain, Pediatric Disorder
RECOVER Clinical Pathway for Pediatric Concussion
The project encompasses the development and implementation of an acute care, pediatric concussion clinical pathway at 5 pediatric emergency departments in the province of Alberta (Canada).
- Conditions
- Concussion, Brain, Pediatric Disorder, Mild Traumatic Brain Injury
- Trial name
- RECOVER (NCT05095012)
- Testing
- Pediatric Acute Care Concussion Clinical Pathway
- Where
- Canada
- Volunteers
- 2,878 people
- Sponsor
- University of Calgary