Clinical trials: sponsored by University of Calgary
Osteo Arthritis Knee, Analgesia
Comparing Local Anesthesia With and Without iPACK Block
Total knee arthroplasty is an effective surgical intervention for patients with chronic osteoarthritis commonly performed worldwide. Postoperative pain management has been a key focus in patient care for this procedure.
- Conditions
- Osteo Arthritis Knee, Analgesia, Pain, Postoperative
- Trial name
- NCT04635176
- Testing
- Real iPACK block (20 mL of 0.25% bupivacaine, 2.5mcg/mL epinephrine, and 50mcg/mL preservative-free dexamethasone)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Calgary
Diabete Mellitus, Kidney Disease
Clinical Information System Impact on Hospitalized Patients With Chronic Disease
This is a retrospective, observational study using routinely collected information collected by Alberta Health Services. The study will identify patients with chronic disease, defined by one or more of the following conditions…
- Conditions
- Diabete Mellitus, Kidney Disease, Heart Failure, Coronary Artery Disease
- Trial name
- NCT07609381
- Testing
- Clinical Information System (CIS) / Connect Care Implementation
- Where
- Canada
- Volunteers
- 124,240 people
- Sponsor
- University of Calgary
Utilization, Health Care
Re-Purposing the Ordering of 'Routine' Laboratory Tests in Hospitalized Medical Patients (RePORT Study)
Laboratory test overuse occurs when tests are ordered repetitively, without due consideration of impact on clinical status. Repetitive inpatient lab testing often provides limited value for patient outcomes while increasing…
- Trial name
- NCT06119464
- Testing
- Multimodal Intervention: Education, Multimodal Intervention: Audit and Feedback, Multimodal Intervention: Patient Engagement
- Where
- Canada
- Volunteers
- 251,817 people, healthy volunteers welcome
- Sponsor
- University of Calgary
ADHD
Investigating Health, Equity, and Resilience in Girls and Women With ADHD Across the Lifespan
The goal of this observational study is to generate a comprehensive, multi-dimensional dataset of health indicators collected from girls and women (aged 10 years and older) with and without ADHD across the lifespan.
- Trial name
- ADHD-Her (NCT07597707)
- Testing
- No Intervention: Observational Cohort
- Where
- Canada
- Volunteers
- 1,460 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection, Hemolytic-Uremic Syndrome
Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection
The objective of this study is to determine if early high volume intravenous fluid administration (hyperhydration) may be effective in mitigating or preventing complications of shiga toxin-producing E.
- Trial name
- HIKO-STEC (NCT05219110)
- Testing
- Infusion of 200% maintenance fluids as balanced crystalloid IV solution, Oral fluids; infusion of up to 110% maintenance fluids as balanced crystalloid IV solution
- Where
- 26 sites in United States, Canada
- Volunteers
- 1,040 people
- Sponsor
- University of Calgary
ARDS (Acute Respiratory Distress Syndrome)
Continuous vs Bolus Neuromuscular Blockade Regimens in Moderate to Severe Hypoxemic Respiratory Failure and ARDS (COBRA)
Current clinical guidelines, such as those from the Surviving Sepsis Campaign and ARDSNet, recommend short-term NMBA use for patients with moderate to severe ARDS who exhibit persistent ventilator dyssynchrony or high plateau…
- Trial name
- COBRA (NCT07567768)
- Testing
- Neuromuscular Blocking Agent - Bolus Dosing, Neuromuscular Blocking Agent - Continuous Infusion
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Surgery
Goal-Directed Therapy Following Cardiac Surgery
Pilot prospective randomized control trial comparing goal-directed therapy algorithm vs routine care in the intensive care unit following cardiac surgery.
- Trial name
- NCT05964374
- Testing
- Goal-directed therapy
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Obsessive-Compulsive Disorder, Anxiety Disorders
Pharmacogenetics of Antidepressant-Induced Disinhibition
The purpose of this study is to identify pharmacogenetic profiles associated with selective serotonin reuptake inhibitors (SSRI)-induced behavioral disinhibition in children with Major depressive disorder (MDD), anxiety disorders…
- Conditions
- Obsessive-Compulsive Disorder, Anxiety Disorders, Major Depressive Disorder, Antidepressant Drug Adverse Reaction
- Trial name
- PGx-AID (NCT03953014)
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of Calgary
Attention-Deficit/Hyperactivity Disorder (ADHD)
Finding Alternatives to Standard Treatment for Attention-Deficit Hyperactivity Disorder
Attention-Deficit/Hyperactivity Disorder (ADHD) is characterized by poor attention, impulsivity, hyperactivity and emotional-motivational dysregulation.
- Trial name
- FAST-ADHD (NCT04532190)
- Testing
- rTMS
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Acute Kidney Injury
UPTAKE - Virtual Care: Virtual Home Hospital With Remote Monitoring to Reduce Acute Care Hospitalization
Method: Randomized Controlled Trial Study Duration: 3 Years Study Centre(s) University of Calgary and University of Alberta Objectives: To fill care gaps by implementing strategies to reduce length of hospital stay, readmission…
- Trial name
- UPTAKE-VC (NCT06537453)
- Testing
- Virtual Care
- Where
- 2 sites in Canada
- Volunteers
- 354 people
- Sponsor
- University of Calgary
Chronic Kidney Disease, Coronary Artery Disease
Feasibility and Pilot Testing of "My Heart and CKD" Online Shared Decision Aid
Many people with kidney disease also have heart disease. The procedures used to diagnose and treat heart disease (e.g., angiograms, angioplasty, or surgery) can improve symptoms and cardiovascular outcomes, but pose greater risks…
- Trial name
- MyHeart&CKD (NCT06920927)
- Testing
- Decision aid
- Where
- 2 sites in Canada
- Volunteers
- 220 people
- Sponsor
- University of Calgary
Coronary Artery Disease, Patient Acceptance of Health Care
Implementing Individualized Patient Reported Outcome Measures in Routine Care of Patients With Coronary Artery Disease
Investigators recently developed the APPROACH electronic patient reported outcome (ePROM) Survey and Clinician Report tools to collect individual results from online quality of life and health status surveys for patients with…
- Conditions
- Coronary Artery Disease, Patient Acceptance of Health Care, Physician-Patient Relations
- Trial name
- NCT06164457
- Testing
- ePROM Survey
- Where
- 2 sites in Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Chronic Exertional Compartment Syndrome
Treatment of Lower Leg Anterolateral Chronic Exertional Compartment Syndrome With Intra-muscular Botulinum Injections.
The goal of this pilot triple-blind randomized clinical trial is to determine the effectiveness of intra-muscular botulism injection for treatment of lower leg anterolateral chronic exertional compartment syndrome (CECS).
- Trial name
- NCT05765071
- Testing
- Botulinum toxin A, Normal saline
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Mental Health Impairment
Pharmacogenetic Supported Prescribing in Kids
Implementation of pharmacogenetic testing for children and adolescents aged 6-24 who are starting or changing psychiatric medication.
- Trial name
- PGx-SParK (NCT04797364)
- Testing
- Pharmacogenetic Testing
- Where
- Canada
- Volunteers
- 6,000 people
- Sponsor
- University of Calgary
Chronic Kidney Disease, Diabetes (DM)
Moxie Self-Management and Education Support Program
Health education and self-management support are key facilitators of health behaviours. Moxie is a mixed media, self-management, education and support program for Albertans living with cardiovascular-related chronic conditions.
- Conditions
- Chronic Kidney Disease, Diabetes (DM), Heart Disease, Stroke
- Trial name
- NCT07280325
- Testing
- Moxie SMES Letters, Facilitated Relay Letter
- Volunteers
- 9,000 people
- Sponsor
- University of Calgary
Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19
CORONA (COvid pRONe hypoxemiA): Prone Positioning for Hypoxemic COVID-19 Patients With Do-not-intubate Goals
The purpose of this trial is to determine whether Prone Positioning (PP) improves outcomes for non-intubated hospitalized patients with hypoxemic respiratory failure due to COVID-19, who are not candidates for mechanical…
- Conditions
- Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19, Acute Respiratory Distress Syndrome, ARDS
- Trial name
- CORONA (NCT04402879)
- Testing
- Prone Positioning (PP)
- Where
- 4 sites in Canada
- Volunteers
- 596 people
- Sponsor
- University of Calgary
Postural Tachycardia Syndrome, Orthostatic Intolerance
Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome
The mechanism behind postural orthostatic tachycardia syndrome (POTS) involves many causes including a sympathetic nervous system problem.
- Trial name
- NCT04271878
- Testing
- RespirAct™ system (Thornhill Research Inc., Toronto, Canada)
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- University of Calgary
Postural Orthostatic Tachycardia Syndrome
Compression Garments in the Community With POTS
Compression Garments are a commonly prescribed treatment in Postural Orthostatic Tachycardia Syndrome (POTS). The effectiveness of a proof-of-concept compression garment has been demonstrated in an acute laboratory setting.
- Trial name
- COM-COM-POTS (NCT04881318)
- Testing
- Waist-High Compression Tights, Abdominal Compression Garments, Medications that modulate heart rate and blood pressure
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Acute Respiratory Distress Syndrome, Hypoxemic Respiratory Failure
Identification and Treatment of Hypoxemic Respiratory Failure and ARDS With Protection, Paralysis, and Proning Pathway
Treatment of patients with Hypoxemic respiratory failure (HRF) and Acute Respiratory Distress Syndrome (ARDS) is complex. Therapies that have been shown to save the lives of patients with HRF and ARDS are available but they are…
- Conditions
- Acute Respiratory Distress Syndrome, Hypoxemic Respiratory Failure, ARDS, Human
- Trial name
- NCT04744298
- Testing
- TheraPPP
- Where
- 17 sites in Canada
- Volunteers
- 19,916 people
- Sponsor
- University of Calgary
Postural Orthostatic Tachycardia Syndrome
CAlgary SAlt for POTS
Many patients with postural orthostatic tachycardia syndrome (POTS) have decreased plasma volume. Current POTS guidelines recommend ~10 g of salt and 2-3 L of fluid per day.
- Trial name
- CASA-POTS (NCT05924646)
- Testing
- Sodium Chloride Capsules, Microcystalline Cellulose Capsules
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary