Clinical trials: sponsored by University of Calgary
Concussion, Mild
Rapid, Accurate, Cost-effective Assessment of Blood Biomarkers for Diagnosis of Concussion
The goal of this observational study is to test if a biosensor can accurately measure a blood biomarker in adult patients presenting to the emergency department with concussion.
- Trial name
- RACE (NCT05588115)
- Where
- Canada
- Volunteers
- 225 people
- Sponsor
- University of Calgary
Atrial Fibrillation
Oral Amiodarone for Acute Cardioversion of Atrial Fibrillation Study
The investigators will seek to determine the safety and efficacy of high-dose amiodarone (2000mg), given as a single uniform oral dose, for the treatment of acute atrial fibrillation in both a hospital inpatient and ambulatory…
- Trial name
- AAA (NCT04594746)
- Testing
- Amiodarone Hydrochloride
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University of Calgary
Anxiety Disorders, Depression
Brain STimulation for ANxiety and Depression in Youth
In this open-label trial, the overall aim is to determine if TMS treatment can improve anxiety and depression in a broad group of children and youth referred by physicians.
- Trial name
- Brain STAND (NCT06892847)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University of Calgary
Vestibular Migraine
Exploring Mild Electrical Vestibular Stimulation as a New Treatment for Dizziness and Migraine Symptoms
Vestibular migraine is a common cause of repeated dizziness, imbalance, and headaches that affects about three percent of Canadians.
- Trial name
- NCT07368140
- Testing
- Electrical Vestibular Stimulation
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Evaluate PK Profile, Evaluate PD Profile
A Study Testing the Effects of Different THC Doses on Psychological and Biological Function
The goal of this clinical trial is to learn how a investigational medicinal product (THC) affects psychological and physical responses in healthy adults with prior cannabis use experience.
- Conditions
- Evaluate PK Profile, Evaluate PD Profile, Healthy Adults, Safety and Tolerability in Healthy Volunteers
- Trial name
- DRATT (NCT07346690)
- Testing
- AVCN319301b (6mg), AVCN319301b (9mg), AVCN319301b (15mg)
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Papillary Thyroid Cancer
Concordance of Molecular Classification Based on Fine Needle Biopsy (FNB) and Surgical Samples
The purpose of this study is to determine whether results from a fine needle biopsy are the same as results from a larger sample that is acquired from the surgical pathology using the Thyroid GuidePx® test in patients with…
- Trial name
- NCT06133374
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- University of Calgary
Depressed
Sensitivity to Ovarian Hormones and Depression in Adolescents
The goal of this observational study is to learn about the relationship between changes in ovarian hormones (estrogen and progesterone) and adolescent depression.
- Trial name
- SOHDA (NCT07317895)
- Where
- Canada
- Volunteers
- 94 people
- Sponsor
- University of Calgary
Cesarean Section, Dystocia
The REDUCED Trial: REDucing the Utilization of CEsarean Sections for Dystocia
This project is a clustered randomized controlled trial of a knowledge translation intervention of new ACOG guidelines for the diagnosis of poor progress in labor.
- Trial name
- REDUCED (NCT02874443)
- Testing
- Knowledge Translation of labor management guidelines
- Where
- Canada
- Volunteers
- 88,918 people
- Sponsor
- University of Calgary
Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Rupture
Altering Bone Microarchitecture and Mechanics by Off-label Pharmaceutical Intervention Following an Acute Knee Injury
The purpose of this study is to assess if a zoledronic acid injection can alter the trajectory of joint degeneration following an acute anterior cruciate ligament (ACL) injury.
- Conditions
- Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Injuries, Osteo Arthritis Knee
- Trial name
- ZAPOA (NCT05204836)
- Testing
- Zoledronic Acid Injection
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University of Calgary
Pregnancy Related, Venous Thromboembolism
PRospective Evaluation of Peripartum Anticoagulation ManaGement for ThrOmboembolism
The PREP and GO study is an international multicentre prospective cohort evaluating anticoagulation management strategies around labor and delivery and the postpartum period.
- Trial name
- PREP and GO (NCT05756244)
- Where
- 14 sites in United States, Canada and 3 more
- Volunteers
- 825 people
- Sponsor
- University of Calgary
Crohn's Disease of Both Small and Large Intestine
Ultrasound and Proteomics for Guselkumab Response Assessment in Crohn's Disease (UPGRADE).
The goal of this observational study is to evaluate the response of guselkumab in adult patients with Crohn's disease (CD) as measured on intestinal ultrasound (IUS), the relative quantities of CD64 in endoscopic tissue biopsies…
- Trial name
- UPGRADE (NCT07246460)
- Testing
- Guselkumab Subcutaneous
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University of Calgary
Healthy, Breast
Measuring Electrical Properties of Breast Tissues
The goal of this observational study is to use a low-powered microwave imaging system to provide insight into the correlation of electrical properties of breast tissue at microwave frequencies and breast density obtained from…
- Trial name
- NCT06157879
- Testing
- WVI-MIS-01-2022
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Stroke, Ischemic Stroke
Post-stroke REhabilitation Start Evaluation for Reducing Vascular Events
The purpose of this research study is to better understand when to start rehabilitation therapies after acute ischemic stroke to prevent further harm to the brain and to improve outcomes for stroke survivors.
- Trial name
- PRESERVE (NCT07212738)
- Testing
- Delayed mobilization (DeM), Standard Care (in control arm)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Cancer, Prostate Cancers
Sustainable Implementation of the EXCEL Exercise Oncology Program Across Canada
EXCEL will provide online and, where feasible, in-person exercise programs to individuals living with and beyond cancer (ILWBC).
- Conditions
- Cancer, Prostate Cancers, Breast Cancers, Colon Cancer
- Trial name
- EXCEL (NCT06960291)
- Testing
- Group Exercise Classes
- Where
- 5 sites in Canada
- Volunteers
- 740 people
- Sponsor
- University of Calgary
Perinatal Stroke, Hemiparetic Cerebral Palsy
Creating an Engaging BCI/FES Therapy for Children With Perinatal Stroke Using Social Media
The goal of this trial is to evaluate the feasibility of a brain-computer interface controlled functional electrical stimulation (BCI-FES) social media integrated system for children with hemiparetic cerebral palsy .
- Trial name
- NCT07133347
- Testing
- Brain computer interface controlled functional electrical stimulation therapy integrated with social media
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Calgary
Fibromyalgia
iTBS-DCS in Fibromyalgia
Background \& Rationale: Fibromyalgia is characterized by widespread pain, fatigue, mood and anxiety as well as cognitive complaints.
- Trial name
- NCT05395494
- Testing
- D-Cycloserine, iTBS repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Canada
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Femoroacetabular Impingement Syndrome
In-Season Prevalence and Management of Hip and Groin Injuries in Competitive Athletes
This study is focused on helping athletes with a common hip condition called femoroacetabular impingement (FAI) syndrome. FAI syndrome occurs when abnormal bone shapes around the hip joint cause friction during movement, leading…
- Trial name
- NCT07108647
- Testing
- Progressive Hip Strengthening Program, Progressive Muscle Relaxation
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Iron Deficiency
Effects of Iron Supplementation on Skeletal Muscle Properties in Females With Suboptimal Iron Storage
The goal of this clinical trial is to learn whether oral iron supplementation will increase skeletal muscle iron storage and its effects on exercise capacity in females with suboptimal iron status.
- Trial name
- MyoIRON (NCT07084298)
- Testing
- Oral iron supplement
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Essential Tremor
Developing a New LIFU Neuromodulation Method to Suppress Tremor
The investigators aim to apply low intensity focused ultrasound neuromodulation to patients with essential tremor to evaluate the efficacy of this intervention in reducing the amplitude of hand tremor compared to sham stimulation.
- Trial name
- NCT07103265
- Testing
- Transcranial focused ultrasound stimulation
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Sleep Disordered Breathing
Evaluation of a "Fast Track" Respiratory Therapy Clinic for Patients With Suspected Severe Sleep-Disordered Breathing
Access to medical care for patients with breathing disorders during sleep is a major problem for Canadians. Recently, there has been increasing interest in how health care providers who are not physicians can help to improve…
- Trial name
- NCT02191085
- Testing
- Fast Track
- Where
- Canada
- Volunteers
- 186 people
- Sponsor
- University of Calgary