Clinical trials: sponsored by University of Calgary
Length of Stay
Alberta Collaborative QI Strategies to Improve Outcomes of Moderate and Late Preterm Infants (ABC-QI Trial)
The ABC-QI Trial aims to implement collaborative quality improvement (QI) strategies to standardize care for 32-36 week infants in Level 2 and 3 Neonatal intensive care units (NICUs) across the province of Alberta.
- Trial name
- ABC-QI (NCT05231200)
- Testing
- QI Team Building, QI education, Standardized care bundle- respiratory care
- Where
- 12 sites in Canada
- Volunteers
- 9,500 people
- Sponsor
- University of Calgary
Mental Health, Mental Disorders
A Patient-Partnered, Pan-Canadian, Comparative Effectiveness Evaluation of an Acute Pediatric Mental Health and Addiction Care Bundle
The investigators will determine, in an 8-site, hybrid Type 1 cluster randomized effectiveness implementation trial, if an acute mental health care bundle, compared to standard care, improves wellbeing at 30 days in children and…
- Conditions
- Mental Health, Mental Disorders, Pediatrics, Emergency Psychiatric
- Trial name
- NCT04902391
- Testing
- Health Services
- Where
- 8 sites in Canada
- Volunteers
- 6,800 people
- Sponsor
- University of Calgary
Other Conditions of Brain
Roflumilast and TMS Motor Plasticity
Repetitive transcranial magnetic stimulation (rTMS) uses a magnetic field to non-invasively induce electrical function within the brain.
- Trial name
- NCT06457191
- Testing
- Roflumilast, Intermittent theta-burst stimulation transcranial magnetic stimulation, Continuous theta-burst stimulation transcranial magnetic stimulation
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Thoracic Aortic Aneurysm, Thoracic Aortic Dissection
Impact of Right Atrial Occlusion on TEVAR Outcomes
Though the application of thoracic endovascular aortic repair (TEVAR) for treatment of aortic pathology is expanding, there remains a gap in the literature examining how intraoperative "reduction or elimination of aortic impulse"…
- Conditions
- Thoracic Aortic Aneurysm, Thoracic Aortic Dissection, Thoracic Aorta Abnormality
- Trial name
- NCT06786351
- Testing
- Right atrial balloon occlusion, Non right atrial balloon occlusion
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Hypoxic Ischemic Encephalopathy (HIE)
Severity of Hypoxic Ischemic Encephalopathy and Neurological Pupil Index in Neonates
The goal of this observational study is to learn if the reactivity of a newborn's eye to light (measured as an index, using a new device -pupillometer) reflect the health of their brain recovering from disruption of blood/oxygen…
- Trial name
- SHINE (NCT07024771)
- Testing
- Automated Pupillometer
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Calgary
Prosthetic Joint Infections of Hip
Bacteriophage Therapy for Morganella Morganii Prosthetic Joint Infection
This is a single-patient, phase I/II clinical trial that aims to evaluate the potential of a bacteriophage drug product to treat and prevent the recurrence of a Morganella morganii prosthetic joint infection of the hip.
- Trial name
- PHAGE-MOM-001 (NCT06814756)
- Testing
- phage therapy
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Calgary
Prosthetic Joint Infections of Hip, Staphylococcus Aureus Infection
Bacteriophage Therapy for Methicillin-Sensitive Staphylococcus Aureus Prosthetic Joint Infection
This is a single-patient, phase I/II clinical trial that aims to evaluate the potential of a bacteriophage cocktail to treat and prevent the recurrence of a methicillin-susceptible Staphylococcus aureus prosthetic joint infection…
- Trial name
- PHAGE-2024-01 (NCT06456424)
- Testing
- Phage therapy
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Calgary
Cytomegalovirus Viremia, Cytomegalovirus Pneumonia
CMV-specific Donor-derived T Lymphocytes for the Treatment of Recalcitrant CMV Infection in a Patient With Primary Immunodeficiency
Treatment of CMV in a patient with profound combined immunodeficiency, who has viremia and pneumonia, using CMV-specific donor-derived T lymphocytes (CMV-VST).
- Conditions
- Cytomegalovirus Viremia, Cytomegalovirus Pneumonia, T-Lymphocyte Immunodeficiency
- Trial name
- NCT07015801
- Testing
- CMV-VST
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Calgary
Type 1 Diabetes Mellitus, Pregnancy Related
Closed-loop Insulin Delivery In Type 1 Diabetes Pregnancies (CIRCUIT)
This trial will assess the efficacy of the Tandem t:slim X2 insulin pump with Control IQ technology compared with standard insulin delivery plus CGM in pregnant women with type 1 diabetes.
- Conditions
- Type 1 Diabetes Mellitus, Pregnancy Related, Glucose Metabolism Disorders, Metabolic Disease
- Trial name
- CIRCUIT (NCT04902378)
- Testing
- Tandem t:slim X2 insulin pump with Control IQ technology
- Where
- 14 sites in Australia, Canada
- Volunteers
- 94 people
- Sponsor
- University of Calgary
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))
Development of a Novel Risk Prediction Tool for Emergency Department Patients Symptoms of Coronary Artery Disease
Patients with chest pain and symptoms of acute coronary syndromes (ACS) account for over 600,000 emergency department (ED) visits annually in Canada.
- Trial name
- NCT06743672
- Where
- Canada
- Volunteers
- 6,500 people
- Sponsor
- University of Calgary
Long COVID Fatigue
Exploring the Therapeutic Effects of Creatine Supplementation for Long COVID-19
Individuals living with Long COVID often experiencing a degree of undue fatigue after physical or cognitive exertion secondary to the condition, timed post-exertional malaise 9PEM).
- Trial name
- NCT06992414
- Testing
- Creatine monohydrate
- Volunteers
- 24 people
- Sponsor
- University of Calgary
Myocardial Infarction, Sudden Death
Efficacy of Implantable Defibrillator Therapy After a Myocardial Infarction
This study will assess whether an implantable defibrillator will increase the likelihood of survival in patients who have had a heart attack, have abnormal test results from a 24 hour heart monitor, and who have low normal heart…
- Trial name
- REFINE-ICD (NCT00673842)
- Testing
- Implantable Cardioverter Defibrillator + Usual Care, Usual care
- Where
- 79 sites in United States, Belgium and 13 more
- Volunteers
- 700 people
- Sponsor
- University of Calgary
Iron Deficiencies
A Novel Iron-Based Supplement for Athletes Aged 18-25: Phase II
Female endurance athletes are susceptible to iron deficiency and this can impact their exercise performance. This study aims to assess the efficacy of a novel iron supplement in improving iron status, gut microbiome, and exercise…
- Trial name
- NCT06269913
- Testing
- FeSC
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Iron Deficiencies
A Novel Iron-Based Supplement for Athletes Aged 14-17
Female endurance athletes are susceptible to iron deficiency and this can impact their exercise performance. This study aims to assess the efficacy of a novel iron supplement in improving iron status, gut microbiome, and exercise…
- Trial name
- NCT06338787
- Testing
- FeSC
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Depression in Adolescence
Pharmacogenetic-Guided Antidepressant Prescribing in Adolescents
This is a parallel arm randomized (1:1) controlled trial. Adolescents aged 12-17 years (n=452) who are starting or changing a selective serotonin reuptake inhibitor (SSRI) for depression will be randomly allocated to receive…
- Trial name
- PGx-GAP (NCT05965401)
- Testing
- Pharmacogenetic-guided dosing, GLAD-PC guided dosing
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- University of Calgary
Acute Gastroenteritis, Viral Illness
Multi-DOSE Oral Ondansetron for Pediatric Acute GastroEnteritis
A phase III, double-blind, parallel-design, randomized, placebo-controlled trial to compare multi-dose oral Ondansetron with placebo as treatment for vomiting secondary to acute gastroenteritis (AGE), after Emergency Department…
- Conditions
- Acute Gastroenteritis, Viral Illness, Vomiting, Diarrhea
- Trial name
- DOSE-AGE (NCT03851835)
- Testing
- Ondansetron Oral Solution
- Where
- 6 sites in Canada
- Volunteers
- 1,030 people
- Sponsor
- University of Calgary
Sleep
Non-invasive Vagus Nerve Stimulation and Sleep in Healthy Volunteers.
Participants will be chosen at random to receive a 30-minute stimulation of a specialized nerve (called a vagus nerve). The aim of this study is to determine whether a battery-operated portable device (current adjustable)…
- Trial name
- NCT06928441
- Testing
- Transcutaneous Pulsed Electrical Stimulation (Device: WL-2103A)
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Sarcoma, Alveolar Soft Part Sarcoma (ASPS)
CAR T Therapy With GCAR1 for Relapsed Alveolar Soft Part Sarcoma
A single patient study to determine whether GCAR1 is safe and effective for re-treatment of alveolar soft part sarcoma (ASPS) with GPNMB surface expression that has relapsed and is not responding to usual treatment.
- Trial name
- SPS-Q2 (NCT06813417)
- Testing
- GCAR1
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Calgary
Eustachian Tube Dysfunction, Barotitis
Efficacy of Balloon Dilation of the Eustachian Tube in Eustachian Tube Dilatory Dysfunction
This study is being conducted to learn more about a procedure, balloon dilation of the eustachian tube, in treating patients with eustachian tube dysfunction.
- Trial name
- NCT05719207
- Testing
- Balloon dilation of eustachian tube
- Where
- 2 sites in Canada
- Volunteers
- 76 people
- Sponsor
- University of Calgary
Sexual Function Disturbances, Pelvic Organ Prolapse
Postoperative Return to Sexual Activity
To determine if standardized counselling regarding first sexual encounter after pelvic reconstructive surgery for pelvic organ prolapse and / or urinary incontinence improves postoperative preparedness to return to sexual…
- Conditions
- Sexual Function Disturbances, Pelvic Organ Prolapse, Stress Urinary Incontinence, Surgery
- Trial name
- PoRS (NCT05342090)
- Testing
- Structured Counselling Tool
- Where
- Canada
- Volunteers
- 186 people
- Sponsor
- University of Calgary