Clinical trials: sponsored by University of Cincinnati
Hypertension
A Nutrition Intervention to Lower Blood Pressure in Adolescents
The purpose of this study is to evaluate the efficacy of a 12-week, clinic-based, behavioral nutrition intervention emphasizing fruits, vegetables, and low fat dairy compared to routine nutrition care on changing diet quality and…
- Trial name
- NCT00431288
- Testing
- diet high in fruits, vegetables, and dairy, Routine nutrition care
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Cincinnati
Chronic Pain
EMPOWER: Randomized Trial of Online Chronic Pain Management Program to Reduce Reliance on Opioid Analgesic Medications
This is a 10-month internet-based randomized controlled trial to evaluate whether an online chronic pain management program ("E-Health") can assist with reduced opioid reliance in chronic pain patients.
- Trial name
- NCT03308188
- Testing
- E-health program
- Where
- 2 sites in United States
- Volunteers
- 402 people
- Sponsor
- University of Cincinnati
Attention Deficit Hyperactivity Disorder
Neuroimaging Study of Risk Factors for Adolescent Bipolar Disorder
The main purpose of this study is to see the affects of the study medication called mixed amphetamine salts-extended release (MAS-XR) on brain function by taking brain pictures.
- Trial name
- NERF (NCT02478788)
- Testing
- mixed amphetamine salts-extended release (MAS-XR)
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Brain Metastasis
Evaluation of the Use of Trental and Vitamin E For Prophylaxis of Radiation Necrosis
The purpose of this study is to determine whether the use of Trental and Vitamin E can help reduce the incidence of radiation necrosis (a lesion that usually occurs at the original tumor site) after radiosurgery.
- Trial name
- NCT01508221
- Testing
- Trental, Vitamin E
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Cincinnati
Recurrent Diffuse Intrinsic Pontine Glioma
Hypofractionated Radiotherapy for Recurrent DIPG
This study evaluates the feasibility of hypofractionated radiotherapy (RT) in the palliative treatment of recurrent diffuse intrinsic pontine glioma (DIPG).
- Trial name
- NCT03841435
- Testing
- Hypofractionated Radiotherapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Cincinnati
Stroke, Chronic Stroke
Quantifying the Role of Sensory Systems Processing in Post-Stroke Walking Recovery
Despite current walking rehabilitation strategies, the majority of stroke survivors are unable to walking independently in the community and remain at increased risk of falls.
- Conditions
- Stroke, Chronic Stroke, Walking, Difficulty, Gait, Hemiplegic
- Trial name
- BLT2 (NCT04553198)
- Testing
- Backward Locomotion Treadmill Training (BLTT)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Cincinnati
Zenker Diverticulum, Progressive Dysphagia
Cricopharyngeal Dysfunction and Esophageal Diverticulum
Patients undergoing open transcervical or endoscopic approach in which a laser or stapler is used to divide the common wall between the diverticulum and esophagus, or who are not surgical candidates but agree to follow-up.
- Conditions
- Zenker Diverticulum, Progressive Dysphagia, Pharyngoesophageal Diverticulum
- Trial name
- NCT03187925
- Testing
- open, transcervical versus rigid endoscopic treatment
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Cincinnati
Colorectal Cancer
A Study of Amifostine (Ethyol) in Patients With Colorectal Cancer
The purpose of this study is to determine the effect of amifostine (ETHYOL) on decreasing the rate and severity of nerve dysfunction or neuropathy (numbness and tingling in hands and feet) associated with FOLFOX chemotherapy.
- Trial name
- NCT00601198
- Testing
- Amifostine
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Cincinnati
Hypoglycemia
Effect of Fasting on Insulin-induced Hypoglycemia Counterregulation in Healthy Humans
Iatrogenic hypoglycemia is still considered to be the number one barrier to effective glycemic control in patients with type 1 diabetes (T1D).
- Trial name
- NCT04392843
- Testing
- Fasting, Feeding
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Atrial Fibrillation
EHR-Embedded Decision Support to Prevent Stroke in Patients With AF
Background and Significance - Atrial fibrillation (AF) is the most common significant cardiac rhythm disorder and is a powerful common risk factor for stroke.
- Trial name
- NCT04099485
- Testing
- Electronic Health Record Best Practice Advisory
- Where
- United States
- Volunteers
- 608 people
- Sponsor
- University of Cincinnati
Pain, Postoperative
Liposomal Bupivacaine Versus Interscalene Nerve Block
The aim of this study is to compare two different pain management interventions in patients undergoing reverse total shoulder arthroplasty.
- Trial name
- NCT03929146
- Testing
- Exparel, Interscalene Nerve Block
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Weight, Body, Diet Habit
Healthy Start to Feeding Intervention
The current study will test the impact of a 3-session obesity prevention program targeting healthy introduction of solid foods in infancy on growth trajectories, appetite regulation, and diet.
- Trial name
- NCT03597061
- Testing
- Healthy Start to Feeding
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Degenerative Intervertebral Discs, Sciatic Radiculopathy
Eplerenone as a Supplement to Epidural Steroid Injections
Low back pain is a leading cause of disability and health care costs in the United States, and treatments are ineffective for many patients.
- Conditions
- Degenerative Intervertebral Discs, Sciatic Radiculopathy, Low Back Pain
- Trial name
- NCT03418649
- Testing
- Eplerenone 50 Mg Tab
- Where
- 2 sites in United States
- Sponsor
- University of Cincinnati
Diarrhea, COVID-19
Studies of COVID-19 Patients Treated With Oral Bismuth Subsalicylate (Pepto-Bismol)
The Center for Disease Control (CDC) and World Health Organization (WHO) have deemed the COVID-19 virus a global pandemic of unprecedented severity in modern times.
- Trial name
- SABER-C (NCT04811339)
- Testing
- Bismuth Subsalicylate 262 milligram (mg) Oral Tablet, Chewable
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Cincinnati
Femur Fracture
Efficacy of Hematoma Block on Postoperative Pain After Femoral Intramedullary Rodding: A Randomized Trial
The purpose of this study is to evaluate the efficacy of an intra-operative, post-fixation fracture hematoma block compared to saline control on postoperative pain control in patients with acute femoral shaft fractures.
- Trial name
- NCT04860856
- Testing
- 0.5% ropivacaine, Normal Saline
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Cincinnati
Cardiovascular Risk Factor, Stress
Stress-reduction Wellness Program for Midlife Black Women (B-SWELL)
This research study examines the unique cultural and gender-based factors that influence how midlife Black women experience stress and incorporate healthy lifestyle behaviors into daily life.
- Conditions
- Cardiovascular Risk Factor, Stress, Self Efficacy, Depressive Symptoms
- Trial name
- B-SWELL (NCT04404478)
- Testing
- B-SWELL: Midlife Black Women's Stress Reduction Wellness Program, WE: Wellness program for Midlife Black Women
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Lymphangioleiomyomatosis
Resveratrol and Sirolimus in Lymphangioleiomyomatosis Trial
RESULT is a phase II dose-escalating, open-label, safety and efficacy study to determine if there is a potential benefit of resveratrol in combination with sirolimus in patients with lymphangioleiomyomatosis (LAM).
- Trial name
- RESULT (NCT03253913)
- Testing
- Sirolimus, Resveratrol
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Cincinnati
Posttraumatic Stress Disorder
A Comparison of CPT Versus ART Versus WL
The purpose of this research study is to compare the effectiveness of two treatments for the symptoms of Posttraumatic Stress Disorder (PTSD) with a no therapy, wait-list control condition.
- Trial name
- NCT03384706
- Testing
- Cognitive Processing Therapy (CPT), Accelerated Resolution Therapy (ART)
- Where
- 2 sites in United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Bipolar Youth Treated With Second-generation Antipsychotics
SGA-induced Metabolic Syndrome in Bipolar Youth
The investigators tested the hypothesis that long-chain omega-3 (LCn-3) fatty acid supplementation will attenuate the adverse cardiometabolic effects of second-generation antipsychotics exposure in first-episode adolescent manic…
- Trial name
- NCT01858948
- Testing
- Omega, Quetiapine fumarate
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Cincinnati
Diabetes Mellitus, Type 2, PreDiabetes
iCan Diabetes Self-management and Prevention Program
The purpose of this study is to test the feasibility and preliminary efficacy of the iCan Diabetes Self-Management and Prevention Support Group using a single arm clinical trial.
- Trial name
- NCT05571436
- Testing
- iCan Diabetes Self-management and Prevention Support Group
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Cincinnati