Clinical trials: sponsored by University of Colorado, Denver
Chronic Pain, Back Pain
Psychological Options for Wellness and Recovery (POWeR) Trial for Veterans With Chronic Back/Neck Pain
The goal of this clinical trial is to learn which treatment works better for veterans with chronic neck or back pain. This study is comparing three treatments: Pain Reprocessing Therapy (PRT), Cognitive Behavioral Therapy (CBT)…
- Conditions
- Chronic Pain, Back Pain, Back Pain Lower Back Chronic, Neck Pain
- Trial name
- POWeR (NCT07137715)
- Testing
- Pain reprocessing therapy (PRT), Cognitive Behavioral Therapy for Chronic Pain (CBT-CP), Usual Care
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- University of Colorado, Denver
Breast Cancer
Promoting Informed Choice for Breast Cancer Screening
Identify the prevalence and predictors of reactance, self-exemption, disbelief, source derogation in reaction to evidence about mammography benefits and harms, and consequences for decision-making and trust.
- Trial name
- NCT05376241
- Testing
- Decision aid
- Where
- United States
- Volunteers
- 637 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes
Sleep Screening and Intervention for Adolescents With Type 1 Diabetes in a Clinical Diabetes Center
This study is evaluating an in-clinic sleep screening and intervention algorithm for youth with type 1 diabetes. This study will assess health care provider feasibility of completion of intervention and long term follow up for…
- Trial name
- NCT07494188
- Testing
- Sleep intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Metastatic Endometrial Cancer
Rucaparib vs Placebo Maintenance Therapy in Metastatic and Recurrent Endometrial Cancer
This study seeks to determine the effectiveness of Rucaparib as maintenance therapy for metastatic and recurrent endometrial cancer, after 1-2 prior lines of therapy.
- Trial name
- NCT03617679
- Testing
- Rucaparib
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- University of Colorado, Denver
Overweight and Obesity
Early vs. Late Time Restricted Eating vs. Daily Caloric Restriction
The goal of this clinical trial is to learn about time restricted eating as a weight loss intervention in adults with obesity. The main questions it aims to answer are: 1.
- Trial name
- Time2Eat (NCT05870982)
- Testing
- Early TRE, Late TRE, DCR
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Knee Osteoarthritis
Evaluating Changes in Synovial Fluid Before and After GAE for Knee Osteoarthritis
The goal of this clinical trial is to learn if genicular artery embolization (GAE) can improve knee pain and decrease inflammation in adults with knee osteoarthritis.
- Trial name
- GAE-KOA (NCT06940479)
- Testing
- GAE procedure
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Colorado, Denver
Partial-thickness Burn, Pain
Banana Leaves as a Wound Dressing for Partial Thickness Second Degree Burns in Adult Patients.
This study plans to look at the benefits of banana leaves as a primary burn wound dressing. Study patients will be compared to historical patients
- Conditions
- Partial-thickness Burn, Pain, Second Degree Burn
- Trial name
- NCT07453732
- Testing
- Banana leaf dressing
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Colorado, Denver
Craniopharyngioma, Child
Prospective Pilot Study Identifying Clinically Relevant Biological Targets for Medical Therapy
New data suggests that the current treatment for pediatric adamantinomatous craniopharyngioma (CPA) may not be as effective as it could be.
- Trial name
- NCT03610906
- Testing
- Tumor and Blood Specimens
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes, Overweight and Obesity
Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes
The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and…
- Trial name
- REACH (NCT04791371)
- Testing
- Cardiovascular exercise
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Anxiety in Pregnancy, Mood Disorder Due to Specified Medical Condition
Preventing Maternal Mood, Anxiety, and Trauma Symptoms After Cesarean Delivery
Perinatal mental health disorders are the most prevalent perinatal comorbidity and are associated with the primary cause of maternal mortality in the United States (US) - suicide.
- Trial name
- NCT06949813
- Testing
- BE-OR: Brief Intervention to the Operating Room, Interaction: Facetime with Clinical Provider
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Overweight/Obesity
Snacking Effects on the Brain Response to Foods and Satiety During Dieting
This study plans to learn more about how different types of snacks may affect brain processes relating to eating behaviors during a diet intervention.
- Trial name
- NCT07428187
- Testing
- Snack Type 1: Walnuts, Snack Type 2: Pretzels
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Colorado, Denver
HNSCC
Alpha Lipoic Acid to Decrease Pain and Side Effects in Concurrent Treatment of HNSCC
This is a phase I, single-center, non-randomized, 3+3 dose-escalation study of alpha lipoic acid given during chemotherapy-radiation in HNSCC patients with non-metastatic disease.
- Trial name
- NCT04042935
- Testing
- Alpha Lipoic Acid
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Colorado, Denver
Pelvic Cancer
Pediatric Oncology Recovery Trial After Surgery
Pediatric Oncologic Recovery Trial After Surgery (PORTS) trial is an investigator-initiated, multicenter, multidisciplinary prospective case-control study of the implementation of an Enhanced Recovery After Surgery (ERAS)…
- Trial name
- PORTS (NCT04344899)
- Testing
- Observational
- Where
- 3 sites in United States
- Volunteers
- 74 people
- Sponsor
- University of Colorado, Denver
Acute Lymphoid Leukemia, Acute Lymphoblastic Leukemia
UCD19 CAR T Therapy in Adults With B-ALL and MRD Positivity in CR1
This open-label, single arm Phase 1/1b trial aims to determine the safety and tolerability of anti-CD19 chimeric antigen receptor-expressing (CAR) T cells (UCD19 CAR T) in adults with B-ALL that are in first complete remission…
- Trial name
- NCT05535855
- Testing
- CD19 Directed CAR T Cell
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Colorado, Denver
Fractures, Open, Wounds and Injuries--Infections
Acute Application of Antibiotic Powder in Open Fracture Wounds
The purpose of this study is to help determine the best treatment for severe injures like open fracture wounds. Some broken bone injuries can be more likely to get an infection. It is mostly due to the way they were injured.
- Conditions
- Fractures, Open, Wounds and Injuries--Infections, Anti-Bacterial Agents, Fractures, Bone
- Trial name
- APOW (NCT04872400)
- Testing
- Vancomycin, Tobramycin
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 1
Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes
This trial plans to learn more about the effects of a medication, semaglutide, on cardiovascular function, kidney function, and insulin sensitivity in adults with type 1 diabetes.
- Trial name
- T1-DISCO (NCT05819138)
- Testing
- Semaglutide Pen Injector
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
HIV Treatment, HIV Prevention
HIV Outpatient Monitoring Evaluation Through Self-collection of Dried Blood Spots
The goal of this observational study is to establish an operational framework for home self-collections of blood samples to be used for antiviral drug concentration measurements.
- Trial name
- HOME-1 (NCT04979728)
- Testing
- At Home Self-Collections
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Denver
Hyperglycemia
Feasibility of CGM Use in Hospitalized Youth
This study is assessing the feasibility of a continuous glucose monitor during hospital admissions in youth and young adults with hyperglycemia due to diabetes or other underlying conditions that requires frequent glucose…
- Trial name
- NCT06143202
- Testing
- Freestyle Libre 3 Continuous Glucose Monitor
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
Obesity, Infertility
Reprometabolic Syndrome Mediates Subfertility in Obesity
Obesity plays an adverse role at every stage of conception and pregnancy and mounting evidence implicates relative hypogonadotropic hypogonadism, and reduced menstrual cycle hormone secretion as likely contributors to the…
- Conditions
- Obesity, Infertility, Hypogonadotropic Hypogonadotropism, Hyperinsulinemia
- Trial name
- NCT02653092
- Testing
- Insulin, Intralipid, Dextrose
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hodgkin Lymphoma, Non Hodgkin Lymphoma
Impact of Respiratory Training in Lymphoma Survivors
High-resistance inspiratory muscle strength training (IMST) is a time-efficient (~5 minutes/day) form of exercise that employs an affordable, handheld device which impedes inspiratory breathing to train the diaphragm and…
- Trial name
- NCT05938127
- Testing
- Inspiratory muscle strength training
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- University of Colorado, Denver