Clinical trials: sponsored by University of Colorado, Denver
Pneumocystis Jirovecii Infection, Pneumocystis
Prospective Observational Study on the Incidence of Opportunistic Fungal Infections
Corticosteroids exposure is a common risk factor for invasive fungal infections. Systemic corticosteroid therapy treats several medical conditions, including rejection in solid organ transplant recipients, malignancy, and…
- Conditions
- Pneumocystis Jirovecii Infection, Pneumocystis, Cryptococcosis, Candidiasis
- Trial name
- NCT05707156
- Where
- United States
- Volunteers
- 12,032 people
- Sponsor
- University of Colorado, Denver
Obesity
Prevention of Obesity in Women Via Estradiol Regulation
The purpose of this study is to evaluate potential mechanisms by which estradiol deficiency accelerates fat gain and abdominal fat accumulation in women.
- Trial name
- POWER (NCT00687739)
- Testing
- leuprolide acetate, Estradiol Transdermal, progressive resistance exercise training
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type1 Diabetes Mellitus, Diabetes Mellitus, Type 1
MEtabolic and Renal Effects of AutoMAted Insulin Delivery Systems in Youth With Type 1 Diabetes Mellitus
In type 1 diabetes (T1DM), automated insulin delivery (AID) systems such as the hybrid closed loop artificial pancreas (HCL AP) combine the use of an insulin pump, continuous blood sugar monitor, and control algorithm to adjust…
- Conditions
- Type1 Diabetes Mellitus, Diabetes Mellitus, Type 1, Autoimmune Diabetes, Juvenile Diabetes
- Trial name
- MERMAID-T1D (NCT03945747)
- Testing
- Blood draw, Urine sample collection, DXA scan
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Pediatric Obesity, Healthy Eating
Childhood Obesity Treatment Designed for Low Income and Hispanic Families
This study is a type-1 hybrid effectiveness-implementation RCT comparing a novel family-inclusive childhood obesity treatment program, the "Healthy Living Program" (HeLP), to a protocol that enhances usual primary care to deliver…
- Conditions
- Pediatric Obesity, Healthy Eating, Physical Activity, Minority Health
- Trial name
- NCT05041855
- Testing
- The Healthy Living Program/La Vida Saludable, Recommended Treatment of Obesity in Primary Care
- Where
- 2 sites in United States
- Volunteers
- 554 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Opioid-use Disorder, Chronic Pain
Advancing STOP: Self-regulation Therapy for Opioid Addiction and Pain
The public health relevance of this proposed project is substantial given the current opioid abuse epidemic as identified by the Centers for Disease Control (CDC).
- Trial name
- NCT03363243
- Testing
- STOP Therapy Treatment group, Treatment as usual (TAU) group
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Colorado, Denver
Child Abuse
Fostering Healthy Futures Efficacy Trial for Preadolescent Youth in Foster Care
This is a multi-county randomized controlled trial of the Fostering Healthy Futures (FHF) preventive intervention program (consisting of mentoring and skills groups) with 256 maltreated preadolescent youth in out-of-home care.
- Trial name
- NCT00810056
- Testing
- Assessment, Fostering Healthy Futures (FHF)
- Where
- United States
- Volunteers
- 426 people
- Sponsor
- University of Colorado, Denver
Menopause, Estrogen Deficiency
Ovarian Hormone Regulation of Central and Cerebrovascular Hemodynamics (NoMEN Study)
This study will evaluate changes in blood vessels around the heart (e.g., aorta and carotid arteries) and in the brain with the loss of female sex hormones (e.g., estrogen) during the menopause transition.
- Conditions
- Menopause, Estrogen Deficiency, Women, Aging
- Trial name
- NCT05057546
- Testing
- GnRH antagonist
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Alcohol Withdrawal, Substance Use Disorders
NCARE, Transition to Recovery
This study tests the effectiveness of patient navigation for increasing enrollment in substance abuse treatment programs and preventing readmission to detoxification.
- Trial name
- NCT03737864
- Testing
- Patient navigation, Motivational interviewing (MI)
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- University of Colorado, Denver
Prostate Cancer
A Study of Grape Seed Extract in Asymptomatic Non-Metastatic Prostate Cancer Patients With Rising PSA
Patients will take 150 mg of GSE product by mouth twice daily and will be evaluated every 6 weeks for 3 months, then every 3 months thereafter for up to one year.
- Trial name
- NCT03087903
- Testing
- Grape Seed Extract
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Implementing Continuous Glucose Monitoring in Primary Care for Patients With Diabetes
The overarching goal of this study is to decrease disparities and increase access to continuous glucose monitoring (CGM) for patients with diabetes, regardless of where people receive their diabetes care.
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Continuous Glucose Monitoring
- Trial name
- PREPARE4CGM (NCT05336214)
- Testing
- Virtual CGM initiation service, Online educational module on CGM, Practice facilitation
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- University of Colorado, Denver
Idiopathic Pulmonary Fibrosis (IPF)
The Genetics of Pulmonary Fibrosis
This study seeks to screen first degree family members of people with Idiopathic Pulmonary Fibrosis (IPF) for the earliest signs of lung fibrosis.
- Trial name
- NCT03478553
- Testing
- Blood draw, Questionnaire
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Aging, Menopause
MitoQ and Exercise Effects on Vascular Health
An impairment in vascular function can lead to the development of age-associated cardiovascular disease (CVD), the leading cause of death in postmenopausal women.
- Trial name
- MITO-STEP (NCT05686967)
- Testing
- MitoQ, Aerobic exercise
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Non-Small Cell Lung Cancer
Pulmonary Physiology and Systemic Inflammatory in EO Pulmonary Events With Brigatinib Use in NSCLC and Other Diseases
To estimate the incidence of Early Onset Pulmonary Events (EOPEs), defined as the proportion of participants with a peak reduction in DLCO of 20% or greater after commencing brigatinib at 90mg QD.
- Trial name
- NCT03389399
- Where
- 5 sites in United States, Canada
- Volunteers
- 18 people
- Sponsor
- University of Colorado, Denver
IPF, Pulmonary Fibrosis
Advancing Prevention of Pulmonary Fibrosis
This study plans to learn more about pulmonary fibrosis and how it develops. We want to determine if the disease can be detected early, before the lung is permanently scarred.
- Conditions
- IPF, Pulmonary Fibrosis, ILD
- Trial name
- APPLe (NCT04564183)
- Testing
- Sample collection, Questionnaires, High resolution CT scan of the chest
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Polycystic Ovarian Syndrome, Obesity
Oral Amino Acid Nutrition to Improve Glucose Excursions in PCOS
The Investigators will measure hepatic glucose and fat metabolism in obese girls with Polycystic Ovarian Syndrome (PCOS) and hepatic steatosis (HS) after taking 4 weeks of an essential amino acid (EAA) supplement or placebo and…
- Conditions
- Polycystic Ovarian Syndrome, Obesity, Hepatic Steatosis
- Trial name
- ORANGE (NCT03717935)
- Testing
- Essential Amino Acid (EAA) Supplement
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes, Cardiovascular Diseases
Impact of SomaSignal Tests on the Choice of Glucose-lowering Medications
The purpose of this study is to learn more about using a proteomic test called the SomaSignal Cardiovascular (CV) Risk Test in Type 2 Diabetes (CVD-T2D) to improve medical care for patients.
- Trial name
- NCT05166382
- Testing
- Informed of results from SomaSignal Cardiovascular Risk Test in Type 2 Diabetes (CVD-T2D), Not informed of results from SomaSignal Cardiovascular Risk Test in Type 2 Diabetes (CVD-T2D)
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes, Chronic Inflammation
Comparing Semaglutide Versus Placebo on Intestinal Barrier Function in Type 2 Diabetes Mellitus (SIB)
This study plans to learn more about the effect of semaglutide once weekly on intestinal permeability in individuals with type 2 diabetes.
- Conditions
- Type 2 Diabetes, Chronic Inflammation, Intestinal Permeability
- Trial name
- SIB (NCT04979130)
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Colorado, Denver
Parkinson Disease
Adaptive DBS to Offset STN Dysregulation During Exercise in PD
The investigators conduct a prospective study to evaluate the effects of exercise on Parkinson's Disease brain biomarkers detected with the PerceptTM PC neurostimulator.
- Trial name
- NCT06296810
- Testing
- aDBS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Parkinson Disease, Idiopathic, Parkinson Disease
LFP Sensing From Directional Leads in the Acute Clinical Setting
This study plans to learn more about the optimal way to program the Medtronic Deep Brain Stimulation system in patients with Parkinson's Disease.
- Trial name
- NCT06872203
- Testing
- Deep brain stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Eosinophilic Esophagitis
Dupilumab Versus Topical Corticosteroid Effectiveness - Comparison in the Treatment of Stenotic EoE
The goal of this clinical trial is to [primary purpose: e.g., learn if intervention or health behavior can treat, prevent, diagnose etc.] in [describe participant population/primary condition; could include any of the following…
- Trial name
- DeTECTS (NCT06705387)
- Testing
- Dupilumab, Fluticasone
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Colorado, Denver
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