Clinical trials: sponsored by University of Colorado, Denver
Sepsis, Septic Shock
Implementation Trial of Predictive Modeling to Enhance Diagnosis and Improve Treatment in Pediatric Septic Shock
This study is a prospective, stepped-wedge implementation trial to test the effects of implementing a Clinical Decision Support (CDS) tool for prediction of septic shock in four Emergency Departments within a pediatric healthcare…
- Conditions
- Sepsis, Septic Shock, Emergencies
- Trial name
- NCT05065333
- Testing
- Septic Shock Clinical Decision Support, Clinical Diagnosis Only
- Where
- United States
- Volunteers
- 1,345 people
- Sponsor
- University of Colorado, Denver
Hypogonadotropic Hypogonadism
Low Energy Availability and Pituitary Function (LEAP Study)
The purpose of this study is to learn more about reproductive hormones and if they change in response to 5-days eating an individualized, standardized diet at two levels: energy balance and low energy intake.
- Trial name
- LEAP (NCT05808647)
- Testing
- 5-day controlled metabolic dietary intake
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Heart Failure, Renal Failure
Personalized Experiences to Inform Improved Communication for Patients With Life Limiting Illness
Disparities in palliative care for patients with serious illness exist because of gaps in knowledge around patient centered psychological, social, and spiritual palliative care interventions.
- Trial name
- NCT04118569
- Testing
- Narrative Intervention
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Colorado, Denver
Polycystic Kidney, Autosomal Dominant
Time Restricted Feeding in Autosomal Dominant Polycystic Kidney Disease
The proposed research will determine the feasibility of a time restricted feeding intervention,a fasting regimen that restricts eating to a feeding window (8 hrs/day) for 1 year in adults with autosomal dominant polycystic kidney…
- Trial name
- NCT04534985
- Testing
- Dietary
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Colorado, Denver
Burnout, Self-compassion
Better Together: an Online Physician Coaching Program for Medical Trainees
This is a single-institution randomized controlled trial. 101 female residents were recurited from the University of Colorado School of Medicine.
- Conditions
- Burnout, Self-compassion, Moral Injury, Impostor Phenomenon
- Trial name
- NCT05280964
- Testing
- Better Together Physician Coaching
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity
Adaptive Responses to Overfeeding and Weight
To more effectively address the problem of weight regain following weight loss for obese individuals, this study will evaluate the underlying biology of the reduced obese state.
- Trial name
- ARrOW (NCT03857048)
- Testing
- Weight Loss, Exercise training, Overfeeding
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Alzheimer Disease, Healthy Aging
Amyloid Imaging With 11C-PiB in Healthy Aging and Mild Cognitive Impairment
The purpose of this study is to measure the amount of amyloid in the brain. Amyloid is a protein found in the brain of patients with Alzheimer's disease and can be detected using a Positron Emission Tomography (PET) scan.
- Trial name
- NCT04505735
- Testing
- 11C-PiB
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Alcohol Use Disorder
In Hospital IM Naltrexone: A Pilot Study
This is a study in-hospital administration of injectable naltrexone vs. oral naltrexone. This is a pilot study to assess provider's and patient's acceptability to be randomized to oral vs.
- Trial name
- IM-NTX (NCT05087771)
- Testing
- injectable naltrexone, oral naltrexone
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Colitis, Ulcerative
Therapeutic Modulation of the Intestinal Creatine Kinase System in Inflammatory Bowel Disease (IBD)
This study plans to learn more about the effects that creatine monohydrate has on disease activity in ulcerative colitis. Creatine is a substance that is naturally produced by the body and is found in foods, such as meat and…
- Trial name
- NCT02463305
- Testing
- Creatine monohydrate
- Where
- United States
- Sponsor
- University of Colorado, Denver
Post Deployment Related Asthma, Asthma
Study to Improve Deployment Related Asthma by Using L-Citrulline Supplementation
Service men and women returning from deployment are significantly more likely to develop asthma and severe respiratory symptoms from airway obstruction.
- Trial name
- SEALS (NCT05259904)
- Testing
- L-citrulline
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Colorado, Denver
Cancer
Creative Arts Therapy (CAT) in the Center for Cancer and Blood Disorders
The purpose of the study is to evaluate the effectiveness of Creative Arts Therapy (CAT) on pediatric patients undergoing chemotherapy in the Infusion Center at Children's Hospital Colorado Center for Cancer and Blood Disorders.
- Trial name
- NCT04208243
- Testing
- Creative Arts Therapy
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- University of Colorado, Denver
Eosinophilic Esophagitis
Non-endoscopic Tracking of Disease Activity in Eosinophilic Esophagitis
To prospectively determine the natural history of inflammation resolution following initiation of diet treatment and to optimize the diet treatment of patients with EoE through the use of a non-endoscopic tracking device, the…
- Trial name
- NCT03834298
- Testing
- Four Food Elimination Diet
- Sponsor
- University of Colorado, Denver
Cystic Fibrosis
Glycemic Monitoring in Cystic Fibrosis
Current guidelines on the diagnoses and management of cystic fibrosis (CF) related diabetes recommend treatment for diabetes based on diagnostic criteria derived from adults with type 2 diabetes.
- Trial name
- GEM (NCT02211235)
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cystic Fibrosis-related Diabetes, Cystic Fibrosis Pulmonary Exacerbation
Sensor Augmented Pump (SAP) Therapy for Inpatient CFRD Management
This research proposes a pilot study using the combination of continuous glucose monitor (CGM) and insulin pump therapy, also known as sensor augmented pump (SAP) therapy, for cystic fibrosis related diabetes (CFRD) management in…
- Conditions
- Cystic Fibrosis-related Diabetes, Cystic Fibrosis Pulmonary Exacerbation, Cystic Fibrosis in Children
- Trial name
- NCT03939065
- Testing
- Sensor Augmented Pump Therapy, Standard of Care with CGM
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Colorado, Denver
Meditation, Pain
Study of Affect Induction for Lab Induced Pain in Healthy Undergraduates
The goal of this clinical trial is to test if a mindfulness-enhanced positive affect induction (MPAI) works well to reduce pain intensity and pain unpleasantness from a cold water pain test in undergraduate college students who…
- Conditions
- Meditation, Pain, Mindfulness, Affect
- Trial name
- NCT05619419
- Testing
- Mindfulness-enhanced positive affect induction, Breathing Meditation
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Gestational Weight Gain
My Baby My Move A Community Wellness Intervention
My Baby, My Move+ (2019-2021) is a peer-led wellness intervention which aims to reduce excessive gestational weight gain (EGWG) by targeting prenatal physical activity, mood, and sleep quality.
- Trial name
- MBMM+ (NCT04294095)
- Testing
- My Baby My Move +, Control
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes Mellitus
Diabetes Autoimmunity Study in the Young
Type 1 diabetes (T1D) affects 1.4 million people in the U.S. and its incidence has doubled over the past 20 years. The Diabetes Autoimmunity in the Young Study (DAISY) will estimate overall burden of T1D and other autoimmune…
- Trial name
- DAISY (NCT03205865)
- Volunteers
- 2,700 people
- Sponsor
- University of Colorado, Denver
Covid19
Lung Ultrasound Implementation in the Management of Patients Hospitalized With COVID-19
Lung ultrasound (LUS) has also been shown to be more accurate than chest x-ray in identifying pulmonary consolidation and pulmonary edema, both of which are found in patients with COVID.
- Trial name
- NCT04542421
- Testing
- Lung ultrasound use in patients hospitalized with COVID
- Where
- United States
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Food Preferences
Improving Protein Intake in Older Adults
To evaluate whether or not high quality protein intake from a mixed meal can be increased by using culinary herbs and spices to increase flavor intensity and food item liking in older adults.
- Trial name
- NCT05175391
- Testing
- Meat based protein with added spice; Plant based protein with added spice
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pulmonary Hypertension, Preterm Infant
Registry of Preterm Newborns With Severe Pulmonary Hypertension
The purpose of this prospective research registry is to collect data on treatment strategies and outcomes for premature newborns with severe pulmonary hypertension (PH).
- Trial name
- NCT03310346
- Where
- United States
- Volunteers
- 232 people
- Sponsor
- University of Colorado, Denver