Clinical trials: sponsored by University of Colorado, Denver
Pancreatic Cancer
A Dose Escalation Trial of SBRT After Induction Chemotherapy for Locally Advanced Pancreatic Cancer
This is a dose escalation trial to evaluate the safety of stereotactic body radiotherapy (SBRT) delivered in 3 fractions for patients with locally advanced pancreatic cancer (LAPC) who have received induction chemotherapy…
- Trial name
- NCT02873598
- Testing
- FOLFIRINOX or gemcitabine/abraxane, SBRT
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Colorado, Denver
Chronic Disease
A Mobile Intervention Merging Yoga and Self-Management Skills
Chronic disease self-management interventions and meditative movement approaches (.e.g., yoga) can independently improve depressive symptoms.
- Trial name
- MYSkillsMobile (NCT04758312)
- Testing
- MY-Skills Mobile
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Triple Negative Breast Cancer, Locally Advanced Breast Cancer
Radiotherapy in Combo With Chemo and Immunotherapy in Patients With PD-L1 Positive Metastatic TNBC
Patients with locally advanced unresectable or metastatic programmed cell death ligand (PD-L1) positive triple negative breast cancer (TNBC) will be treated with radiation to one-four sites of metastasis amenable to radiation…
- Conditions
- Triple Negative Breast Cancer, Locally Advanced Breast Cancer, Unresectable Breast Carcinoma, Metastatic Breast Cancer
- Trial name
- NCT05233696
- Testing
- Nab-paclitaxel, Paclitaxel, Radiation Therapy
- Where
- United States
- Sponsor
- University of Colorado, Denver
Overweight/Obesity
Reducing Diabetes Risk Factors in American Indian Children: Tribal Turning Point
This study will evaluate a behavioral intervention designed to reduce risk factors for type 2 diabetes in American Indian youth aged 7-10 years.
- Trial name
- TTP (NCT03573856)
- Testing
- Active Living, Health and Safety
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Covid-19, Deconditioning
Predictors of Recovery and the App-Facilitated Tele-Rehabilitation (AFTER) Program for COVID-19 Survivors
The aim of this study is to investigate the feasibility (safety, adherence) and initial efficacy (physical function and patient reported outcomes) of a multicomponent tele-rehabilitation program during COVID-19 recovery of…
- Trial name
- AFTER (NCT04663945)
- Testing
- Biobehavioral Tele-rehabilitation Sessions
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Colorado, Denver
Lung Transplant Rejection
Longitudinal Study of Cell Free DNA in Lung Transplant
Lung transplant is a viable treatment strategy for many with end-stage lung diseases. Despite advances in both the surgical and medical management, lung transplant recipients experience episodes of allograft insult and injury…
- Trial name
- LoSt (NCT04234919)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Colorado, Denver
Caries,Dental
Diagnostic Ability of Near Infrared Transillumination Detecting Interproximal Caries as Compared to Conventional Bitewing Radiographs
Specific Aims 1. To determine the diagnostic efficacy of CariVu and BWX for detecting interproximal carious lesions in primary dentition BWX and CariVu images will be taken in random order.
- Trial name
- NCT05362461
- Testing
- Near Infrared Transillumination
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Obesity
Pilot Study of Time Restricted Feeding as a Weight Loss Intervention
The circadian timing of Energy Intake (EI) has emerged as a key factor in the regulation of body weight. Studies have suggested that eating later in the evening or at night when the circadian system is promoting sleep adversely…
- Trial name
- NCT03571048
- Testing
- Reduced Calorie Diet (RCD), Time Restricted Feeding (TRF)
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Brain Metastases, Lung Cancer
Brigatinib Before Brain Irradiation Trial (B3i Trial)
This is a single arm phase II study of brigatinib alone for patients with brain metastases from anaplastic lymphoma kinase (ALK) positive non-small cell lung cancer (NSCLC), who have either not been treated previously with a…
- Trial name
- NCT04634110
- Testing
- Brigatinib
- Where
- 3 sites in United States
- Volunteers
- 1 people
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes
Barriers to Physical Activity in People With Type 2 Diabetes
The investigators plan to learn more about how different levels of exercise feel to people with Type 2 Diabetes and how it feels to people without Type 2 Diabetes.
- Trial name
- Rxercise (NCT01701570)
- Testing
- Supervised Exercise Training
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes
What Makes Exercise Feel More Difficult to Women With and Without Type 2 Diabetes
Given that sedentary behavior is associated with T2DM, the purpose of this study is to evaluate whether subjects with T2DM have a significant disincentive to performing exercise (due to greater perceived effort) .
- Trial name
- ExPRESS (NCT00785005)
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Non-Small Cell Lung Cancer
Detection of Resistance Mechanisms in Cerebrospinal Fluid for EGFR-mutant, ALK- and ROS1-rearranged
To determine the detection rate of driver oncogenes and resistance mechanisms in cerebrospinal fluid (CSF) for patients with CNS progression (with or without extra-CNS (eCNS) progression) and concordance with plasma/tissue
- Trial name
- NCT05116618
- Testing
- InVisionFirst-Lung ctDNA assay
- Where
- 3 sites in United States
- Sponsor
- University of Colorado, Denver
Feeding Behavior, Obesity
Neuronal and Behavioral Effects of Implicit Priming in Obese Individuals
The overall goals of this project are to determine the impact of an implicit priming intervention, designed to alter food perceptions, on both brain responses to food and on food intake behaviors in overweight/obese individuals.
- Conditions
- Feeding Behavior, Obesity, Overweight
- Trial name
- NCT02347527
- Testing
- Active Implicit Priming, Control Implicit Priming
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Peritoneal Dialysis Complication, Hyperphosphatemia
Effect of Velphoro on Serum Phosphate and Albumin in Peritoneal Dialysis Patients
Prospective pilot study to determine if changing the phosphate binder to sucroferric oxyhydroxide for for 6 months improves disordered mineral metabolism and nutrition status in peritoneal dialysis patients.
- Conditions
- Peritoneal Dialysis Complication, Hyperphosphatemia, Hypoalbuminemia
- Trial name
- NCT04046263
- Testing
- Sucroferric Oxyhydroxide Chewable Tablet
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Colorado, Denver
Hospice, End-of-life Decision Making
Pilot Evaluation of Hospice Decision Support Tools
The goal of this project is to determine the feasibility and acceptability of a hospice decision aid among a diverse population of older adults at multiple stages of illness (Aim 1) and to determine the preliminary efficacy of…
- Conditions
- Hospice, End-of-life Decision Making, Hospice Decision Making
- Trial name
- NCT03794700
- Testing
- Hospice Decision Aids
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- University of Colorado, Denver
Emotional Disorder
Youth PHP Pilot Transdiagnostic Treatment Implementation and Effectiveness Study
The purpose of this study is to examine patient effectiveness outcomes of a transdiagnostic treatment for youth emotional disorders, implemented in a partial hospitalization program (PHP).
- Trial name
- PHP TIES (NCT04792151)
- Testing
- Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- University of Colorado, Denver
Mental Disorder, Child, Mental Health
Navigation and Parent Peer Support to Promote Access
Nearly one in five children in the United States has a mental health problem that interferes with daily functioning and requires intervention, and yet less than 50% of children who need mental health care receive any services.
- Conditions
- Mental Disorder, Child, Mental Health, Family Health
- Trial name
- NCT04029220
- Testing
- Parent Peer Navigation
- Where
- 4 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Contraception
Pharmacogenomics of Contraception: Genetic Variants and Etonogestrel Pharmacokinetics
The proposed study will investigate the relationship between genetic variants and serum contraceptive hormone levels, specifically the progestin etonogestrel.
- Trial name
- NCT03092037
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Primary Prevention
Using Boot Camp Translation to Address Rural Disparities in Adolescent Vaccination
The overall goal of this project is to implement the Boot Camp Translation process to develop a replicable approach for increasing adolescent vaccine uptake that can be adaptable and feasible to use in rural settings more broadly.
- Trial name
- RADVax (NCT03955757)
- Testing
- Boot Camp Translation, Control
- Where
- United States
- Volunteers
- 6,000 people
- Sponsor
- University of Colorado, Denver
Mental Health Wellness 1, Stress, Psychological
Heartfulness Meditation to Improve Resilience Among Health Care Students: A 90 Day Program
This investigation will examine the feasibility of delivery and effect on resilience, depression and anxiety of a 90-day Heartfulness Practice delivered virtually for health care students.
- Conditions
- Mental Health Wellness 1, Stress, Psychological, Depression, Anxiety
- Trial name
- HEART (NCT04790162)
- Testing
- Heartfulness Meditation
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
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