Clinical trials: sponsored by University of Copenhagen
Postprandial Hypotension, Healthy
GastroFlow: Investigation of the Gastrointestinal Blood Flow in Patients With Postprandial Hypotension
This project will describe the mechanisms of action and the relative contributions of GIP to changes in gastrointestinal blood flow induced by oral glucose and endogenous GIP with the use of a receptor antagonists GIP(3-30)NH2 in…
- Conditions
- Postprandial Hypotension, Healthy, Blood Flow
- Trial name
- Gastroflow (NCT07381816)
- Testing
- MRI + GIPR antagonist (Tool), MRI + hangrip, Saline and oral glucose
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Aging, Healthy Aging
FAXAGE: Fasting And Exercise To Slow Aging In Humans
FAXAge is a randomized controlled trial investigating the effects of fasting and exercise on human aging. 240 participants over the age of 65 will be divided into 4 groups - an exercise group, a fasting group, a combined exercise…
- Conditions
- Aging, Healthy Aging, Aging Frailty
- Trial name
- FAXAGE (NCT07207044)
- Testing
- Exercise - Strength + Cardio, Time-restricted feeding, Time-restricted feeding + Exercise
- Where
- Denmark
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Hypothyroidism Primary
Ayurvedic Diet in Myxedema
Primary hypothyroidism is diagnosed by elevated thyroid stimulating hormone (TSH) level and a reduced thyroxine (T4) level in plasma.
- Trial name
- AYUS-MYX (NCT07323706)
- Testing
- Ayurvedic diet, habitual diet
- Where
- 2 sites in Denmark
- Volunteers
- 88 people
- Sponsor
- University of Copenhagen
CKD, Renal Insufficiency Chronic
The CPH-MBD Cohort Dietary Substudy - Comparison of Methods for Dietary Registrations
The aim of the study is to assess the association between the calcium and phosphorus balance and the stage of kidney disease measured by creatinine clearence in patients with chronic kidney disease stage 4 and 5.
- Conditions
- CKD, Renal Insufficiency Chronic, CKD-MBD - Chronic Kidney Disease Mineral and Bone Disorder, Pre-dialysis
- Trial name
- NCT07312981
- Where
- 2 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- University of Copenhagen
Insulin Sensitivity
Physical Activity and Insulin Sensitivity Dynamics
The study investigates the role of one single bout of exercise in mediating enhancement of muscle insulin sensitivity following a single bout of exercise.
- Trial name
- NCT06776094
- Testing
- One-legged-knee extensor exercise, Insulin infusion, Muscle Biopsy Medication: Lidocaine
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Childhood Obesity, Well-Being, Psychological
Generation Healthy Kids: A Cluster-randomized Trial of a Multi-component, Multi-setting Intervention
The GHK intervention was developed according to the United Kingdom Medical Research Council's framework for developing and evaluating complex interventions.
- Conditions
- Childhood Obesity, Well-Being, Psychological, Physical Inactivity, Sleep
- Trial name
- GHK (NCT05940675)
- Testing
- Food and Nutrition, Physical Activity (FitFirst), Sleep and screen media
- Where
- 2 sites in Denmark
- Volunteers
- 1,372 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Sleep Duration, Child Obesity
Effect of Sleep Extension on Body Weight and Learning in Children (More2Sleep)
More2Sleep is a randomized, controlled, parallel trial with two groups (sleep extension vs control) including 142 school-aged children (6-12 years) who have a BMI above average, defined as age- and sex-specific BMI Z-score above…
- Conditions
- Sleep Duration, Child Obesity, Child Development, Child Behavior
- Trial name
- More2Sleep (NCT06341179)
- Testing
- Sleep extension
- Where
- 3 sites in Denmark
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Common Mental Disorders and/or Stress Related Symptoms
The Effectiveness of Psychological Interventions for Common Mental Disorders
The primary aim of "the Effectiveness of Psychological Interventions for Common mental disorders" (EPIC) randomized controlled trial is to investigate whether a significantly larger symptom improvement is observed after…
- Trial name
- EPIC (NCT06916429)
- Testing
- Psychotherapeutic treatment, Waiting List for Psychotherapeutic Treatment
- Where
- Denmark
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Dental Caries
3D Scanning and Transillumination vs Conventional Examination to Assess Caries Progression, Stability or Regression
The objective of this study is to investigate whether the 3D scanner and accompanying software, as well as the transillumination method, can identify changes in primary caries lesions in caries-active patients, where selected…
- Trial name
- NCT05409625
- Testing
- Intraoral Scanner (TRIOS 4, 3Shape TRIOS A/S, Copenhagen, Denmark), Intraoral camera (DIAGNOcam, KaVo, Biberach, Germany, software version 3.0.1/2.9.1), X-ray device (X-ray device SOREDEX, MINRAY®; Image plates VistaScan; Image plate scanner VistaScan Mini View, Dürr Dental)
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- University of Copenhagen
Bioavailability of Vitamin K
Bioavailability of Different Vitamin K Vitamers Studied Using 13C-labelled Vitamin K Vitamers
Objectives The main objectives are: Study part I: to investigate the bioavailability of vitamin K vitamers (PK, MK-4, MK-7 and MK-9) in humans using 13C-labelled compounds Hypotheses Study part I: it is hypothesized that there is…
- Trial name
- BioMicro (NCT07041645)
- Testing
- Vitamin K
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Postural Orthostatic Tachycardia Syndrome (POTS), Healthy
POTS-FLOW: Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS
This study will describe the interplay between the gut hormones GIP and CCK and their regulation of blood flow to the large vessels in patients with Postural Orthostatic Tachycardia Syndrome (POTS) and GIP, CCK and GLP-1 in…
- Trial name
- GA22 (NCT07019519)
- Testing
- GIPR antagonist, GLP-1R antagonist, CCK agonist
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Cerebral Palsy
Home-Based Training With Feedback to Improve Outcomes in Adolescents and Young Adults With Cerebral Palsy..
This clinical trial aims to determine whether extrinsic feedback through music enhances the effects of home-based motor training for adolescents and young adults with cerebral palsy (CP) and whether feedback improves adherence to…
- Trial name
- THRIVE-CP (NCT06962618)
- Testing
- Music Motion Group, Control
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- University of Copenhagen
Healthy
Blocking of the Gut Hormone Receptor for Glucagon-like Peptide 2 (GLP-2) by the GLP-2 Receptor Antagonist GLP-2(3-33)
This project will describe the role of physiological levels of GLP-2 in regulating the blood flow to the intestines and the effect of the antagonist GLP-2(3-33) in blocking these effects of GLP-2.
- Trial name
- GLP-2ant (NCT06774807)
- Testing
- Saline infusion, Saline injection, 1nmol antagonist infusion
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Depressive Disorder, Depression
The Danish Neuropsychological Study of the Adverse Effects of ECT
The main purpose of this study is to investigate the adverse cognitive side-effects of electroconvulsive therapy (ECT). The second aim is to investigate the mechanisms of effect of ECT.
- Conditions
- Depressive Disorder, Depression, Cognitive Dysfunction, Electroconvulsive Therapy
- Trial name
- DANSECT (NCT04160286)
- Testing
- Electroconvulsive therapy
- Where
- Denmark
- Volunteers
- 73 people
- Sponsor
- University of Copenhagen
Micronutrient Status
Bioavailability of Micronutrients With a Special Focus on Vitamin K Dependent on Consumed Diet
Objectives The main objectives are: Study part II: to investigate the effect of a plant-based diet on micronutrient status compared to an average Danish diet Hypotheses Study part II: it is hypothesised that the status of some…
- Trial name
- BioMicro (NCT06921018)
- Testing
- change in diet
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy
Muscle Anabolic Response to β2-adrenergic Stimulation With Increased Amino Acid Availability.
The purpose of the project is to investigate the effect of amino acid availability on the muscle anabolic response to beta2-adrenergic stimulation in young healthy men and women.
- Trial name
- NCT06654986
- Testing
- Salmeterol + amino acid availability
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy
Urinary Concentration After Salmeterol
The purpose of the project is to investigate urine concentration after inhalation of salmeterol. This will be examined following acute physical activity under both normal conditions and heated conditions.
- Trial name
- NCT06657547
- Testing
- Normal conditions, Heated conditions, Salmeterol inhalation and urine samples
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- University of Copenhagen
Healthy
Salmeterol Effect on Exercise Performance
The purpose of the project is to investigate the muscle anabolic response to acute beta2-adrenergic stimulation in young healthy men and women.
- Trial name
- NCT06655012
- Testing
- Salmeterol
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Nutrition, Healthy, Heart Failure
The Effect of Medium-chain Fatty Acids on Cardiac Function
The effect of an acute intake of medium-chain fatty acids on heart function measured by cardiac magnetic resonance imaging (CMR) will be measured in individuals with heart failure with reduced ejection fraction (HFrEF) and in…
- Trial name
- MediHeart (NCT06399354)
- Testing
- acute intake of medium-chain fatty acids or long-chain fatty acids in patients, Acute intake of medium-chain fatty acids or long-chain fatty acids in healthy individuals
- Where
- Denmark
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Diet, Healthy, Metabolic Disease
Effects of Changing Intestinal Transit Time on Gut Microbial Composition and Metabolism
The aim of this study is to investigate how a short versus a long transit time impacts the gut microbiome's response to a high-fiber and a low-fiber diet, respectively.
- Trial name
- PRIMA-KOST (NCT06022302)
- Testing
- Diet + laxative, Diet only
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen