Clinical trials: sponsored by University of Edinburgh
Gastrointestinal Cancer, Cancer of Unknown Primary Site
Study to Compare Cardiovascular Side Effects of Teysuno Versus Capecitabine
Capecitabine is a chemotherapy drug used to treat many types of cancer including bowel and stomach cancer. Unfortunately a side effect of this drug is that it causes heart problems including heart attacks.
- Conditions
- Gastrointestinal Cancer, Cancer of Unknown Primary Site, Pancreatic Cancer, Bile Duct Neoplasms
- Trial name
- TOFFEE (NCT01845337)
- Testing
- Teysuno, Capecitabine
- Where
- United Kingdom
- Volunteers
- 59 people
- Sponsor
- University of Edinburgh
Chronic Kidney Diseases, Cardiovascular Diseases
Apelin as a Potential Treatment for Chronic Kidney Disease
Chronic kidney disease (CKD) affects 8-16% of the world's population, and is independently associated with cardiovascular disease (CVD).
- Conditions
- Chronic Kidney Diseases, Cardiovascular Diseases, Endothelial Dysfunction
- Trial name
- AlPaCKa (NCT03956576)
- Testing
- [Pyr]apelin-13
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Psychological Adjustment, Compassion
Rebalance: Compassion Focused Therapy in a Transdiagnostic Health Group
This study evaluates the use of group Compassion Focussed Therapy in a population with various and/or multiple long term health conditions.
- Conditions
- Psychological Adjustment, Compassion, Chronic Disease
- Trial name
- NCT04040972
- Testing
- Compassion Focussed Therapy
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University of Edinburgh
Lung Disease
Sensing Using Neutrophil Activation Probe on the Intensive Therapy Unit
Critically ill patients often succumb to acute respiratory disease (rapidly developing disease affecting the lungs). The lungs are the commonest organ to fail and require support in the intensive care environment.
- Trial name
- SNAP-IT (NCT02804854)
- Testing
- Neutrophil Activation Probe (NAP)
- Where
- 2 sites in United Kingdom
- Volunteers
- 11 people
- Sponsor
- University of Edinburgh
Sleep Disorder Rem Sleep Behavior, Parkinson's Disease, Lewy Body
Establishing Alpha-synuclein RT-QuIC Assay as a Diagnostic Technique in REM Sleep Behaviour Disorder
We hypothesise that a real-time quaking induced conversion assay for the detection of pathological alpha-synuclein (α -syn RTQuIC) can be used to differentiate between cases of idiopathic REM-sleep behaviour disorder (RBD) and…
- Trial name
- NCT04266457
- Testing
- No Intervention
- Where
- United Kingdom
- Sponsor
- University of Edinburgh
Chemotherapy-induced Peripheral Neuropathy
Menthol In Neuropathy Trial
Patients will be recruited who have peripheral neuropathy due to chemotherapy. They will be given a blinded treatment of gel containing either menthol (3%) or placebo to be applied for 6 weeks, twice a day.
- Trial name
- MINT (NCT04276727)
- Testing
- MINT study IMP
- Where
- 2 sites in United Kingdom
- Volunteers
- 52 people
- Sponsor
- University of Edinburgh
Breast Cancer
Microwave Radiometry for the Diagnosis and Monitoring of Breast Cancer
A malignant tumor has higher temperature than normal tissue and the temperature of the tumor is dependent on the tumor growth rate. Thus tumor temperature is the universal indicator of tumor activity.
- Trial name
- RTM (NCT02514837)
- Testing
- RTM
- Sponsor
- University of Edinburgh
Myocardial Infarction, Acute, Myocardial Ischemia
Determining the Mechanism of Myocardial Injury and Role of Coronary Disease in Type 2 Myocardial Infarction
Myocardial injury is common in patients without acute coronary syndrome, and therefore international guidelines propose a classification of patients with myocardial infarction by aetiology.
- Conditions
- Myocardial Infarction, Acute, Myocardial Ischemia, Myocardial Injury
- Trial name
- DEMAND-MI (NCT03338504)
- Testing
- Invasive coronary angiography, CT coronary angiography, Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Edinburgh
Large Vessel Vasculitis
Monitoring Large Vessel Vasculitis With PET/MR Imaging
Large vessel vasculitis (LVV) causes blood vessel inflammation leading to pain, fatigue and complications such as aneurysm formation and stroke. Treatments used can have significant side-effects.
- Trial name
- NCT03914248
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- University of Edinburgh
Intracranial Hemorrhages, Intracranial Hemorrhage, Hypertensive
Start or STop Anticoagulants Randomised Trial (SoSTART)
Primary research question: For adults surviving spontaneous (non-traumatic) symptomatic intracranial haemorrhage with persistent/paroxysmal atrial fibrillation/flutter (AF), does starting full treatment dose oral anticoagulation…
- Conditions
- Intracranial Hemorrhages, Intracranial Hemorrhage, Hypertensive, Subarachnoid Hemorrhage, Subdural Hematoma
- Trial name
- SoSTART (NCT03153150)
- Testing
- Apixaban, Rivaroxaban, Edoxaban
- Where
- 67 sites in United Kingdom
- Volunteers
- 203 people
- Sponsor
- University of Edinburgh
Pancreatitis, Acute
Resolution of Organ Injury in Acute Pancreatitis - RESORP
Acute pancreatitis (AP) is inflammation of the pancreas usually triggered by gallstones or drinking excessive alcohol. 80% of people who have an episode of AP will recover without complications.
- Trial name
- RESORP (NCT03342716)
- Where
- United Kingdom
- Volunteers
- 229 people
- Sponsor
- University of Edinburgh
Type 1 Diabetes
Pancreatic Calcium Handling in Islet Beta Cells in Patients With Type 1 Diabetes Mellitus
Approximately 400,000 people are living with type 1 diabetes mellitus (T1DM) in the United Kingdom: one of the highest rates in the world.
- Trial name
- Pancreas MEMRI (NCT05298735)
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Premature Infant, Hypoxia
Measuring Oxygenation of Newborn Infants in Targeted Oxygen Ranges
The investigators aim to measure the effect of targeting premature babies to a slightly higher oxygen saturation target range (92-97%) than routinely used, for a brief period, to plan a future larger study of the effect of this…
- Conditions
- Premature Infant, Hypoxia, Hyperoxia
- Trial name
- MONITOR (NCT03360292)
- Testing
- Higher target range
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Edinburgh
Premature Infant, Oxygen Therapy
Servo Controlled Oxygen Targeting Study
Most premature babies require oxygen therapy. There is uncertainty about what oxygen levels are the best. The oxygen levels in the blood are measured using a monitor called a saturation monitor and the oxygen the baby breathes is…
- Conditions
- Premature Infant, Oxygen Therapy, Hypoxia, Hyperoxia
- Trial name
- SCO2T (NCT04177992)
- Testing
- Servo control
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Edinburgh
Hypertension, Blood Pressure
REtinaL Imaging & Ambulatory BLood PrEssure
High blood pressure is a common condition which generally does not have any symptoms. Its estimated that around one third of people with high blood pressure do not know they have it.
- Trial name
- RELIABLE (NCT04118205)
- Where
- United Kingdom
- Volunteers
- 591 people
- Sponsor
- University of Edinburgh
Acute Aortic Syndrome, Aortic Dissection
18F Sodium Fluoride PET/CT in Acute Aortic Syndrome
The purpose of this study is to determine whether Sodium Fluoride imaging (using Positron Emission Tomography-Computed Tomography - PET-CT) is able to predict disease progression in acute aortic syndrome.
- Conditions
- Acute Aortic Syndrome, Aortic Dissection, Penetrating Aortic Ulcer, Intramural Hematoma
- Trial name
- FAASt (NCT03647566)
- Testing
- 18F Sodium Fluoride Positron Emission Tomography / Computed Tomography, CT Aortic Angiogram, Aortic MRI
- Where
- United Kingdom
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Antenatal Depression
Enjoy Your Bump - Implementation Study
Enjoy Your Bump is an implementation study relating to antenatal maternal mental health in women who have mild to moderate feelings of depression and anxiety.
- Trial name
- NCT04700501
- Testing
- Enjoy Your Bump - CBT life skills learning programme
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Pneumonia, Perception, Self
Pneumonia Perception Project-Pakistan
Pneumonia and recurrent wheeze contribute extensively to under five childhood morbidity and mortality in Pakistan. Among the avoidable causes of death due to these diseases, delayed care seeking is a major one whereby around 38%…
- Trial name
- NCT03756259
- Testing
- Mobile Health (mHealth) for Pneumonia
- Where
- Pakistan
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Psychosis
Improving Psychological Therapy for Psychosis: A Case Series
Standard psychological therapy for psychosis (Cognitive Behavioural Therapy) is made up of different 'ingredients', also called treatment components.
- Trial name
- NCT03920384
- Testing
- Experimental intervention arm, Active control arm
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- University of Edinburgh
Eyelid Ptoses
The Effect of Varying Brightness on Palpebral Aperture
We aim to establish the point at which glare from bright lights begins to engage our eyelids - causing us to "squint". We will be using a video camera with an LED ring light around it facing the volunteer and we will record the…
- Trial name
- NCT05210491
- Testing
- Review of eyelid positioning in increasing brightness levels
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh